int-snw-9169

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.923 1.82e-16 1.62e-04 1.56e-03
chia-screen-data-Fav-int-snw-9169 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
[ SCAF11 ] 9169 1-1.5802.92310--
TPR 7175 18-2.6383.07228YesYes
PSMD2 5708 47-4.1723.157386YesYes
LARS 51520 14-2.5743.157105YesYes
MED19 219541 30-2.6573.449115Yes-
PXN 5829 19-2.5543.193206YesYes
ZNF43 7594 4-2.5552.9231YesYes
LUC7L3 51747 33-3.5233.44918Yes-
ODF2 4957 4-2.5682.9233YesYes
PHB 5245 15-2.7433.004127YesYes
APC 324 13-2.2933.004353Yes-
SRSF3 6428 73-2.9923.53854Yes-
POU5F1 5460 133-5.1483.538179YesYes

Interactions (13)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
APC 324 PHB 5245 pp -- int.I2D: Jorgensen_EphR
APC 324 PXN 5829 pp -- int.I2D: MINT, MINT_Mouse;
int.Mint: MI:0914(association)
APC 324 SCAF11 9169 pp -- int.I2D: SOURAV_MAPK_LOW
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
PXN 5829 SRSF3 6428 pp -- int.I2D: BIND
APC 324 ZNF43 7594 pp -- int.I2D: IntAct, SOURAV_MAPK_LOW
APC 324 LARS 51520 pp -- int.I2D: Jorgensen_EphR
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
SRSF3 6428 SCAF11 9169 pp -- int.I2D: BioGrid, HPRD
APC 324 ODF2 4957 pp -- int.I2D: IntAct, SOURAV_MAPK_LOW
PSMD2 5708 LARS 51520 pp -- int.I2D: BioGrid_Yeast
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
APC 324 TPR 7175 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct, SOURAV_MAPK_HIGH

Related GO terms (260)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005634nucleus1.23e-041.00e+001.421111594559
GO:0007094mitotic spindle assembly checkpoint3.44e-041.00e+006.1612331
GO:0035019somatic stem cell maintenance5.74e-041.00e+005.7942640
GO:1901673regulation of spindle assembly involved in mitosis9.01e-041.00e+0010.116111
GO:0043578nuclear matrix organization9.01e-041.00e+0010.116111
GO:0010965regulation of mitotic sister chromatid separation9.01e-041.00e+0010.116111
GO:0051435BH4 domain binding9.01e-041.00e+0010.116111
GO:0006404RNA import into nucleus9.01e-041.00e+0010.116111
GO:0090308regulation of methylation-dependent chromatin silencing9.01e-041.00e+0010.116111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway9.01e-041.00e+0010.116111
GO:0060965negative regulation of gene silencing by miRNA9.01e-041.00e+0010.116111
GO:0042483negative regulation of odontogenesis9.01e-041.00e+0010.116111
GO:0060795cell fate commitment involved in formation of primary germ layer9.01e-041.00e+0010.116111
GO:0051171regulation of nitrogen compound metabolic process9.01e-041.00e+0010.116111
GO:0031453positive regulation of heterochromatin assembly9.01e-041.00e+0010.116111
GO:0008380RNA splicing9.92e-041.00e+003.868322228
GO:0008013beta-catenin binding1.29e-031.00e+005.2092960
GO:0000776kinetochore1.42e-031.00e+005.1382563
GO:0044822poly(A) RNA binding1.63e-031.00e+002.3935501056
GO:0006429leucyl-tRNA aminoacylation1.80e-031.00e+009.116112
GO:0031990mRNA export from nucleus in response to heat stress1.80e-031.00e+009.116122
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process1.80e-031.00e+009.116112
GO:0009786regulation of asymmetric cell division1.80e-031.00e+009.116112
GO:0070840dynein complex binding1.80e-031.00e+009.116112
GO:0046832negative regulation of RNA export from nucleus1.80e-031.00e+009.116112
GO:0000189MAPK import into nucleus1.80e-031.00e+009.116112
GO:0004823leucine-tRNA ligase activity1.80e-031.00e+009.116112
GO:0009798axis specification1.80e-031.00e+009.116112
GO:0005654nucleoplasm1.82e-031.00e+002.3585641082
GO:0003729mRNA binding1.85e-031.00e+004.9462472
GO:0005515protein binding2.00e-031.00e+001.019111986024
GO:0042306regulation of protein import into nucleus2.70e-031.00e+008.531123
GO:0060913cardiac cell fate determination2.70e-031.00e+008.531113
GO:0006405RNA export from nucleus2.70e-031.00e+008.531123
GO:0003130BMP signaling pathway involved in heart induction2.70e-031.00e+008.531113
GO:0006999nuclear pore organization3.60e-031.00e+008.116114
GO:0044615nuclear pore nuclear basket3.60e-031.00e+008.116114
GO:0019887protein kinase regulator activity3.60e-031.00e+008.116114
GO:0001714endodermal cell fate specification4.50e-031.00e+007.794115
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint4.50e-031.00e+007.794115
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process4.50e-031.00e+007.794125
GO:0010793regulation of mRNA export from nucleus4.50e-031.00e+007.794115
GO:0070849response to epidermal growth factor4.50e-031.00e+007.794115
GO:0000278mitotic cell cycle4.62e-031.00e+003.090315391
GO:0030858positive regulation of epithelial cell differentiation5.40e-031.00e+007.531116
GO:0050847progesterone receptor signaling pathway5.40e-031.00e+007.531126
GO:0001520outer dense fiber5.40e-031.00e+007.531116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway5.40e-031.00e+007.531116
GO:0030027lamellipodium5.46e-031.00e+004.15027125
GO:0006366transcription from RNA polymerase II promoter5.60e-031.00e+002.990330419
GO:0007091metaphase/anaphase transition of mitotic cell cycle6.29e-031.00e+007.308127
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development6.29e-031.00e+007.308117
GO:0046825regulation of protein export from nucleus6.29e-031.00e+007.308127
GO:0071354cellular response to interleukin-66.29e-031.00e+007.308127
GO:0051988regulation of attachment of spindle microtubules to kinetochore6.29e-031.00e+007.308127
GO:0002161aminoacyl-tRNA editing activity6.29e-031.00e+007.308127
GO:0045670regulation of osteoclast differentiation7.19e-031.00e+007.116128
GO:0051292nuclear pore complex assembly7.19e-031.00e+007.116148
GO:0035457cellular response to interferon-alpha7.19e-031.00e+007.116118
GO:0007172signal complex assembly7.19e-031.00e+007.116118
GO:0060396growth hormone receptor signaling pathway7.19e-031.00e+007.116118
GO:0042981regulation of apoptotic process7.77e-031.00e+003.88724150
GO:0045667regulation of osteoblast differentiation8.09e-031.00e+006.946119
GO:0042405nuclear inclusion body8.09e-031.00e+006.946129
GO:0006450regulation of translational fidelity8.09e-031.00e+006.946129
GO:0043495protein anchor8.09e-031.00e+006.946119
GO:0010944negative regulation of transcription by competitive promoter binding8.09e-031.00e+006.946119
GO:0031274positive regulation of pseudopodium assembly8.98e-031.00e+006.7941210
GO:0035413positive regulation of catenin import into nucleus8.98e-031.00e+006.7941210
GO:0030877beta-catenin destruction complex8.98e-031.00e+006.7941210
GO:0044212transcription regulatory region DNA binding9.67e-031.00e+003.723217168
GO:0051010microtubule plus-end binding9.87e-031.00e+006.6561111
GO:0017166vinculin binding9.87e-031.00e+006.6561111
GO:0031116positive regulation of microtubule polymerization9.87e-031.00e+006.6561111
GO:0060391positive regulation of SMAD protein import into nucleus9.87e-031.00e+006.6561411
GO:0016607nuclear speck1.01e-021.00e+003.689212172
GO:0032886regulation of microtubule-based process1.08e-021.00e+006.5311112
GO:0045947negative regulation of translational initiation1.08e-021.00e+006.5311212
GO:0045295gamma-catenin binding1.08e-021.00e+006.5311112
GO:0034399nuclear periphery1.08e-021.00e+006.5311512
GO:0005838proteasome regulatory particle1.08e-021.00e+006.5311112
GO:0035198miRNA binding1.08e-021.00e+006.5311112
GO:0042789mRNA transcription from RNA polymerase II promoter1.17e-021.00e+006.4151213
GO:0060766negative regulation of androgen receptor signaling pathway1.17e-021.00e+006.4151313
GO:0044295axonal growth cone1.17e-021.00e+006.4151113
GO:0051019mitogen-activated protein kinase binding1.17e-021.00e+006.4151213
GO:0043409negative regulation of MAPK cascade1.17e-021.00e+006.4151213
GO:0005868cytoplasmic dynein complex1.17e-021.00e+006.4151113
GO:0030234enzyme regulator activity1.17e-021.00e+006.4151213
GO:0046827positive regulation of protein export from nucleus1.17e-021.00e+006.4151113
GO:0035371microtubule plus-end1.26e-021.00e+006.3081114
GO:0005685U1 snRNP1.26e-021.00e+006.3081114
GO:0034614cellular response to reactive oxygen species1.26e-021.00e+006.3081214
GO:0005487nucleocytoplasmic transporter activity1.26e-021.00e+006.3081314
GO:0042307positive regulation of protein import into nucleus1.34e-021.00e+006.2091415
GO:0001824blastocyst development1.34e-021.00e+006.2091215
GO:0006376mRNA splice site selection1.34e-021.00e+006.2091115
GO:0007026negative regulation of microtubule depolymerization1.43e-021.00e+006.1161116
GO:0042176regulation of protein catabolic process1.43e-021.00e+006.1161216
GO:0046716muscle cell cellular homeostasis1.43e-021.00e+006.1161116
GO:0043274phospholipase binding1.43e-021.00e+006.1161116
GO:0051276chromosome organization1.43e-021.00e+006.1161216
GO:0090316positive regulation of intracellular protein transport1.52e-021.00e+006.0281217
GO:0022624proteasome accessory complex1.52e-021.00e+006.0281117
GO:0031122cytoplasmic microtubule organization1.61e-021.00e+005.9461118
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity1.70e-021.00e+005.8681219
GO:0000245spliceosomal complex assembly1.88e-021.00e+005.7231221
GO:0048041focal adhesion assembly1.88e-021.00e+005.7231121
GO:0009954proximal/distal pattern formation1.88e-021.00e+005.7231121
GO:0016575histone deacetylation1.88e-021.00e+005.7231321
GO:0000281mitotic cytokinesis1.88e-021.00e+005.7231221
GO:0010467gene expression2.01e-021.00e+002.315345669
GO:0045296cadherin binding2.14e-021.00e+005.5311324
GO:1902017regulation of cilium assembly2.14e-021.00e+005.5311224
GO:0006611protein export from nucleus2.23e-021.00e+005.4721325
GO:0000375RNA splicing, via transesterification reactions2.23e-021.00e+005.4721325
GO:0072372primary cilium2.32e-021.00e+005.4151126
GO:0048754branching morphogenesis of an epithelial tube2.41e-021.00e+005.3611127
GO:0015631tubulin binding2.41e-021.00e+005.3611227
GO:0005875microtubule associated complex2.50e-021.00e+005.3081128
GO:0034605cellular response to heat2.50e-021.00e+005.3081128
GO:0070830tight junction assembly2.50e-021.00e+005.3081128
GO:0071897DNA biosynthetic process2.50e-021.00e+005.3081128
GO:0005913cell-cell adherens junction2.58e-021.00e+005.2581329
GO:0030032lamellipodium assembly2.58e-021.00e+005.2581129
GO:0072686mitotic spindle2.58e-021.00e+005.2581329
GO:0006606protein import into nucleus2.67e-021.00e+005.2091230
GO:0031647regulation of protein stability2.67e-021.00e+005.2091430
GO:0010827regulation of glucose transport2.67e-021.00e+005.2091430
GO:0009953dorsal/ventral pattern formation2.76e-021.00e+005.1611231
GO:0033077T cell differentiation in thymus2.94e-021.00e+005.0711133
GO:0031072heat shock protein binding2.94e-021.00e+005.0711233
GO:0001104RNA polymerase II transcription cofactor activity2.94e-021.00e+005.0711833
GO:0005737cytoplasm3.06e-021.00e+001.04471243767
GO:0016592mediator complex3.11e-021.00e+004.98611035
GO:0001942hair follicle development3.11e-021.00e+004.9861235
GO:0007077mitotic nuclear envelope disassembly3.20e-021.00e+004.9461436
GO:0019901protein kinase binding3.20e-021.00e+002.807218317
GO:0034446substrate adhesion-dependent cell spreading3.20e-021.00e+004.9461236
GO:0048538thymus development3.20e-021.00e+004.9461236
GO:0005813centrosome3.37e-021.00e+002.76727326
GO:0008645hexose transport3.46e-021.00e+004.8301439
GO:0051781positive regulation of cell division3.46e-021.00e+004.8301139
GO:0005881cytoplasmic microtubule3.55e-021.00e+004.7941140
GO:0045785positive regulation of cell adhesion3.55e-021.00e+004.7941240
GO:0007286spermatid development3.63e-021.00e+004.7581141
GO:0006418tRNA aminoacylation for protein translation3.72e-021.00e+004.7231342
GO:0031124mRNA 3'-end processing3.72e-021.00e+004.7231242
GO:0019898extrinsic component of membrane3.72e-021.00e+004.7231242
GO:0008285negative regulation of cell proliferation3.90e-021.00e+002.652210353
GO:0006369termination of RNA polymerase II transcription3.98e-021.00e+004.6241245
GO:0016328lateral plasma membrane4.07e-021.00e+004.5921346
GO:0006921cellular component disassembly involved in execution phase of apoptosis4.16e-021.00e+004.5611247
GO:0005925focal adhesion4.16e-021.00e+002.60029366
GO:0007155cell adhesion4.23e-021.00e+002.58825369
GO:0006521regulation of cellular amino acid metabolic process4.42e-021.00e+004.4721150
GO:0045732positive regulation of protein catabolic process4.42e-021.00e+004.4721150
GO:0060041retina development in camera-type eye4.50e-021.00e+004.4431251
GO:0009611response to wounding4.59e-021.00e+004.4151552
GO:0015758glucose transport4.85e-021.00e+004.3341455
GO:0001725stress fiber4.85e-021.00e+004.3341455
GO:0036064ciliary basal body5.02e-021.00e+004.2831257
GO:0005643nuclear pore5.02e-021.00e+004.28311157
GO:0000502proteasome complex5.11e-021.00e+004.2581358
GO:0006406mRNA export from nucleus5.36e-021.00e+004.1851461
GO:0006355regulation of transcription, DNA-templated5.59e-021.00e+001.739343997
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.62e-021.00e+004.1161164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.71e-021.00e+004.0931265
GO:0007409axonogenesis5.71e-021.00e+004.0931265
GO:0005829cytosol5.88e-021.00e+001.1525862496
GO:0010468regulation of gene expression5.96e-021.00e+004.0281268
GO:0034329cell junction assembly5.96e-021.00e+004.0281368
GO:0032587ruffle membrane6.13e-021.00e+003.9861370
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.13e-021.00e+003.9861270
GO:0042826histone deacetylase binding6.30e-021.00e+003.9461472
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.30e-021.00e+003.9461172
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity6.47e-021.00e+003.9061474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.47e-021.00e+003.9061274
GO:0060070canonical Wnt signaling pathway6.56e-021.00e+003.8871475
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.56e-021.00e+003.8871175
GO:0017137Rab GTPase binding6.64e-021.00e+003.8681176
GO:0001822kidney development6.81e-021.00e+003.8301378
GO:0007229integrin-mediated signaling pathway6.81e-021.00e+003.8301378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.89e-021.00e+003.8121279
GO:0005814centriole6.89e-021.00e+003.8121279
GO:0009653anatomical structure morphogenesis7.23e-021.00e+003.7411283
GO:0009952anterior/posterior pattern specification7.23e-021.00e+003.7411483
GO:0005923tight junction7.48e-021.00e+003.6891286
GO:0090090negative regulation of canonical Wnt signaling pathway7.48e-021.00e+003.6891886
GO:0000922spindle pole7.57e-021.00e+003.6731487
GO:0006936muscle contraction7.57e-021.00e+003.6731387
GO:0000187activation of MAPK activity7.82e-021.00e+003.6241390
GO:0007010cytoskeleton organization7.90e-021.00e+003.6081491
GO:0006928cellular component movement7.90e-021.00e+003.6081391
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.99e-021.00e+003.5921192
GO:0001649osteoblast differentiation7.99e-021.00e+003.5921592
GO:0016032viral process8.15e-021.00e+002.055226534
GO:0005178integrin binding8.32e-021.00e+003.5311496
GO:0006915apoptotic process8.71e-021.00e+001.999212555
GO:0008360regulation of cell shape8.90e-021.00e+003.42914103
GO:0005938cell cortex8.98e-021.00e+003.41515104
GO:0003677DNA binding9.07e-021.00e+001.4503491218
GO:0000122negative regulation of transcription from RNA polymerase II promoter9.12e-021.00e+001.961237570
GO:0030308negative regulation of cell growth9.48e-021.00e+003.33416110
GO:0006461protein complex assembly9.56e-021.00e+003.32114111
GO:0005635nuclear envelope9.72e-021.00e+003.29515113
GO:0000209protein polyubiquitination9.97e-021.00e+003.25813116
GO:0007050cell cycle arrest1.06e-011.00e+003.16115124
GO:0007179transforming growth factor beta receptor signaling pathway1.09e-011.00e+003.116111128
GO:0016477cell migration1.09e-011.00e+003.11614128
GO:0030335positive regulation of cell migration1.09e-011.00e+003.12715127
GO:0005215transporter activity1.11e-011.00e+003.09313130
GO:0018108peptidyl-tyrosine phosphorylation1.13e-011.00e+003.07114132
GO:0000086G2/M transition of mitotic cell cycle1.16e-011.00e+003.02814136
GO:0008017microtubule binding1.25e-011.00e+002.91612147
GO:0000082G1/S transition of mitotic cell cycle1.26e-011.00e+002.89613149
GO:0005198structural molecule activity1.27e-011.00e+002.88713150
GO:0006974cellular response to DNA damage stimulus1.28e-011.00e+002.87717151
GO:0003700sequence-specific DNA binding transcription factor activity1.29e-011.00e+001.666239699
GO:0006397mRNA processing1.35e-011.00e+002.794110160
GO:0000398mRNA splicing, via spliceosome1.38e-011.00e+002.758115164
GO:0031965nuclear membrane1.41e-011.00e+002.723110168
GO:0034641cellular nitrogen compound metabolic process1.44e-011.00e+002.69812171
GO:0005667transcription factor complex1.47e-011.00e+002.664117175
GO:0031625ubiquitin protein ligase binding1.49e-011.00e+002.64015178
GO:0007173epidermal growth factor receptor signaling pathway1.58e-011.00e+002.55315189
GO:0005730nucleolus1.77e-011.00e+001.0203661641
GO:0019221cytokine-mediated signaling pathway1.82e-011.00e+002.32818221
GO:0016071mRNA metabolic process1.83e-011.00e+002.31518223
GO:0007067mitotic nuclear division1.86e-011.00e+002.28916227
GO:0007165signal transduction1.95e-011.00e+001.291213907
GO:0008134transcription factor binding1.98e-011.00e+002.197118242
GO:0016070RNA metabolic process2.01e-011.00e+002.16718247
GO:0005874microtubule2.03e-011.00e+002.15617249
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13318253
GO:0000166nucleotide binding2.10e-011.00e+002.099113259
GO:0006357regulation of transcription from RNA polymerase II promoter2.14e-011.00e+002.071123264
GO:0043065positive regulation of apoptotic process2.16e-011.00e+002.05017268
GO:0005743mitochondrial inner membrane2.23e-011.00e+002.00216277
GO:0019899enzyme binding2.23e-011.00e+002.00219277
GO:0008270zinc ion binding2.25e-011.00e+001.154227997
GO:0007275multicellular organismal development2.50e-011.00e+001.81217316
GO:0003682chromatin binding2.58e-011.00e+001.762119327
GO:0003723RNA binding2.68e-011.00e+001.698118342
GO:0043565sequence-specific DNA binding2.71e-011.00e+001.681111346
GO:0044281small molecule metabolic process2.99e-011.00e+000.8742201211
GO:0045892negative regulation of transcription, DNA-templated3.15e-011.00e+001.426124413
GO:0043066negative regulation of apoptotic process3.22e-011.00e+001.388116424
GO:0055085transmembrane transport3.29e-011.00e+001.35118435
GO:0045893positive regulation of transcription, DNA-templated3.55e-011.00e+001.215124478
GO:0005886plasma membrane4.19e-011.00e+000.3663492582
GO:0042803protein homodimerization activity4.22e-011.00e+000.899119595
GO:0016020membrane4.58e-011.00e+000.4012461681
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.19e-011.00e+000.492141789
GO:0005887integral component of plasma membrane5.62e-011.00e+000.321110888
GO:0005739mitochondrion6.06e-011.00e+000.153123998
GO:0070062extracellular vesicular exosome6.63e-011.00e+00-0.1132572400
GO:0005524ATP binding7.07e-011.00e+00-0.2261311298
GO:0046872metal ion binding7.09e-011.00e+00-0.2361291307
GO:0006351transcription, DNA-templated7.47e-011.00e+00-0.3821571446