int-snw-89870

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.862	8.56e-16	3.51e-04	2.70e-03

chia-screen-data-Fav-int-snw-89870 subnetwork

Genes (13)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
MED13L	23389	12	-2.550	3.159	21	Yes	-
GJA8	2703	1	-2.483	2.862	3	Yes	Yes
MED24	9862	6	-2.482	3.033	39	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
[ TRIM15 ]	89870	1	-1.450	2.862	9	-	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
MED7	9443	2	-1.913	3.137	37	-	-
MED14	9282	6	-2.420	3.137	49	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes

Interactions (19)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED24	9862	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
MED24	9862	MED28	80306	pp	--	int.I2D: BioGrid
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED7	9443	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MED14	9282	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED7	9443	MED28	80306	pp	--	int.I2D: BioGrid
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED14	9282	MED28	80306	pp	--	int.I2D: BioGrid
GJA8	2703	MED14	9282	pp	--	int.I2D: BioGrid
MED14	9282	MED7	9443	pp	--	int.I2D: BioGrid
MED7	9443	TRIM15	89870	pp	--	int.I2D: BioGrid; int.Ravasi: -
MED13L	23389	MED28	80306	pp	--	int.I2D: BioGrid
MED13L	23389	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED14	9282	MED24	9862	pp	--	int.I2D: BioGrid

Related GO terms (125)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016592	mediator complex	2.20e-13	3.18e-09	7.571	6	10	35
GO:0001104	RNA polymerase II transcription cofactor activity	5.80e-11	8.37e-07	7.393	5	8	33
GO:0019827	stem cell maintenance	6.93e-08	9.99e-04	6.561	4	7	47
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.26e-06	3.26e-02	4.393	5	23	264
GO:0005654	nucleoplasm	1.51e-05	2.17e-01	2.844	7	64	1082
GO:0006367	transcription initiation from RNA polymerase II promoter	1.68e-05	2.42e-01	4.592	4	22	184
GO:0006366	transcription from RNA polymerase II promoter	2.14e-05	3.09e-01	3.727	5	30	419
GO:0003713	transcription coactivator activity	4.52e-05	6.52e-01	4.227	4	24	237
GO:0030518	intracellular steroid hormone receptor signaling pathway	6.78e-05	9.78e-01	7.308	2	6	14
GO:0042809	vitamin D receptor binding	7.82e-05	1.00e+00	7.209	2	6	15
GO:0010467	gene expression	1.99e-04	1.00e+00	3.052	5	45	669
GO:0046966	thyroid hormone receptor binding	2.41e-04	1.00e+00	6.415	2	6	26
GO:0030521	androgen receptor signaling pathway	6.03e-04	1.00e+00	5.758	2	5	41
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	6.63e-04	1.00e+00	5.689	2	7	43
GO:0003712	transcription cofactor activity	6.94e-04	1.00e+00	5.656	2	8	44
GO:0060795	cell fate commitment involved in formation of primary germ layer	9.01e-04	1.00e+00	10.116	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	9.01e-04	1.00e+00	10.116	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	9.01e-04	1.00e+00	10.116	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	9.01e-04	1.00e+00	10.116	1	1	1
GO:0019046	release from viral latency	1.80e-03	1.00e+00	9.116	1	2	2
GO:1901253	negative regulation of intracellular transport of viral material	1.80e-03	1.00e+00	9.116	1	1	2
GO:0009786	regulation of asymmetric cell division	1.80e-03	1.00e+00	9.116	1	1	2
GO:0060242	contact inhibition	1.80e-03	1.00e+00	9.116	1	1	2
GO:0060913	cardiac cell fate determination	2.70e-03	1.00e+00	8.531	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.70e-03	1.00e+00	8.531	1	1	3
GO:0007500	mesodermal cell fate determination	2.70e-03	1.00e+00	8.531	1	1	3
GO:0051151	negative regulation of smooth muscle cell differentiation	3.60e-03	1.00e+00	8.116	1	1	4
GO:1900246	positive regulation of RIG-I signaling pathway	3.60e-03	1.00e+00	8.116	1	1	4
GO:0070461	SAGA-type complex	4.50e-03	1.00e+00	7.794	1	2	5
GO:0001714	endodermal cell fate specification	4.50e-03	1.00e+00	7.794	1	1	5
GO:0015267	channel activity	6.29e-03	1.00e+00	7.308	1	1	7
GO:0070688	MLL5-L complex	7.19e-03	1.00e+00	7.116	1	1	8
GO:0043254	regulation of protein complex assembly	7.19e-03	1.00e+00	7.116	1	1	8
GO:0005243	gap junction channel activity	7.19e-03	1.00e+00	7.116	1	1	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	8.09e-03	1.00e+00	6.946	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	8.09e-03	1.00e+00	6.946	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	8.09e-03	1.00e+00	6.946	1	5	9
GO:0048188	Set1C/COMPASS complex	8.09e-03	1.00e+00	6.946	1	4	9
GO:0035413	positive regulation of catenin import into nucleus	8.98e-03	1.00e+00	6.794	1	2	10
GO:0044212	transcription regulatory region DNA binding	9.67e-03	1.00e+00	3.723	2	17	168
GO:0006355	regulation of transcription, DNA-templated	9.80e-03	1.00e+00	2.154	4	43	997
GO:0060391	positive regulation of SMAD protein import into nucleus	9.87e-03	1.00e+00	6.656	1	4	11
GO:0016607	nuclear speck	1.01e-02	1.00e+00	3.689	2	12	172
GO:0005667	transcription factor complex	1.05e-02	1.00e+00	3.664	2	17	175
GO:0035198	miRNA binding	1.08e-02	1.00e+00	6.531	1	1	12
GO:0071480	cellular response to gamma radiation	1.17e-02	1.00e+00	6.415	1	1	13
GO:0005922	connexon complex	1.17e-02	1.00e+00	6.415	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.17e-02	1.00e+00	6.415	1	2	13
GO:0004872	receptor activity	1.21e-02	1.00e+00	3.553	2	8	189
GO:0005685	U1 snRNP	1.26e-02	1.00e+00	6.308	1	1	14
GO:0043981	histone H4-K5 acetylation	1.34e-02	1.00e+00	6.209	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.34e-02	1.00e+00	6.209	1	3	15
GO:0006376	mRNA splice site selection	1.34e-02	1.00e+00	6.209	1	1	15
GO:0001824	blastocyst development	1.34e-02	1.00e+00	6.209	1	2	15
GO:0043982	histone H4-K8 acetylation	1.34e-02	1.00e+00	6.209	1	5	15
GO:1902187	negative regulation of viral release from host cell	1.34e-02	1.00e+00	6.209	1	1	15
GO:0043274	phospholipase binding	1.43e-02	1.00e+00	6.116	1	1	16
GO:0043984	histone H4-K16 acetylation	1.70e-02	1.00e+00	5.868	1	5	19
GO:0008380	RNA splicing	1.73e-02	1.00e+00	3.283	2	22	228
GO:0000123	histone acetyltransferase complex	1.88e-02	1.00e+00	5.723	1	6	21
GO:0045787	positive regulation of cell cycle	1.97e-02	1.00e+00	5.656	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.97e-02	1.00e+00	5.656	1	4	22
GO:0016573	histone acetylation	2.05e-02	1.00e+00	5.592	1	2	23
GO:0030864	cortical actin cytoskeleton	2.05e-02	1.00e+00	5.592	1	1	23
GO:0002088	lens development in camera-type eye	2.14e-02	1.00e+00	5.531	1	1	24
GO:0035329	hippo signaling	2.32e-02	1.00e+00	5.415	1	5	26
GO:0071339	MLL1 complex	2.41e-02	1.00e+00	5.361	1	6	27
GO:0005634	nucleus	2.51e-02	1.00e+00	0.961	8	159	4559
GO:1903507	negative regulation of nucleic acid-templated transcription	2.85e-02	1.00e+00	5.116	1	2	32
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.09e-02	1.00e+00	2.077	3	41	789
GO:0035019	somatic stem cell maintenance	3.55e-02	1.00e+00	4.794	1	6	40
GO:0031124	mRNA 3'-end processing	3.72e-02	1.00e+00	4.723	1	2	42
GO:0004402	histone acetyltransferase activity	3.81e-02	1.00e+00	4.689	1	6	43
GO:0006369	termination of RNA polymerase II transcription	3.98e-02	1.00e+00	4.624	1	2	45
GO:0009611	response to wounding	4.59e-02	1.00e+00	4.415	1	5	52
GO:0051291	protein heterooligomerization	4.93e-02	1.00e+00	4.308	1	4	56
GO:0032481	positive regulation of type I interferon production	5.36e-02	1.00e+00	4.185	1	6	61
GO:0006406	mRNA export from nucleus	5.36e-02	1.00e+00	4.185	1	4	61
GO:0010468	regulation of gene expression	5.96e-02	1.00e+00	4.028	1	2	68
GO:0003729	mRNA binding	6.30e-02	1.00e+00	3.946	1	4	72
GO:0044822	poly(A) RNA binding	6.44e-02	1.00e+00	1.656	3	50	1056
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	6.47e-02	1.00e+00	3.906	1	4	74
GO:0045893	positive regulation of transcription, DNA-templated	6.72e-02	1.00e+00	2.215	2	24	478
GO:0009653	anatomical structure morphogenesis	7.23e-02	1.00e+00	3.741	1	2	83
GO:0050821	protein stabilization	7.65e-02	1.00e+00	3.656	1	3	88
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	7.99e-02	1.00e+00	3.592	1	7	92
GO:0006325	chromatin organization	1.01e-01	1.00e+00	3.233	1	12	118
GO:0051092	positive regulation of NF-kappaB transcription factor activity	1.06e-01	1.00e+00	3.161	1	5	124
GO:0051260	protein homooligomerization	1.23e-01	1.00e+00	2.936	1	3	145
GO:0010628	positive regulation of gene expression	1.24e-01	1.00e+00	2.926	1	7	146
GO:0006974	cellular response to DNA damage stimulus	1.28e-01	1.00e+00	2.877	1	7	151
GO:0003700	sequence-specific DNA binding transcription factor activity	1.29e-01	1.00e+00	1.666	2	39	699
GO:0007601	visual perception	1.33e-01	1.00e+00	2.821	1	5	157
GO:0000398	mRNA splicing, via spliceosome	1.38e-01	1.00e+00	2.758	1	15	164
GO:0031965	nuclear membrane	1.41e-01	1.00e+00	2.723	1	10	168
GO:0007049	cell cycle	1.46e-01	1.00e+00	2.673	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.49e-01	1.00e+00	2.640	1	5	178
GO:0003714	transcription corepressor activity	1.49e-01	1.00e+00	2.640	1	11	178
GO:0005622	intracellular	1.71e-01	1.00e+00	2.422	1	6	207
GO:0007267	cell-cell signaling	1.80e-01	1.00e+00	2.341	1	2	219
GO:0016020	membrane	1.87e-01	1.00e+00	0.986	3	46	1681
GO:0006810	transport	1.98e-01	1.00e+00	2.197	1	2	242
GO:0008134	transcription factor binding	1.98e-01	1.00e+00	2.197	1	18	242
GO:0043025	neuronal cell body	2.00e-01	1.00e+00	2.179	1	9	245
GO:0000166	nucleotide binding	2.10e-01	1.00e+00	2.099	1	13	259
GO:0003779	actin binding	2.15e-01	1.00e+00	2.060	1	10	266
GO:0005739	mitochondrion	2.26e-01	1.00e+00	1.153	2	23	998
GO:0003682	chromatin binding	2.58e-01	1.00e+00	1.762	1	19	327
GO:0008283	cell proliferation	2.59e-01	1.00e+00	1.758	1	14	328
GO:0003723	RNA binding	2.68e-01	1.00e+00	1.698	1	18	342
GO:0043565	sequence-specific DNA binding	2.71e-01	1.00e+00	1.681	1	11	346
GO:0005515	protein binding	2.71e-01	1.00e+00	0.366	7	198	6024
GO:0005925	focal adhesion	2.84e-01	1.00e+00	1.600	1	9	366
GO:0003677	DNA binding	3.02e-01	1.00e+00	0.865	2	49	1218
GO:0055085	transmembrane transport	3.29e-01	1.00e+00	1.351	1	8	435
GO:0042802	identical protein binding	3.58e-01	1.00e+00	1.197	1	19	484
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.08e-01	1.00e+00	0.961	1	37	570
GO:0045087	innate immune response	4.22e-01	1.00e+00	0.896	1	15	596
GO:0005730	nucleolus	4.45e-01	1.00e+00	0.435	2	66	1641
GO:0005737	cytoplasm	4.53e-01	1.00e+00	0.236	4	124	3767
GO:0005887	integral component of plasma membrane	5.62e-01	1.00e+00	0.321	1	10	888
GO:0008270	zinc ion binding	6.06e-01	1.00e+00	0.154	1	27	997
GO:0005829	cytosol	6.86e-01	1.00e+00	-0.170	2	86	2496
GO:0006351	transcription, DNA-templated	7.47e-01	1.00e+00	-0.382	1	57	1446
GO:0005886	plasma membrane	9.23e-01	1.00e+00	-1.219	1	49	2582

chia-Fav

int-snw-89870

Statistics

Genes (13)

Interactions (19)

Related GO terms (125)