Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.971 | 5.30e-17 | 8.63e-05 | 1.00e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
HCFC1 | 3054 | 40 | -2.925 | 3.449 | 71 | Yes | Yes |
MED19 | 219541 | 30 | -2.657 | 3.449 | 115 | Yes | - |
LUC7L3 | 51747 | 33 | -3.523 | 3.449 | 18 | Yes | - |
MED28 | 80306 | 16 | -2.404 | 3.216 | 80 | Yes | - |
MED13L | 23389 | 12 | -2.550 | 3.159 | 21 | Yes | - |
MED24 | 9862 | 6 | -2.482 | 3.033 | 39 | Yes | - |
MED12 | 9968 | 14 | -2.465 | 3.206 | 65 | Yes | - |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
SRSF3 | 6428 | 73 | -2.992 | 3.538 | 54 | Yes | - |
MED14 | 9282 | 6 | -2.420 | 3.137 | 49 | Yes | - |
[ CDC23 ] | 8697 | 1 | -1.829 | 2.971 | 74 | - | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
MED14 | 9282 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
MED28 | 80306 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
HCFC1 | 3054 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
MED14 | 9282 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
MED24 | 9862 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
MED12 | 9968 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
MED12 | 9968 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
YAP1 | 10413 | MED28 | 80306 | pp | -- | int.I2D: MINT; int.Mint: MI:0915(physical association) |
CDC23 | 8697 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
MED24 | 9862 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
MED14 | 9282 | MED12 | 9968 | pp | -- | int.I2D: BioGrid |
SRSF3 | 6428 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
POU5F1 | 5460 | SRSF3 | 6428 | pp | -- | int.I2D: BioGrid |
HCFC1 | 3054 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
MED24 | 9862 | MED12 | 9968 | pp | -- | int.I2D: BioGrid |
LUC7L3 | 51747 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
MED13L | 23389 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
MED13L | 23389 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
MED14 | 9282 | MED24 | 9862 | pp | -- | int.I2D: BioGrid |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016592 | mediator complex | 1.19e-13 | 1.71e-09 | 7.687 | 6 | 10 | 35 |
GO:0001104 | RNA polymerase II transcription cofactor activity | 3.58e-11 | 5.16e-07 | 7.509 | 5 | 8 | 33 |
GO:0019827 | stem cell maintenance | 4.81e-08 | 6.93e-04 | 6.677 | 4 | 7 | 47 |
GO:0030518 | intracellular steroid hormone receptor signaling pathway | 1.59e-07 | 2.30e-03 | 8.009 | 3 | 6 | 14 |
GO:0042809 | vitamin D receptor binding | 1.99e-07 | 2.87e-03 | 7.909 | 3 | 6 | 15 |
GO:0005654 | nucleoplasm | 3.69e-07 | 5.32e-03 | 3.152 | 8 | 64 | 1082 |
GO:0046966 | thyroid hormone receptor binding | 1.13e-06 | 1.63e-02 | 7.116 | 3 | 6 | 26 |
GO:0030521 | androgen receptor signaling pathway | 4.61e-06 | 6.65e-02 | 6.459 | 3 | 5 | 41 |
GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity | 5.33e-06 | 7.69e-02 | 6.390 | 3 | 7 | 43 |
GO:0003712 | transcription cofactor activity | 5.72e-06 | 8.25e-02 | 6.357 | 3 | 8 | 44 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.17e-05 | 1.69e-01 | 4.708 | 4 | 22 | 184 |
GO:0006366 | transcription from RNA polymerase II promoter | 1.35e-05 | 1.95e-01 | 3.842 | 5 | 30 | 419 |
GO:0003713 | transcription coactivator activity | 3.17e-05 | 4.58e-01 | 4.342 | 4 | 24 | 237 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 4.84e-05 | 6.98e-01 | 4.187 | 4 | 23 | 264 |
GO:0010467 | gene expression | 1.28e-04 | 1.00e+00 | 3.167 | 5 | 45 | 669 |
GO:0004872 | receptor activity | 4.47e-04 | 1.00e+00 | 4.254 | 3 | 8 | 189 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060242 | contact inhibition | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0019046 | release from viral latency | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 2 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0060913 | cardiac cell fate determination | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0090245 | axis elongation involved in somitogenesis | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 3.09e-03 | 1.00e+00 | 2.607 | 4 | 41 | 789 |
GO:0014044 | Schwann cell development | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0051151 | negative regulation of smooth muscle cell differentiation | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0070461 | SAGA-type complex | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 2 | 5 |
GO:0001714 | endodermal cell fate specification | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0030071 | regulation of mitotic metaphase/anaphase transition | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 2 | 7 |
GO:0007096 | regulation of exit from mitosis | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0045893 | positive regulation of transcription, DNA-templated | 6.36e-03 | 1.00e+00 | 2.915 | 3 | 24 | 478 |
GO:0070688 | MLL5-L complex | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0043254 | regulation of protein complex assembly | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0006355 | regulation of transcription, DNA-templated | 7.17e-03 | 1.00e+00 | 2.270 | 4 | 43 | 997 |
GO:0043995 | histone acetyltransferase activity (H4-K5 specific) | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 5 | 9 |
GO:0046972 | histone acetyltransferase activity (H4-K16 specific) | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 5 | 9 |
GO:0048188 | Set1C/COMPASS complex | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 4 | 9 |
GO:0043996 | histone acetyltransferase activity (H4-K8 specific) | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 5 | 9 |
GO:0044212 | transcription regulatory region DNA binding | 8.24e-03 | 1.00e+00 | 3.839 | 2 | 17 | 168 |
GO:0035413 | positive regulation of catenin import into nucleus | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 10 |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0016607 | nuclear speck | 8.63e-03 | 1.00e+00 | 3.805 | 2 | 12 | 172 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 4 | 11 |
GO:0035198 | miRNA binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0071480 | cellular response to gamma radiation | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0007080 | mitotic metaphase plate congression | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
GO:0005685 | U1 snRNP | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0043981 | histone H4-K5 acetylation | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 5 | 15 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 3 | 15 |
GO:0001824 | blastocyst development | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 15 |
GO:0043982 | histone H4-K8 acetylation | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 5 | 15 |
GO:0006376 | mRNA splice site selection | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 15 |
GO:0043274 | phospholipase binding | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 16 |
GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 2 | 16 |
GO:0005634 | nucleus | 1.33e-02 | 1.00e+00 | 1.077 | 8 | 159 | 4559 |
GO:0008380 | RNA splicing | 1.48e-02 | 1.00e+00 | 3.398 | 2 | 22 | 228 |
GO:0043984 | histone H4-K16 acetylation | 1.57e-02 | 1.00e+00 | 5.983 | 1 | 5 | 19 |
GO:0005680 | anaphase-promoting complex | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0014003 | oligodendrocyte development | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 5 | 20 |
GO:0000123 | histone acetyltransferase complex | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 6 | 21 |
GO:0045787 | positive regulation of cell cycle | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 2 | 22 |
GO:0001205 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 4 | 22 |
GO:0030864 | cortical actin cytoskeleton | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 1 | 23 |
GO:0016573 | histone acetylation | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 2 | 23 |
GO:0035329 | hippo signaling | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 5 | 26 |
GO:0070979 | protein K11-linked ubiquitination | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 1 | 26 |
GO:0071339 | MLL1 complex | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 6 | 27 |
GO:0007094 | mitotic spindle assembly checkpoint | 2.55e-02 | 1.00e+00 | 5.277 | 1 | 3 | 31 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 2.63e-02 | 1.00e+00 | 5.231 | 1 | 2 | 32 |
GO:0030178 | negative regulation of Wnt signaling pathway | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 4 | 35 |
GO:0003682 | chromatin binding | 2.91e-02 | 1.00e+00 | 2.878 | 2 | 19 | 327 |
GO:0035019 | somatic stem cell maintenance | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 6 | 40 |
GO:0031124 | mRNA 3'-end processing | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 2 | 42 |
GO:0004402 | histone acetyltransferase activity | 3.52e-02 | 1.00e+00 | 4.805 | 1 | 6 | 43 |
GO:0006369 | termination of RNA polymerase II transcription | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 2 | 45 |
GO:0016020 | membrane | 4.22e-02 | 1.00e+00 | 1.516 | 4 | 46 | 1681 |
GO:0009611 | response to wounding | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 5 | 52 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 5 | 53 |
GO:0051291 | protein heterooligomerization | 4.56e-02 | 1.00e+00 | 4.424 | 1 | 4 | 56 |
GO:0008013 | beta-catenin binding | 4.88e-02 | 1.00e+00 | 4.324 | 1 | 9 | 60 |
GO:0006406 | mRNA export from nucleus | 4.96e-02 | 1.00e+00 | 4.300 | 1 | 4 | 61 |
GO:0044822 | poly(A) RNA binding | 5.23e-02 | 1.00e+00 | 1.772 | 3 | 50 | 1056 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 2 | 65 |
GO:0010468 | regulation of gene expression | 5.52e-02 | 1.00e+00 | 4.144 | 1 | 2 | 68 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.67e-02 | 1.00e+00 | 4.102 | 1 | 2 | 70 |
GO:0003729 | mRNA binding | 5.83e-02 | 1.00e+00 | 4.061 | 1 | 4 | 72 |
GO:0001843 | neural tube closure | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0060070 | canonical Wnt signaling pathway | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 4 | 75 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 6.38e-02 | 1.00e+00 | 3.927 | 1 | 2 | 79 |
GO:0009653 | anatomical structure morphogenesis | 6.69e-02 | 1.00e+00 | 3.856 | 1 | 2 | 83 |
GO:0050821 | protein stabilization | 7.08e-02 | 1.00e+00 | 3.772 | 1 | 3 | 88 |
GO:0006325 | chromatin organization | 9.39e-02 | 1.00e+00 | 3.348 | 1 | 12 | 118 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.00e-01 | 1.00e+00 | 3.254 | 1 | 5 | 126 |
GO:0007507 | heart development | 1.10e-01 | 1.00e+00 | 3.112 | 1 | 7 | 139 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 1.12e-01 | 1.00e+00 | 1.782 | 2 | 39 | 699 |
GO:0010628 | positive regulation of gene expression | 1.15e-01 | 1.00e+00 | 3.041 | 1 | 7 | 146 |
GO:0006974 | cellular response to DNA damage stimulus | 1.19e-01 | 1.00e+00 | 2.993 | 1 | 7 | 151 |
GO:0008022 | protein C-terminus binding | 1.26e-01 | 1.00e+00 | 2.900 | 1 | 8 | 161 |
GO:0000398 | mRNA splicing, via spliceosome | 1.28e-01 | 1.00e+00 | 2.874 | 1 | 15 | 164 |
GO:0005667 | transcription factor complex | 1.36e-01 | 1.00e+00 | 2.780 | 1 | 17 | 175 |
GO:0007049 | cell cycle | 1.36e-01 | 1.00e+00 | 2.788 | 1 | 6 | 174 |
GO:0031625 | ubiquitin protein ligase binding | 1.38e-01 | 1.00e+00 | 2.755 | 1 | 5 | 178 |
GO:0003714 | transcription corepressor activity | 1.38e-01 | 1.00e+00 | 2.755 | 1 | 11 | 178 |
GO:0019904 | protein domain specific binding | 1.39e-01 | 1.00e+00 | 2.747 | 1 | 8 | 179 |
GO:0005622 | intracellular | 1.59e-01 | 1.00e+00 | 2.538 | 1 | 6 | 207 |
GO:0007067 | mitotic nuclear division | 1.73e-01 | 1.00e+00 | 2.405 | 1 | 6 | 227 |
GO:0008134 | transcription factor binding | 1.84e-01 | 1.00e+00 | 2.312 | 1 | 18 | 242 |
GO:0043025 | neuronal cell body | 1.86e-01 | 1.00e+00 | 2.294 | 1 | 9 | 245 |
GO:0005515 | protein binding | 1.91e-01 | 1.00e+00 | 0.482 | 7 | 198 | 6024 |
GO:0004842 | ubiquitin-protein transferase activity | 1.93e-01 | 1.00e+00 | 2.237 | 1 | 5 | 255 |
GO:0000166 | nucleotide binding | 1.95e-01 | 1.00e+00 | 2.214 | 1 | 13 | 259 |
GO:0003779 | actin binding | 2.00e-01 | 1.00e+00 | 2.176 | 1 | 10 | 266 |
GO:0008283 | cell proliferation | 2.41e-01 | 1.00e+00 | 1.874 | 1 | 14 | 328 |
GO:0003723 | RNA binding | 2.50e-01 | 1.00e+00 | 1.813 | 1 | 18 | 342 |
GO:0043565 | sequence-specific DNA binding | 2.53e-01 | 1.00e+00 | 1.796 | 1 | 11 | 346 |
GO:0005925 | focal adhesion | 2.65e-01 | 1.00e+00 | 1.715 | 1 | 9 | 366 |
GO:0003677 | DNA binding | 2.69e-01 | 1.00e+00 | 0.981 | 2 | 49 | 1218 |
GO:0000278 | mitotic cell cycle | 2.81e-01 | 1.00e+00 | 1.620 | 1 | 15 | 391 |
GO:0042802 | identical protein binding | 3.36e-01 | 1.00e+00 | 1.312 | 1 | 19 | 484 |
GO:0005829 | cytosol | 3.45e-01 | 1.00e+00 | 0.531 | 3 | 86 | 2496 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 3.84e-01 | 1.00e+00 | 1.076 | 1 | 37 | 570 |
GO:0005737 | cytoplasm | 3.86e-01 | 1.00e+00 | 0.352 | 4 | 124 | 3767 |
GO:0005730 | nucleolus | 4.04e-01 | 1.00e+00 | 0.551 | 2 | 66 | 1641 |
GO:0005739 | mitochondrion | 5.77e-01 | 1.00e+00 | 0.268 | 1 | 23 | 998 |
GO:0006351 | transcription, DNA-templated | 7.19e-01 | 1.00e+00 | -0.267 | 1 | 57 | 1446 |
GO:0005886 | plasma membrane | 9.06e-01 | 1.00e+00 | -1.103 | 1 | 49 | 2582 |