int-snw-785

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.861 8.65e-16 3.52e-04 2.71e-03
chia-screen-data-Fav-int-snw-785 subnetwork

Genes (10)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EP300 2033 22-2.2743.120415YesYes
TUBB4A 10382 7-2.3122.97588Yes-
ACTR1B 10120 2-2.3203.06219Yes-
ANXA4 307 7-2.4783.06215YesYes
ACTA1 58 3-2.1283.062180Yes-
YAP1 10413 94-4.2563.53853Yes-
NFRKB 4798 48-3.1293.10823YesYes
POU5F1 5460 133-5.1483.538179YesYes
[ CACNB4 ] 785 1-1.7422.86114--
DDIT3 1649 60-2.8253.504343YesYes

Interactions (12)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTA1 58 POU5F1 5460 pp -- int.I2D: BioGrid
ACTA1 58 ACTR1B 10120 pp -- int.I2D: HPRD;
int.HPRD: in vitro
ACTA1 58 ANXA4 307 pp -- int.I2D: IntAct_Mouse
CACNB4 785 TUBB4A 10382 pp -- int.I2D: IntAct_Mouse
ACTA1 58 CACNB4 785 pp -- int.I2D: IntAct_Mouse
POU5F1 5460 TUBB4A 10382 pp -- int.I2D: BioGrid
DDIT3 1649 TUBB4A 10382 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
ACTA1 58 EP300 2033 pp -- int.I2D: BioGrid
DDIT3 1649 EP300 2033 pp -- int.Intact: MI:0915(physical association)
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
ACTA1 58 DDIT3 1649 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (255)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0042789mRNA transcription from RNA polymerase II promoter3.36e-054.85e-017.7942213
GO:0051059NF-kappaB binding1.29e-041.00e+006.8502325
GO:0044212transcription regulatory region DNA binding1.75e-041.00e+004.687317168
GO:0006355regulation of transcription, DNA-templated2.94e-041.00e+002.855543997
GO:0005829cytosol3.39e-041.00e+002.0167862496
GO:0008134transcription factor binding5.13e-041.00e+004.160318242
GO:0060795cell fate commitment involved in formation of primary germ layer6.93e-041.00e+0010.494111
GO:0060177regulation of angiotensin metabolic process6.93e-041.00e+0010.494111
GO:1901985positive regulation of protein acetylation6.93e-041.00e+0010.494111
GO:2000016negative regulation of determination of dorsal identity6.93e-041.00e+0010.494111
GO:0043969histone H2B acetylation6.93e-041.00e+0010.494111
GO:2000629negative regulation of miRNA metabolic process6.93e-041.00e+0010.494111
GO:0090308regulation of methylation-dependent chromatin silencing6.93e-041.00e+0010.494111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway6.93e-041.00e+0010.494111
GO:0060965negative regulation of gene silencing by miRNA6.93e-041.00e+0010.494111
GO:0060242contact inhibition1.39e-031.00e+009.494112
GO:0014737positive regulation of muscle atrophy1.39e-031.00e+009.494112
GO:2000483negative regulation of interleukin-8 secretion1.39e-031.00e+009.494112
GO:0009786regulation of asymmetric cell division1.39e-031.00e+009.494112
GO:0090043regulation of tubulin deacetylation1.39e-031.00e+009.494122
GO:0035984cellular response to trichostatin A1.39e-031.00e+009.494112
GO:0071389cellular response to mineralocorticoid stimulus1.39e-031.00e+009.494112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.39e-031.00e+009.494112
GO:0043503skeletal muscle fiber adaptation1.39e-031.00e+009.494112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.39e-031.00e+009.494112
GO:0005200structural constituent of cytoskeleton1.71e-031.00e+004.9862691
GO:0046058cAMP metabolic process2.08e-031.00e+008.909113
GO:0018076N-terminal peptidyl-lysine acetylation2.08e-031.00e+008.909113
GO:0060913cardiac cell fate determination2.08e-031.00e+008.909113
GO:1901385regulation of voltage-gated calcium channel activity2.08e-031.00e+008.909113
GO:0003130BMP signaling pathway involved in heart induction2.08e-031.00e+008.909113
GO:0010560positive regulation of glycoprotein biosynthetic process2.08e-031.00e+008.909113
GO:0005515protein binding2.41e-031.00e+001.10891986024
GO:0014051gamma-aminobutyric acid secretion2.77e-031.00e+008.494124
GO:0097157pre-mRNA intronic binding2.77e-031.00e+008.494114
GO:0033269internode region of axon2.77e-031.00e+008.494114
GO:0018393internal peptidyl-lysine acetylation2.77e-031.00e+008.494114
GO:0009991response to extracellular stimulus2.77e-031.00e+008.494114
GO:0001714endodermal cell fate specification3.46e-031.00e+008.172115
GO:0030240skeletal muscle thin filament assembly3.46e-031.00e+008.172115
GO:0065004protein-DNA complex assembly3.46e-031.00e+008.172115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor3.46e-031.00e+008.172115
GO:0043620regulation of DNA-templated transcription in response to stress3.46e-031.00e+008.172115
GO:0060298positive regulation of sarcomere organization3.46e-031.00e+008.172115
GO:0032025response to cobalt ion3.46e-031.00e+008.172115
GO:0000086G2/M transition of mitotic cell cycle3.78e-031.00e+004.40724136
GO:0004859phospholipase inhibitor activity4.15e-031.00e+007.909116
GO:0005865striated muscle thin filament4.15e-031.00e+007.909116
GO:0005654nucleoplasm4.58e-031.00e+002.4154641082
GO:0006974cellular response to DNA damage stimulus4.64e-031.00e+004.25627151
GO:0019227neuronal action potential propagation4.84e-031.00e+007.687117
GO:0006475internal protein amino acid acetylation4.84e-031.00e+007.687117
GO:0001955blood vessel maturation5.53e-031.00e+007.494118
GO:0005869dynactin complex5.53e-031.00e+007.494118
GO:0005667transcription factor complex6.18e-031.00e+004.043217175
GO:0060765regulation of androgen receptor signaling pathway6.22e-031.00e+007.324119
GO:0006983ER overload response6.22e-031.00e+007.324119
GO:0035259glucocorticoid receptor binding6.22e-031.00e+007.324119
GO:0048541Peyer's patch development6.22e-031.00e+007.324119
GO:0045793positive regulation of cell size6.22e-031.00e+007.324129
GO:0003714transcription corepressor activity6.39e-031.00e+004.018211178
GO:0035413positive regulation of catenin import into nucleus6.91e-031.00e+007.1721210
GO:0008331high voltage-gated calcium channel activity6.91e-031.00e+007.1721210
GO:0016407acetyltransferase activity6.91e-031.00e+007.1721210
GO:0010226response to lithium ion6.91e-031.00e+007.1721210
GO:0003677DNA binding7.02e-031.00e+002.2444491218
GO:0043923positive regulation by host of viral transcription7.60e-031.00e+007.0351111
GO:0033160positive regulation of protein import into nucleus, translocation7.60e-031.00e+007.0351311
GO:0045662negative regulation of myoblast differentiation7.60e-031.00e+007.0351311
GO:0042975peroxisome proliferator activated receptor binding7.60e-031.00e+007.0351111
GO:0060391positive regulation of SMAD protein import into nucleus7.60e-031.00e+007.0351411
GO:0048747muscle fiber development8.29e-031.00e+006.9091112
GO:0035198miRNA binding8.29e-031.00e+006.9091112
GO:0048545response to steroid hormone8.98e-031.00e+006.7941113
GO:0050908detection of light stimulus involved in visual perception8.98e-031.00e+006.7941113
GO:0071480cellular response to gamma radiation8.98e-031.00e+006.7941113
GO:0051019mitogen-activated protein kinase binding8.98e-031.00e+006.7941213
GO:0016746transferase activity, transferring acyl groups8.98e-031.00e+006.7941113
GO:0070542response to fatty acid9.67e-031.00e+006.6871114
GO:0031011Ino80 complex9.67e-031.00e+006.6871614
GO:0032993protein-DNA complex9.67e-031.00e+006.6871214
GO:0001824blastocyst development1.04e-021.00e+006.5871215
GO:1990090cellular response to nerve growth factor stimulus1.04e-021.00e+006.5871115
GO:0003700sequence-specific DNA binding transcription factor activity1.05e-021.00e+002.630339699
GO:0048741skeletal muscle fiber development1.10e-021.00e+006.4941116
GO:0043209myelin sheath1.10e-021.00e+006.4941116
GO:0003713transcription coactivator activity1.11e-021.00e+003.605224237
GO:0017022myosin binding1.17e-021.00e+006.4071217
GO:0012506vesicle membrane1.17e-021.00e+006.4071117
GO:0045773positive regulation of axon extension1.24e-021.00e+006.3241118
GO:0033613activating transcription factor binding1.24e-021.00e+006.3241318
GO:0051899membrane depolarization1.31e-021.00e+006.2461219
GO:0007214gamma-aminobutyric acid signaling pathway1.31e-021.00e+006.2461219
GO:0035257nuclear hormone receptor binding1.31e-021.00e+006.2461119
GO:0071549cellular response to dexamethasone stimulus1.38e-021.00e+006.1721320
GO:0010942positive regulation of cell death1.38e-021.00e+006.1721120
GO:0032757positive regulation of interleukin-8 production1.38e-021.00e+006.1721120
GO:0005634nucleus1.44e-021.00e+001.14771594559
GO:0000123histone acetyltransferase complex1.45e-021.00e+006.1021621
GO:0032967positive regulation of collagen biosynthetic process1.45e-021.00e+006.1021321
GO:0045862positive regulation of proteolysis1.45e-021.00e+006.1021221
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.47e-021.00e+002.455341789
GO:0003823antigen binding1.52e-021.00e+006.0351222
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.58e-021.00e+005.9711123
GO:0043388positive regulation of DNA binding1.65e-021.00e+005.9091224
GO:0005891voltage-gated calcium channel complex1.65e-021.00e+005.9091224
GO:0043425bHLH transcription factor binding1.65e-021.00e+005.9091124
GO:0035329hippo signaling1.79e-021.00e+005.7941526
GO:0051209release of sequestered calcium ion into cytosol1.79e-021.00e+005.7941126
GO:0048565digestive tract development1.79e-021.00e+005.7941226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.79e-021.00e+005.7941126
GO:0007017microtubule-based process1.86e-021.00e+005.7391227
GO:0034612response to tumor necrosis factor1.86e-021.00e+005.7391227
GO:0043967histone H4 acetylation1.86e-021.00e+005.7391127
GO:0051258protein polymerization1.86e-021.00e+005.7391227
GO:0043531ADP binding1.93e-021.00e+005.6871328
GO:0050714positive regulation of protein secretion1.93e-021.00e+005.6871328
GO:0007628adult walking behavior1.93e-021.00e+005.6871328
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator2.06e-021.00e+005.5871130
GO:0005544calcium-dependent phospholipid binding2.06e-021.00e+005.5871130
GO:0048536spleen development2.13e-021.00e+005.5401131
GO:0042594response to starvation2.13e-021.00e+005.5401431
GO:0005245voltage-gated calcium channel activity2.20e-021.00e+005.4941232
GO:0035249synaptic transmission, glutamatergic2.20e-021.00e+005.4941332
GO:0007528neuromuscular junction development2.20e-021.00e+005.4941132
GO:0043491protein kinase B signaling2.20e-021.00e+005.4941232
GO:1903507negative regulation of nucleic acid-templated transcription2.20e-021.00e+005.4941232
GO:0071333cellular response to glucose stimulus2.27e-021.00e+005.4501133
GO:0001756somitogenesis2.27e-021.00e+005.4501133
GO:0043565sequence-specific DNA binding2.27e-021.00e+003.060211346
GO:0030017sarcomere2.33e-021.00e+005.4071234
GO:0001102RNA polymerase II activating transcription factor binding2.47e-021.00e+005.3241136
GO:0048538thymus development2.47e-021.00e+005.3241236
GO:0051084'de novo' posttranslational protein folding2.54e-021.00e+005.2851537
GO:0030049muscle filament sliding2.60e-021.00e+005.2461338
GO:0032092positive regulation of protein binding2.60e-021.00e+005.2461238
GO:0031490chromatin DNA binding2.60e-021.00e+005.2461238
GO:0050681androgen receptor binding2.60e-021.00e+005.2461138
GO:0035019somatic stem cell maintenance2.74e-021.00e+005.1721640
GO:0007519skeletal muscle tissue development2.74e-021.00e+005.1721240
GO:0046332SMAD binding2.74e-021.00e+005.1721240
GO:0071320cellular response to cAMP2.74e-021.00e+005.1721140
GO:0009898cytoplasmic side of plasma membrane2.81e-021.00e+005.1371241
GO:0070301cellular response to hydrogen peroxide2.81e-021.00e+005.1371241
GO:0000278mitotic cell cycle2.86e-021.00e+002.883215391
GO:0004402histone acetyltransferase activity2.94e-021.00e+005.0681643
GO:0045727positive regulation of translation3.01e-021.00e+005.0351244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.01e-021.00e+005.0351444
GO:0005884actin filament3.01e-021.00e+005.0351344
GO:0043966histone H3 acetylation3.08e-021.00e+005.0021545
GO:0001047core promoter binding3.08e-021.00e+005.0021545
GO:0043525positive regulation of neuron apoptotic process3.14e-021.00e+004.9711446
GO:0006366transcription from RNA polymerase II promoter3.25e-021.00e+002.783230419
GO:0016049cell growth3.35e-021.00e+004.8791349
GO:0035690cellular response to drug3.35e-021.00e+004.8791349
GO:0006986response to unfolded protein3.41e-021.00e+004.8501450
GO:0009612response to mechanical stimulus3.41e-021.00e+004.8501150
GO:0034976response to endoplasmic reticulum stress3.48e-021.00e+004.8221251
GO:0045454cell redox homeostasis3.48e-021.00e+004.8221151
GO:0009611response to wounding3.55e-021.00e+004.7941552
GO:0007623circadian rhythm3.62e-021.00e+004.7661153
GO:0001725stress fiber3.75e-021.00e+004.7131455
GO:0071300cellular response to retinoic acid3.75e-021.00e+004.7131155
GO:0051592response to calcium ion3.75e-021.00e+004.7131155
GO:0002039p53 binding3.75e-021.00e+004.7131455
GO:0048306calcium-dependent protein binding3.82e-021.00e+004.6871256
GO:0043627response to estrogen3.82e-021.00e+004.6871556
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.02e-021.00e+004.6121659
GO:0044267cellular protein metabolic process4.07e-021.00e+002.605220474
GO:0008013beta-catenin binding4.08e-021.00e+004.5871960
GO:0032481positive regulation of type I interferon production4.15e-021.00e+004.5631661
GO:0030855epithelial cell differentiation4.15e-021.00e+004.5631161
GO:0006987activation of signaling protein activity involved in unfolded protein response4.15e-021.00e+004.5631261
GO:0032088negative regulation of NF-kappaB transcription factor activity4.28e-021.00e+004.5171363
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process4.28e-021.00e+004.5171463
GO:0006310DNA recombination4.42e-021.00e+004.4721765
GO:0010468regulation of gene expression4.62e-021.00e+004.4071268
GO:0006874cellular calcium ion homeostasis4.75e-021.00e+004.3651270
GO:0043086negative regulation of catalytic activity4.88e-021.00e+004.3241272
GO:0030324lung development4.88e-021.00e+004.3241172
GO:0000785chromatin4.95e-021.00e+004.3041673
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.02e-021.00e+004.2851474
GO:0002020protease binding5.02e-021.00e+004.2851674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.08e-021.00e+004.2651175
GO:0001889liver development5.21e-021.00e+004.2271377
GO:0005929cilium5.21e-021.00e+004.2271277
GO:0030968endoplasmic reticulum unfolded protein response5.35e-021.00e+004.1901279
GO:0009653anatomical structure morphogenesis5.61e-021.00e+004.1191283
GO:0050852T cell receptor signaling pathway5.74e-021.00e+004.0851285
GO:0009887organ morphogenesis5.81e-021.00e+004.0681586
GO:0090090negative regulation of canonical Wnt signaling pathway5.81e-021.00e+004.0681886
GO:0045471response to ethanol5.81e-021.00e+004.0681386
GO:0006936muscle contraction5.87e-021.00e+004.0511387
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II6.07e-021.00e+004.0021190
GO:0071456cellular response to hypoxia6.20e-021.00e+003.9711392
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity6.20e-021.00e+003.9711792
GO:0005770late endosome6.27e-021.00e+003.9551293
GO:0070588calcium ion transmembrane transport6.40e-021.00e+003.9241295
GO:0051726regulation of cell cycle6.53e-021.00e+003.8941597
GO:0070062extracellular vesicular exosome6.93e-021.00e+001.2654572400
GO:0001934positive regulation of protein phosphorylation6.98e-021.00e+003.79415104
GO:0072562blood microparticle7.44e-021.00e+003.70013111
GO:0006325chromatin organization7.89e-021.00e+003.612112118
GO:0007219Notch signaling pathway8.02e-021.00e+003.58715120
GO:0007050cell cycle arrest8.27e-021.00e+003.54015124
GO:0045202synapse9.04e-021.00e+003.40715136
GO:0016055Wnt signaling pathway9.17e-021.00e+003.38614138
GO:0005737cytoplasm9.18e-021.00e+000.93751243767
GO:0007507heart development9.23e-021.00e+003.37517139
GO:0006457protein folding9.49e-021.00e+003.33417143
GO:0001666response to hypoxia9.87e-021.00e+003.27517149
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.09e-011.00e+003.128112165
GO:0031965nuclear membrane1.11e-011.00e+003.102110168
GO:0015629actin cytoskeleton1.16e-011.00e+003.02715177
GO:0031625ubiquitin protein ligase binding1.17e-011.00e+003.01815178
GO:0032403protein complex binding1.20e-011.00e+002.97816183
GO:0006367transcription initiation from RNA polymerase II promoter1.21e-011.00e+002.971122184
GO:0003924GTPase activity1.29e-011.00e+002.87217197
GO:0006184GTP catabolic process1.39e-011.00e+002.75317214
GO:0007399nervous system development1.49e-011.00e+002.64216231
GO:0006810transport1.56e-011.00e+002.57512242
GO:0043025neuronal cell body1.57e-011.00e+002.55819245
GO:0005874microtubule1.60e-011.00e+002.53417249
GO:0006281DNA repair1.67e-011.00e+002.466114261
GO:0006357regulation of transcription from RNA polymerase II promoter1.69e-011.00e+002.450123264
GO:0006954inflammatory response1.76e-011.00e+002.38016277
GO:0005525GTP binding1.95e-011.00e+002.218112310
GO:0019901protein kinase binding1.99e-011.00e+002.186118317
GO:0007411axon guidance2.00e-011.00e+002.17715319
GO:0005813centrosome2.04e-011.00e+002.14517326
GO:0003682chromatin binding2.05e-011.00e+002.141119327
GO:0008283cell proliferation2.06e-011.00e+002.137114328
GO:0007268synaptic transmission2.08e-011.00e+002.11915332
GO:0005524ATP binding2.25e-011.00e+001.1522311298
GO:0046982protein heterodimerization activity2.34e-011.00e+001.92418380
GO:0009986cell surface2.46e-011.00e+001.84319402
GO:0045892negative regulation of transcription, DNA-templated2.52e-011.00e+001.804124413
GO:0043066negative regulation of apoptotic process2.58e-011.00e+001.766116424
GO:0045893positive regulation of transcription, DNA-templated2.86e-011.00e+001.593124478
GO:0042802identical protein binding2.89e-011.00e+001.575119484
GO:0048471perinuclear region of cytoplasm2.98e-011.00e+001.52318502
GO:0005509calcium ion binding3.13e-011.00e+001.442111531
GO:0016032viral process3.14e-011.00e+001.433126534
GO:0005730nucleolus3.18e-011.00e+000.8142661641
GO:0006915apoptotic process3.25e-011.00e+001.378112555
GO:0000122negative regulation of transcription from RNA polymerase II promoter3.32e-011.00e+001.339137570
GO:0045087innate immune response3.44e-011.00e+001.275115596
GO:0010467gene expression3.78e-011.00e+001.108145669
GO:0007165signal transduction4.78e-011.00e+000.669113907
GO:0005615extracellular space4.97e-011.00e+000.592120957
GO:0008270zinc ion binding5.12e-011.00e+000.533127997
GO:0044822poly(A) RNA binding5.33e-011.00e+000.4501501056
GO:0005886plasma membrane5.58e-011.00e+000.1602492582
GO:0006351transcription, DNA-templated6.52e-011.00e+00-0.0041571446
GO:0016020membrane7.11e-011.00e+00-0.2211461681