int-snw-6879

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.899	3.40e-16	2.22e-04	1.95e-03

chia-screen-data-Fav-int-snw-6879 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
TAF2	6873	1	-2.384	2.899	68	Yes	Yes
TCL1A	8115	8	-2.457	3.120	11	Yes	Yes
[ TAF7 ]	6879	3	-2.176	2.899	38	Yes	Yes
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
INO80E	283899	10	-2.663	3.079	20	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
YY1	7528	24	-2.572	3.120	114	Yes	Yes

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
YY1	7528	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
TAF7	6879	TCL1A	8115	pp	--	int.I2D: VidalHuman_non_core
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
YY1	7528	MCRS1	10445	pp	--	int.I2D: BioGrid
TAF2	6873	TAF7	6879	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vitro, in vivo
NFRKB	4798	YY1	7528	pp	--	int.I2D: BioGrid
MCRS1	10445	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
TAF7	6879	YY1	7528	pp	--	int.Transfac: -
NFRKB	4798	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid

Related GO terms (96)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0031011	Ino80 complex	3.88e-11	5.59e-07	9.009	4	6	14
GO:0044212	transcription regulatory region DNA binding	1.20e-06	1.73e-02	5.424	4	17	168
GO:0006310	DNA recombination	4.81e-06	6.94e-02	6.379	3	7	65
GO:0033276	transcription factor TFTC complex	2.44e-05	3.52e-01	8.009	2	4	14
GO:0005669	transcription factor TFIID complex	6.18e-05	8.92e-01	7.357	2	4	22
GO:0071339	MLL1 complex	9.38e-05	1.00e+00	7.061	2	6	27
GO:0006281	DNA repair	3.07e-04	1.00e+00	4.373	3	14	261
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0000296	spermine transport	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0005515	protein binding	9.24e-04	1.00e+00	1.260	8	198	6024
GO:0034696	response to prostaglandin F	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006403	RNA localization	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006366	transcription from RNA polymerase II promoter	1.22e-03	1.00e+00	3.690	3	30	419
GO:0006355	regulation of transcription, DNA-templated	1.27e-03	1.00e+00	2.855	4	43	997
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0008024	positive transcription elongation factor complex b	2.77e-03	1.00e+00	8.494	1	1	5
GO:0005667	transcription factor complex	3.91e-03	1.00e+00	4.365	2	17	175
GO:0006367	transcription initiation from RNA polymerase II promoter	4.31e-03	1.00e+00	4.293	2	22	184
GO:0035067	negative regulation of histone acetylation	4.43e-03	1.00e+00	7.816	1	2	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	4.98e-03	1.00e+00	7.646	1	5	9
GO:0000400	four-way junction DNA binding	4.98e-03	1.00e+00	7.646	1	1	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	4.98e-03	1.00e+00	7.646	1	5	9
GO:0010225	response to UV-C	4.98e-03	1.00e+00	7.646	1	2	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	4.98e-03	1.00e+00	7.646	1	5	9
GO:0003700	sequence-specific DNA binding transcription factor activity	5.28e-03	1.00e+00	2.952	3	39	699
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0045120	pronucleus	6.09e-03	1.00e+00	7.357	1	2	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0003713	transcription coactivator activity	7.05e-03	1.00e+00	3.927	2	24	237
GO:0042789	mRNA transcription from RNA polymerase II promoter	7.19e-03	1.00e+00	7.116	1	2	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	7.42e-03	1.00e+00	2.777	3	41	789
GO:0005730	nucleolus	8.01e-03	1.00e+00	2.136	4	66	1641
GO:0043981	histone H4-K5 acetylation	8.29e-03	1.00e+00	6.909	1	5	15
GO:0042809	vitamin D receptor binding	8.29e-03	1.00e+00	6.909	1	6	15
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0043982	histone H4-K8 acetylation	8.29e-03	1.00e+00	6.909	1	5	15
GO:0048593	camera-type eye morphogenesis	8.84e-03	1.00e+00	6.816	1	1	16
GO:0051276	chromosome organization	8.84e-03	1.00e+00	6.816	1	2	16
GO:0030520	intracellular estrogen receptor signaling pathway	9.94e-03	1.00e+00	6.646	1	4	18
GO:0035035	histone acetyltransferase binding	1.05e-02	1.00e+00	6.568	1	1	19
GO:0043984	histone H4-K16 acetylation	1.05e-02	1.00e+00	6.568	1	5	19
GO:0006352	DNA-templated transcription, initiation	1.10e-02	1.00e+00	6.494	1	2	20
GO:0000123	histone acetyltransferase complex	1.16e-02	1.00e+00	6.424	1	6	21
GO:0031519	PcG protein complex	1.38e-02	1.00e+00	6.172	1	1	25
GO:0046966	thyroid hormone receptor binding	1.43e-02	1.00e+00	6.116	1	6	26
GO:0005634	nucleus	1.49e-02	1.00e+00	1.247	6	159	4559
GO:0034644	cellular response to UV	1.65e-02	1.00e+00	5.909	1	1	30
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0014070	response to organic cyclic compound	2.36e-02	1.00e+00	5.390	1	1	43
GO:0003677	DNA binding	2.44e-02	1.00e+00	2.151	3	49	1218
GO:0019827	stem cell maintenance	2.58e-02	1.00e+00	5.261	1	7	47
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0008237	metallopeptidase activity	2.85e-02	1.00e+00	5.116	1	1	52
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	2	55
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	3.23e-02	1.00e+00	4.933	1	5	59
GO:0006469	negative regulation of protein kinase activity	3.55e-02	1.00e+00	4.794	1	4	65
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.73e-02	1.00e+00	2.661	2	37	570
GO:0006351	transcription, DNA-templated	3.83e-02	1.00e+00	1.903	3	57	1446
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0002020	protease binding	4.03e-02	1.00e+00	4.607	1	6	74
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0009952	anterior/posterior pattern specification	4.51e-02	1.00e+00	4.441	1	4	83
GO:0006464	cellular protein modification process	4.57e-02	1.00e+00	4.424	1	4	84
GO:0016363	nuclear matrix	4.94e-02	1.00e+00	4.308	1	6	91
GO:0005938	cell cortex	5.63e-02	1.00e+00	4.116	1	5	104
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	12	118
GO:0006260	DNA replication	6.52e-02	1.00e+00	3.897	1	3	121
GO:0000086	G2/M transition of mitotic cell cycle	7.30e-02	1.00e+00	3.729	1	4	136
GO:0006974	cellular response to DNA damage stimulus	8.08e-02	1.00e+00	3.578	1	7	151
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0003714	transcription corepressor activity	9.46e-02	1.00e+00	3.340	1	11	178
GO:0008270	zinc ion binding	1.01e-01	1.00e+00	1.855	2	27	997
GO:0005654	nucleoplasm	1.16e-01	1.00e+00	1.737	2	64	1082
GO:0007283	spermatogenesis	1.36e-01	1.00e+00	2.783	1	3	262
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.37e-01	1.00e+00	2.772	1	23	264
GO:0006954	inflammatory response	1.44e-01	1.00e+00	2.702	1	6	277
GO:0030154	cell differentiation	1.55e-01	1.00e+00	2.582	1	5	301
GO:0007275	multicellular organismal development	1.62e-01	1.00e+00	2.512	1	7	316
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	18	342
GO:0043565	sequence-specific DNA binding	1.77e-01	1.00e+00	2.381	1	11	346
GO:0006508	proteolysis	1.91e-01	1.00e+00	2.254	1	6	378
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0005783	endoplasmic reticulum	2.70e-01	1.00e+00	1.697	1	13	556
GO:0005794	Golgi apparatus	2.92e-01	1.00e+00	1.563	1	9	610
GO:0044822	poly(A) RNA binding	4.56e-01	1.00e+00	0.772	1	50	1056
GO:0005737	cytoplasm	6.60e-01	1.00e+00	-0.063	2	124	3767
GO:0005829	cytosol	7.81e-01	1.00e+00	-0.469	1	86	2496

chia-Fav

int-snw-6879

Statistics

Genes (8)

Interactions (10)

Related GO terms (96)