int-snw-55161

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.994	2.86e-17	6.27e-05	7.97e-04

chia-screen-data-Fav-int-snw-55161 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
PHB2	11331	5	-2.236	2.994	140	Yes	-
PHB	5245	15	-2.743	3.004	127	Yes	Yes
NDN	4692	1	-1.801	2.994	32	-	-
FTSJ1	24140	4	-2.463	2.994	95	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ TMEM33 ]	55161	1	-1.429	2.994	26	-	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PHB2	11331	FTSJ1	24140	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
HNRNPU	3192	NDN	4692	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: in vitro
PHB	5245	PHB2	11331	pp	--	int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
NDN	4692	TMEM33	55161	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid
FTSJ1	24140	TMEM33	55161	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMD2	5708	PHB2	11331	pp	--	int.I2D: IntAct_Yeast

Related GO terms (158)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0044212	transcription regulatory region DNA binding	3.53e-06	5.09e-02	5.102	4	17	168
GO:0005654	nucleoplasm	2.84e-05	4.09e-01	3.000	6	64	1082
GO:0042789	mRNA transcription from RNA polymerase II promoter	3.36e-05	4.85e-01	7.794	2	2	13
GO:0006355	regulation of transcription, DNA-templated	2.94e-04	1.00e+00	2.855	5	43	997
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:0002128	tRNA nucleoside ribose methylation	6.93e-04	1.00e+00	10.494	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0008175	tRNA methyltransferase activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.39e-03	1.00e+00	9.494	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.39e-03	1.00e+00	9.494	1	1	2
GO:0001649	osteoblast differentiation	1.75e-03	1.00e+00	4.971	2	5	92
GO:0048871	multicellular organismal homeostasis	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0045892	negative regulation of transcription, DNA-templated	2.41e-03	1.00e+00	3.389	3	24	413
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.46e-03	1.00e+00	8.172	1	2	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	3.46e-03	1.00e+00	8.172	1	1	5
GO:0050847	progesterone receptor signaling pathway	4.15e-03	1.00e+00	7.909	1	2	6
GO:0002181	cytoplasmic translation	4.15e-03	1.00e+00	7.909	1	1	6
GO:0071514	genetic imprinting	4.15e-03	1.00e+00	7.909	1	1	6
GO:0060744	mammary gland branching involved in thelarche	4.15e-03	1.00e+00	7.909	1	2	6
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	4.15e-03	1.00e+00	7.909	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.15e-03	1.00e+00	7.909	1	3	6
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	4.15e-03	1.00e+00	7.909	1	2	6
GO:0042981	regulation of apoptotic process	4.58e-03	1.00e+00	4.265	2	4	150
GO:0006974	cellular response to DNA damage stimulus	4.64e-03	1.00e+00	4.256	2	7	151
GO:0008347	glial cell migration	4.84e-03	1.00e+00	7.687	1	1	7
GO:0071354	cellular response to interleukin-6	4.84e-03	1.00e+00	7.687	1	2	7
GO:0001955	blood vessel maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0003016	respiratory system process	5.53e-03	1.00e+00	7.494	1	1	8
GO:0006983	ER overload response	6.22e-03	1.00e+00	7.324	1	1	9
GO:0010944	negative regulation of transcription by competitive promoter binding	6.22e-03	1.00e+00	7.324	1	1	9
GO:0003714	transcription corepressor activity	6.39e-03	1.00e+00	4.018	2	11	178
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	6.91e-03	1.00e+00	7.172	1	2	10
GO:0003677	DNA binding	7.02e-03	1.00e+00	2.244	4	49	1218
GO:0045662	negative regulation of myoblast differentiation	7.60e-03	1.00e+00	7.035	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	1	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0060766	negative regulation of androgen receptor signaling pathway	8.98e-03	1.00e+00	6.794	1	3	13
GO:0007413	axonal fasciculation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0030234	enzyme regulator activity	8.98e-03	1.00e+00	6.794	1	2	13
GO:0010467	gene expression	9.33e-03	1.00e+00	2.693	3	45	669
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0060749	mammary gland alveolus development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0042176	regulation of protein catabolic process	1.10e-02	1.00e+00	6.494	1	2	16
GO:0008134	transcription factor binding	1.15e-02	1.00e+00	3.575	2	18	242
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	1	17
GO:0043015	gamma-tubulin binding	1.24e-02	1.00e+00	6.324	1	1	18
GO:0032757	positive regulation of interleukin-8 production	1.38e-02	1.00e+00	6.172	1	1	20
GO:0005634	nucleus	1.44e-02	1.00e+00	1.147	7	159	4559
GO:0048675	axon extension	1.45e-02	1.00e+00	6.102	1	2	21
GO:0016575	histone deacetylation	1.45e-02	1.00e+00	6.102	1	3	21
GO:0005743	mitochondrial inner membrane	1.49e-02	1.00e+00	3.380	2	6	277
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.58e-02	1.00e+00	5.971	1	1	23
GO:0035329	hippo signaling	1.79e-02	1.00e+00	5.794	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.79e-02	1.00e+00	5.794	1	1	26
GO:0005829	cytosol	1.81e-02	1.00e+00	1.531	5	86	2496
GO:0030331	estrogen receptor binding	1.86e-02	1.00e+00	5.739	1	2	27
GO:0071897	DNA biosynthetic process	1.93e-02	1.00e+00	5.687	1	1	28
GO:0042594	response to starvation	2.13e-02	1.00e+00	5.540	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0008285	negative regulation of cell proliferation	2.36e-02	1.00e+00	3.031	2	10	353
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	4	46
GO:0019233	sensory perception of pain	3.28e-02	1.00e+00	4.909	1	1	48
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	1	50
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	4	50
GO:0040008	regulation of growth	3.41e-02	1.00e+00	4.850	1	2	50
GO:0034976	response to endoplasmic reticulum stress	3.48e-02	1.00e+00	4.822	1	2	51
GO:0045454	cell redox homeostasis	3.48e-02	1.00e+00	4.822	1	1	51
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0043204	perikaryon	3.75e-02	1.00e+00	4.713	1	1	55
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	3	58
GO:0006396	RNA processing	4.02e-02	1.00e+00	4.612	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.02e-02	1.00e+00	4.612	1	6	59
GO:0042995	cell projection	4.08e-02	1.00e+00	4.587	1	3	60
GO:0045893	positive regulation of transcription, DNA-templated	4.14e-02	1.00e+00	2.593	2	24	478
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.15e-02	1.00e+00	4.563	1	2	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	2	65
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	2	70
GO:0042826	histone deacetylase binding	4.88e-02	1.00e+00	4.324	1	4	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	1	72
GO:0009791	post-embryonic development	4.95e-02	1.00e+00	4.304	1	3	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	2	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	5.35e-02	1.00e+00	4.190	1	2	79
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.81e-02	1.00e+00	4.068	1	8	86
GO:0042470	melanosome	6.14e-02	1.00e+00	3.986	1	2	91
GO:0016363	nuclear matrix	6.14e-02	1.00e+00	3.986	1	6	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	1	92
GO:0001764	neuron migration	6.27e-02	1.00e+00	3.955	1	1	93
GO:0005770	late endosome	6.27e-02	1.00e+00	3.955	1	2	93
GO:0007417	central nervous system development	6.46e-02	1.00e+00	3.909	1	5	96
GO:0005515	protein binding	6.90e-02	1.00e+00	0.745	7	198	6024
GO:0070062	extracellular vesicular exosome	6.93e-02	1.00e+00	1.265	4	57	2400
GO:0030308	negative regulation of cell growth	7.37e-02	1.00e+00	3.713	1	6	110
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	5	112
GO:0000209	protein polyubiquitination	7.76e-02	1.00e+00	3.636	1	3	116
GO:0003700	sequence-specific DNA binding transcription factor activity	8.15e-02	1.00e+00	2.045	2	39	699
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0016055	Wnt signaling pathway	9.17e-02	1.00e+00	3.386	1	4	138
GO:0000082	G1/S transition of mitotic cell cycle	9.87e-02	1.00e+00	3.275	1	3	149
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.00e-01	1.00e+00	1.870	2	41	789
GO:0016020	membrane	1.01e-01	1.00e+00	1.364	3	46	1681
GO:0000398	mRNA splicing, via spliceosome	1.08e-01	1.00e+00	3.137	1	15	164
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	2	171
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.21e-01	1.00e+00	2.971	1	22	184
GO:0016071	mRNA metabolic process	1.44e-01	1.00e+00	2.693	1	8	223
GO:0008380	RNA splicing	1.47e-01	1.00e+00	2.661	1	22	228
GO:0007399	nervous system development	1.49e-01	1.00e+00	2.642	1	6	231
GO:0005739	mitochondrion	1.49e-01	1.00e+00	1.531	2	23	998
GO:0003713	transcription coactivator activity	1.53e-01	1.00e+00	2.605	1	24	237
GO:0016070	RNA metabolic process	1.59e-01	1.00e+00	2.546	1	8	247
GO:0044822	poly(A) RNA binding	1.63e-01	1.00e+00	1.450	2	50	1056
GO:0048011	neurotrophin TRK receptor signaling pathway	1.72e-01	1.00e+00	2.423	1	7	269
GO:0019899	enzyme binding	1.76e-01	1.00e+00	2.380	1	9	277
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	11	295
GO:0005813	centrosome	2.04e-01	1.00e+00	2.145	1	7	326
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0003723	RNA binding	2.13e-01	1.00e+00	2.076	1	18	342
GO:0046982	protein heterodimerization activity	2.34e-01	1.00e+00	1.924	1	8	380
GO:0008150	biological_process	2.39e-01	1.00e+00	1.891	1	4	389
GO:0000278	mitotic cell cycle	2.40e-01	1.00e+00	1.883	1	15	391
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	9	402
GO:0005737	cytoplasm	2.51e-01	1.00e+00	0.615	4	124	3767
GO:0006366	transcription from RNA polymerase II promoter	2.55e-01	1.00e+00	1.783	1	30	419
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	16	424
GO:0006351	transcription, DNA-templated	2.65e-01	1.00e+00	0.996	2	57	1446
GO:0044267	cellular protein metabolic process	2.84e-01	1.00e+00	1.605	1	20	474
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0006915	apoptotic process	3.25e-01	1.00e+00	1.378	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.32e-01	1.00e+00	1.339	1	37	570
GO:0005887	integral component of plasma membrane	4.70e-01	1.00e+00	0.700	1	10	888
GO:0007165	signal transduction	4.78e-01	1.00e+00	0.669	1	13	907
GO:0044281	small molecule metabolic process	5.84e-01	1.00e+00	0.252	1	20	1211
GO:0005524	ATP binding	6.11e-01	1.00e+00	0.152	1	31	1298
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	17	1982

chia-Fav

int-snw-55161

Statistics

Genes (10)

Interactions (9)

Related GO terms (158)