int-snw-5441

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.159	3.33e-19	5.71e-06	1.46e-04

chia-screen-data-Fav-int-snw-5441 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
[ POLR2L ]	5441	2	-1.972	3.159	63	-	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
MED13L	23389	12	-2.550	3.159	21	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED13L	23389	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POLR2L	5441	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POLR2L	5441	MED28	80306	pp	--	int.I2D: BioGrid
MED13L	23389	MED28	80306	pp	--	int.I2D: BioGrid

Related GO terms (115)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006366	transcription from RNA polymerase II promoter	4.53e-08	6.53e-04	4.520	6	30	419
GO:0016592	mediator complex	1.09e-06	1.57e-02	7.102	3	10	35
GO:0001104	RNA polymerase II transcription cofactor activity	1.81e-04	1.00e+00	6.602	2	8	33
GO:0005654	nucleoplasm	2.30e-04	1.00e+00	2.889	5	64	1082
GO:0008380	RNA splicing	3.05e-04	1.00e+00	4.398	3	22	228
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0019046	release from viral latency	1.25e-03	1.00e+00	9.646	1	2	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060242	contact inhibition	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006355	regulation of transcription, DNA-templated	2.16e-03	1.00e+00	2.685	4	43	997
GO:0051151	negative regulation of smooth muscle cell differentiation	2.49e-03	1.00e+00	8.646	1	1	4
GO:0070461	SAGA-type complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006356	regulation of transcription from RNA polymerase I promoter	3.74e-03	1.00e+00	8.061	1	1	6
GO:0000398	mRNA splicing, via spliceosome	4.39e-03	1.00e+00	4.289	2	15	164
GO:0044212	transcription regulatory region DNA binding	4.60e-03	1.00e+00	4.254	2	17	168
GO:0016607	nuclear speck	4.82e-03	1.00e+00	4.220	2	12	172
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0001055	RNA polymerase II activity	4.98e-03	1.00e+00	7.646	1	3	8
GO:0043254	regulation of protein complex assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0006367	transcription initiation from RNA polymerase II promoter	5.49e-03	1.00e+00	4.123	2	22	184
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0048188	Set1C/COMPASS complex	5.60e-03	1.00e+00	7.476	1	4	9
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0010467	gene expression	6.76e-03	1.00e+00	2.845	3	45	669
GO:0001054	RNA polymerase I activity	6.85e-03	1.00e+00	7.187	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0005736	DNA-directed RNA polymerase I complex	7.47e-03	1.00e+00	7.061	1	3	12
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0071480	cellular response to gamma radiation	8.09e-03	1.00e+00	6.946	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.09e-03	1.00e+00	6.946	1	2	13
GO:0005685	U1 snRNP	8.70e-03	1.00e+00	6.839	1	1	14
GO:0003713	transcription coactivator activity	8.97e-03	1.00e+00	3.757	2	24	237
GO:0043981	histone H4-K5 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	9.32e-03	1.00e+00	6.739	1	3	15
GO:0006376	mRNA splice site selection	9.32e-03	1.00e+00	6.739	1	1	15
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0043982	histone H4-K8 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0005665	DNA-directed RNA polymerase II, core complex	9.94e-03	1.00e+00	6.646	1	4	16
GO:0001056	RNA polymerase III activity	9.94e-03	1.00e+00	6.646	1	3	16
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0005666	DNA-directed RNA polymerase III complex	1.06e-02	1.00e+00	6.559	1	3	17
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.10e-02	1.00e+00	3.602	2	23	264
GO:0006385	transcription elongation from RNA polymerase III promoter	1.12e-02	1.00e+00	6.476	1	3	18
GO:0006386	termination of RNA polymerase III transcription	1.12e-02	1.00e+00	6.476	1	3	18
GO:0043984	histone H4-K16 acetylation	1.18e-02	1.00e+00	6.398	1	5	19
GO:0000123	histone acetyltransferase complex	1.30e-02	1.00e+00	6.254	1	6	21
GO:0045787	positive regulation of cell cycle	1.36e-02	1.00e+00	6.187	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.36e-02	1.00e+00	6.187	1	4	22
GO:0030864	cortical actin cytoskeleton	1.43e-02	1.00e+00	6.123	1	1	23
GO:0003899	DNA-directed RNA polymerase activity	1.55e-02	1.00e+00	6.002	1	3	25
GO:0035329	hippo signaling	1.61e-02	1.00e+00	5.946	1	5	26
GO:0071339	MLL1 complex	1.67e-02	1.00e+00	5.891	1	6	27
GO:0006360	transcription from RNA polymerase I promoter	1.86e-02	1.00e+00	5.739	1	3	30
GO:0006370	7-methylguanosine mRNA capping	1.86e-02	1.00e+00	5.739	1	5	30
GO:1903507	negative regulation of nucleic acid-templated transcription	1.98e-02	1.00e+00	5.646	1	2	32
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	50	1056
GO:0006383	transcription from RNA polymerase III promoter	2.41e-02	1.00e+00	5.361	1	3	39
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0031124	mRNA 3'-end processing	2.59e-02	1.00e+00	5.254	1	2	42
GO:0050434	positive regulation of viral transcription	2.71e-02	1.00e+00	5.187	1	5	44
GO:0006369	termination of RNA polymerase II transcription	2.77e-02	1.00e+00	5.154	1	2	45
GO:0006283	transcription-coupled nucleotide-excision repair	2.83e-02	1.00e+00	5.123	1	4	46
GO:0019827	stem cell maintenance	2.90e-02	1.00e+00	5.092	1	7	47
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0005634	nucleus	3.27e-02	1.00e+00	1.077	6	159	4559
GO:0003677	DNA binding	3.43e-02	1.00e+00	1.981	3	49	1218
GO:0032481	positive regulation of type I interferon production	3.74e-02	1.00e+00	4.715	1	6	61
GO:0006406	mRNA export from nucleus	3.74e-02	1.00e+00	4.715	1	4	61
GO:0006368	transcription elongation from RNA polymerase II promoter	4.11e-02	1.00e+00	4.580	1	6	67
GO:0006289	nucleotide-excision repair	4.17e-02	1.00e+00	4.559	1	5	68
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0003729	mRNA binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0050821	protein stabilization	5.36e-02	1.00e+00	4.187	1	3	88
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	12	118
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.33e-02	1.00e+00	2.022	2	41	789
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	7	146
GO:0006974	cellular response to DNA damage stimulus	9.04e-02	1.00e+00	3.408	1	7	151
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0007049	cell cycle	1.04e-01	1.00e+00	3.203	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0003714	transcription corepressor activity	1.06e-01	1.00e+00	3.170	1	11	178
GO:0005515	protein binding	1.20e-01	1.00e+00	0.675	6	198	6024
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	18	242
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0000166	nucleotide binding	1.51e-01	1.00e+00	2.629	1	13	259
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	14	261
GO:0003779	actin binding	1.54e-01	1.00e+00	2.591	1	10	266
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	124	3767
GO:0003682	chromatin binding	1.87e-01	1.00e+00	2.293	1	19	327
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0005829	cytosol	1.93e-01	1.00e+00	0.946	3	86	2496
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	18	342
GO:0043565	sequence-specific DNA binding	1.96e-01	1.00e+00	2.212	1	11	346
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	19	484
GO:0005730	nucleolus	2.73e-01	1.00e+00	0.966	2	66	1641
GO:0016020	membrane	2.83e-01	1.00e+00	0.931	2	46	1681
GO:0016032	viral process	2.88e-01	1.00e+00	1.585	1	26	534
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.04e-01	1.00e+00	1.491	1	37	570
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	15	596
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	27	997
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	23	998
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	57	1446
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	49	2582

chia-Fav

int-snw-5441

Statistics

Genes (9)

Interactions (11)

Related GO terms (115)