int-snw-5433

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.216	6.51e-20	2.30e-06	7.60e-05

chia-screen-data-Fav-int-snw-5433 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
EMX1	2016	4	-2.369	3.216	19	Yes	-
MED19	219541	30	-2.657	3.449	115	Yes	-
KDM4B	23030	5	-3.892	3.216	5	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
[ POLR2D ]	5433	3	-1.998	3.216	36	-	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POLR2D	5433	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POLR2D	5433	MED28	80306	pp	--	int.I2D: BioGrid
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
EMX1	2016	KDM4B	23030	pp	--	int.I2D: BioGrid_Mouse
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
EMX1	2016	POLR2D	5433	pp	--	int.I2D: BioGrid; int.Ravasi: -
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct

Related GO terms (122)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006366	transcription from RNA polymerase II promoter	4.51e-06	6.51e-02	4.105	5	30	419
GO:0006355	regulation of transcription, DNA-templated	1.77e-05	2.56e-01	3.118	6	43	997
GO:0016592	mediator complex	2.54e-04	1.00e+00	6.365	2	10	35
GO:0005654	nucleoplasm	4.31e-04	1.00e+00	2.737	5	64	1082
GO:0008380	RNA splicing	4.31e-04	1.00e+00	4.246	3	22	228
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0019046	release from viral latency	1.39e-03	1.00e+00	9.494	1	2	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0031990	mRNA export from nucleus in response to heat stress	1.39e-03	1.00e+00	9.494	1	2	2
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005634	nucleus	2.32e-03	1.00e+00	1.340	8	159	4559
GO:0051151	negative regulation of smooth muscle cell differentiation	2.77e-03	1.00e+00	8.494	1	1	4
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070461	SAGA-type complex	3.46e-03	1.00e+00	8.172	1	2	5
GO:0021796	cerebral cortex regionalization	3.46e-03	1.00e+00	8.172	1	1	5
GO:1990138	neuron projection extension	3.46e-03	1.00e+00	8.172	1	1	5
GO:0000398	mRNA splicing, via spliceosome	5.45e-03	1.00e+00	4.137	2	15	164
GO:0070688	MLL5-L complex	5.53e-03	1.00e+00	7.494	1	1	8
GO:0043254	regulation of protein complex assembly	5.53e-03	1.00e+00	7.494	1	1	8
GO:0044212	transcription regulatory region DNA binding	5.71e-03	1.00e+00	4.102	2	17	168
GO:0016607	nuclear speck	5.97e-03	1.00e+00	4.068	2	12	172
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	6.22e-03	1.00e+00	7.324	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	6.22e-03	1.00e+00	7.324	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	6.22e-03	1.00e+00	7.324	1	5	9
GO:0021895	cerebral cortex neuron differentiation	6.22e-03	1.00e+00	7.324	1	1	9
GO:0048188	Set1C/COMPASS complex	6.22e-03	1.00e+00	7.324	1	4	9
GO:0006367	transcription initiation from RNA polymerase II promoter	6.81e-03	1.00e+00	3.971	2	22	184
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0045948	positive regulation of translational initiation	8.29e-03	1.00e+00	6.909	1	1	12
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0051213	dioxygenase activity	8.98e-03	1.00e+00	6.794	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.98e-03	1.00e+00	6.794	1	2	13
GO:0010467	gene expression	9.33e-03	1.00e+00	2.693	3	45	669
GO:0005685	U1 snRNP	9.67e-03	1.00e+00	6.687	1	1	14
GO:0043981	histone H4-K5 acetylation	1.04e-02	1.00e+00	6.587	1	5	15
GO:0031369	translation initiation factor binding	1.04e-02	1.00e+00	6.587	1	2	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.04e-02	1.00e+00	6.587	1	3	15
GO:0048854	brain morphogenesis	1.04e-02	1.00e+00	6.587	1	2	15
GO:0006376	mRNA splice site selection	1.04e-02	1.00e+00	6.587	1	1	15
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0043982	histone H4-K8 acetylation	1.04e-02	1.00e+00	6.587	1	5	15
GO:0005665	DNA-directed RNA polymerase II, core complex	1.10e-02	1.00e+00	6.494	1	4	16
GO:0043274	phospholipase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0003713	transcription coactivator activity	1.11e-02	1.00e+00	3.605	2	24	237
GO:0000166	nucleotide binding	1.31e-02	1.00e+00	3.477	2	13	259
GO:0043984	histone H4-K16 acetylation	1.31e-02	1.00e+00	6.246	1	5	19
GO:0000123	histone acetyltransferase complex	1.45e-02	1.00e+00	6.102	1	6	21
GO:0045787	positive regulation of cell cycle	1.52e-02	1.00e+00	6.035	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.52e-02	1.00e+00	6.035	1	4	22
GO:0030864	cortical actin cytoskeleton	1.58e-02	1.00e+00	5.971	1	1	23
GO:0003899	DNA-directed RNA polymerase activity	1.72e-02	1.00e+00	5.850	1	3	25
GO:0035329	hippo signaling	1.79e-02	1.00e+00	5.794	1	5	26
GO:0071339	MLL1 complex	1.86e-02	1.00e+00	5.739	1	6	27
GO:0003727	single-stranded RNA binding	1.93e-02	1.00e+00	5.687	1	2	28
GO:0006370	7-methylguanosine mRNA capping	2.06e-02	1.00e+00	5.587	1	5	30
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0001104	RNA polymerase II transcription cofactor activity	2.27e-02	1.00e+00	5.450	1	8	33
GO:0005925	focal adhesion	2.53e-02	1.00e+00	2.978	2	9	366
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0031124	mRNA 3'-end processing	2.88e-02	1.00e+00	5.102	1	2	42
GO:0050434	positive regulation of viral transcription	3.01e-02	1.00e+00	5.035	1	5	44
GO:0006369	termination of RNA polymerase II transcription	3.08e-02	1.00e+00	5.002	1	2	45
GO:0006283	transcription-coupled nucleotide-excision repair	3.14e-02	1.00e+00	4.971	1	4	46
GO:0044822	poly(A) RNA binding	3.18e-02	1.00e+00	2.035	3	50	1056
GO:0019827	stem cell maintenance	3.21e-02	1.00e+00	4.940	1	7	47
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	3.62e-02	1.00e+00	4.766	1	4	53
GO:0000932	cytoplasmic mRNA processing body	3.68e-02	1.00e+00	4.739	1	4	54
GO:0006406	mRNA export from nucleus	4.15e-02	1.00e+00	4.563	1	4	61
GO:0006368	transcription elongation from RNA polymerase II promoter	4.55e-02	1.00e+00	4.428	1	6	67
GO:0006289	nucleotide-excision repair	4.62e-02	1.00e+00	4.407	1	5	68
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0003697	single-stranded DNA binding	4.62e-02	1.00e+00	4.407	1	5	68
GO:0003729	mRNA binding	4.88e-02	1.00e+00	4.324	1	4	72
GO:0009791	post-embryonic development	4.95e-02	1.00e+00	4.304	1	3	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0050821	protein stabilization	5.94e-02	1.00e+00	4.035	1	3	88
GO:0016568	chromatin modification	6.59e-02	1.00e+00	3.879	1	4	98
GO:0005515	protein binding	6.90e-02	1.00e+00	0.745	7	198	6024
GO:0006325	chromatin organization	7.89e-02	1.00e+00	3.612	1	12	118
GO:0003700	sequence-specific DNA binding transcription factor activity	8.15e-02	1.00e+00	2.045	2	39	699
GO:0005737	cytoplasm	9.18e-02	1.00e+00	0.937	5	124	3767
GO:0010628	positive regulation of gene expression	9.68e-02	1.00e+00	3.304	1	7	146
GO:0006974	cellular response to DNA damage stimulus	9.99e-02	1.00e+00	3.256	1	7	151
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.00e-01	1.00e+00	1.870	2	41	789
GO:0007049	cell cycle	1.14e-01	1.00e+00	3.051	1	6	174
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0003714	transcription corepressor activity	1.17e-01	1.00e+00	3.018	1	11	178
GO:0001701	in utero embryonic development	1.31e-01	1.00e+00	2.843	1	8	201
GO:0008134	transcription factor binding	1.56e-01	1.00e+00	2.575	1	18	242
GO:0043025	neuronal cell body	1.57e-01	1.00e+00	2.558	1	9	245
GO:0006281	DNA repair	1.67e-01	1.00e+00	2.466	1	14	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.69e-01	1.00e+00	2.450	1	23	264
GO:0003779	actin binding	1.70e-01	1.00e+00	2.439	1	10	266
GO:0042493	response to drug	1.80e-01	1.00e+00	2.344	1	6	284
GO:0003677	DNA binding	2.04e-01	1.00e+00	1.244	2	49	1218
GO:0003682	chromatin binding	2.05e-01	1.00e+00	2.141	1	19	327
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0030054	cell junction	2.10e-01	1.00e+00	2.102	1	5	336
GO:0003723	RNA binding	2.13e-01	1.00e+00	2.076	1	18	342
GO:0055114	oxidation-reduction process	2.56e-01	1.00e+00	1.780	1	10	420
GO:0006351	transcription, DNA-templated	2.65e-01	1.00e+00	0.996	2	57	1446
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	19	484
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0005730	nucleolus	3.18e-01	1.00e+00	0.814	2	66	1641
GO:0016020	membrane	3.28e-01	1.00e+00	0.779	2	46	1681
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.32e-01	1.00e+00	1.339	1	37	570
GO:0005739	mitochondrion	5.12e-01	1.00e+00	0.531	1	23	998
GO:0008270	zinc ion binding	5.12e-01	1.00e+00	0.533	1	27	997
GO:0005829	cytosol	5.38e-01	1.00e+00	0.209	2	86	2496
GO:0005886	plasma membrane	8.61e-01	1.00e+00	-0.840	1	49	2582

chia-Fav

int-snw-5433

Statistics

Genes (10)

Interactions (11)

Related GO terms (122)