int-snw-51366

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.078	3.07e-18	1.92e-05	3.44e-04

chia-screen-data-Fav-int-snw-51366 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
INO80E	283899	10	-2.663	3.079	20	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ UBR5 ]	51366	1	-2.006	3.078	48	Yes	-

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MCRS1	10445	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MCRS1	10445	UBR5	51366	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
NFRKB	4798	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
UBR5	51366	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct

Related GO terms (103)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0031011	Ino80 complex	6.09e-08	8.79e-04	8.424	3	6	14
GO:0006366	transcription from RNA polymerase II promoter	2.31e-06	3.33e-02	4.257	5	30	419
GO:0006310	DNA recombination	7.20e-06	1.04e-01	6.209	3	7	65
GO:0006281	DNA repair	1.23e-05	1.77e-01	4.618	4	14	261
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	1.24e-05	1.79e-01	8.476	2	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	1.24e-05	1.79e-01	8.476	2	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	1.24e-05	1.79e-01	8.476	2	5	9
GO:0035413	positive regulation of catenin import into nucleus	1.55e-05	2.24e-01	8.324	2	2	10
GO:0043981	histone H4-K5 acetylation	3.62e-05	5.22e-01	7.739	2	5	15
GO:0043982	histone H4-K8 acetylation	3.62e-05	5.22e-01	7.739	2	5	15
GO:0043984	histone H4-K16 acetylation	5.89e-05	8.49e-01	7.398	2	5	19
GO:0000123	histone acetyltransferase complex	7.22e-05	1.00e+00	7.254	2	6	21
GO:0071339	MLL1 complex	1.21e-04	1.00e+00	6.891	2	6	27
GO:0005730	nucleolus	1.33e-04	1.00e+00	2.551	6	66	1641
GO:0006355	regulation of transcription, DNA-templated	1.56e-04	1.00e+00	3.007	5	43	997
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0005634	nucleus	6.43e-04	1.00e+00	1.492	8	159	4559
GO:0019046	release from viral latency	1.25e-03	1.00e+00	9.646	1	2	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006325	chromatin organization	2.30e-03	1.00e+00	4.764	2	12	118
GO:0005654	nucleoplasm	2.92e-03	1.00e+00	2.567	4	64	1082
GO:0070461	SAGA-type complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:2000780	negative regulation of double-strand break repair	3.12e-03	1.00e+00	8.324	1	1	5
GO:0050847	progesterone receptor signaling pathway	3.74e-03	1.00e+00	8.061	1	2	6
GO:0016607	nuclear speck	4.82e-03	1.00e+00	4.220	2	12	172
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0043254	regulation of protein complex assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0034450	ubiquitin-ubiquitin ligase activity	4.98e-03	1.00e+00	7.646	1	1	8
GO:0005515	protein binding	5.23e-03	1.00e+00	1.090	8	198	6024
GO:0048188	Set1C/COMPASS complex	5.60e-03	1.00e+00	7.476	1	4	9
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0033160	positive regulation of protein import into nucleus, translocation	6.85e-03	1.00e+00	7.187	1	3	11
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.09e-03	1.00e+00	6.946	1	2	13
GO:0008380	RNA splicing	8.32e-03	1.00e+00	3.813	2	22	228
GO:0005685	U1 snRNP	8.70e-03	1.00e+00	6.839	1	1	14
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	9.32e-03	1.00e+00	6.739	1	3	15
GO:0006376	mRNA splice site selection	9.32e-03	1.00e+00	6.739	1	1	15
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0045787	positive regulation of cell cycle	1.36e-02	1.00e+00	6.187	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.36e-02	1.00e+00	6.187	1	4	22
GO:0003723	RNA binding	1.81e-02	1.00e+00	3.228	2	18	342
GO:0001104	RNA polymerase II transcription cofactor activity	2.04e-02	1.00e+00	5.602	1	8	33
GO:0016592	mediator complex	2.16e-02	1.00e+00	5.517	1	10	35
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	50	1056
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0031124	mRNA 3'-end processing	2.59e-02	1.00e+00	5.254	1	2	42
GO:0043130	ubiquitin binding	2.77e-02	1.00e+00	5.154	1	2	45
GO:0006369	termination of RNA polymerase II transcription	2.77e-02	1.00e+00	5.154	1	2	45
GO:0090263	positive regulation of canonical Wnt signaling pathway	2.96e-02	1.00e+00	5.061	1	3	48
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	3.32e-02	1.00e+00	4.891	1	3	54
GO:0003677	DNA binding	3.43e-02	1.00e+00	1.981	3	49	1218
GO:0006406	mRNA export from nucleus	3.74e-02	1.00e+00	4.715	1	4	61
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0003729	mRNA binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0002020	protease binding	4.53e-02	1.00e+00	4.437	1	6	74
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0006464	cellular protein modification process	5.12e-02	1.00e+00	4.254	1	4	84
GO:0050821	protein stabilization	5.36e-02	1.00e+00	4.187	1	3	88
GO:0005737	cytoplasm	5.81e-02	1.00e+00	1.089	5	124	3767
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0000209	protein polyubiquitination	7.01e-02	1.00e+00	3.788	1	3	116
GO:0006260	DNA replication	7.30e-02	1.00e+00	3.727	1	3	121
GO:0006511	ubiquitin-dependent protein catabolic process	7.60e-02	1.00e+00	3.669	1	5	126
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.33e-02	1.00e+00	2.022	2	41	789
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	7	146
GO:0006974	cellular response to DNA damage stimulus	9.04e-02	1.00e+00	3.408	1	7	151
GO:0000398	mRNA splicing, via spliceosome	9.78e-02	1.00e+00	3.289	1	15	164
GO:0044212	transcription regulatory region DNA binding	1.00e-01	1.00e+00	3.254	1	17	168
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0007049	cell cycle	1.04e-01	1.00e+00	3.203	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0016874	ligase activity	1.26e-01	1.00e+00	2.905	1	4	214
GO:0003713	transcription coactivator activity	1.39e-01	1.00e+00	2.757	1	24	237
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	18	242
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0004842	ubiquitin-protein transferase activity	1.48e-01	1.00e+00	2.652	1	5	255
GO:0000166	nucleotide binding	1.51e-01	1.00e+00	2.629	1	13	259
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.53e-01	1.00e+00	2.602	1	23	264
GO:0006954	inflammatory response	1.60e-01	1.00e+00	2.532	1	6	277
GO:0003682	chromatin binding	1.87e-01	1.00e+00	2.293	1	19	327
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0043565	sequence-specific DNA binding	1.96e-01	1.00e+00	2.212	1	11	346
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0006351	transcription, DNA-templated	2.26e-01	1.00e+00	1.148	2	57	1446
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	19	484
GO:0016020	membrane	2.83e-01	1.00e+00	0.931	2	46	1681
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.04e-01	1.00e+00	1.491	1	37	570
GO:0010467	gene expression	3.48e-01	1.00e+00	1.260	1	45	669
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	27	997
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	23	998
GO:0005829	cytosol	8.19e-01	1.00e+00	-0.639	1	86	2496
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	49	2582

chia-Fav

int-snw-51366

Statistics

Genes (9)

Interactions (11)

Related GO terms (103)