int-snw-4901

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.857	9.61e-16	3.71e-04	2.81e-03

chia-screen-data-Fav-int-snw-4901 subnetwork

Genes (13)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
EIF2S2	8894	9	-2.999	2.968	81	Yes	Yes
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
RREB1	6239	2	-1.830	2.857	39	-	-
TADA2B	93624	11	-3.061	3.082	19	Yes	-
EIF2B2	8892	8	-2.462	2.968	95	Yes	Yes
[ NRL ]	4901	1	-1.599	2.857	14	-	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
INO80E	283899	10	-2.663	3.079	20	Yes	-
EDF1	8721	2	-2.377	2.974	66	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
EIF2B4	8890	2	-2.471	2.957	47	Yes	Yes
YY1	7528	24	-2.572	3.120	114	Yes	Yes

Interactions (16)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EIF2B2	8892	TADA2B	93624	pp	--	int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
NFRKB	4798	YY1	7528	pp	--	int.I2D: BioGrid
MCRS1	10445	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
EDF1	8721	EIF2B2	8892	pp	--	int.I2D: IntAct_Yeast
PSMD2	5708	EIF2B2	8892	pp	--	int.I2D: IntAct_Yeast
RREB1	6239	YY1	7528	pp	--	int.Yu: larynx
NFRKB	4798	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
EIF2B4	8890	EIF2S2	8894	pp	--	int.I2D: BioGrid_Yeast, HPRD, YeastHigh; int.HPRD: in vitro
YY1	7528	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
EIF2B2	8892	EIF2S2	8894	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
NRL	4901	RREB1	6239	pp	--	int.Yu: heart, brain
NRL	4901	EDF1	8721	pp	--	int.I2D: BioGrid
YY1	7528	MCRS1	10445	pp	--	int.I2D: BioGrid
EIF2B4	8890	EIF2B2	8892	pp	--	int.I2D: BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, Krogan_Core, MINT_Fly, MINT_Yeast, MIPS, YeastHigh, BioGrid_Fly, FlyHigh, HPRD, IntAct_Fly, Tarassov_PCA; int.HPRD: in vitro, in vivo

Related GO terms (154)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0031011	Ino80 complex	3.95e-10	5.70e-06	8.308	4	6	14
GO:0051716	cellular response to stimulus	4.50e-06	6.48e-02	9.116	2	4	4
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	4.50e-06	6.48e-02	9.116	2	3	4
GO:0006355	regulation of transcription, DNA-templated	8.76e-06	1.26e-01	2.962	7	43	997
GO:0003743	translation initiation factor activity	1.03e-05	1.48e-01	6.086	3	7	49
GO:0005851	eukaryotic translation initiation factor 2B complex	1.12e-05	1.62e-01	8.531	2	4	6
GO:0006310	DNA recombination	2.42e-05	3.49e-01	5.678	3	7	65
GO:0019509	L-methionine biosynthetic process from methylthioadenosine	2.69e-05	3.88e-01	7.946	2	3	9
GO:0014003	oligodendrocyte development	1.41e-04	1.00e+00	6.794	2	5	20
GO:0006413	translational initiation	1.96e-04	1.00e+00	4.667	3	7	131
GO:0003700	sequence-specific DNA binding transcription factor activity	2.45e-04	1.00e+00	2.988	5	39	699
GO:0003677	DNA binding	3.66e-04	1.00e+00	2.450	6	49	1218
GO:0006366	transcription from RNA polymerase II promoter	4.08e-04	1.00e+00	3.405	4	30	419
GO:0042552	myelination	4.39e-04	1.00e+00	5.986	2	4	35
GO:0006446	regulation of translational initiation	4.64e-04	1.00e+00	5.946	2	4	36
GO:0001541	ovarian follicle development	4.91e-04	1.00e+00	5.906	2	2	37
GO:0009408	response to heat	5.74e-04	1.00e+00	5.794	2	6	40
GO:0043434	response to peptide hormone	7.26e-04	1.00e+00	5.624	2	5	45
GO:0060795	cell fate commitment involved in formation of primary germ layer	9.01e-04	1.00e+00	10.116	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	9.01e-04	1.00e+00	10.116	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	9.01e-04	1.00e+00	10.116	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	9.01e-04	1.00e+00	10.116	1	1	1
GO:0006412	translation	1.02e-03	1.00e+00	3.855	3	8	230
GO:0006281	DNA repair	1.46e-03	1.00e+00	3.673	3	14	261
GO:0009749	response to glucose	1.47e-03	1.00e+00	5.116	2	7	64
GO:0005085	guanyl-nucleotide exchange factor activity	1.80e-03	1.00e+00	4.966	2	5	71
GO:0034696	response to prostaglandin F	1.80e-03	1.00e+00	9.116	1	1	2
GO:0045872	positive regulation of rhodopsin gene expression	1.80e-03	1.00e+00	9.116	1	1	2
GO:0006403	RNA localization	1.80e-03	1.00e+00	9.116	1	1	2
GO:0007468	regulation of rhodopsin gene expression	1.80e-03	1.00e+00	9.116	1	1	2
GO:0002176	male germ cell proliferation	1.80e-03	1.00e+00	9.116	1	1	2
GO:0009786	regulation of asymmetric cell division	1.80e-03	1.00e+00	9.116	1	1	2
GO:0005515	protein binding	2.00e-03	1.00e+00	1.019	11	198	6024
GO:0010467	gene expression	2.34e-03	1.00e+00	2.730	4	45	669
GO:0005850	eukaryotic translation initiation factor 2 complex	2.70e-03	1.00e+00	8.531	1	1	3
GO:0060913	cardiac cell fate determination	2.70e-03	1.00e+00	8.531	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.70e-03	1.00e+00	8.531	1	1	3
GO:0043565	sequence-specific DNA binding	3.27e-03	1.00e+00	3.266	3	11	346
GO:0070461	SAGA-type complex	4.50e-03	1.00e+00	7.794	1	2	5
GO:0001714	endodermal cell fate specification	4.50e-03	1.00e+00	7.794	1	1	5
GO:0032057	negative regulation of translational initiation in response to stress	4.50e-03	1.00e+00	7.794	1	3	5
GO:0006325	chromatin organization	4.88e-03	1.00e+00	4.233	2	12	118
GO:0046548	retinal rod cell development	6.29e-03	1.00e+00	7.308	1	1	7
GO:0045446	endothelial cell differentiation	6.29e-03	1.00e+00	7.308	1	1	7
GO:0006351	transcription, DNA-templated	6.50e-03	1.00e+00	1.940	5	57	1446
GO:0043522	leucine zipper domain binding	7.19e-03	1.00e+00	7.116	1	1	8
GO:0044267	cellular protein metabolic process	7.89e-03	1.00e+00	2.812	3	20	474
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	8.09e-03	1.00e+00	6.946	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	8.09e-03	1.00e+00	6.946	1	5	9
GO:0010225	response to UV-C	8.09e-03	1.00e+00	6.946	1	2	9
GO:0000400	four-way junction DNA binding	8.09e-03	1.00e+00	6.946	1	1	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	8.09e-03	1.00e+00	6.946	1	5	9
GO:0035413	positive regulation of catenin import into nucleus	8.98e-03	1.00e+00	6.794	1	2	10
GO:0044212	transcription regulatory region DNA binding	9.67e-03	1.00e+00	3.723	2	17	168
GO:0060391	positive regulation of SMAD protein import into nucleus	9.87e-03	1.00e+00	6.656	1	4	11
GO:0005667	transcription factor complex	1.05e-02	1.00e+00	3.664	2	17	175
GO:0045947	negative regulation of translational initiation	1.08e-02	1.00e+00	6.531	1	2	12
GO:0005838	proteasome regulatory particle	1.08e-02	1.00e+00	6.531	1	1	12
GO:0035198	miRNA binding	1.08e-02	1.00e+00	6.531	1	1	12
GO:0043547	positive regulation of GTPase activity	1.10e-02	1.00e+00	3.624	2	9	180
GO:0005730	nucleolus	1.11e-02	1.00e+00	1.757	5	66	1641
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.17e-02	1.00e+00	6.415	1	2	13
GO:0030914	STAGA complex	1.17e-02	1.00e+00	6.415	1	3	13
GO:0030234	enzyme regulator activity	1.17e-02	1.00e+00	6.415	1	2	13
GO:0043981	histone H4-K5 acetylation	1.34e-02	1.00e+00	6.209	1	5	15
GO:0031369	translation initiation factor binding	1.34e-02	1.00e+00	6.209	1	2	15
GO:0001824	blastocyst development	1.34e-02	1.00e+00	6.209	1	2	15
GO:0043982	histone H4-K8 acetylation	1.34e-02	1.00e+00	6.209	1	5	15
GO:0019216	regulation of lipid metabolic process	1.43e-02	1.00e+00	6.116	1	1	16
GO:0042176	regulation of protein catabolic process	1.43e-02	1.00e+00	6.116	1	2	16
GO:0051276	chromosome organization	1.43e-02	1.00e+00	6.116	1	2	16
GO:0048593	camera-type eye morphogenesis	1.43e-02	1.00e+00	6.116	1	1	16
GO:0022624	proteasome accessory complex	1.52e-02	1.00e+00	6.028	1	1	17
GO:0043984	histone H4-K16 acetylation	1.70e-02	1.00e+00	5.868	1	5	19
GO:0003713	transcription coactivator activity	1.86e-02	1.00e+00	3.227	2	24	237
GO:0000123	histone acetyltransferase complex	1.88e-02	1.00e+00	5.723	1	6	21
GO:0005669	transcription factor TFIID complex	1.97e-02	1.00e+00	5.656	1	4	22
GO:0043388	positive regulation of DNA binding	2.14e-02	1.00e+00	5.531	1	2	24
GO:0008135	translation factor activity, nucleic acid binding	2.14e-02	1.00e+00	5.531	1	3	24
GO:0031519	PcG protein complex	2.23e-02	1.00e+00	5.472	1	1	25
GO:0071339	MLL1 complex	2.41e-02	1.00e+00	5.361	1	6	27
GO:0005634	nucleus	2.51e-02	1.00e+00	0.961	8	159	4559
GO:0034644	cellular response to UV	2.67e-02	1.00e+00	5.209	1	1	30
GO:0016604	nuclear body	2.76e-02	1.00e+00	5.161	1	3	31
GO:0007275	multicellular organismal development	3.18e-02	1.00e+00	2.812	2	7	316
GO:0035019	somatic stem cell maintenance	3.55e-02	1.00e+00	4.794	1	6	40
GO:0050896	response to stimulus	3.55e-02	1.00e+00	4.794	1	2	40
GO:0008168	methyltransferase activity	3.63e-02	1.00e+00	4.758	1	2	41
GO:0003723	RNA binding	3.68e-02	1.00e+00	2.698	2	18	342
GO:0004402	histone acetyltransferase activity	3.81e-02	1.00e+00	4.689	1	6	43
GO:0006521	regulation of cellular amino acid metabolic process	4.42e-02	1.00e+00	4.472	1	1	50
GO:0009611	response to wounding	4.59e-02	1.00e+00	4.415	1	5	52
GO:0000724	double-strand break repair via homologous recombination	4.85e-02	1.00e+00	4.334	1	2	55
GO:0000502	proteasome complex	5.11e-02	1.00e+00	4.258	1	3	58
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	5.19e-02	1.00e+00	4.233	1	5	59
GO:0006417	regulation of translation	5.45e-02	1.00e+00	4.161	1	2	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.62e-02	1.00e+00	4.116	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.71e-02	1.00e+00	4.093	1	2	65
GO:0005829	cytosol	5.88e-02	1.00e+00	1.152	5	86	2496
GO:0010468	regulation of gene expression	5.96e-02	1.00e+00	4.028	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.13e-02	1.00e+00	3.986	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	6.30e-02	1.00e+00	3.946	1	1	72
GO:0044822	poly(A) RNA binding	6.44e-02	1.00e+00	1.656	3	50	1056
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	6.47e-02	1.00e+00	3.906	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.47e-02	1.00e+00	3.906	1	2	74
GO:0002020	protease binding	6.47e-02	1.00e+00	3.906	1	6	74
GO:0008584	male gonad development	6.56e-02	1.00e+00	3.887	1	3	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.56e-02	1.00e+00	3.887	1	1	75
GO:0007265	Ras protein signal transduction	6.56e-02	1.00e+00	3.887	1	3	75
GO:0045893	positive regulation of transcription, DNA-templated	6.72e-02	1.00e+00	2.215	2	24	478
GO:0005654	nucleoplasm	6.83e-02	1.00e+00	1.621	3	64	1082
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.89e-02	1.00e+00	3.812	1	2	79
GO:0009653	anatomical structure morphogenesis	7.23e-02	1.00e+00	3.741	1	2	83
GO:0009952	anterior/posterior pattern specification	7.23e-02	1.00e+00	3.741	1	4	83
GO:0006464	cellular protein modification process	7.32e-02	1.00e+00	3.723	1	4	84
GO:0016363	nuclear matrix	7.90e-02	1.00e+00	3.608	1	6	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	7.99e-02	1.00e+00	3.592	1	1	92
GO:0007417	central nervous system development	8.32e-02	1.00e+00	3.531	1	5	96
GO:0005737	cytoplasm	9.60e-02	1.00e+00	0.821	6	124	3767
GO:0000209	protein polyubiquitination	9.97e-02	1.00e+00	3.258	1	3	116
GO:0006260	DNA replication	1.04e-01	1.00e+00	3.197	1	3	121
GO:0000082	G1/S transition of mitotic cell cycle	1.26e-01	1.00e+00	2.896	1	3	149
GO:0042981	regulation of apoptotic process	1.27e-01	1.00e+00	2.887	1	4	150
GO:0006974	cellular response to DNA damage stimulus	1.28e-01	1.00e+00	2.877	1	7	151
GO:0007601	visual perception	1.33e-01	1.00e+00	2.821	1	5	157
GO:0005516	calmodulin binding	1.35e-01	1.00e+00	2.794	1	2	160
GO:0016607	nuclear speck	1.44e-01	1.00e+00	2.689	1	12	172
GO:0034641	cellular nitrogen compound metabolic process	1.44e-01	1.00e+00	2.698	1	2	171
GO:0031625	ubiquitin protein ligase binding	1.49e-01	1.00e+00	2.640	1	5	178
GO:0003714	transcription corepressor activity	1.49e-01	1.00e+00	2.640	1	11	178
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.57e-01	1.00e+00	1.492	2	41	789
GO:0001701	in utero embryonic development	1.67e-01	1.00e+00	2.465	1	8	201
GO:0005622	intracellular	1.71e-01	1.00e+00	2.422	1	6	207
GO:0016071	mRNA metabolic process	1.83e-01	1.00e+00	2.315	1	8	223
GO:0008134	transcription factor binding	1.98e-01	1.00e+00	2.197	1	18	242
GO:0016070	RNA metabolic process	2.01e-01	1.00e+00	2.167	1	8	247
GO:0007283	spermatogenesis	2.12e-01	1.00e+00	2.082	1	3	262
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.14e-01	1.00e+00	2.071	1	23	264
GO:0006954	inflammatory response	2.23e-01	1.00e+00	2.002	1	6	277
GO:0008270	zinc ion binding	2.25e-01	1.00e+00	1.154	2	27	997
GO:0030154	cell differentiation	2.40e-01	1.00e+00	1.882	1	5	301
GO:0005525	GTP binding	2.46e-01	1.00e+00	1.840	1	12	310
GO:0003682	chromatin binding	2.58e-01	1.00e+00	1.762	1	19	327
GO:0000278	mitotic cell cycle	3.01e-01	1.00e+00	1.505	1	15	391
GO:0045892	negative regulation of transcription, DNA-templated	3.15e-01	1.00e+00	1.426	1	24	413
GO:0043066	negative regulation of apoptotic process	3.22e-01	1.00e+00	1.388	1	16	424
GO:0046872	metal ion binding	3.32e-01	1.00e+00	0.764	2	29	1307
GO:0070062	extracellular vesicular exosome	3.71e-01	1.00e+00	0.472	3	57	2400
GO:0016032	viral process	3.88e-01	1.00e+00	1.055	1	26	534
GO:0006915	apoptotic process	4.00e-01	1.00e+00	0.999	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.08e-01	1.00e+00	0.961	1	37	570
GO:0044281	small molecule metabolic process	6.80e-01	1.00e+00	-0.126	1	20	1211
GO:0005524	ATP binding	7.07e-01	1.00e+00	-0.226	1	31	1298
GO:0016020	membrane	8.00e-01	1.00e+00	-0.599	1	46	1681

chia-Fav

int-snw-4901

Statistics

Genes (13)

Interactions (16)

Related GO terms (154)