int-snw-2099

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.898	3.46e-16	2.24e-04	1.96e-03

chia-screen-data-Fav-int-snw-2099 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
KDM4B	23030	5	-3.892	3.216	5	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
PHB	5245	15	-2.743	3.004	127	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
MVP	9961	16	-2.846	3.193	20	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ ESR1 ]	2099	1	2.117	2.898	608	-	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ESR1	2099	LUC7L3	51747	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
ESR1	2099	MVP	9961	pp	--	int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vitro, in vivo
ESR1	2099	PHB	5245	pp	--	int.I2D: BioGrid
ESR1	2099	HNRNPU	3192	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
ESR1	2099	SRSF3	6428	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
ESR1	2099	KDM4B	23030	pp	--	int.I2D: BioGrid_Mouse
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (176)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	1.29e-06	1.86e-02	3.222	7	64	1082
GO:0044212	transcription regulatory region DNA binding	3.53e-06	5.09e-02	5.102	4	17	168
GO:0006355	regulation of transcription, DNA-templated	1.77e-05	2.56e-01	3.118	6	43	997
GO:0042789	mRNA transcription from RNA polymerase II promoter	3.36e-05	4.85e-01	7.794	2	2	13
GO:0005634	nucleus	2.24e-04	1.00e+00	1.510	9	159	4559
GO:0008380	RNA splicing	4.31e-04	1.00e+00	4.246	3	22	228
GO:0008134	transcription factor binding	5.13e-04	1.00e+00	4.160	3	18	242
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:0023057	negative regulation of signaling	6.93e-04	1.00e+00	10.494	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0072376	protein activation cascade	6.93e-04	1.00e+00	10.494	1	1	1
GO:0038052	estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	7.25e-04	1.00e+00	5.612	2	6	59
GO:0010467	gene expression	7.70e-04	1.00e+00	3.108	4	45	669
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0001547	antral ovarian follicle growth	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.39e-03	1.00e+00	9.494	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.39e-03	1.00e+00	9.494	1	1	2
GO:0001649	osteoblast differentiation	1.75e-03	1.00e+00	4.971	2	5	92
GO:0060745	mammary gland branching involved in pregnancy	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060523	prostate epithelial cord elongation	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	198	6024
GO:0030529	ribonucleoprotein complex	2.58e-03	1.00e+00	4.687	2	5	112
GO:0034056	estrogen response element binding	2.77e-03	1.00e+00	8.494	1	1	4
GO:0038127	ERBB signaling pathway	2.77e-03	1.00e+00	8.494	1	1	4
GO:0030284	estrogen receptor activity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.46e-03	1.00e+00	8.172	1	2	5
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	3.46e-03	1.00e+00	8.172	1	1	5
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	3.46e-03	1.00e+00	8.172	1	1	5
GO:0050847	progesterone receptor signaling pathway	4.15e-03	1.00e+00	7.909	1	2	6
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	4.15e-03	1.00e+00	7.909	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.15e-03	1.00e+00	7.909	1	3	6
GO:0044822	poly(A) RNA binding	4.19e-03	1.00e+00	2.450	4	50	1056
GO:0042981	regulation of apoptotic process	4.58e-03	1.00e+00	4.265	2	4	150
GO:0006974	cellular response to DNA damage stimulus	4.64e-03	1.00e+00	4.256	2	7	151
GO:0060687	regulation of branching involved in prostate gland morphogenesis	4.84e-03	1.00e+00	7.687	1	1	7
GO:0071354	cellular response to interleukin-6	4.84e-03	1.00e+00	7.687	1	2	7
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	4.84e-03	1.00e+00	7.687	1	1	7
GO:0061099	negative regulation of protein tyrosine kinase activity	4.84e-03	1.00e+00	7.687	1	1	7
GO:0000398	mRNA splicing, via spliceosome	5.45e-03	1.00e+00	4.137	2	15	164
GO:0002064	epithelial cell development	5.53e-03	1.00e+00	7.494	1	1	8
GO:0001955	blood vessel maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0010863	positive regulation of phospholipase C activity	5.53e-03	1.00e+00	7.494	1	1	8
GO:0016607	nuclear speck	5.97e-03	1.00e+00	4.068	2	12	172
GO:0030235	nitric-oxide synthase regulator activity	6.22e-03	1.00e+00	7.324	1	1	9
GO:0006983	ER overload response	6.22e-03	1.00e+00	7.324	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	6.22e-03	1.00e+00	7.324	1	1	9
GO:0010944	negative regulation of transcription by competitive promoter binding	6.22e-03	1.00e+00	7.324	1	1	9
GO:0003714	transcription corepressor activity	6.39e-03	1.00e+00	4.018	2	11	178
GO:0006367	transcription initiation from RNA polymerase II promoter	6.81e-03	1.00e+00	3.971	2	22	184
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0003677	DNA binding	7.02e-03	1.00e+00	2.244	4	49	1218
GO:0060068	vagina development	7.60e-03	1.00e+00	7.035	1	1	11
GO:0060065	uterus development	7.60e-03	1.00e+00	7.035	1	1	11
GO:0045662	negative regulation of myoblast differentiation	7.60e-03	1.00e+00	7.035	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0008209	androgen metabolic process	8.29e-03	1.00e+00	6.909	1	1	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0060766	negative regulation of androgen receptor signaling pathway	8.98e-03	1.00e+00	6.794	1	3	13
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0051213	dioxygenase activity	8.98e-03	1.00e+00	6.794	1	1	13
GO:0030518	intracellular steroid hormone receptor signaling pathway	9.67e-03	1.00e+00	6.687	1	6	14
GO:0005685	U1 snRNP	9.67e-03	1.00e+00	6.687	1	1	14
GO:0005496	steroid binding	1.04e-02	1.00e+00	6.587	1	1	15
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0060749	mammary gland alveolus development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0006376	mRNA splice site selection	1.04e-02	1.00e+00	6.587	1	1	15
GO:0051000	positive regulation of nitric-oxide synthase activity	1.04e-02	1.00e+00	6.587	1	1	15
GO:0003700	sequence-specific DNA binding transcription factor activity	1.05e-02	1.00e+00	2.630	3	39	699
GO:0043274	phospholipase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0035327	transcriptionally active chromatin	1.17e-02	1.00e+00	6.407	1	2	17
GO:0071392	cellular response to estradiol stimulus	1.24e-02	1.00e+00	6.324	1	2	18
GO:0030520	intracellular estrogen receptor signaling pathway	1.24e-02	1.00e+00	6.324	1	4	18
GO:0032757	positive regulation of interleukin-8 production	1.38e-02	1.00e+00	6.172	1	1	20
GO:0016575	histone deacetylation	1.45e-02	1.00e+00	6.102	1	3	21
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.47e-02	1.00e+00	2.455	3	41	789
GO:0019899	enzyme binding	1.49e-02	1.00e+00	3.380	2	9	277
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.58e-02	1.00e+00	5.971	1	1	23
GO:0035329	hippo signaling	1.79e-02	1.00e+00	5.794	1	5	26
GO:0001046	core promoter sequence-specific DNA binding	1.79e-02	1.00e+00	5.794	1	1	26
GO:0051209	release of sequestered calcium ion into cytosol	1.79e-02	1.00e+00	5.794	1	1	26
GO:0071897	DNA biosynthetic process	1.93e-02	1.00e+00	5.687	1	1	28
GO:0008283	cell proliferation	2.06e-02	1.00e+00	3.137	2	14	328
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	2.06e-02	1.00e+00	5.587	1	2	30
GO:0042594	response to starvation	2.13e-02	1.00e+00	5.540	1	4	31
GO:0016020	membrane	2.16e-02	1.00e+00	1.779	4	46	1681
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0003723	RNA binding	2.22e-02	1.00e+00	3.076	2	18	342
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	2.33e-02	1.00e+00	5.407	1	1	34
GO:0045429	positive regulation of nitric oxide biosynthetic process	2.40e-02	1.00e+00	5.365	1	1	35
GO:0005737	cytoplasm	2.44e-02	1.00e+00	1.200	6	124	3767
GO:0005925	focal adhesion	2.53e-02	1.00e+00	2.978	2	9	366
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0031124	mRNA 3'-end processing	2.88e-02	1.00e+00	5.102	1	2	42
GO:0048146	positive regulation of fibroblast proliferation	3.01e-02	1.00e+00	5.035	1	1	44
GO:0003707	steroid hormone receptor activity	3.08e-02	1.00e+00	5.002	1	1	45
GO:0006369	termination of RNA polymerase II transcription	3.08e-02	1.00e+00	5.002	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	4	46
GO:0045892	negative regulation of transcription, DNA-templated	3.16e-02	1.00e+00	2.804	2	24	413
GO:0006366	transcription from RNA polymerase II promoter	3.25e-02	1.00e+00	2.783	2	30	419
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.48e-02	1.00e+00	4.822	1	2	51
GO:0045454	cell redox homeostasis	3.48e-02	1.00e+00	4.822	1	1	51
GO:0043401	steroid hormone mediated signaling pathway	3.48e-02	1.00e+00	4.822	1	1	51
GO:0051028	mRNA transport	3.55e-02	1.00e+00	4.794	1	4	52
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0043627	response to estrogen	3.82e-02	1.00e+00	4.687	1	5	56
GO:0005643	nuclear pore	3.88e-02	1.00e+00	4.661	1	11	57
GO:0006396	RNA processing	4.02e-02	1.00e+00	4.612	1	5	59
GO:0008013	beta-catenin binding	4.08e-02	1.00e+00	4.587	1	9	60
GO:0045893	positive regulation of transcription, DNA-templated	4.14e-02	1.00e+00	2.593	2	24	478
GO:0006406	mRNA export from nucleus	4.15e-02	1.00e+00	4.563	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.15e-02	1.00e+00	4.563	1	2	61
GO:0019903	protein phosphatase binding	4.22e-02	1.00e+00	4.540	1	2	62
GO:0006338	chromatin remodeling	4.48e-02	1.00e+00	4.450	1	3	66
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0032355	response to estradiol	4.82e-02	1.00e+00	4.344	1	3	71
GO:0042826	histone deacetylase binding	4.88e-02	1.00e+00	4.324	1	4	72
GO:0003729	mRNA binding	4.88e-02	1.00e+00	4.324	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0008584	male gonad development	5.08e-02	1.00e+00	4.265	1	3	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	1	75
GO:0010629	negative regulation of gene expression	5.21e-02	1.00e+00	4.227	1	4	77
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	5.35e-02	1.00e+00	4.190	1	2	79
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.81e-02	1.00e+00	4.068	1	8	86
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	6.20e-02	1.00e+00	3.971	1	7	92
GO:0005770	late endosome	6.27e-02	1.00e+00	3.955	1	2	93
GO:0016568	chromatin modification	6.59e-02	1.00e+00	3.879	1	4	98
GO:0007204	positive regulation of cytosolic calcium ion concentration	6.85e-02	1.00e+00	3.822	1	2	102
GO:0030308	negative regulation of cell growth	7.37e-02	1.00e+00	3.713	1	6	110
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0016055	Wnt signaling pathway	9.17e-02	1.00e+00	3.386	1	4	138
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	9.74e-02	1.00e+00	3.294	1	6	147
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.09e-01	1.00e+00	3.128	1	12	165
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0007165	signal transduction	1.27e-01	1.00e+00	1.669	2	13	907
GO:0008270	zinc ion binding	1.49e-01	1.00e+00	1.533	2	27	997
GO:0003713	transcription coactivator activity	1.53e-01	1.00e+00	2.605	1	24	237
GO:0000166	nucleotide binding	1.66e-01	1.00e+00	2.477	1	13	259
GO:0005743	mitochondrial inner membrane	1.76e-01	1.00e+00	2.380	1	6	277
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	9	291
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	18	317
GO:0003682	chromatin binding	2.05e-01	1.00e+00	2.141	1	19	327
GO:0030054	cell junction	2.10e-01	1.00e+00	2.102	1	5	336
GO:0015031	protein transport	2.13e-01	1.00e+00	2.081	1	11	341
GO:0008285	negative regulation of cell proliferation	2.20e-01	1.00e+00	2.031	1	10	353
GO:0046982	protein heterodimerization activity	2.34e-01	1.00e+00	1.924	1	8	380
GO:0005829	cytosol	2.43e-01	1.00e+00	0.794	3	86	2496
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	9	402
GO:0055114	oxidation-reduction process	2.56e-01	1.00e+00	1.780	1	10	420
GO:0006351	transcription, DNA-templated	2.65e-01	1.00e+00	0.996	2	57	1446
GO:0044267	cellular protein metabolic process	2.84e-01	1.00e+00	1.605	1	20	474
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	19	484
GO:0048471	perinuclear region of cytoplasm	2.98e-01	1.00e+00	1.523	1	8	502
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.32e-01	1.00e+00	1.339	1	37	570
GO:0005794	Golgi apparatus	3.51e-01	1.00e+00	1.241	1	9	610
GO:0005887	integral component of plasma membrane	4.70e-01	1.00e+00	0.700	1	10	888
GO:0005739	mitochondrion	5.12e-01	1.00e+00	0.531	1	23	998
GO:0070062	extracellular vesicular exosome	5.15e-01	1.00e+00	0.265	2	57	2400
GO:0005886	plasma membrane	5.58e-01	1.00e+00	0.160	2	49	2582
GO:0005524	ATP binding	6.11e-01	1.00e+00	0.152	1	31	1298
GO:0005730	nucleolus	7.01e-01	1.00e+00	-0.186	1	66	1641
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	17	1982

chia-Fav

int-snw-2099

Statistics

Genes (10)

Interactions (10)

Related GO terms (176)