int-snw-1601

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.837 1.59e-15 4.75e-04 3.34e-03
chia-screen-data-Fav-int-snw-1601 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
PSMD2 5708 47-4.1723.157386YesYes
MED19 219541 30-2.6573.449115Yes-
APLP2 334 12-2.7323.20635YesYes
RHOA 387 5-2.4082.845151YesYes
[ DAB2 ] 1601 1-1.6412.83749--
LUC7L3 51747 33-3.5233.44918Yes-
EPS15 2060 2-1.9122.83775--
SH3BP4 23677 2-2.3542.83733Yes-
MED12 9968 14-2.4653.20665Yes-
SRSF3 6428 73-2.9923.53854Yes-
POU5F1 5460 133-5.1483.538179YesYes
MYO6 4646 1-2.0372.83734Yes-

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
DAB2 1601 EPS15 2060 pp -- int.Intact: MI:0915(physical association)
APLP2 334 DAB2 1601 pp -- int.I2D: BioGrid
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
APLP2 334 MED12 9968 pp -- int.I2D: MINT;
int.Mint: MI:0407(direct interaction)
MED12 9968 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
DAB2 1601 MYO6 4646 pp -- int.Intact: MI:0915(physical association), MI:0403(colocalization);
int.I2D: BioGrid, HPRD;
int.HPRD: in vitro, in vivo, yeast 2-hybrid
RHOA 387 PSMD2 5708 pp -- int.I2D: BioGrid_Yeast
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
APLP2 334 RHOA 387 pp -- int.I2D: IntAct_Mouse
EPS15 2060 SH3BP4 23677 pp -- int.I2D: BIND, MINT;
int.Mint: MI:0915(physical association)

Related GO terms (273)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005905coated pit6.20e-088.94e-046.5874650
GO:0060391positive regulation of SMAD protein import into nucleus3.48e-055.01e-017.7722411
GO:0048268clathrin coat assembly4.92e-057.10e-017.5312213
GO:0030665clathrin-coated vesicle membrane4.92e-057.10e-017.5312313
GO:0006897endocytosis8.09e-051.00e+005.08837106
GO:0001104RNA polymerase II transcription cofactor activity3.30e-041.00e+006.1872833
GO:0016592mediator complex3.72e-041.00e+006.10221035
GO:0005515protein binding4.97e-041.00e+001.134111986024
GO:0030136clathrin-coated vesicle5.36e-041.00e+005.8392542
GO:0038024cargo receptor activity8.32e-041.00e+0010.231111
GO:0090308regulation of methylation-dependent chromatin silencing8.32e-041.00e+0010.231111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway8.32e-041.00e+0010.231111
GO:0060965negative regulation of gene silencing by miRNA8.32e-041.00e+0010.231111
GO:0043090amino acid import8.32e-041.00e+0010.231111
GO:0060795cell fate commitment involved in formation of primary germ layer8.32e-041.00e+0010.231111
GO:0061383trabecula morphogenesis8.32e-041.00e+0010.231111
GO:0060001minus-end directed microfilament motor activity8.32e-041.00e+0010.231111
GO:0005654nucleoplasm1.19e-031.00e+002.4745641082
GO:0007626locomotory behavior1.53e-031.00e+005.0812271
GO:0035026leading edge cell differentiation1.66e-031.00e+009.231112
GO:0051046regulation of secretion1.66e-031.00e+009.231112
GO:0009786regulation of asymmetric cell division1.66e-031.00e+009.231112
GO:2000370positive regulation of clathrin-mediated endocytosis2.49e-031.00e+008.646113
GO:0046914transition metal ion binding2.49e-031.00e+008.646113
GO:0060913cardiac cell fate determination2.49e-031.00e+008.646113
GO:0090245axis elongation involved in somitogenesis2.49e-031.00e+008.646113
GO:0061462protein localization to lysosome2.49e-031.00e+008.646113
GO:0033688regulation of osteoblast proliferation2.49e-031.00e+008.646113
GO:0003130BMP signaling pathway involved in heart induction2.49e-031.00e+008.646113
GO:0005925focal adhesion3.01e-031.00e+003.30039366
GO:0005938cell cortex3.24e-031.00e+004.53125104
GO:0014044Schwann cell development3.32e-031.00e+008.231114
GO:0038027apolipoprotein A-I-mediated signaling pathway3.32e-031.00e+008.231114
GO:2000643positive regulation of early endosome to late endosome transport3.32e-031.00e+008.231114
GO:0000904cell morphogenesis involved in differentiation3.32e-031.00e+008.231114
GO:1903077negative regulation of protein localization to plasma membrane3.32e-031.00e+008.231114
GO:0070022transforming growth factor beta receptor homodimeric complex3.32e-031.00e+008.231114
GO:0001714endodermal cell fate specification4.15e-031.00e+007.909115
GO:0045334clathrin-coated endocytic vesicle4.15e-031.00e+007.909115
GO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway4.15e-031.00e+007.909115
GO:0006907pinocytosis4.15e-031.00e+007.909115
GO:2001046positive regulation of integrin-mediated signaling pathway4.15e-031.00e+007.909115
GO:0007176regulation of epidermal growth factor-activated receptor activity4.15e-031.00e+007.909115
GO:0006366transcription from RNA polymerase II promoter4.40e-031.00e+003.105330419
GO:0036089cleavage furrow formation4.98e-031.00e+007.646126
GO:0016461unconventional myosin complex5.81e-031.00e+007.424117
GO:0043931ossification involved in bone maturation5.81e-031.00e+007.424117
GO:0035612AP-2 adaptor complex binding5.81e-031.00e+007.424117
GO:0030132clathrin coat of coated pit5.81e-031.00e+007.424117
GO:0043297apical junction assembly5.81e-031.00e+007.424117
GO:0005092GDP-dissociation inhibitor activity5.81e-031.00e+007.424117
GO:0061024membrane organization6.20e-031.00e+004.05124145
GO:0042802identical protein binding6.59e-031.00e+002.897319484
GO:0035615clathrin adaptor activity6.64e-031.00e+007.231118
GO:0007617mating behavior6.64e-031.00e+007.231118
GO:0016591DNA-directed RNA polymerase II, holoenzyme7.47e-031.00e+007.061129
GO:0042491auditory receptor cell differentiation7.47e-031.00e+007.061119
GO:0001921positive regulation of receptor recycling7.47e-031.00e+007.061119
GO:0043296apical junction complex7.47e-031.00e+007.061119
GO:0008022protein C-terminus binding7.59e-031.00e+003.90028161
GO:0070062extracellular vesicular exosome7.84e-031.00e+001.5876572400
GO:0030122AP-2 adaptor complex8.29e-031.00e+006.9091110
GO:0060071Wnt signaling pathway, planar cell polarity pathway8.29e-031.00e+006.9091110
GO:0090307spindle assembly involved in mitosis8.29e-031.00e+006.9091110
GO:0035413positive regulation of catenin import into nucleus8.29e-031.00e+006.9091210
GO:0034260negative regulation of GTPase activity8.29e-031.00e+006.9091210
GO:0016020membrane8.36e-031.00e+001.8385461681
GO:0016607nuclear speck8.63e-031.00e+003.805212172
GO:0071257cellular response to electrical stimulus9.12e-031.00e+006.7721211
GO:0016050vesicle organization9.12e-031.00e+006.7721111
GO:0006895Golgi to endosome transport9.12e-031.00e+006.7721111
GO:0006878cellular copper ion homeostasis9.94e-031.00e+006.6461112
GO:0005838proteasome regulatory particle9.94e-031.00e+006.6461112
GO:0035198miRNA binding9.94e-031.00e+006.6461112
GO:0042789mRNA transcription from RNA polymerase II promoter1.08e-021.00e+006.5311213
GO:0060766negative regulation of androgen receptor signaling pathway1.08e-021.00e+006.5311313
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter1.08e-021.00e+006.5311113
GO:0030234enzyme regulator activity1.08e-021.00e+006.5311213
GO:0005886plasma membrane1.13e-021.00e+001.4826492582
GO:0001967suckling behavior1.16e-021.00e+006.4241114
GO:0030518intracellular steroid hormone receptor signaling pathway1.16e-021.00e+006.4241614
GO:0005685U1 snRNP1.16e-021.00e+006.4241114
GO:0030048actin filament-based movement1.16e-021.00e+006.4241114
GO:0030330DNA damage response, signal transduction by p53 class mediator1.16e-021.00e+006.4241114
GO:0017016Ras GTPase binding1.16e-021.00e+006.4241114
GO:0045807positive regulation of endocytosis1.16e-021.00e+006.4241114
GO:0005765lysosomal membrane1.19e-021.00e+003.56623203
GO:0042809vitamin D receptor binding1.24e-021.00e+006.3241615
GO:0032456endocytic recycling1.24e-021.00e+006.3241115
GO:0001824blastocyst development1.24e-021.00e+006.3241215
GO:0006376mRNA splice site selection1.24e-021.00e+006.3241115
GO:0042176regulation of protein catabolic process1.32e-021.00e+006.2311216
GO:0043274phospholipase binding1.32e-021.00e+006.2311116
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription1.32e-021.00e+006.2311216
GO:0050919negative chemotaxis1.41e-021.00e+006.1441117
GO:0017022myosin binding1.41e-021.00e+006.1441217
GO:0022624proteasome accessory complex1.41e-021.00e+006.1441117
GO:0008380RNA splicing1.48e-021.00e+003.398222228
GO:0050772positive regulation of axonogenesis1.49e-021.00e+006.0611118
GO:0014047glutamate secretion1.49e-021.00e+006.0611118
GO:0042346positive regulation of NF-kappaB import into nucleus1.49e-021.00e+006.0611118
GO:0010467gene expression1.60e-021.00e+002.430345669
GO:0050771negative regulation of axonogenesis1.65e-021.00e+005.9091120
GO:0032007negative regulation of TOR signaling1.65e-021.00e+005.9091120
GO:0014003oligodendrocyte development1.65e-021.00e+005.9091520
GO:0043393regulation of protein binding1.65e-021.00e+005.9091120
GO:0030099myeloid cell differentiation1.65e-021.00e+005.9091220
GO:0007492endoderm development1.73e-021.00e+005.8391221
GO:0031593polyubiquitin binding1.82e-021.00e+005.7721122
GO:0060170ciliary membrane1.82e-021.00e+005.7721122
GO:0031941filamentous actin1.82e-021.00e+005.7721222
GO:0010508positive regulation of autophagy1.82e-021.00e+005.7721222
GO:1900026positive regulation of substrate adhesion-dependent cell spreading1.90e-021.00e+005.7081323
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway1.90e-021.00e+005.7081223
GO:0010718positive regulation of epithelial to mesenchymal transition2.06e-021.00e+005.5871425
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation2.06e-021.00e+005.5871325
GO:0050770regulation of axonogenesis2.14e-021.00e+005.5311226
GO:0046966thyroid hormone receptor binding2.14e-021.00e+005.5311626
GO:0032467positive regulation of cytokinesis2.22e-021.00e+005.4761227
GO:0043531ADP binding2.31e-021.00e+005.4241328
GO:0030901midbrain development2.39e-021.00e+005.3731129
GO:0016358dendrite development2.47e-021.00e+005.3241130
GO:0048167regulation of synaptic plasticity2.47e-021.00e+005.3241230
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.48e-021.00e+002.192341789
GO:0032091negative regulation of protein binding2.63e-021.00e+005.2311332
GO:0007416synapse assembly2.71e-021.00e+005.1871333
GO:0043231intracellular membrane-bounded organelle2.76e-021.00e+002.91826318
GO:0007588excretion2.87e-021.00e+005.1021235
GO:2001237negative regulation of extrinsic apoptotic signaling pathway2.87e-021.00e+005.1021235
GO:0006605protein targeting2.87e-021.00e+005.1021135
GO:0030178negative regulation of Wnt signaling pathway2.87e-021.00e+005.1021435
GO:0008283cell proliferation2.93e-021.00e+002.874214328
GO:0007257activation of JUN kinase activity2.96e-021.00e+005.0611536
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway2.96e-021.00e+005.0611236
GO:0071560cellular response to transforming growth factor beta stimulus2.96e-021.00e+005.0611336
GO:0005902microvillus3.12e-021.00e+004.9831338
GO:0051496positive regulation of stress fiber assembly3.12e-021.00e+004.9831438
GO:0032154cleavage furrow3.12e-021.00e+004.9831138
GO:0015031protein transport3.15e-021.00e+002.817211341
GO:0005546phosphatidylinositol-4,5-bisphosphate binding3.20e-021.00e+004.9461239
GO:0046332SMAD binding3.28e-021.00e+004.9091240
GO:0035019somatic stem cell maintenance3.28e-021.00e+004.9091640
GO:0050885neuromuscular process controlling balance3.28e-021.00e+004.9091240
GO:0030521androgen receptor signaling pathway3.36e-021.00e+004.8741541
GO:0031124mRNA 3'-end processing3.44e-021.00e+004.8391242
GO:0071230cellular response to amino acid stimulus3.44e-021.00e+004.8391142
GO:0003774motor activity3.52e-021.00e+004.8051143
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity3.52e-021.00e+004.8051743
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process3.60e-021.00e+004.7721344
GO:0021762substantia nigra development3.60e-021.00e+004.7721444
GO:0003712transcription cofactor activity3.60e-021.00e+004.7721844
GO:0030139endocytic vesicle3.60e-021.00e+004.7721244
GO:0006369termination of RNA polymerase II transcription3.68e-021.00e+004.7391245
GO:0007266Rho protein signal transduction3.84e-021.00e+004.6771147
GO:0019827stem cell maintenance3.84e-021.00e+004.6771747
GO:0030900forebrain development4.00e-021.00e+004.6161149
GO:0006521regulation of cellular amino acid metabolic process4.08e-021.00e+004.5871150
GO:0042472inner ear morphogenesis4.08e-021.00e+004.5871250
GO:0030334regulation of cell migration4.08e-021.00e+004.5871550
GO:0005829cytosol4.20e-021.00e+001.2685862496
GO:0009611response to wounding4.24e-021.00e+004.5311552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0008203cholesterol metabolic process4.64e-021.00e+004.3981257
GO:0043066negative regulation of apoptotic process4.68e-021.00e+002.503216424
GO:0000502proteasome complex4.72e-021.00e+004.3731358
GO:0008013beta-catenin binding4.88e-021.00e+004.3241960
GO:0006406mRNA export from nucleus4.96e-021.00e+004.3001461
GO:0005634nucleus5.06e-021.00e+000.88471594559
GO:0004867serine-type endopeptidase inhibitor activity5.12e-021.00e+004.2541363
GO:0045666positive regulation of neuron differentiation5.12e-021.00e+004.2541363
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.20e-021.00e+004.2311164
GO:0044822poly(A) RNA binding5.23e-021.00e+001.7723501056
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.28e-021.00e+004.2091265
GO:0010468regulation of gene expression5.52e-021.00e+004.1441268
GO:0050790regulation of catalytic activity5.59e-021.00e+004.1231169
GO:0032587ruffle membrane5.67e-021.00e+004.1021370
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.67e-021.00e+004.1021270
GO:0045893positive regulation of transcription, DNA-templated5.81e-021.00e+002.330224478
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.83e-021.00e+004.0611172
GO:0003729mRNA binding5.83e-021.00e+004.0611472
GO:0001843neural tube closure5.99e-021.00e+004.0221274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.99e-021.00e+004.0221474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.99e-021.00e+004.0221274
GO:0060070canonical Wnt signaling pathway6.07e-021.00e+004.0021475
GO:0031901early endosome membrane6.07e-021.00e+004.0021175
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.07e-021.00e+004.0021175
GO:0007229integrin-mediated signaling pathway6.30e-021.00e+003.9461378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.38e-021.00e+003.9271279
GO:0001726ruffle6.46e-021.00e+003.9091480
GO:0045177apical part of cell6.54e-021.00e+003.8911381
GO:0009653anatomical structure morphogenesis6.69e-021.00e+003.8561283
GO:0006898receptor-mediated endocytosis6.77e-021.00e+003.8391384
GO:0090090negative regulation of canonical Wnt signaling pathway6.93e-021.00e+003.8051886
GO:0016032viral process7.07e-021.00e+002.170226534
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.39e-021.00e+003.7081192
GO:0051015actin filament binding7.39e-021.00e+003.7081392
GO:0003677DNA binding7.43e-021.00e+001.5663491218
GO:0006915apoptotic process7.56e-021.00e+002.115212555
GO:0005178integrin binding7.70e-021.00e+003.6461496
GO:0001934positive regulation of protein phosphorylation8.32e-021.00e+003.53115104
GO:0010951negative regulation of endopeptidase activity8.32e-021.00e+003.53116104
GO:0007605sensory perception of sound8.32e-021.00e+003.53112104
GO:0016023cytoplasmic membrane-bounded vesicle8.40e-021.00e+003.51718105
GO:0030496midbody8.63e-021.00e+003.47612108
GO:0030308negative regulation of cell growth8.78e-021.00e+003.45016110
GO:0017124SH3 domain binding9.01e-021.00e+003.41111113
GO:0048015phosphatidylinositol-mediated signaling9.09e-021.00e+003.39812114
GO:0051056regulation of small GTPase mediated signal transduction9.16e-021.00e+003.38613115
GO:0000209protein polyubiquitination9.24e-021.00e+003.37313116
GO:0008201heparin binding9.69e-021.00e+003.30011122
GO:0030036actin cytoskeleton organization9.77e-021.00e+003.28913123
GO:0030027lamellipodium9.92e-021.00e+003.26517125
GO:0007179transforming growth factor beta receptor signaling pathway1.01e-011.00e+003.231111128
GO:0030335positive regulation of cell migration1.01e-011.00e+003.24215127
GO:0016055Wnt signaling pathway1.09e-011.00e+003.12314138
GO:0007507heart development1.10e-011.00e+003.11217139
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling1.14e-011.00e+003.05114145
GO:0000082G1/S transition of mitotic cell cycle1.17e-011.00e+003.01213149
GO:0042981regulation of apoptotic process1.18e-011.00e+003.00214150
GO:0005516calmodulin binding1.25e-011.00e+002.90912160
GO:0000398mRNA splicing, via spliceosome1.28e-011.00e+002.874115164
GO:0030424axon1.30e-011.00e+002.85614166
GO:0031965nuclear membrane1.31e-011.00e+002.839110168
GO:0044212transcription regulatory region DNA binding1.31e-011.00e+002.839117168
GO:0006886intracellular protein transport1.33e-011.00e+002.81314171
GO:0034641cellular nitrogen compound metabolic process1.33e-011.00e+002.81312171
GO:0005667transcription factor complex1.36e-011.00e+002.780117175
GO:0031625ubiquitin protein ligase binding1.38e-011.00e+002.75515178
GO:0019904protein domain specific binding1.39e-011.00e+002.74718179
GO:0006367transcription initiation from RNA polymerase II promoter1.43e-011.00e+002.708122184
GO:0004872receptor activity1.46e-011.00e+002.66918189
GO:0007173epidermal growth factor receptor signaling pathway1.46e-011.00e+002.66915189
GO:0003924GTPase activity1.52e-011.00e+002.60917197
GO:0016324apical plasma membrane1.54e-011.00e+002.59411199
GO:0001701in utero embryonic development1.55e-011.00e+002.58018201
GO:0030168platelet activation1.58e-011.00e+002.55216205
GO:0006184GTP catabolic process1.64e-011.00e+002.49017214
GO:0016071mRNA metabolic process1.71e-011.00e+002.43018223
GO:0003713transcription coactivator activity1.80e-011.00e+002.342124237
GO:0005737cytoplasm1.81e-011.00e+000.67451243767
GO:0008134transcription factor binding1.84e-011.00e+002.312118242
GO:0043025neuronal cell body1.86e-011.00e+002.29419245
GO:0016070RNA metabolic process1.87e-011.00e+002.28318247
GO:0008152metabolic process1.95e-011.00e+002.22011258
GO:0000166nucleotide binding1.95e-011.00e+002.214113259
GO:0006357regulation of transcription from RNA polymerase II promoter1.99e-011.00e+002.187123264
GO:0003779actin binding2.00e-011.00e+002.176110266
GO:0048011neurotrophin TRK receptor signaling pathway2.02e-011.00e+002.16017269
GO:0007264small GTPase mediated signal transduction2.09e-011.00e+002.10713279
GO:0042493response to drug2.12e-011.00e+002.08116284
GO:0030198extracellular matrix organization2.12e-011.00e+002.08616283
GO:0007186G-protein coupled receptor signaling pathway2.16e-011.00e+002.05611289
GO:0005856cytoskeleton2.17e-011.00e+002.04619291
GO:0005525GTP binding2.30e-011.00e+001.955112310
GO:0007411axon guidance2.35e-011.00e+001.91415319
GO:0003682chromatin binding2.41e-011.00e+001.878119327
GO:0007268synaptic transmission2.44e-011.00e+001.85615332
GO:0030054cell junction2.46e-011.00e+001.83915336
GO:0003723RNA binding2.50e-011.00e+001.813118342
GO:0043565sequence-specific DNA binding2.53e-011.00e+001.796111346
GO:0008285negative regulation of cell proliferation2.57e-011.00e+001.768110353
GO:0000278mitotic cell cycle2.81e-011.00e+001.620115391
GO:0045892negative regulation of transcription, DNA-templated2.94e-011.00e+001.541124413
GO:0007596blood coagulation3.19e-011.00e+001.401111455
GO:0048471perinuclear region of cytoplasm3.46e-011.00e+001.26018502
GO:0005509calcium ion binding3.63e-011.00e+001.179111531
GO:0005730nucleolus4.04e-011.00e+000.5512661641
GO:0005794Golgi apparatus4.05e-011.00e+000.97819610
GO:0003700sequence-specific DNA binding transcription factor activity4.49e-011.00e+000.782139699
GO:0006355regulation of transcription, DNA-templated5.77e-011.00e+000.270143997
GO:0044281small molecule metabolic process6.51e-011.00e+00-0.0111201211
GO:0005524ATP binding6.78e-011.00e+00-0.1111311298
GO:0016021integral component of membrane8.30e-011.00e+00-0.7221171982