Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.837 | 1.59e-15 | 4.75e-04 | 3.34e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
MED19 | 219541 | 30 | -2.657 | 3.449 | 115 | Yes | - |
APLP2 | 334 | 12 | -2.732 | 3.206 | 35 | Yes | Yes |
RHOA | 387 | 5 | -2.408 | 2.845 | 151 | Yes | Yes |
[ DAB2 ] | 1601 | 1 | -1.641 | 2.837 | 49 | - | - |
LUC7L3 | 51747 | 33 | -3.523 | 3.449 | 18 | Yes | - |
EPS15 | 2060 | 2 | -1.912 | 2.837 | 75 | - | - |
SH3BP4 | 23677 | 2 | -2.354 | 2.837 | 33 | Yes | - |
MED12 | 9968 | 14 | -2.465 | 3.206 | 65 | Yes | - |
SRSF3 | 6428 | 73 | -2.992 | 3.538 | 54 | Yes | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
MYO6 | 4646 | 1 | -2.037 | 2.837 | 34 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
DAB2 | 1601 | EPS15 | 2060 | pp | -- | int.Intact: MI:0915(physical association) |
APLP2 | 334 | DAB2 | 1601 | pp | -- | int.I2D: BioGrid |
LUC7L3 | 51747 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
APLP2 | 334 | MED12 | 9968 | pp | -- | int.I2D: MINT; int.Mint: MI:0407(direct interaction) |
MED12 | 9968 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
DAB2 | 1601 | MYO6 | 4646 | pp | -- | int.Intact: MI:0915(physical association), MI:0403(colocalization); int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid |
RHOA | 387 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
SRSF3 | 6428 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
POU5F1 | 5460 | SRSF3 | 6428 | pp | -- | int.I2D: BioGrid |
APLP2 | 334 | RHOA | 387 | pp | -- | int.I2D: IntAct_Mouse |
EPS15 | 2060 | SH3BP4 | 23677 | pp | -- | int.I2D: BIND, MINT; int.Mint: MI:0915(physical association) |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005905 | coated pit | 6.20e-08 | 8.94e-04 | 6.587 | 4 | 6 | 50 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 3.48e-05 | 5.01e-01 | 7.772 | 2 | 4 | 11 |
GO:0048268 | clathrin coat assembly | 4.92e-05 | 7.10e-01 | 7.531 | 2 | 2 | 13 |
GO:0030665 | clathrin-coated vesicle membrane | 4.92e-05 | 7.10e-01 | 7.531 | 2 | 3 | 13 |
GO:0006897 | endocytosis | 8.09e-05 | 1.00e+00 | 5.088 | 3 | 7 | 106 |
GO:0001104 | RNA polymerase II transcription cofactor activity | 3.30e-04 | 1.00e+00 | 6.187 | 2 | 8 | 33 |
GO:0016592 | mediator complex | 3.72e-04 | 1.00e+00 | 6.102 | 2 | 10 | 35 |
GO:0005515 | protein binding | 4.97e-04 | 1.00e+00 | 1.134 | 11 | 198 | 6024 |
GO:0030136 | clathrin-coated vesicle | 5.36e-04 | 1.00e+00 | 5.839 | 2 | 5 | 42 |
GO:0038024 | cargo receptor activity | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0043090 | amino acid import | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0061383 | trabecula morphogenesis | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060001 | minus-end directed microfilament motor activity | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0005654 | nucleoplasm | 1.19e-03 | 1.00e+00 | 2.474 | 5 | 64 | 1082 |
GO:0007626 | locomotory behavior | 1.53e-03 | 1.00e+00 | 5.081 | 2 | 2 | 71 |
GO:0035026 | leading edge cell differentiation | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0051046 | regulation of secretion | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:2000370 | positive regulation of clathrin-mediated endocytosis | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0046914 | transition metal ion binding | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0090245 | axis elongation involved in somitogenesis | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0061462 | protein localization to lysosome | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0033688 | regulation of osteoblast proliferation | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0005925 | focal adhesion | 3.01e-03 | 1.00e+00 | 3.300 | 3 | 9 | 366 |
GO:0005938 | cell cortex | 3.24e-03 | 1.00e+00 | 4.531 | 2 | 5 | 104 |
GO:0014044 | Schwann cell development | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0038027 | apolipoprotein A-I-mediated signaling pathway | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:2000643 | positive regulation of early endosome to late endosome transport | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0000904 | cell morphogenesis involved in differentiation | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:1903077 | negative regulation of protein localization to plasma membrane | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0070022 | transforming growth factor beta receptor homodimeric complex | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0001714 | endodermal cell fate specification | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0045334 | clathrin-coated endocytic vesicle | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0006907 | pinocytosis | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:2001046 | positive regulation of integrin-mediated signaling pathway | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0007176 | regulation of epidermal growth factor-activated receptor activity | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0006366 | transcription from RNA polymerase II promoter | 4.40e-03 | 1.00e+00 | 3.105 | 3 | 30 | 419 |
GO:0036089 | cleavage furrow formation | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 2 | 6 |
GO:0016461 | unconventional myosin complex | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0043931 | ossification involved in bone maturation | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0035612 | AP-2 adaptor complex binding | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0030132 | clathrin coat of coated pit | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0043297 | apical junction assembly | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0005092 | GDP-dissociation inhibitor activity | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0061024 | membrane organization | 6.20e-03 | 1.00e+00 | 4.051 | 2 | 4 | 145 |
GO:0042802 | identical protein binding | 6.59e-03 | 1.00e+00 | 2.897 | 3 | 19 | 484 |
GO:0035615 | clathrin adaptor activity | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0007617 | mating behavior | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0016591 | DNA-directed RNA polymerase II, holoenzyme | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 2 | 9 |
GO:0042491 | auditory receptor cell differentiation | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0001921 | positive regulation of receptor recycling | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0043296 | apical junction complex | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0008022 | protein C-terminus binding | 7.59e-03 | 1.00e+00 | 3.900 | 2 | 8 | 161 |
GO:0070062 | extracellular vesicular exosome | 7.84e-03 | 1.00e+00 | 1.587 | 6 | 57 | 2400 |
GO:0030122 | AP-2 adaptor complex | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0090307 | spindle assembly involved in mitosis | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0035413 | positive regulation of catenin import into nucleus | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 10 |
GO:0034260 | negative regulation of GTPase activity | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 10 |
GO:0016020 | membrane | 8.36e-03 | 1.00e+00 | 1.838 | 5 | 46 | 1681 |
GO:0016607 | nuclear speck | 8.63e-03 | 1.00e+00 | 3.805 | 2 | 12 | 172 |
GO:0071257 | cellular response to electrical stimulus | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 2 | 11 |
GO:0016050 | vesicle organization | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 1 | 11 |
GO:0006895 | Golgi to endosome transport | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 1 | 11 |
GO:0006878 | cellular copper ion homeostasis | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
GO:0060766 | negative regulation of androgen receptor signaling pathway | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 3 | 13 |
GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0030234 | enzyme regulator activity | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
GO:0005886 | plasma membrane | 1.13e-02 | 1.00e+00 | 1.482 | 6 | 49 | 2582 |
GO:0001967 | suckling behavior | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0030518 | intracellular steroid hormone receptor signaling pathway | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 6 | 14 |
GO:0005685 | U1 snRNP | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0030048 | actin filament-based movement | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0017016 | Ras GTPase binding | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0045807 | positive regulation of endocytosis | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0005765 | lysosomal membrane | 1.19e-02 | 1.00e+00 | 3.566 | 2 | 3 | 203 |
GO:0042809 | vitamin D receptor binding | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 6 | 15 |
GO:0032456 | endocytic recycling | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 15 |
GO:0001824 | blastocyst development | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 15 |
GO:0006376 | mRNA splice site selection | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 15 |
GO:0042176 | regulation of protein catabolic process | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 2 | 16 |
GO:0043274 | phospholipase binding | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 16 |
GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 2 | 16 |
GO:0050919 | negative chemotaxis | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 17 |
GO:0017022 | myosin binding | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 2 | 17 |
GO:0022624 | proteasome accessory complex | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 17 |
GO:0008380 | RNA splicing | 1.48e-02 | 1.00e+00 | 3.398 | 2 | 22 | 228 |
GO:0050772 | positive regulation of axonogenesis | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 18 |
GO:0014047 | glutamate secretion | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 18 |
GO:0042346 | positive regulation of NF-kappaB import into nucleus | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 18 |
GO:0010467 | gene expression | 1.60e-02 | 1.00e+00 | 2.430 | 3 | 45 | 669 |
GO:0050771 | negative regulation of axonogenesis | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0032007 | negative regulation of TOR signaling | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0014003 | oligodendrocyte development | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 5 | 20 |
GO:0043393 | regulation of protein binding | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0030099 | myeloid cell differentiation | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 2 | 20 |
GO:0007492 | endoderm development | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 2 | 21 |
GO:0031593 | polyubiquitin binding | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 1 | 22 |
GO:0060170 | ciliary membrane | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 1 | 22 |
GO:0031941 | filamentous actin | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 2 | 22 |
GO:0010508 | positive regulation of autophagy | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 2 | 22 |
GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 3 | 23 |
GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 2 | 23 |
GO:0010718 | positive regulation of epithelial to mesenchymal transition | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 4 | 25 |
GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 3 | 25 |
GO:0050770 | regulation of axonogenesis | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 2 | 26 |
GO:0046966 | thyroid hormone receptor binding | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 6 | 26 |
GO:0032467 | positive regulation of cytokinesis | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 2 | 27 |
GO:0043531 | ADP binding | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 3 | 28 |
GO:0030901 | midbrain development | 2.39e-02 | 1.00e+00 | 5.373 | 1 | 1 | 29 |
GO:0016358 | dendrite development | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 1 | 30 |
GO:0048167 | regulation of synaptic plasticity | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 2 | 30 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 2.48e-02 | 1.00e+00 | 2.192 | 3 | 41 | 789 |
GO:0032091 | negative regulation of protein binding | 2.63e-02 | 1.00e+00 | 5.231 | 1 | 3 | 32 |
GO:0007416 | synapse assembly | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 3 | 33 |
GO:0043231 | intracellular membrane-bounded organelle | 2.76e-02 | 1.00e+00 | 2.918 | 2 | 6 | 318 |
GO:0007588 | excretion | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 2 | 35 |
GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 2 | 35 |
GO:0006605 | protein targeting | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 1 | 35 |
GO:0030178 | negative regulation of Wnt signaling pathway | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 4 | 35 |
GO:0008283 | cell proliferation | 2.93e-02 | 1.00e+00 | 2.874 | 2 | 14 | 328 |
GO:0007257 | activation of JUN kinase activity | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 5 | 36 |
GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 2 | 36 |
GO:0071560 | cellular response to transforming growth factor beta stimulus | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 3 | 36 |
GO:0005902 | microvillus | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 3 | 38 |
GO:0051496 | positive regulation of stress fiber assembly | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 4 | 38 |
GO:0032154 | cleavage furrow | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 1 | 38 |
GO:0015031 | protein transport | 3.15e-02 | 1.00e+00 | 2.817 | 2 | 11 | 341 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 3.20e-02 | 1.00e+00 | 4.946 | 1 | 2 | 39 |
GO:0046332 | SMAD binding | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 2 | 40 |
GO:0035019 | somatic stem cell maintenance | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 6 | 40 |
GO:0050885 | neuromuscular process controlling balance | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 2 | 40 |
GO:0030521 | androgen receptor signaling pathway | 3.36e-02 | 1.00e+00 | 4.874 | 1 | 5 | 41 |
GO:0031124 | mRNA 3'-end processing | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 2 | 42 |
GO:0071230 | cellular response to amino acid stimulus | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 1 | 42 |
GO:0003774 | motor activity | 3.52e-02 | 1.00e+00 | 4.805 | 1 | 1 | 43 |
GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity | 3.52e-02 | 1.00e+00 | 4.805 | 1 | 7 | 43 |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 3 | 44 |
GO:0021762 | substantia nigra development | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 4 | 44 |
GO:0003712 | transcription cofactor activity | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 8 | 44 |
GO:0030139 | endocytic vesicle | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 2 | 44 |
GO:0006369 | termination of RNA polymerase II transcription | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 2 | 45 |
GO:0007266 | Rho protein signal transduction | 3.84e-02 | 1.00e+00 | 4.677 | 1 | 1 | 47 |
GO:0019827 | stem cell maintenance | 3.84e-02 | 1.00e+00 | 4.677 | 1 | 7 | 47 |
GO:0030900 | forebrain development | 4.00e-02 | 1.00e+00 | 4.616 | 1 | 1 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 1 | 50 |
GO:0042472 | inner ear morphogenesis | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 2 | 50 |
GO:0030334 | regulation of cell migration | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 5 | 50 |
GO:0005829 | cytosol | 4.20e-02 | 1.00e+00 | 1.268 | 5 | 86 | 2496 |
GO:0009611 | response to wounding | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 5 | 52 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 5 | 53 |
GO:0008203 | cholesterol metabolic process | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 2 | 57 |
GO:0043066 | negative regulation of apoptotic process | 4.68e-02 | 1.00e+00 | 2.503 | 2 | 16 | 424 |
GO:0000502 | proteasome complex | 4.72e-02 | 1.00e+00 | 4.373 | 1 | 3 | 58 |
GO:0008013 | beta-catenin binding | 4.88e-02 | 1.00e+00 | 4.324 | 1 | 9 | 60 |
GO:0006406 | mRNA export from nucleus | 4.96e-02 | 1.00e+00 | 4.300 | 1 | 4 | 61 |
GO:0005634 | nucleus | 5.06e-02 | 1.00e+00 | 0.884 | 7 | 159 | 4559 |
GO:0004867 | serine-type endopeptidase inhibitor activity | 5.12e-02 | 1.00e+00 | 4.254 | 1 | 3 | 63 |
GO:0045666 | positive regulation of neuron differentiation | 5.12e-02 | 1.00e+00 | 4.254 | 1 | 3 | 63 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 5.20e-02 | 1.00e+00 | 4.231 | 1 | 1 | 64 |
GO:0044822 | poly(A) RNA binding | 5.23e-02 | 1.00e+00 | 1.772 | 3 | 50 | 1056 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 2 | 65 |
GO:0010468 | regulation of gene expression | 5.52e-02 | 1.00e+00 | 4.144 | 1 | 2 | 68 |
GO:0050790 | regulation of catalytic activity | 5.59e-02 | 1.00e+00 | 4.123 | 1 | 1 | 69 |
GO:0032587 | ruffle membrane | 5.67e-02 | 1.00e+00 | 4.102 | 1 | 3 | 70 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.67e-02 | 1.00e+00 | 4.102 | 1 | 2 | 70 |
GO:0045893 | positive regulation of transcription, DNA-templated | 5.81e-02 | 1.00e+00 | 2.330 | 2 | 24 | 478 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 5.83e-02 | 1.00e+00 | 4.061 | 1 | 1 | 72 |
GO:0003729 | mRNA binding | 5.83e-02 | 1.00e+00 | 4.061 | 1 | 4 | 72 |
GO:0001843 | neural tube closure | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0060070 | canonical Wnt signaling pathway | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 4 | 75 |
GO:0031901 | early endosome membrane | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 1 | 75 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 1 | 75 |
GO:0007229 | integrin-mediated signaling pathway | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 3 | 78 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 6.38e-02 | 1.00e+00 | 3.927 | 1 | 2 | 79 |
GO:0001726 | ruffle | 6.46e-02 | 1.00e+00 | 3.909 | 1 | 4 | 80 |
GO:0045177 | apical part of cell | 6.54e-02 | 1.00e+00 | 3.891 | 1 | 3 | 81 |
GO:0009653 | anatomical structure morphogenesis | 6.69e-02 | 1.00e+00 | 3.856 | 1 | 2 | 83 |
GO:0006898 | receptor-mediated endocytosis | 6.77e-02 | 1.00e+00 | 3.839 | 1 | 3 | 84 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 6.93e-02 | 1.00e+00 | 3.805 | 1 | 8 | 86 |
GO:0016032 | viral process | 7.07e-02 | 1.00e+00 | 2.170 | 2 | 26 | 534 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 1 | 92 |
GO:0051015 | actin filament binding | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 3 | 92 |
GO:0003677 | DNA binding | 7.43e-02 | 1.00e+00 | 1.566 | 3 | 49 | 1218 |
GO:0006915 | apoptotic process | 7.56e-02 | 1.00e+00 | 2.115 | 2 | 12 | 555 |
GO:0005178 | integrin binding | 7.70e-02 | 1.00e+00 | 3.646 | 1 | 4 | 96 |
GO:0001934 | positive regulation of protein phosphorylation | 8.32e-02 | 1.00e+00 | 3.531 | 1 | 5 | 104 |
GO:0010951 | negative regulation of endopeptidase activity | 8.32e-02 | 1.00e+00 | 3.531 | 1 | 6 | 104 |
GO:0007605 | sensory perception of sound | 8.32e-02 | 1.00e+00 | 3.531 | 1 | 2 | 104 |
GO:0016023 | cytoplasmic membrane-bounded vesicle | 8.40e-02 | 1.00e+00 | 3.517 | 1 | 8 | 105 |
GO:0030496 | midbody | 8.63e-02 | 1.00e+00 | 3.476 | 1 | 2 | 108 |
GO:0030308 | negative regulation of cell growth | 8.78e-02 | 1.00e+00 | 3.450 | 1 | 6 | 110 |
GO:0017124 | SH3 domain binding | 9.01e-02 | 1.00e+00 | 3.411 | 1 | 1 | 113 |
GO:0048015 | phosphatidylinositol-mediated signaling | 9.09e-02 | 1.00e+00 | 3.398 | 1 | 2 | 114 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 9.16e-02 | 1.00e+00 | 3.386 | 1 | 3 | 115 |
GO:0000209 | protein polyubiquitination | 9.24e-02 | 1.00e+00 | 3.373 | 1 | 3 | 116 |
GO:0008201 | heparin binding | 9.69e-02 | 1.00e+00 | 3.300 | 1 | 1 | 122 |
GO:0030036 | actin cytoskeleton organization | 9.77e-02 | 1.00e+00 | 3.289 | 1 | 3 | 123 |
GO:0030027 | lamellipodium | 9.92e-02 | 1.00e+00 | 3.265 | 1 | 7 | 125 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.01e-01 | 1.00e+00 | 3.231 | 1 | 11 | 128 |
GO:0030335 | positive regulation of cell migration | 1.01e-01 | 1.00e+00 | 3.242 | 1 | 5 | 127 |
GO:0016055 | Wnt signaling pathway | 1.09e-01 | 1.00e+00 | 3.123 | 1 | 4 | 138 |
GO:0007507 | heart development | 1.10e-01 | 1.00e+00 | 3.112 | 1 | 7 | 139 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 1.14e-01 | 1.00e+00 | 3.051 | 1 | 4 | 145 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.17e-01 | 1.00e+00 | 3.012 | 1 | 3 | 149 |
GO:0042981 | regulation of apoptotic process | 1.18e-01 | 1.00e+00 | 3.002 | 1 | 4 | 150 |
GO:0005516 | calmodulin binding | 1.25e-01 | 1.00e+00 | 2.909 | 1 | 2 | 160 |
GO:0000398 | mRNA splicing, via spliceosome | 1.28e-01 | 1.00e+00 | 2.874 | 1 | 15 | 164 |
GO:0030424 | axon | 1.30e-01 | 1.00e+00 | 2.856 | 1 | 4 | 166 |
GO:0031965 | nuclear membrane | 1.31e-01 | 1.00e+00 | 2.839 | 1 | 10 | 168 |
GO:0044212 | transcription regulatory region DNA binding | 1.31e-01 | 1.00e+00 | 2.839 | 1 | 17 | 168 |
GO:0006886 | intracellular protein transport | 1.33e-01 | 1.00e+00 | 2.813 | 1 | 4 | 171 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.33e-01 | 1.00e+00 | 2.813 | 1 | 2 | 171 |
GO:0005667 | transcription factor complex | 1.36e-01 | 1.00e+00 | 2.780 | 1 | 17 | 175 |
GO:0031625 | ubiquitin protein ligase binding | 1.38e-01 | 1.00e+00 | 2.755 | 1 | 5 | 178 |
GO:0019904 | protein domain specific binding | 1.39e-01 | 1.00e+00 | 2.747 | 1 | 8 | 179 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.43e-01 | 1.00e+00 | 2.708 | 1 | 22 | 184 |
GO:0004872 | receptor activity | 1.46e-01 | 1.00e+00 | 2.669 | 1 | 8 | 189 |
GO:0007173 | epidermal growth factor receptor signaling pathway | 1.46e-01 | 1.00e+00 | 2.669 | 1 | 5 | 189 |
GO:0003924 | GTPase activity | 1.52e-01 | 1.00e+00 | 2.609 | 1 | 7 | 197 |
GO:0016324 | apical plasma membrane | 1.54e-01 | 1.00e+00 | 2.594 | 1 | 1 | 199 |
GO:0001701 | in utero embryonic development | 1.55e-01 | 1.00e+00 | 2.580 | 1 | 8 | 201 |
GO:0030168 | platelet activation | 1.58e-01 | 1.00e+00 | 2.552 | 1 | 6 | 205 |
GO:0006184 | GTP catabolic process | 1.64e-01 | 1.00e+00 | 2.490 | 1 | 7 | 214 |
GO:0016071 | mRNA metabolic process | 1.71e-01 | 1.00e+00 | 2.430 | 1 | 8 | 223 |
GO:0003713 | transcription coactivator activity | 1.80e-01 | 1.00e+00 | 2.342 | 1 | 24 | 237 |
GO:0005737 | cytoplasm | 1.81e-01 | 1.00e+00 | 0.674 | 5 | 124 | 3767 |
GO:0008134 | transcription factor binding | 1.84e-01 | 1.00e+00 | 2.312 | 1 | 18 | 242 |
GO:0043025 | neuronal cell body | 1.86e-01 | 1.00e+00 | 2.294 | 1 | 9 | 245 |
GO:0016070 | RNA metabolic process | 1.87e-01 | 1.00e+00 | 2.283 | 1 | 8 | 247 |
GO:0008152 | metabolic process | 1.95e-01 | 1.00e+00 | 2.220 | 1 | 1 | 258 |
GO:0000166 | nucleotide binding | 1.95e-01 | 1.00e+00 | 2.214 | 1 | 13 | 259 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 1.99e-01 | 1.00e+00 | 2.187 | 1 | 23 | 264 |
GO:0003779 | actin binding | 2.00e-01 | 1.00e+00 | 2.176 | 1 | 10 | 266 |
GO:0048011 | neurotrophin TRK receptor signaling pathway | 2.02e-01 | 1.00e+00 | 2.160 | 1 | 7 | 269 |
GO:0007264 | small GTPase mediated signal transduction | 2.09e-01 | 1.00e+00 | 2.107 | 1 | 3 | 279 |
GO:0042493 | response to drug | 2.12e-01 | 1.00e+00 | 2.081 | 1 | 6 | 284 |
GO:0030198 | extracellular matrix organization | 2.12e-01 | 1.00e+00 | 2.086 | 1 | 6 | 283 |
GO:0007186 | G-protein coupled receptor signaling pathway | 2.16e-01 | 1.00e+00 | 2.056 | 1 | 1 | 289 |
GO:0005856 | cytoskeleton | 2.17e-01 | 1.00e+00 | 2.046 | 1 | 9 | 291 |
GO:0005525 | GTP binding | 2.30e-01 | 1.00e+00 | 1.955 | 1 | 12 | 310 |
GO:0007411 | axon guidance | 2.35e-01 | 1.00e+00 | 1.914 | 1 | 5 | 319 |
GO:0003682 | chromatin binding | 2.41e-01 | 1.00e+00 | 1.878 | 1 | 19 | 327 |
GO:0007268 | synaptic transmission | 2.44e-01 | 1.00e+00 | 1.856 | 1 | 5 | 332 |
GO:0030054 | cell junction | 2.46e-01 | 1.00e+00 | 1.839 | 1 | 5 | 336 |
GO:0003723 | RNA binding | 2.50e-01 | 1.00e+00 | 1.813 | 1 | 18 | 342 |
GO:0043565 | sequence-specific DNA binding | 2.53e-01 | 1.00e+00 | 1.796 | 1 | 11 | 346 |
GO:0008285 | negative regulation of cell proliferation | 2.57e-01 | 1.00e+00 | 1.768 | 1 | 10 | 353 |
GO:0000278 | mitotic cell cycle | 2.81e-01 | 1.00e+00 | 1.620 | 1 | 15 | 391 |
GO:0045892 | negative regulation of transcription, DNA-templated | 2.94e-01 | 1.00e+00 | 1.541 | 1 | 24 | 413 |
GO:0007596 | blood coagulation | 3.19e-01 | 1.00e+00 | 1.401 | 1 | 11 | 455 |
GO:0048471 | perinuclear region of cytoplasm | 3.46e-01 | 1.00e+00 | 1.260 | 1 | 8 | 502 |
GO:0005509 | calcium ion binding | 3.63e-01 | 1.00e+00 | 1.179 | 1 | 11 | 531 |
GO:0005730 | nucleolus | 4.04e-01 | 1.00e+00 | 0.551 | 2 | 66 | 1641 |
GO:0005794 | Golgi apparatus | 4.05e-01 | 1.00e+00 | 0.978 | 1 | 9 | 610 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 4.49e-01 | 1.00e+00 | 0.782 | 1 | 39 | 699 |
GO:0006355 | regulation of transcription, DNA-templated | 5.77e-01 | 1.00e+00 | 0.270 | 1 | 43 | 997 |
GO:0044281 | small molecule metabolic process | 6.51e-01 | 1.00e+00 | -0.011 | 1 | 20 | 1211 |
GO:0005524 | ATP binding | 6.78e-01 | 1.00e+00 | -0.111 | 1 | 31 | 1298 |
GO:0016021 | integral component of membrane | 8.30e-01 | 1.00e+00 | -0.722 | 1 | 17 | 1982 |