int-snw-11168

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.880 5.46e-16 2.81e-04 2.30e-03
chia-screen-data-Fav-int-snw-11168 subnetwork

Genes (15)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
TPR 7175 18-2.6383.07228YesYes
SUB1 10923 2-2.0422.88027Yes-
MED19 219541 30-2.6573.449115Yes-
LUC7L3 51747 33-3.5233.44918Yes-
ZC3H18 124245 3-2.4262.9376Yes-
YAP1 10413 94-4.2563.53853Yes-
MED12 9968 14-2.4653.20665Yes-
WDR82 80335 7-2.4553.12964Yes-
POU5F1 5460 133-5.1483.538179YesYes
HNRNPU 3192 76-2.8693.538139Yes-
SON 6651 9-3.8443.1089YesYes
[ PSIP1 ] 11168 1-1.5372.88017--
CDK12 51755 6-2.7142.94415Yes-
SUMO1 7341 7-1.6963.050439--

Interactions (17)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1 3054 WDR82 80335 pp -- int.I2D: BioGrid
SUMO1 7341 MED12 9968 pp -- int.I2D: BioGrid
HCFC1 3054 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
SUMO1 7341 PSIP1 11168 pp -- int.Mint: MI:0914(association)
SON 6651 SUMO1 7341 pp -- int.I2D: BioGrid
SUMO1 7341 ZC3H18 124245 pp -- int.I2D: BioGrid
SUMO1 7341 CDK12 51755 pp -- int.I2D: BioGrid
SUB1 10923 PSIP1 11168 pp -- int.I2D: BioGrid
HNRNPU 3192 SUMO1 7341 pp -- int.I2D: BioGrid
HCFC1 3054 PSIP1 11168 pp -- int.I2D: HPRD, BCI;
int.Ravasi: -;
int.HPRD: in vitro
MED12 9968 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
POU5F1 5460 SUMO1 7341 pp -- int.I2D: BioGrid, BioGrid_Mouse
TPR 7175 SUMO1 7341 pp -- int.I2D: BioGrid

Related GO terms (224)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0044822poly(A) RNA binding1.96e-072.82e-033.0359501056
GO:0005634nucleus1.04e-061.50e-021.562141594559
GO:0005654nucleoplasm3.91e-065.63e-022.8308641082
GO:0003682chromatin binding1.45e-052.09e-013.878519327
GO:0016607nuclear speck2.41e-053.47e-014.483412172
GO:0048188Set1C/COMPASS complex3.62e-055.22e-017.739249
GO:0034399nuclear periphery6.62e-059.55e-017.3242512
GO:0008380RNA splicing7.24e-051.00e+004.076422228
GO:0003713transcription coactivator activity8.41e-051.00e+004.020424237
GO:0005730nucleolus8.49e-051.00e+002.2298661641
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.30e-041.00e+006.4502422
GO:0005515protein binding4.61e-041.00e+001.053131986024
GO:0001104RNA polymerase II transcription cofactor activity5.23e-041.00e+005.8652833
GO:0016592mediator complex5.89e-041.00e+005.78021035
GO:0045944positive regulation of transcription from RNA polymerase II promoter9.17e-041.00e+002.607541789
GO:0060795cell fate commitment involved in formation of primary germ layer1.04e-031.00e+009.909111
GO:1901673regulation of spindle assembly involved in mitosis1.04e-031.00e+009.909111
GO:0043578nuclear matrix organization1.04e-031.00e+009.909111
GO:0010965regulation of mitotic sister chromatid separation1.04e-031.00e+009.909111
GO:0006404RNA import into nucleus1.04e-031.00e+009.909111
GO:0090308regulation of methylation-dependent chromatin silencing1.04e-031.00e+009.909111
GO:0031453positive regulation of heterochromatin assembly1.04e-031.00e+009.909111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.04e-031.00e+009.909111
GO:0097100supercoiled DNA binding1.04e-031.00e+009.909111
GO:0060965negative regulation of gene silencing by miRNA1.04e-031.00e+009.909111
GO:0005643nuclear pore1.56e-031.00e+005.07621157
GO:0000189MAPK import into nucleus2.08e-031.00e+008.909112
GO:0060242contact inhibition2.08e-031.00e+008.909112
GO:0031990mRNA export from nucleus in response to heat stress2.08e-031.00e+008.909122
GO:0019046release from viral latency2.08e-031.00e+008.909122
GO:0070816phosphorylation of RNA polymerase II C-terminal domain2.08e-031.00e+008.909112
GO:0090204protein localization to nuclear pore2.08e-031.00e+008.909112
GO:0009786regulation of asymmetric cell division2.08e-031.00e+008.909112
GO:0070840dynein complex binding2.08e-031.00e+008.909112
GO:0002944cyclin K-CDK12 complex2.08e-031.00e+008.909112
GO:0046832negative regulation of RNA export from nucleus2.08e-031.00e+008.909112
GO:0003729mRNA binding2.47e-031.00e+004.7392472
GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex3.12e-031.00e+008.324113
GO:0006405RNA export from nucleus3.12e-031.00e+008.324123
GO:0042306regulation of protein import into nucleus3.12e-031.00e+008.324123
GO:0060913cardiac cell fate determination3.12e-031.00e+008.324113
GO:0003130BMP signaling pathway involved in heart induction3.12e-031.00e+008.324113
GO:0001650fibrillar center3.12e-031.00e+008.324113
GO:0090245axis elongation involved in somitogenesis3.12e-031.00e+008.324113
GO:0014044Schwann cell development4.15e-031.00e+007.909114
GO:0000395mRNA 5'-splice site recognition4.15e-031.00e+007.909114
GO:0030578PML body organization4.15e-031.00e+007.909114
GO:0006999nuclear pore organization4.15e-031.00e+007.909114
GO:0044615nuclear pore nuclear basket4.15e-031.00e+007.909114
GO:0051726regulation of cell cycle4.44e-031.00e+004.3092597
GO:0070461SAGA-type complex5.19e-031.00e+007.587125
GO:0001714endodermal cell fate specification5.19e-031.00e+007.587115
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint5.19e-031.00e+007.587115
GO:0070934CRD-mediated mRNA stabilization5.19e-031.00e+007.587125
GO:0010793regulation of mRNA export from nucleus5.19e-031.00e+007.587115
GO:0043405regulation of MAP kinase activity5.19e-031.00e+007.587115
GO:0070849response to epidermal growth factor5.19e-031.00e+007.587115
GO:0050733RS domain binding6.22e-031.00e+007.324116
GO:0070937CRD-mediated mRNA stability complex6.22e-031.00e+007.324136
GO:0046825regulation of protein export from nucleus7.26e-031.00e+007.102127
GO:0072357PTW/PP1 phosphatase complex7.26e-031.00e+007.102127
GO:0051292nuclear pore complex assembly8.29e-031.00e+006.909148
GO:0075713establishment of integrated proviral latency8.29e-031.00e+006.909118
GO:0070688MLL5-L complex8.29e-031.00e+006.909118
GO:0043254regulation of protein complex assembly8.29e-031.00e+006.909118
GO:0035457cellular response to interferon-alpha8.29e-031.00e+006.909118
GO:0006366transcription from RNA polymerase II promoter8.54e-031.00e+002.783330419
GO:0043995histone acetyltransferase activity (H4-K5 specific)9.32e-031.00e+006.739159
GO:0046972histone acetyltransferase activity (H4-K16 specific)9.32e-031.00e+006.739159
GO:0042405nuclear inclusion body9.32e-031.00e+006.739129
GO:0043495protein anchor9.32e-031.00e+006.739119
GO:0043996histone acetyltransferase activity (H4-K8 specific)9.32e-031.00e+006.739159
GO:0035413positive regulation of catenin import into nucleus1.04e-021.00e+006.5871210
GO:0060071Wnt signaling pathway, planar cell polarity pathway1.04e-021.00e+006.5871110
GO:0019789SUMO ligase activity1.14e-021.00e+006.4501111
GO:0060391positive regulation of SMAD protein import into nucleus1.14e-021.00e+006.4501411
GO:0006397mRNA processing1.17e-021.00e+003.587210160
GO:0045947negative regulation of translational initiation1.24e-021.00e+006.3241212
GO:0035198miRNA binding1.24e-021.00e+006.3241112
GO:0031965nuclear membrane1.28e-021.00e+003.517210168
GO:0044212transcription regulatory region DNA binding1.28e-021.00e+003.517217168
GO:0071480cellular response to gamma radiation1.34e-021.00e+006.2091113
GO:0042789mRNA transcription from RNA polymerase II promoter1.34e-021.00e+006.2091213
GO:0051019mitogen-activated protein kinase binding1.34e-021.00e+006.2091213
GO:0031334positive regulation of protein complex assembly1.34e-021.00e+006.2091213
GO:0005868cytoplasmic dynein complex1.34e-021.00e+006.2091113
GO:0042800histone methyltransferase activity (H3-K4 specific)1.34e-021.00e+006.2091313
GO:0046827positive regulation of protein export from nucleus1.34e-021.00e+006.2091113
GO:0005667transcription factor complex1.39e-021.00e+003.458217175
GO:0031625ubiquitin protein ligase binding1.43e-021.00e+003.43325178
GO:0030518intracellular steroid hormone receptor signaling pathway1.45e-021.00e+006.1021614
GO:0005685U1 snRNP1.45e-021.00e+006.1021114
GO:0005487nucleocytoplasmic transporter activity1.45e-021.00e+006.1021314
GO:0006367transcription initiation from RNA polymerase II promoter1.52e-021.00e+003.386222184
GO:0043981histone H4-K5 acetylation1.55e-021.00e+006.0021515
GO:0042809vitamin D receptor binding1.55e-021.00e+006.0021615
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.55e-021.00e+006.0021315
GO:0042307positive regulation of protein import into nucleus1.55e-021.00e+006.0021415
GO:0001824blastocyst development1.55e-021.00e+006.0021215
GO:0043982histone H4-K8 acetylation1.55e-021.00e+006.0021515
GO:0006376mRNA splice site selection1.55e-021.00e+006.0021115
GO:0060334regulation of interferon-gamma-mediated signaling pathway1.65e-021.00e+005.9091116
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription1.65e-021.00e+005.9091216
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity1.65e-021.00e+005.9091116
GO:0006355regulation of transcription, DNA-templated1.67e-021.00e+001.948443997
GO:0051568histone H3-K4 methylation1.75e-021.00e+005.8221317
GO:0090316positive regulation of intracellular protein transport1.75e-021.00e+005.8221217
GO:0035327transcriptionally active chromatin1.75e-021.00e+005.8221217
GO:0030332cyclin binding1.86e-021.00e+005.7391118
GO:0033613activating transcription factor binding1.86e-021.00e+005.7391318
GO:0043984histone H4-K16 acetylation1.96e-021.00e+005.6611519
GO:0014003oligodendrocyte development2.06e-021.00e+005.5871520
GO:0019221cytokine-mediated signaling pathway2.15e-021.00e+003.12128221
GO:0000123histone acetyltransferase complex2.16e-021.00e+005.5171621
GO:0035097histone methyltransferase complex2.16e-021.00e+005.5171321
GO:0045787positive regulation of cell cycle2.26e-021.00e+005.4501222
GO:0043484regulation of RNA splicing2.26e-021.00e+005.4501122
GO:0005720nuclear heterochromatin2.26e-021.00e+005.4501222
GO:0036464cytoplasmic ribonucleoprotein granule2.26e-021.00e+005.4501222
GO:0001105RNA polymerase II transcription coactivator activity2.47e-021.00e+005.3241224
GO:0008134transcription factor binding2.55e-021.00e+002.990218242
GO:0006611protein export from nucleus2.57e-021.00e+005.2651325
GO:0016925protein sumoylation2.57e-021.00e+005.2651225
GO:0043392negative regulation of DNA binding2.67e-021.00e+005.2091426
GO:0035329hippo signaling2.67e-021.00e+005.2091526
GO:0046966thyroid hormone receptor binding2.67e-021.00e+005.2091626
GO:0015631tubulin binding2.77e-021.00e+005.1541227
GO:0071339MLL1 complex2.77e-021.00e+005.1541627
GO:0034605cellular response to heat2.87e-021.00e+005.1021128
GO:0072686mitotic spindle2.98e-021.00e+005.0511329
GO:0010467gene expression2.98e-021.00e+002.108345669
GO:0006357regulation of transcription from RNA polymerase II promoter3.00e-021.00e+002.865223264
GO:0006606protein import into nucleus3.08e-021.00e+005.0021230
GO:0031647regulation of protein stability3.08e-021.00e+005.0021430
GO:0010827regulation of glucose transport3.08e-021.00e+005.0021430
GO:0004693cyclin-dependent protein serine/threonine kinase activity3.18e-021.00e+004.9551131
GO:0007094mitotic spindle assembly checkpoint3.18e-021.00e+004.9551331
GO:0003677DNA binding3.25e-021.00e+001.6594491218
GO:1903507negative regulation of nucleic acid-templated transcription3.28e-021.00e+004.9091232
GO:0031072heat shock protein binding3.38e-021.00e+004.8651233
GO:0030178negative regulation of Wnt signaling pathway3.58e-021.00e+004.7801435
GO:0007077mitotic nuclear envelope disassembly3.68e-021.00e+004.7391436
GO:0032880regulation of protein localization3.78e-021.00e+004.7001237
GO:0008645hexose transport3.98e-021.00e+004.6241439
GO:0009408response to heat4.08e-021.00e+004.5871640
GO:0035019somatic stem cell maintenance4.08e-021.00e+004.5871640
GO:0030521androgen receptor signaling pathway4.18e-021.00e+004.5521541
GO:0019898extrinsic component of membrane4.28e-021.00e+004.5171242
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity4.38e-021.00e+004.4831743
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process4.48e-021.00e+004.4501344
GO:0003712transcription cofactor activity4.48e-021.00e+004.4501844
GO:0019827stem cell maintenance4.78e-021.00e+004.3551747
GO:0003723RNA binding4.80e-021.00e+002.491218342
GO:0000910cytokinesis5.18e-021.00e+004.2371251
GO:0000226microtubule cytoskeleton organization5.28e-021.00e+004.2091252
GO:0009611response to wounding5.28e-021.00e+004.2091552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.38e-021.00e+004.1811553
GO:0015758glucose transport5.57e-021.00e+004.1281455
GO:0006396RNA processing5.97e-021.00e+004.0271559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.97e-021.00e+004.0271659
GO:0008013beta-catenin binding6.06e-021.00e+004.0021960
GO:0060333interferon-gamma-mediated signaling pathway6.26e-021.00e+003.9551362
GO:0000776kinetochore6.36e-021.00e+003.9321563
GO:0010468regulation of gene expression6.85e-021.00e+003.8221268
GO:0003697single-stranded DNA binding6.85e-021.00e+003.8221568
GO:0060021palate development7.24e-021.00e+003.7391172
GO:0000785chromatin7.33e-021.00e+003.7191673
GO:0001843neural tube closure7.43e-021.00e+003.7001274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity7.43e-021.00e+003.7001474
GO:0060070canonical Wnt signaling pathway7.53e-021.00e+003.6801475
GO:0071013catalytic step 2 spliceosome7.82e-021.00e+003.6241778
GO:0009653anatomical structure morphogenesis8.30e-021.00e+003.5341283
GO:0006979response to oxidative stress8.68e-021.00e+003.4661687
GO:0016605PML body8.78e-021.00e+003.4501388
GO:0050821protein stabilization8.78e-021.00e+003.4501388
GO:0001649osteoblast differentiation9.16e-021.00e+003.3861592
GO:0016032viral process1.05e-011.00e+001.848226534
GO:0003676nucleic acid binding1.06e-011.00e+003.16812107
GO:0030529ribonucleoprotein complex1.10e-011.00e+003.10215112
GO:0005635nuclear envelope1.11e-011.00e+003.08915113
GO:0006325chromatin organization1.16e-011.00e+003.027112118
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.17e-011.00e+001.754237570
GO:0005215transporter activity1.27e-011.00e+002.88713130
GO:0045202synapse1.33e-011.00e+002.82215136
GO:0007507heart development1.35e-011.00e+002.79017139
GO:0010628positive regulation of gene expression1.42e-011.00e+002.71917146
GO:0006974cellular response to DNA damage stimulus1.46e-011.00e+002.67117151
GO:0046777protein autophosphorylation1.52e-011.00e+002.60514158
GO:0008022protein C-terminus binding1.55e-011.00e+002.57818161
GO:0043687post-translational protein modification1.56e-011.00e+002.56915162
GO:0000398mRNA splicing, via spliceosome1.58e-011.00e+002.552115164
GO:0003700sequence-specific DNA binding transcription factor activity1.63e-011.00e+001.460239699
GO:0007049cell cycle1.67e-011.00e+002.46616174
GO:0004672protein kinase activity1.69e-011.00e+002.44213177
GO:0003714transcription corepressor activity1.70e-011.00e+002.433111178
GO:0019904protein domain specific binding1.71e-011.00e+002.42518179
GO:0004872receptor activity1.80e-011.00e+002.34718189
GO:0007067mitotic nuclear division2.12e-011.00e+002.08316227
GO:0030425dendrite2.14e-011.00e+002.06416230
GO:0043025neuronal cell body2.27e-011.00e+001.97319245
GO:0005975carbohydrate metabolic process2.33e-011.00e+001.92618253
GO:0006281DNA repair2.40e-011.00e+001.881114261
GO:0016020membrane2.51e-011.00e+000.7793461681
GO:0008283cell proliferation2.92e-011.00e+001.552114328
GO:0043565sequence-specific DNA binding3.05e-011.00e+001.475111346
GO:0005925focal adhesion3.20e-011.00e+001.39319366
GO:0000278mitotic cell cycle3.38e-011.00e+001.298115391
GO:0009986cell surface3.46e-011.00e+001.25819402
GO:0005737cytoplasm3.51e-011.00e+000.35251243767
GO:0045892negative regulation of transcription, DNA-templated3.53e-011.00e+001.219124413
GO:0043066negative regulation of apoptotic process3.61e-011.00e+001.181116424
GO:0055085transmembrane transport3.68e-011.00e+001.14418435
GO:0044267cellular protein metabolic process3.94e-011.00e+001.020120474
GO:0005524ATP binding3.97e-011.00e+000.5672311298
GO:0045893positive regulation of transcription, DNA-templated3.97e-011.00e+001.008124478
GO:0042802identical protein binding4.01e-011.00e+000.990119484
GO:0006351transcription, DNA-templated4.52e-011.00e+000.4112571446
GO:0042803protein homodimerization activity4.69e-011.00e+000.692119595
GO:0005829cytosol4.95e-011.00e+000.2093862496
GO:0005739mitochondrion6.59e-011.00e+00-0.054123998
GO:0044281small molecule metabolic process7.32e-011.00e+00-0.3331201211
GO:0046872metal ion binding7.60e-011.00e+00-0.4431291307
GO:0070062extracellular vesicular exosome9.35e-011.00e+00-1.3201572400
GO:0005886plasma membrane9.48e-011.00e+00-1.4251492582