int-snw-11033

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.870 6.99e-16 3.17e-04 2.51e-03
chia-screen-data-Fav-int-snw-11033 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EP300 2033 22-2.2743.120415YesYes
SUB1 10923 2-2.0422.88027Yes-
[ ADAP1 ] 11033 1-1.7712.87019--
TADA2B 93624 11-3.0613.08219Yes-
FTSJ1 24140 4-2.4632.99495YesYes
YAP1 10413 94-4.2563.53853Yes-
SF3A3 10946 1-2.0712.87040YesYes
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
DDIT3 1649 60-2.8253.504343YesYes
SF3A1 10291 4-2.7873.12943YesYes

Interactions (12)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
SF3A3 10946 FTSJ1 24140 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
SF3A1 10291 SF3A3 10946 pp -- int.I2D: BIND, HPRD, BCI, BioGrid, BioGrid_Worm;
int.Mint: MI:0915(physical association);
int.HPRD: in vitro, in vivo;
int.DIP: MI:0407(direct interaction)
DDIT3 1649 EP300 2033 pp -- int.Intact: MI:0915(physical association)
SF3A3 10946 TADA2B 93624 pp -- int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
SF3A3 10946 ADAP1 11033 pp -- int.I2D: HPRD;
int.HPRD: in vitro
EP300 2033 SUB1 10923 pp -- int.I2D: BCI, BioGrid, HPRD;
int.Ravasi: -;
int.HPRD: in vitro
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
SUB1 10923 ADAP1 11033 pp -- int.I2D: HPRD;
int.HPRD: in vitro
EP300 2033 HNRNPU 3192 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vitro, in vivo
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo

Related GO terms (205)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm3.31e-064.77e-023.0857641082
GO:0000389mRNA 3'-splice site recognition5.28e-067.62e-029.035225
GO:0071013catalytic step 2 spliceosome2.43e-053.51e-015.6563778
GO:0042789mRNA transcription from RNA polymerase II promoter4.11e-055.92e-017.6562213
GO:0000398mRNA splicing, via spliceosome2.23e-041.00e+004.584315164
GO:0044212transcription regulatory region DNA binding2.39e-041.00e+004.549317168
GO:0005667transcription factor complex2.70e-041.00e+004.490317175
GO:0006355regulation of transcription, DNA-templated5.08e-041.00e+002.717543997
GO:0008380RNA splicing5.86e-041.00e+004.109322228
GO:0003713transcription coactivator activity6.56e-041.00e+004.053324237
GO:0044822poly(A) RNA binding6.63e-041.00e+002.6345501056
GO:0008134transcription factor binding6.97e-041.00e+004.023318242
GO:0060795cell fate commitment involved in formation of primary germ layer7.63e-041.00e+0010.357111
GO:0060177regulation of angiotensin metabolic process7.63e-041.00e+0010.357111
GO:0002128tRNA nucleoside ribose methylation7.63e-041.00e+0010.357111
GO:1901985positive regulation of protein acetylation7.63e-041.00e+0010.357111
GO:2000016negative regulation of determination of dorsal identity7.63e-041.00e+0010.357111
GO:0043969histone H2B acetylation7.63e-041.00e+0010.357111
GO:2000629negative regulation of miRNA metabolic process7.63e-041.00e+0010.357111
GO:0090308regulation of methylation-dependent chromatin silencing7.63e-041.00e+0010.357111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway7.63e-041.00e+0010.357111
GO:0060965negative regulation of gene silencing by miRNA7.63e-041.00e+0010.357111
GO:0005634nucleus8.85e-041.00e+001.37291594559
GO:0010467gene expression1.17e-031.00e+002.971445669
GO:0003677DNA binding1.28e-031.00e+002.4285491218
GO:0060242contact inhibition1.52e-031.00e+009.357112
GO:0005684U2-type spliceosomal complex1.52e-031.00e+009.357112
GO:0014737positive regulation of muscle atrophy1.52e-031.00e+009.357112
GO:0008175tRNA methyltransferase activity1.52e-031.00e+009.357112
GO:0009786regulation of asymmetric cell division1.52e-031.00e+009.357112
GO:0090043regulation of tubulin deacetylation1.52e-031.00e+009.357122
GO:0035984cellular response to trichostatin A1.52e-031.00e+009.357112
GO:0071389cellular response to mineralocorticoid stimulus1.52e-031.00e+009.357112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.52e-031.00e+009.357112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.52e-031.00e+009.357112
GO:0005681spliceosomal complex1.74e-031.00e+004.9822383
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.15e-031.00e+002.733441789
GO:0043533inositol 1,3,4,5 tetrakisphosphate binding2.29e-031.00e+008.772113
GO:0018076N-terminal peptidyl-lysine acetylation2.29e-031.00e+008.772113
GO:0060913cardiac cell fate determination2.29e-031.00e+008.772113
GO:0003130BMP signaling pathway involved in heart induction2.29e-031.00e+008.772113
GO:0010560positive regulation of glycoprotein biosynthetic process2.29e-031.00e+008.772113
GO:0097157pre-mRNA intronic binding3.05e-031.00e+008.357114
GO:0018393internal peptidyl-lysine acetylation3.05e-031.00e+008.357114
GO:0006325chromatin organization3.48e-031.00e+004.474212118
GO:0070461SAGA-type complex3.81e-031.00e+008.035125
GO:0001714endodermal cell fate specification3.81e-031.00e+008.035115
GO:0065004protein-DNA complex assembly3.81e-031.00e+008.035115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor3.81e-031.00e+008.035115
GO:0043620regulation of DNA-templated transcription in response to stress3.81e-031.00e+008.035115
GO:0070934CRD-mediated mRNA stabilization3.81e-031.00e+008.035125
GO:0060298positive regulation of sarcomere organization3.81e-031.00e+008.035115
GO:0032025response to cobalt ion3.81e-031.00e+008.035115
GO:0002181cytoplasmic translation4.57e-031.00e+007.772116
GO:0070937CRD-mediated mRNA stability complex4.57e-031.00e+007.772136
GO:0008270zinc ion binding5.05e-031.00e+002.395427997
GO:0006475internal protein amino acid acetylation5.33e-031.00e+007.549117
GO:0006974cellular response to DNA damage stimulus5.63e-031.00e+004.11827151
GO:0001955blood vessel maturation6.09e-031.00e+007.357118
GO:0006397mRNA processing6.30e-031.00e+004.035210160
GO:0060765regulation of androgen receptor signaling pathway6.85e-031.00e+007.187119
GO:0006983ER overload response6.85e-031.00e+007.187119
GO:0035259glucocorticoid receptor binding6.85e-031.00e+007.187119
GO:0045793positive regulation of cell size6.85e-031.00e+007.187129
GO:0043087regulation of GTPase activity6.85e-031.00e+007.187119
GO:0035413positive regulation of catenin import into nucleus7.60e-031.00e+007.0351210
GO:0016407acetyltransferase activity7.60e-031.00e+007.0351210
GO:0003714transcription corepressor activity7.74e-031.00e+003.881211178
GO:0005515protein binding8.30e-031.00e+000.97091986024
GO:0043923positive regulation by host of viral transcription8.36e-031.00e+006.8971111
GO:0033160positive regulation of protein import into nucleus, translocation8.36e-031.00e+006.8971311
GO:0045662negative regulation of myoblast differentiation8.36e-031.00e+006.8971311
GO:0042975peroxisome proliferator activated receptor binding8.36e-031.00e+006.8971111
GO:0060391positive regulation of SMAD protein import into nucleus8.36e-031.00e+006.8971411
GO:0035198miRNA binding9.12e-031.00e+006.7721112
GO:0071480cellular response to gamma radiation9.87e-031.00e+006.6561113
GO:0051019mitogen-activated protein kinase binding9.87e-031.00e+006.6561213
GO:0030914STAGA complex9.87e-031.00e+006.6561313
GO:0016746transferase activity, transferring acyl groups9.87e-031.00e+006.6561113
GO:0070542response to fatty acid1.06e-021.00e+006.5491114
GO:0032993protein-DNA complex1.06e-021.00e+006.5491214
GO:0001824blastocyst development1.14e-021.00e+006.4501215
GO:1990090cellular response to nerve growth factor stimulus1.14e-021.00e+006.4501115
GO:0045773positive regulation of axon extension1.36e-021.00e+006.1871118
GO:0033613activating transcription factor binding1.36e-021.00e+006.1871318
GO:0003700sequence-specific DNA binding transcription factor activity1.40e-021.00e+002.492339699
GO:0035257nuclear hormone receptor binding1.44e-021.00e+006.1091119
GO:0071549cellular response to dexamethasone stimulus1.52e-021.00e+006.0351320
GO:0010942positive regulation of cell death1.52e-021.00e+006.0351120
GO:0032757positive regulation of interleukin-8 production1.52e-021.00e+006.0351120
GO:0032312regulation of ARF GTPase activity1.59e-021.00e+005.9641221
GO:0000123histone acetyltransferase complex1.59e-021.00e+005.9641621
GO:0032967positive regulation of collagen biosynthetic process1.59e-021.00e+005.9641321
GO:0045862positive regulation of proteolysis1.59e-021.00e+005.9641221
GO:0003823antigen binding1.67e-021.00e+005.8971222
GO:0036464cytoplasmic ribonucleoprotein granule1.67e-021.00e+005.8971222
GO:0008060ARF GTPase activator activity1.67e-021.00e+005.8971222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.67e-021.00e+005.8971422
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.74e-021.00e+005.8331123
GO:0043388positive regulation of DNA binding1.82e-021.00e+005.7721224
GO:0043425bHLH transcription factor binding1.82e-021.00e+005.7721124
GO:0000375RNA splicing, via transesterification reactions1.89e-021.00e+005.7131325
GO:0051059NF-kappaB binding1.89e-021.00e+005.7131325
GO:0035329hippo signaling1.97e-021.00e+005.6561526
GO:0051209release of sequestered calcium ion into cytosol1.97e-021.00e+005.6561126
GO:0048565digestive tract development1.97e-021.00e+005.6561226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.97e-021.00e+005.6561126
GO:0034612response to tumor necrosis factor2.04e-021.00e+005.6021227
GO:0043967histone H4 acetylation2.04e-021.00e+005.6021127
GO:0050714positive regulation of protein secretion2.12e-021.00e+005.5491328
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding2.19e-021.00e+005.4991229
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator2.27e-021.00e+005.4501130
GO:0042594response to starvation2.34e-021.00e+005.4021431
GO:0043491protein kinase B signaling2.41e-021.00e+005.3571232
GO:1903507negative regulation of nucleic acid-templated transcription2.41e-021.00e+005.3571232
GO:0003682chromatin binding2.46e-021.00e+003.004219327
GO:0071333cellular response to glucose stimulus2.49e-021.00e+005.3121133
GO:0001756somitogenesis2.49e-021.00e+005.3121133
GO:0003723RNA binding2.68e-021.00e+002.939218342
GO:0001102RNA polymerase II activating transcription factor binding2.71e-021.00e+005.1871136
GO:0043565sequence-specific DNA binding2.74e-021.00e+002.922211346
GO:0005730nucleolus2.86e-021.00e+001.6764661641
GO:0032092positive regulation of protein binding2.86e-021.00e+005.1091238
GO:0031490chromatin DNA binding2.86e-021.00e+005.1091238
GO:0050681androgen receptor binding2.86e-021.00e+005.1091138
GO:0035019somatic stem cell maintenance3.01e-021.00e+005.0351640
GO:0007519skeletal muscle tissue development3.01e-021.00e+005.0351240
GO:0046332SMAD binding3.01e-021.00e+005.0351240
GO:0071320cellular response to cAMP3.01e-021.00e+005.0351140
GO:0070301cellular response to hydrogen peroxide3.08e-021.00e+004.9991241
GO:0004402histone acetyltransferase activity3.23e-021.00e+004.9301643
GO:0045727positive regulation of translation3.31e-021.00e+004.8971244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.31e-021.00e+004.8971444
GO:0043966histone H3 acetylation3.38e-021.00e+004.8651545
GO:0001047core promoter binding3.38e-021.00e+004.8651545
GO:0043525positive regulation of neuron apoptotic process3.45e-021.00e+004.8331446
GO:0035690cellular response to drug3.68e-021.00e+004.7421349
GO:0006986response to unfolded protein3.75e-021.00e+004.7131450
GO:0034976response to endoplasmic reticulum stress3.82e-021.00e+004.6841251
GO:0045454cell redox homeostasis3.82e-021.00e+004.6841151
GO:0009611response to wounding3.90e-021.00e+004.6561552
GO:0007623circadian rhythm3.97e-021.00e+004.6291153
GO:0071300cellular response to retinoic acid4.12e-021.00e+004.5751155
GO:0051592response to calcium ion4.12e-021.00e+004.5751155
GO:0002039p53 binding4.12e-021.00e+004.5751455
GO:0043627response to estrogen4.19e-021.00e+004.5491556
GO:0006396RNA processing4.41e-021.00e+004.4741559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.41e-021.00e+004.4741659
GO:0008013beta-catenin binding4.48e-021.00e+004.4501960
GO:0032481positive regulation of type I interferon production4.56e-021.00e+004.4261661
GO:0006987activation of signaling protein activity involved in unfolded protein response4.56e-021.00e+004.4261261
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process4.70e-021.00e+004.3791463
GO:0010468regulation of gene expression5.07e-021.00e+004.2691268
GO:0003697single-stranded DNA binding5.07e-021.00e+004.2691568
GO:0030324lung development5.36e-021.00e+004.1871172
GO:0000785chromatin5.43e-021.00e+004.1671673
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.50e-021.00e+004.1471474
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.58e-021.00e+004.1281175
GO:0001889liver development5.72e-021.00e+004.0901377
GO:0030968endoplasmic reticulum unfolded protein response5.86e-021.00e+004.0531279
GO:0009653anatomical structure morphogenesis6.15e-021.00e+003.9821283
GO:0009887organ morphogenesis6.37e-021.00e+003.9301586
GO:0090090negative regulation of canonical Wnt signaling pathway6.37e-021.00e+003.9301886
GO:0045471response to ethanol6.37e-021.00e+003.9301386
GO:0001649osteoblast differentiation6.80e-021.00e+003.8331592
GO:0071456cellular response to hypoxia6.80e-021.00e+003.8331392
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity6.80e-021.00e+003.8331792
GO:0005770late endosome6.87e-021.00e+003.8171293
GO:0051726regulation of cell cycle7.16e-021.00e+003.7571597
GO:0001934positive regulation of protein phosphorylation7.65e-021.00e+003.65615104
GO:0030529ribonucleoprotein complex8.22e-021.00e+003.54915112
GO:0007219Notch signaling pathway8.78e-021.00e+003.45015120
GO:0006351transcription, DNA-templated9.00e-021.00e+001.4443571446
GO:0007050cell cycle arrest9.06e-021.00e+003.40215124
GO:0000086G2/M transition of mitotic cell cycle9.90e-021.00e+003.26914136
GO:0016055Wnt signaling pathway1.00e-011.00e+003.24814138
GO:0007507heart development1.01e-011.00e+003.23817139
GO:0007166cell surface receptor signaling pathway1.07e-011.00e+003.15714147
GO:0001666response to hypoxia1.08e-011.00e+003.13717149
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.19e-011.00e+002.990112165
GO:0016607nuclear speck1.24e-011.00e+002.930112172
GO:0031625ubiquitin protein ligase binding1.28e-011.00e+002.88115178
GO:0043547positive regulation of GTPase activity1.29e-011.00e+002.86519180
GO:0032403protein complex binding1.31e-011.00e+002.84116183
GO:0006367transcription initiation from RNA polymerase II promoter1.32e-011.00e+002.833122184
GO:0005737cytoplasm1.33e-011.00e+000.79951243767
GO:0007399nervous system development1.63e-011.00e+002.50516231
GO:0006357regulation of transcription from RNA polymerase II promoter1.84e-011.00e+002.312123264
GO:0008283cell proliferation2.24e-011.00e+001.999114328
GO:0046982protein heterodimerization activity2.55e-011.00e+001.78718380
GO:0000278mitotic cell cycle2.61e-011.00e+001.746115391
GO:0009986cell surface2.67e-011.00e+001.70619402
GO:0045892negative regulation of transcription, DNA-templated2.74e-011.00e+001.667124413
GO:0006366transcription from RNA polymerase II promoter2.77e-011.00e+001.646130419
GO:0005829cytosol2.94e-011.00e+000.6563862496
GO:0044267cellular protein metabolic process3.08e-011.00e+001.468120474
GO:0045893positive regulation of transcription, DNA-templated3.10e-011.00e+001.456124478
GO:0016032viral process3.40e-011.00e+001.296126534
GO:0006915apoptotic process3.51e-011.00e+001.240112555
GO:0000122negative regulation of transcription from RNA polymerase II promoter3.58e-011.00e+001.202137570
GO:0045087innate immune response3.71e-011.00e+001.137115596
GO:0005524ATP binding6.46e-011.00e+000.0151311298
GO:0016020membrane7.44e-011.00e+00-0.3581461681
GO:0070062extracellular vesicular exosome8.65e-011.00e+00-0.8721572400
GO:0005886plasma membrane8.86e-011.00e+00-0.9781492582