int-snw-10055

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.863 8.31e-16 3.45e-04 2.67e-03
chia-screen-data-Fav-int-snw-10055 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
SP100 6672 1-1.8402.86321--
POLR2E 5434 4-2.0373.157115Yes-
YAP1 10413 94-4.2563.53853Yes-
[ SAE1 ] 10055 1-1.6192.86348--
SRSF3 6428 73-2.9923.53854Yes-
NFRKB 4798 48-3.1293.10823YesYes
HSPD1 3329 3-1.8522.870286--
POU5F1 5460 133-5.1483.538179YesYes
HNRNPU 3192 76-2.8693.538139Yes-
DDIT3 1649 60-2.8253.504343YesYes

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
POLR2E 5434 SAE1 10055 pp -- int.I2D: YeastLow, IntAct_Yeast
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
SP100 6672 SAE1 10055 pp -- int.I2D: BioGrid
POU5F1 5460 SAE1 10055 pp -- int.I2D: BioGrid_Mouse
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3 1649 HSPD1 3329 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HSPD1 3329 SAE1 10055 pp -- int.I2D: IntAct_Yeast, Krogan_NonCore

Related GO terms (222)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm3.49e-095.04e-053.4479641082
GO:0006366transcription from RNA polymerase II promoter8.08e-061.17e-013.968530419
GO:0042789mRNA transcription from RNA polymerase II promoter4.11e-055.92e-017.6562213
GO:0005515protein binding6.71e-059.68e-011.260111986024
GO:0003677DNA binding1.14e-041.00e+002.6916491218
GO:0000398mRNA splicing, via spliceosome2.23e-041.00e+004.584315164
GO:0044212transcription regulatory region DNA binding2.39e-041.00e+004.549317168
GO:1903507negative regulation of nucleic acid-templated transcription2.59e-041.00e+006.3572232
GO:0003714transcription corepressor activity2.84e-041.00e+004.466311178
GO:0006355regulation of transcription, DNA-templated5.08e-041.00e+002.717543997
GO:0008380RNA splicing5.86e-041.00e+004.109322228
GO:0006986response to unfolded protein6.35e-041.00e+005.7132450
GO:0003713transcription coactivator activity6.56e-041.00e+004.053324237
GO:0008134transcription factor binding6.97e-041.00e+004.023318242
GO:0060795cell fate commitment involved in formation of primary germ layer7.63e-041.00e+0010.357111
GO:0002842positive regulation of T cell mediated immune response to tumor cell7.63e-041.00e+0010.357111
GO:1902044regulation of Fas signaling pathway7.63e-041.00e+0010.357111
GO:2000016negative regulation of determination of dorsal identity7.63e-041.00e+0010.357111
GO:0048291isotype switching to IgG isotypes7.63e-041.00e+0010.357111
GO:0090308regulation of methylation-dependent chromatin silencing7.63e-041.00e+0010.357111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway7.63e-041.00e+0010.357111
GO:0060965negative regulation of gene silencing by miRNA7.63e-041.00e+0010.357111
GO:0002368B cell cytokine production7.63e-041.00e+0010.357111
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity8.84e-041.00e+005.4742659
GO:0005634nucleus8.85e-041.00e+001.37291594559
GO:0010467gene expression1.17e-031.00e+002.971445669
GO:0019948SUMO activating enzyme activity1.52e-031.00e+009.357112
GO:0060242contact inhibition1.52e-031.00e+009.357112
GO:0019046release from viral latency1.52e-031.00e+009.357122
GO:0009786regulation of asymmetric cell division1.52e-031.00e+009.357112
GO:0031510SUMO activating enzyme complex1.52e-031.00e+009.357112
GO:0019950SMT3-dependent protein catabolic process1.52e-031.00e+009.357112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.52e-031.00e+009.357112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.52e-031.00e+009.357112
GO:0050821protein stabilization1.95e-031.00e+004.8972388
GO:0006458'de novo' protein folding2.29e-031.00e+008.772113
GO:0060913cardiac cell fate determination2.29e-031.00e+008.772113
GO:0003130BMP signaling pathway involved in heart induction2.29e-031.00e+008.772113
GO:0030135coated vesicle2.29e-031.00e+008.772113
GO:0034340response to type I interferon3.05e-031.00e+008.357114
GO:0004839ubiquitin activating enzyme activity3.05e-031.00e+008.357114
GO:0070461SAGA-type complex3.81e-031.00e+008.035125
GO:0001714endodermal cell fate specification3.81e-031.00e+008.035115
GO:0046696lipopolysaccharide receptor complex3.81e-031.00e+008.035115
GO:0043620regulation of DNA-templated transcription in response to stress3.81e-031.00e+008.035115
GO:0070934CRD-mediated mRNA stabilization3.81e-031.00e+008.035125
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors3.81e-031.00e+008.035115
GO:0003688DNA replication origin binding4.57e-031.00e+007.772116
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex4.57e-031.00e+007.772116
GO:0070087chromo shadow domain binding4.57e-031.00e+007.772116
GO:0070937CRD-mediated mRNA stability complex4.57e-031.00e+007.772136
GO:0030870Mre11 complex4.57e-031.00e+007.772116
GO:0051271negative regulation of cellular component movement4.57e-031.00e+007.772116
GO:0046826negative regulation of protein export from nucleus5.33e-031.00e+007.549127
GO:0043008ATP-dependent protein binding5.33e-031.00e+007.549117
GO:0005829cytosol5.58e-031.00e+001.6566862496
GO:0006974cellular response to DNA damage stimulus5.63e-031.00e+004.11827151
GO:0001055RNA polymerase II activity6.09e-031.00e+007.357138
GO:0001955blood vessel maturation6.09e-031.00e+007.357118
GO:0070688MLL5-L complex6.09e-031.00e+007.357118
GO:0043254regulation of protein complex assembly6.09e-031.00e+007.357118
GO:0051604protein maturation6.09e-031.00e+007.357128
GO:0044822poly(A) RNA binding6.21e-031.00e+002.3124501056
GO:0016032viral process6.67e-031.00e+002.881326534
GO:0043995histone acetyltransferase activity (H4-K5 specific)6.85e-031.00e+007.187159
GO:0046972histone acetyltransferase activity (H4-K16 specific)6.85e-031.00e+007.187159
GO:0048188Set1C/COMPASS complex6.85e-031.00e+007.187149
GO:0006983ER overload response6.85e-031.00e+007.187119
GO:0043996histone acetyltransferase activity (H4-K8 specific)6.85e-031.00e+007.187159
GO:0035413positive regulation of catenin import into nucleus7.60e-031.00e+007.0351210
GO:0043032positive regulation of macrophage activation7.60e-031.00e+007.0351110
GO:0006367transcription initiation from RNA polymerase II promoter8.25e-031.00e+003.833222184
GO:0032727positive regulation of interferon-alpha production8.36e-031.00e+006.8971111
GO:0045662negative regulation of myoblast differentiation8.36e-031.00e+006.8971311
GO:0001054RNA polymerase I activity8.36e-031.00e+006.8971311
GO:0060391positive regulation of SMAD protein import into nucleus8.36e-031.00e+006.8971411
GO:0005736DNA-directed RNA polymerase I complex9.12e-031.00e+006.7721312
GO:0032897negative regulation of viral transcription9.12e-031.00e+006.7721112
GO:0034399nuclear periphery9.12e-031.00e+006.7721512
GO:0035198miRNA binding9.12e-031.00e+006.7721112
GO:0071480cellular response to gamma radiation9.87e-031.00e+006.6561113
GO:0001530lipopolysaccharide binding9.87e-031.00e+006.6561113
GO:0051131chaperone-mediated protein complex assembly9.87e-031.00e+006.6561113
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator1.06e-021.00e+006.5491114
GO:0010596negative regulation of endothelial cell migration1.06e-021.00e+006.5491114
GO:0031011Ino80 complex1.06e-021.00e+006.5491614
GO:0043981histone H4-K5 acetylation1.14e-021.00e+006.4501515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.14e-021.00e+006.4501315
GO:0048384retinoic acid receptor signaling pathway1.14e-021.00e+006.4501115
GO:0001824blastocyst development1.14e-021.00e+006.4501215
GO:0043982histone H4-K8 acetylation1.14e-021.00e+006.4501515
GO:0042026protein refolding1.14e-021.00e+006.4501115
GO:0043274phospholipase binding1.21e-021.00e+006.3571116
GO:0005665DNA-directed RNA polymerase II, core complex1.21e-021.00e+006.3571416
GO:0001056RNA polymerase III activity1.21e-021.00e+006.3571316
GO:0005666DNA-directed RNA polymerase III complex1.29e-021.00e+006.2691317
GO:0050870positive regulation of T cell activation1.29e-021.00e+006.2691117
GO:0006386termination of RNA polymerase III transcription1.36e-021.00e+006.1871318
GO:0006385transcription elongation from RNA polymerase III promoter1.36e-021.00e+006.1871318
GO:0003700sequence-specific DNA binding transcription factor activity1.40e-021.00e+002.492339699
GO:0032733positive regulation of interleukin-10 production1.44e-021.00e+006.1091219
GO:0043984histone H4-K16 acetylation1.44e-021.00e+006.1091519
GO:0032757positive regulation of interleukin-8 production1.52e-021.00e+006.0351120
GO:0042100B cell proliferation1.59e-021.00e+005.9641121
GO:0000123histone acetyltransferase complex1.59e-021.00e+005.9641621
GO:0034341response to interferon-gamma1.59e-021.00e+005.9641221
GO:0006281DNA repair1.61e-021.00e+003.329214261
GO:0045787positive regulation of cell cycle1.67e-021.00e+005.8971222
GO:0036464cytoplasmic ribonucleoprotein granule1.67e-021.00e+005.8971222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.67e-021.00e+005.8971422
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.74e-021.00e+005.8331123
GO:0045765regulation of angiogenesis1.82e-021.00e+005.7721224
GO:0003899DNA-directed RNA polymerase activity1.89e-021.00e+005.7131325
GO:0016925protein sumoylation1.89e-021.00e+005.7131225
GO:0042113B cell activation1.89e-021.00e+005.7131225
GO:0032735positive regulation of interleukin-12 production1.89e-021.00e+005.7131225
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.93e-021.00e+002.318341789
GO:0043392negative regulation of DNA binding1.97e-021.00e+005.6561426
GO:0035329hippo signaling1.97e-021.00e+005.6561526
GO:0051209release of sequestered calcium ion into cytosol1.97e-021.00e+005.6561126
GO:0071339MLL1 complex2.04e-021.00e+005.6021627
GO:0007346regulation of mitotic cell cycle2.19e-021.00e+005.4991129
GO:0006360transcription from RNA polymerase I promoter2.27e-021.00e+005.4501330
GO:00063707-methylguanosine mRNA capping2.27e-021.00e+005.4501530
GO:0042594response to starvation2.34e-021.00e+005.4021431
GO:0003723RNA binding2.68e-021.00e+002.939218342
GO:0032755positive regulation of interleukin-6 production2.71e-021.00e+005.1871236
GO:0043565sequence-specific DNA binding2.74e-021.00e+002.922211346
GO:0005730nucleolus2.86e-021.00e+001.6764661641
GO:0032729positive regulation of interferon-gamma production2.94e-021.00e+005.0711139
GO:0006383transcription from RNA polymerase III promoter2.94e-021.00e+005.0711339
GO:0008047enzyme activator activity2.94e-021.00e+005.0711339
GO:0035019somatic stem cell maintenance3.01e-021.00e+005.0351640
GO:0042110T cell activation3.16e-021.00e+004.9641142
GO:0031124mRNA 3'-end processing3.16e-021.00e+004.9641242
GO:0046982protein heterodimerization activity3.25e-021.00e+002.78728380
GO:0050434positive regulation of viral transcription3.31e-021.00e+004.8971544
GO:0006369termination of RNA polymerase II transcription3.38e-021.00e+004.8651245
GO:0043525positive regulation of neuron apoptotic process3.45e-021.00e+004.8331446
GO:0032526response to retinoic acid3.45e-021.00e+004.8331146
GO:0006283transcription-coupled nucleotide-excision repair3.45e-021.00e+004.8331446
GO:0009986cell surface3.61e-021.00e+002.70629402
GO:0034097response to cytokine3.75e-021.00e+004.7131250
GO:0005905coated pit3.75e-021.00e+004.7131650
GO:0045892negative regulation of transcription, DNA-templated3.79e-021.00e+002.667224413
GO:0034976response to endoplasmic reticulum stress3.82e-021.00e+004.6841251
GO:0045454cell redox homeostasis3.82e-021.00e+004.6841151
GO:0003725double-stranded RNA binding3.90e-021.00e+004.6561152
GO:0009611response to wounding3.90e-021.00e+004.6561552
GO:0019900kinase binding3.90e-021.00e+004.6561152
GO:0002039p53 binding4.12e-021.00e+004.5751455
GO:0000723telomere maintenance4.19e-021.00e+004.5491156
GO:0005737cytoplasm4.20e-021.00e+001.06261243767
GO:0060337type I interferon signaling pathway4.34e-021.00e+004.4991258
GO:0006396RNA processing4.41e-021.00e+004.4741559
GO:0051087chaperone binding4.41e-021.00e+004.4741359
GO:0032481positive regulation of type I interferon production4.56e-021.00e+004.4261661
GO:0006406mRNA export from nucleus4.56e-021.00e+004.4261461
GO:0006987activation of signaling protein activity involved in unfolded protein response4.56e-021.00e+004.4261261
GO:0043085positive regulation of catalytic activity4.56e-021.00e+004.4261261
GO:0060333interferon-gamma-mediated signaling pathway4.63e-021.00e+004.4021362
GO:0030141secretory granule4.63e-021.00e+004.4021462
GO:0006310DNA recombination4.85e-021.00e+004.3341765
GO:0044267cellular protein metabolic process4.87e-021.00e+002.468220474
GO:0045893positive regulation of transcription, DNA-templated4.95e-021.00e+002.456224478
GO:0006368transcription elongation from RNA polymerase II promoter4.99e-021.00e+004.2911667
GO:0042802identical protein binding5.06e-021.00e+002.438219484
GO:0006289nucleotide-excision repair5.07e-021.00e+004.2691568
GO:0010468regulation of gene expression5.07e-021.00e+004.2691268
GO:0003697single-stranded DNA binding5.07e-021.00e+004.2691568
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.50e-021.00e+004.1471474
GO:0002020protease binding5.50e-021.00e+004.1471674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.58e-021.00e+004.1281175
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process5.72e-021.00e+004.0901377
GO:0071013catalytic step 2 spliceosome5.79e-021.00e+004.0711778
GO:0030968endoplasmic reticulum unfolded protein response5.86e-021.00e+004.0531279
GO:0002755MyD88-dependent toll-like receptor signaling pathway5.94e-021.00e+004.0351580
GO:0009653anatomical structure morphogenesis6.15e-021.00e+003.9821283
GO:0090090negative regulation of canonical Wnt signaling pathway6.37e-021.00e+003.9301886
GO:0016605PML body6.51e-021.00e+003.8971388
GO:0000122negative regulation of transcription from RNA polymerase II promoter6.77e-021.00e+002.202237570
GO:0001649osteoblast differentiation6.80e-021.00e+003.8331592
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity6.80e-021.00e+003.8331792
GO:0005770late endosome6.87e-021.00e+003.8171293
GO:0051082unfolded protein binding6.87e-021.00e+003.8171793
GO:0030529ribonucleoprotein complex8.22e-021.00e+003.54915112
GO:0006325chromatin organization8.64e-021.00e+003.474112118
GO:0007050cell cycle arrest9.06e-021.00e+003.40215124
GO:0016055Wnt signaling pathway1.00e-011.00e+003.24814138
GO:0016887ATPase activity1.02e-011.00e+003.22711140
GO:0010628positive regulation of gene expression1.06e-011.00e+003.16717146
GO:0005769early endosome1.10e-011.00e+003.10911152
GO:0008022protein C-terminus binding1.16e-011.00e+003.02618161
GO:0043687post-translational protein modification1.17e-011.00e+003.01715162
GO:0016607nuclear speck1.24e-011.00e+002.930112172
GO:0007049cell cycle1.25e-011.00e+002.91416174
GO:0005667transcription factor complex1.26e-011.00e+002.905117175
GO:0031625ubiquitin protein ligase binding1.28e-011.00e+002.88115178
GO:0016020membrane1.28e-011.00e+001.2273461681
GO:0019904protein domain specific binding1.28e-011.00e+002.87318179
GO:0019221cytokine-mediated signaling pathway1.56e-011.00e+002.56918221
GO:0005759mitochondrial matrix1.61e-011.00e+002.52414228
GO:0043025neuronal cell body1.72e-011.00e+002.42019245
GO:0005739mitochondrion1.74e-011.00e+001.394223998
GO:0000166nucleotide binding1.81e-011.00e+002.340113259
GO:0043065positive regulation of apoptotic process1.86e-011.00e+002.29117268
GO:0005743mitochondrial inner membrane1.92e-011.00e+002.24316277
GO:0006954inflammatory response1.92e-011.00e+002.24316277
GO:0006200ATP catabolic process2.02e-011.00e+002.16712292
GO:0043234protein complex2.03e-011.00e+002.152111295
GO:0016567protein ubiquitination2.03e-011.00e+002.15214295
GO:0043231intracellular membrane-bounded organelle2.18e-011.00e+002.04416318
GO:0003682chromatin binding2.23e-011.00e+002.004119327
GO:0008283cell proliferation2.24e-011.00e+001.999114328
GO:0005524ATP binding2.60e-011.00e+001.0152311298
GO:0043066negative regulation of apoptotic process2.80e-011.00e+001.629116424
GO:0042803protein homodimerization activity3.71e-011.00e+001.140119595
GO:0045087innate immune response3.71e-011.00e+001.137115596
GO:0005615extracellular space5.30e-011.00e+000.454120957
GO:0006351transcription, DNA-templated6.87e-011.00e+00-0.1411571446
GO:0070062extracellular vesicular exosome8.65e-011.00e+00-0.8721572400
GO:0005886plasma membrane8.86e-011.00e+00-0.9781492582