meta-int-snw-10209

Interacting subnets

Subnetwork	Dataset	Score	p-value 1	p-value 2	p-value 3	Size	Highlighted genes
reg-snw-11277	wolf-screen-ratio-mammosphere-adherent	0.882	1.09e-07	9.11e-04	1.96e-03	10	9
int-snw-10209	wolf-screen-ratio-mammosphere-adherent	0.936	1.51e-15	2.42e-03	3.95e-02	14	13
reg-snw-56655	wolf-screen-ratio-mammosphere-adherent	0.828	9.29e-07	2.91e-03	5.53e-03	8	7
reg-snw-4800	wolf-screen-ratio-mammosphere-adherent	0.833	7.78e-07	2.65e-03	5.08e-03	7	5
reg-snw-1478	wolf-screen-ratio-mammosphere-adherent	0.940	8.80e-09	2.25e-04	5.65e-04	7	7
reg-snw-2237	wolf-screen-ratio-mammosphere-adherent	0.894	6.72e-08	6.99e-04	1.55e-03	9	8
reg-snw-9134	wolf-screen-ratio-mammosphere-adherent	0.872	1.64e-07	1.14e-03	2.40e-03	8	7

wolf-screen-ratio-mammosphere-adherent-meta-int-snw-10209 subnetwork

Genes (36)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	Transcription factor	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CCNE2	9134	5	-0.164	0.872	126	TF	-	-
PSMB1	5689	61	0.688	0.901	113	-	Yes	-
PSMA3	5684	90	0.533	0.815	238	-	Yes	-
COPA	1314	7	0.434	0.833	170	TF	Yes	-
PSMA2	5683	112	1.093	1.106	108	-	Yes	-
TP53	7157	23	0.432	0.833	665	TF	-	-
RRM1	6240	15	0.587	0.872	117	-	Yes	-
VARS	7407	86	0.549	1.002	204	TF	Yes	-
CAD	790	91	0.807	0.973	400	-	-	-
PSMD2	5708	17	0.463	0.961	386	-	Yes	-
CCNA2	890	54	0.550	0.973	246	TF	Yes	-
EIF2S2	8894	39	1.075	0.940	103	-	Yes	-
IARS	3376	7	0.399	0.936	175	-	Yes	-
EIF1	10209	7	-0.215	0.936	64	-	-	-
EFTUD2	9343	93	0.883	0.956	108	-	Yes	-
TUBG1	7283	98	0.974	0.973	91	-	Yes	-
PSMD11	5717	124	1.095	1.106	218	TF	Yes	-
RAN	5901	89	0.632	0.899	258	-	Yes	-
FEN1	2237	10	0.014	0.894	89	-	-	-
RBX1	9978	115	1.185	0.934	148	TF	Yes	-
POLA1	5422	17	0.593	0.894	114	TF	Yes	-
RPL8	6132	24	0.778	0.874	234	TF	Yes	-
HNRNPC	3183	108	1.812	0.973	181	-	Yes	-
PSMB7	5695	118	0.982	0.934	90	-	Yes	-
TREX1	11277	51	-0.051	0.882	91	TF	Yes	-
POLE4	56655	63	0.177	0.828	56	TF	-	-
PSMB3	5691	64	0.668	0.901	19	-	Yes	-
PGD	5226	89	1.201	1.106	152	-	Yes	-
NFYA	4800	7	0.198	0.833	80	TF	-	-
PSMD13	5719	56	0.848	0.801	114	TF	Yes	-
RUVBL1	8607	95	0.720	0.973	469	TF	Yes	-
RPL14	9045	49	1.250	1.113	166	-	Yes	-
CSTF2	1478	10	-0.050	0.940	98	TF	-	Yes
PSMB2	5690	116	0.877	0.956	169	-	Yes	-
ACTB	60	134	1.153	1.151	610	-	Yes	-
RUVBL2	10856	95	0.693	0.956	532	TF	Yes	-

Interactions (139)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA3	5684	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, Krogan_Core
HNRNPC	3183	PSMA3	5684	pp	--	int.I2D: BioGrid
FEN1	2237	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
PSMD11	5717	RUVBL1	8607	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD13	5719	pp	--	int.I2D: YeastLow
PSMA3	5684	EIF1	10209	pp	--	int.I2D: BioGrid_Yeast, BIND_Yeast, IntAct_Yeast
EFTUD2	9343	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
EFTUD2	9343	RUVBL2	10856	pp	--	int.I2D: BioGrid
PSMB2	5690	TREX1	11277	pd	<	reg.ITFP.txt: no annot
CAD	790	IARS	3376	pp	--	int.I2D: YeastMedium
ACTB	60	RUVBL1	8607	pp	--	int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD2	5708	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastLow
PSMA2	5683	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PGD	5226	RAN	5901	pp	--	int.I2D: YeastLow
CCNA2	890	RUVBL1	8607	pd	<>	reg.ITFP.txt: no annot
CAD	790	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMB1	5689	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
RAN	5901	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
IARS	3376	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast
PSMB1	5689	PSMB3	5691	pp	--	int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, HPRD, MINT, YeastHigh, IntAct, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
PSMB2	5690	POLE4	56655	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL1	8607	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
IARS	3376	EIF1	10209	pp	--	int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast
PSMA3	5684	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid
ACTB	60	NFYA	4800	pd	<	reg.pazar.txt: no annot; reg.oreganno.txt: no annot
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
COPA	1314	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
TP53	7157	EIF2S2	8894	pp	--	int.Intact: MI:0915(physical association); int.I2D: HPRD, IntAct, BioGrid, MINT, StelzlHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
PSMB2	5690	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
ACTB	60	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast
PSMB1	5689	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast, MINT, YeastHigh, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast; int.Mint: MI:0915(physical association)
RRM1	6240	TP53	7157	pd	<	reg.pazar.txt: no annot; reg.oreganno.txt: no annot
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	TP53	7157	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, MINT, StelzlHigh, HPRD, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
FEN1	2237	PSMD11	5717	pd	<	reg.ITFP.txt: no annot
PSMA3	5684	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
TUBG1	7283	VARS	7407	pd	<	reg.ITFP.txt: no annot
ACTB	60	PSMA3	5684	pp	--	int.I2D: BioGrid, BioGrid_Yeast
PSMB2	5690	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
CCNA2	890	RRM1	6240	pd	>	reg.ITFP.txt: no annot
RUVBL1	8607	RUVBL2	10856	pd	<>	reg.ITFP.txt: no annot
RUVBL1	8607	RUVBL2	10856	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd; int.Ravasi: -; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association)
ACTB	60	CAD	790	pp	--	int.I2D: IntAct_Yeast
PSMB7	5695	RBX1	9978	pd	<	reg.ITFP.txt: no annot
PSMA3	5684	RUVBL2	10856	pp	--	int.I2D: YeastLow
CAD	790	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL2	10856	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RPL8	6132	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
CSTF2	1478	FEN1	2237	pd	>	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
VARS	7407	POLE4	56655	pd	<>	reg.ITFP.txt: no annot
PSMA2	5683	PSMB3	5691	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMB7	5695	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMD2	5708	VARS	7407	pp	--	int.I2D: BioGrid_Yeast
HNRNPC	3183	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	TP53	7157	pd	<	reg.ITFP.txt: no annot
PSMD2	5708	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
PSMA2	5683	POLE4	56655	pd	<	reg.ITFP.txt: no annot
ACTB	60	COPA	1314	pd	<	reg.ITFP.txt: no annot
ACTB	60	COPA	1314	pp	--	int.I2D: BioGrid_Yeast
PSMB1	5689	PSMB7	5695	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, HPRD, MINT, YeastLow, IntAct, Krogan_Core, MINT_Yeast, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
VARS	7407	RUVBL1	8607	pd	<>	reg.ITFP.txt: no annot
CSTF2	1478	EFTUD2	9343	pd	>	reg.ITFP.txt: no annot
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMA3	5684	EFTUD2	9343	pp	--	int.I2D: BioGrid
PSMB2	5690	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
IARS	3376	VARS	7407	pp	--	int.I2D: YeastLow
PSMD13	5719	RUVBL2	10856	pp	--	int.I2D: YeastHigh
COPA	1314	PSMB2	5690	pp	--	int.I2D: YeastLow
PSMB7	5695	POLE4	56655	pd	<	reg.ITFP.txt: no annot
PSMA3	5684	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast, IntAct_Mouse, MINT_Yeast, YeastLow, Krogan_Core
PSMB2	5690	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
FEN1	2237	CCNE2	9134	pd	<	reg.ITFP.txt: no annot
PSMA2	5683	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
PSMB2	5690	RPL8	6132	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
PSMD2	5708	RAN	5901	pp	--	int.I2D: BioGrid_Yeast
TUBG1	7283	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
POLA1	5422	TP53	7157	pp	--	int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vivo
COPA	1314	RPL14	9045	pd	>	reg.ITFP.txt: no annot
FEN1	2237	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMA3	5684	RUVBL1	8607	pp	--	int.I2D: BioGrid
NFYA	4800	TP53	7157	pd	>	reg.pazar.txt: no annot
NFYA	4800	TP53	7157	pp	--	int.Intact: MI:0914(association), MI:0915(physical association), MI:0403(colocalization); int.I2D: BioGrid, HPRD, IntAct, BCI; int.Ravasi: -; int.HPRD: in vivo
RPL8	6132	EIF1	10209	pp	--	int.I2D: YeastMedium
ACTB	60	RAN	5901	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, NON_CORE
RAN	5901	VARS	7407	pd	<	reg.ITFP.txt: no annot
TUBG1	7283	RUVBL1	8607	pd	<	reg.ITFP.txt: no annot
CCNA2	890	TP53	7157	pp	--	int.I2D: HPRD, BCI, BioGrid; int.HPRD: in vitro
CAD	790	RAN	5901	pp	--	int.I2D: IntAct_Yeast
PSMB3	5691	PSMB7	5695	pp	--	int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS; int.HPRD: yeast 2-hybrid
PSMB7	5695	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMD11	5717	TUBG1	7283	pd	>	reg.ITFP.txt: no annot
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
COPA	1314	PSMB3	5691	pp	--	int.I2D: YeastLow
PSMB2	5690	PSMB3	5691	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
CAD	790	PSMB2	5690	pp	--	int.I2D: BioGrid_Yeast
CCNA2	890	FEN1	2237	pd	>	reg.ITFP.txt: no annot
CCNA2	890	FEN1	2237	pp	--	int.I2D: BioGrid
PSMD11	5717	EFTUD2	9343	pd	>	reg.ITFP.txt: no annot
CCNA2	890	CCNE2	9134	pd	<>	reg.ITFP.txt: no annot
PSMD11	5717	RUVBL2	10856	pp	--	int.I2D: YeastLow
PSMB7	5695	PSMD13	5719	pd	<	reg.ITFP.txt: no annot
PSMD13	5719	RRM1	6240	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMB3	5691	POLE4	56655	pd	<	reg.ITFP.txt: no annot
IARS	3376	PGD	5226	pp	--	int.I2D: YeastLow
PSMA3	5684	PSMB1	5689	pp	--	int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, IntAct_Yeast, YeastHigh
CCNA2	890	NFYA	4800	pd	<	reg.TRANSFAC.txt: no annot
VARS	7407	RUVBL2	10856	pd	<>	reg.ITFP.txt: no annot
PSMB1	5689	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
FEN1	2237	POLA1	5422	pd	<	reg.ITFP.txt: no annot
COPA	1314	PSMA3	5684	pp	--	int.I2D: YeastLow
COPA	1314	PSMB7	5695	pp	--	int.I2D: BCI
PSMB1	5689	TREX1	11277	pd	<	reg.ITFP.txt: no annot
COPA	1314	PSMB1	5689	pp	--	int.I2D: BCI
PSMA3	5684	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB2	5690	PSMD11	5717	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMD2	5708	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
PSMB2	5690	VARS	7407	pd	<	reg.ITFP.txt: no annot
RRM1	6240	CCNE2	9134	pd	<	reg.ITFP.txt: no annot
PSMA2	5683	PSMB1	5689	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, BCI, BioGrid, IntAct, YeastHigh
PSMD13	5719	EIF1	10209	pp	--	int.I2D: IntAct_Yeast, BioGrid_Yeast, BIND_Yeast
PSMD11	5717	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
CAD	790	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMB3	5691	PSMD13	5719	pp	--	int.I2D: YeastLow
PSMD2	5708	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastLow, BioGrid, Krogan_Core
PSMD2	5708	EIF1	10209	pp	--	int.I2D: IntAct_Yeast, BioGrid_Yeast, BIND_Yeast
PSMB3	5691	PSMD11	5717	pp	--	int.I2D: YeastLow
EIF2S2	8894	EIF1	10209	pp	--	int.I2D: BioGrid_Yeast
IARS	3376	RUVBL2	10856	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RAN	5901	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMB1	5689	PSMD13	5719	pd	<	reg.ITFP.txt: no annot
PSMB1	5689	PSMD13	5719	pp	--	int.I2D: YeastLow
PSMD11	5717	RRM1	6240	pd	>	reg.ITFP.txt: no annot
PSMD2	5708	RUVBL2	10856	pp	--	int.I2D: YeastLow, IntAct_Yeast
RUVBL2	10856	TREX1	11277	pd	<>	reg.ITFP.txt: no annot
PSMD2	5708	RUVBL1	8607	pp	--	int.I2D: YeastLow
ACTB	60	RUVBL2	10856	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid
PSMA2	5683	PSMA3	5684	pp	--	int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BIND_Yeast, HPRD; int.HPRD: yeast 2-hybrid
PSMA3	5684	PSMB3	5691	pp	--	int.I2D: BioGrid_Yeast, IntAct_Fly, IntAct_Yeast, YeastHigh
PSMD11	5717	EIF2S2	8894	pd	>	reg.ITFP.txt: no annot
PSMA2	5683	PSMB2	5690	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core
COPA	1314	RUVBL2	10856	pp	--	int.I2D: YeastLow
COPA	1314	NFYA	4800	pd	>	reg.ITFP.txt: no annot

Related GO terms (462)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	3.13e-20	5.10e-16	3.313	24	83	1095
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.14e-16	1.86e-12	6.124	10	22	65
GO:0010467	gene expression	3.88e-16	6.33e-12	3.609	18	58	669
GO:0006521	regulation of cellular amino acid metabolic process	9.82e-16	1.60e-11	6.351	9	21	50
GO:0000278	mitotic cell cycle	1.72e-15	2.81e-11	4.095	15	52	398
GO:0000502	proteasome complex	4.12e-15	6.73e-11	6.136	9	22	58
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.23e-14	2.00e-10	5.972	9	24	65
GO:0000082	G1/S transition of mitotic cell cycle	1.35e-14	2.20e-10	5.055	11	33	150
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.47e-14	4.04e-10	5.865	9	24	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.68e-14	6.00e-10	5.805	9	23	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.18e-14	6.82e-10	5.785	9	24	74
GO:0005829	cytosol	5.57e-14	9.09e-10	2.202	26	125	2562
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.07e-14	9.91e-10	5.728	9	23	77
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	7.72e-14	1.26e-09	5.691	9	25	79
GO:0016032	viral process	1.51e-13	2.46e-09	3.655	15	55	540
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	3.90e-13	6.37e-09	5.440	9	23	94
GO:0042981	regulation of apoptotic process	7.04e-13	1.15e-08	4.908	10	26	151
GO:0016071	mRNA metabolic process	1.08e-12	1.76e-08	4.483	11	34	223
GO:0005839	proteasome core complex	1.35e-12	2.21e-08	7.240	6	11	18
GO:0000209	protein polyubiquitination	2.71e-12	4.42e-08	5.136	9	21	116
GO:0004298	threonine-type endopeptidase activity	2.82e-12	4.60e-08	7.088	6	11	20
GO:0016070	RNA metabolic process	3.29e-12	5.36e-08	4.336	11	34	247
GO:0034641	cellular nitrogen compound metabolic process	1.24e-10	2.02e-06	4.527	9	25	177
GO:0043066	negative regulation of apoptotic process	2.14e-08	3.48e-04	3.388	10	30	433
GO:0070062	extracellular vesicular exosome	3.19e-08	5.20e-04	1.850	20	98	2516
GO:0016020	membrane	2.48e-07	4.06e-03	2.055	16	80	1746
GO:0044281	small molecule metabolic process	2.63e-07	4.29e-03	2.293	14	57	1295
GO:0006915	apoptotic process	2.84e-07	4.63e-03	2.989	10	34	571
GO:0005515	protein binding	9.92e-07	1.62e-02	1.051	28	172	6127
GO:0016363	nuclear matrix	1.67e-06	2.73e-02	4.623	5	11	92
GO:0005838	proteasome regulatory particle	2.14e-06	3.49e-02	6.825	3	7	12
GO:0035267	NuA4 histone acetyltransferase complex	3.53e-06	5.76e-02	6.602	3	4	14
GO:0022624	proteasome accessory complex	6.56e-06	1.07e-01	6.322	3	9	17
GO:0005634	nucleus	2.07e-05	3.38e-01	1.111	23	131	4828
GO:0006281	DNA repair	2.19e-05	3.58e-01	3.365	6	22	264
GO:0002161	aminoacyl-tRNA editing activity	9.87e-05	1.00e+00	7.017	2	2	7
GO:0000812	Swr1 complex	1.31e-04	1.00e+00	6.825	2	3	8
GO:0019773	proteasome core complex, alpha-subunit complex	1.31e-04	1.00e+00	6.825	2	5	8
GO:0006260	DNA replication	1.60e-04	1.00e+00	3.859	4	12	125
GO:0006413	translational initiation	1.91e-04	1.00e+00	3.791	4	12	131
GO:0003684	damaged DNA binding	1.91e-04	1.00e+00	4.737	3	11	51
GO:0006450	regulation of translational fidelity	2.11e-04	1.00e+00	6.503	2	2	10
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.26e-04	1.00e+00	4.655	3	5	54
GO:0043968	histone H2A acetylation	3.08e-04	1.00e+00	6.240	2	3	12
GO:0000738	DNA catabolic process, exonucleolytic	3.63e-04	1.00e+00	6.124	2	2	13
GO:0031011	Ino80 complex	4.23e-04	1.00e+00	6.017	2	3	14
GO:0006310	DNA recombination	4.29e-04	1.00e+00	4.343	3	4	67
GO:0000785	chromatin	5.51e-04	1.00e+00	4.220	3	5	73
GO:0008408	3'-5' exonuclease activity	5.57e-04	1.00e+00	5.825	2	2	16
GO:0019901	protein kinase binding	6.43e-04	1.00e+00	2.825	5	21	320
GO:0005730	nucleolus	7.14e-04	1.00e+00	1.566	11	70	1684
GO:0006259	DNA metabolic process	7.90e-04	1.00e+00	5.577	2	3	19
GO:0003678	DNA helicase activity	7.90e-04	1.00e+00	5.577	2	3	19
GO:0003723	RNA binding	1.02e-03	1.00e+00	2.675	5	19	355
GO:0032201	telomere maintenance via semi-conservative replication	1.06e-03	1.00e+00	5.365	2	7	22
GO:0006270	DNA replication initiation	1.06e-03	1.00e+00	5.365	2	5	22
GO:0043044	ATP-dependent chromatin remodeling	1.16e-03	1.00e+00	5.301	2	4	23
GO:0008135	translation factor activity, nucleic acid binding	1.27e-03	1.00e+00	5.240	2	4	24
GO:0006206	pyrimidine nucleobase metabolic process	1.27e-03	1.00e+00	5.240	2	2	24
GO:0000722	telomere maintenance via recombination	1.49e-03	1.00e+00	5.124	2	7	26
GO:0071339	MLL1 complex	1.60e-03	1.00e+00	5.070	2	3	27
GO:0043967	histone H4 acetylation	1.72e-03	1.00e+00	5.017	2	3	28
GO:0031492	nucleosomal DNA binding	1.72e-03	1.00e+00	5.017	2	4	28
GO:0003887	DNA-directed DNA polymerase activity	1.85e-03	1.00e+00	4.967	2	3	29
GO:0030529	ribonucleoprotein complex	2.00e-03	1.00e+00	3.577	3	8	114
GO:0044822	poly(A) RNA binding	2.03e-03	1.00e+00	1.750	8	50	1078
GO:0019058	viral life cycle	2.05e-03	1.00e+00	3.564	3	10	115
GO:0005635	nuclear envelope	2.11e-03	1.00e+00	3.551	3	6	116
GO:0006271	DNA strand elongation involved in DNA replication	2.11e-03	1.00e+00	4.870	2	9	31
GO:0008309	double-stranded DNA exodeoxyribonuclease activity	2.21e-03	1.00e+00	8.825	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	2.21e-03	1.00e+00	8.825	1	1	1
GO:0070335	aspartate binding	2.21e-03	1.00e+00	8.825	1	1	1
GO:0032558	adenyl deoxyribonucleotide binding	2.21e-03	1.00e+00	8.825	1	1	1
GO:0004151	dihydroorotase activity	2.21e-03	1.00e+00	8.825	1	1	1
GO:0019521	D-gluconate metabolic process	2.21e-03	1.00e+00	8.825	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	2.21e-03	1.00e+00	8.825	1	1	1
GO:0034644	cellular response to UV	2.25e-03	1.00e+00	4.825	2	5	32
GO:0006325	chromatin organization	2.49e-03	1.00e+00	3.467	3	4	123
GO:0000790	nuclear chromatin	3.10e-03	1.00e+00	3.354	3	7	133
GO:0006284	base-excision repair	3.33e-03	1.00e+00	4.539	2	7	39
GO:0006418	tRNA aminoacylation for protein translation	3.85e-03	1.00e+00	4.432	2	5	42
GO:0032508	DNA duplex unwinding	3.85e-03	1.00e+00	4.432	2	4	42
GO:0043234	protein complex	4.15e-03	1.00e+00	2.596	4	17	300
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	4.22e-03	1.00e+00	4.365	2	2	44
GO:0004832	valine-tRNA ligase activity	4.41e-03	1.00e+00	7.825	1	1	2
GO:0097252	oligodendrocyte apoptotic process	4.41e-03	1.00e+00	7.825	1	1	2
GO:0006272	leading strand elongation	4.41e-03	1.00e+00	7.825	1	2	2
GO:1901525	negative regulation of macromitophagy	4.41e-03	1.00e+00	7.825	1	1	2
GO:0006428	isoleucyl-tRNA aminoacylation	4.41e-03	1.00e+00	7.825	1	1	2
GO:0002176	male germ cell proliferation	4.41e-03	1.00e+00	7.825	1	1	2
GO:0006438	valyl-tRNA aminoacylation	4.41e-03	1.00e+00	7.825	1	1	2
GO:0071920	cleavage body	4.41e-03	1.00e+00	7.825	1	1	2
GO:0090343	positive regulation of cell aging	4.41e-03	1.00e+00	7.825	1	1	2
GO:0004822	isoleucine-tRNA ligase activity	4.41e-03	1.00e+00	7.825	1	1	2
GO:0008296	3'-5'-exodeoxyribonuclease activity	4.41e-03	1.00e+00	7.825	1	1	2
GO:0019322	pentose biosynthetic process	4.41e-03	1.00e+00	7.825	1	1	2
GO:0007127	meiosis I	4.41e-03	1.00e+00	7.825	1	1	2
GO:0070409	carbamoyl phosphate biosynthetic process	4.41e-03	1.00e+00	7.825	1	1	2
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	4.80e-03	1.00e+00	4.270	2	3	47
GO:0003743	translation initiation factor activity	5.21e-03	1.00e+00	4.210	2	4	49
GO:0022625	cytosolic large ribosomal subunit	5.21e-03	1.00e+00	4.210	2	5	49
GO:0031100	organ regeneration	5.42e-03	1.00e+00	4.181	2	4	50
GO:0035690	cellular response to drug	5.42e-03	1.00e+00	4.181	2	2	50
GO:0040008	regulation of growth	5.64e-03	1.00e+00	4.152	2	3	51
GO:0000398	mRNA splicing, via spliceosome	5.67e-03	1.00e+00	3.043	3	12	165
GO:0090305	nucleic acid phosphodiester bond hydrolysis	6.30e-03	1.00e+00	4.070	2	2	54
GO:0005737	cytoplasm	6.54e-03	1.00e+00	0.867	16	98	3976
GO:0009263	deoxyribonucleotide biosynthetic process	6.60e-03	1.00e+00	7.240	1	1	3
GO:0009048	dosage compensation by inactivation of X chromosome	6.60e-03	1.00e+00	7.240	1	1	3
GO:0035794	positive regulation of mitochondrial membrane permeability	6.60e-03	1.00e+00	7.240	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	6.60e-03	1.00e+00	7.240	1	1	3
GO:0071899	negative regulation of estrogen receptor binding	6.60e-03	1.00e+00	7.240	1	1	3
GO:0051097	negative regulation of helicase activity	6.60e-03	1.00e+00	7.240	1	1	3
GO:0005850	eukaryotic translation initiation factor 2 complex	6.60e-03	1.00e+00	7.240	1	1	3
GO:0071733	transcriptional activation by promoter-enhancer looping	6.60e-03	1.00e+00	7.240	1	1	3
GO:0035033	histone deacetylase regulator activity	6.60e-03	1.00e+00	7.240	1	1	3
GO:0000056	ribosomal small subunit export from nucleus	6.60e-03	1.00e+00	7.240	1	1	3
GO:0002360	T cell lineage commitment	6.60e-03	1.00e+00	7.240	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	6.60e-03	1.00e+00	7.240	1	1	3
GO:0034103	regulation of tissue remodeling	6.60e-03	1.00e+00	7.240	1	1	3
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	6.60e-03	1.00e+00	7.240	1	1	3
GO:0044205	'de novo' UMP biosynthetic process	6.60e-03	1.00e+00	7.240	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	6.60e-03	1.00e+00	7.240	1	1	3
GO:0000723	telomere maintenance	7.48e-03	1.00e+00	3.942	2	8	59
GO:0005524	ATP binding	8.15e-03	1.00e+00	1.422	8	46	1354
GO:0006302	double-strand break repair	8.23e-03	1.00e+00	3.870	2	8	62
GO:0042995	cell projection	8.49e-03	1.00e+00	3.847	2	6	63
GO:0000212	meiotic spindle organization	8.79e-03	1.00e+00	6.825	1	1	4
GO:0005658	alpha DNA polymerase:primase complex	8.79e-03	1.00e+00	6.825	1	1	4
GO:0043137	DNA replication, removal of RNA primer	8.79e-03	1.00e+00	6.825	1	1	4
GO:0019788	NEDD8 ligase activity	8.79e-03	1.00e+00	6.825	1	1	4
GO:0090403	oxidative stress-induced premature senescence	8.79e-03	1.00e+00	6.825	1	1	4
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	8.79e-03	1.00e+00	6.825	1	1	4
GO:0002326	B cell lineage commitment	8.79e-03	1.00e+00	6.825	1	1	4
GO:0006543	glutamine catabolic process	8.79e-03	1.00e+00	6.825	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	8.79e-03	1.00e+00	6.825	1	1	4
GO:0000055	ribosomal large subunit export from nucleus	8.79e-03	1.00e+00	6.825	1	1	4
GO:0008853	exodeoxyribonuclease III activity	8.79e-03	1.00e+00	6.825	1	1	4
GO:0006273	lagging strand elongation	8.79e-03	1.00e+00	6.825	1	1	4
GO:0003896	DNA primase activity	8.79e-03	1.00e+00	6.825	1	2	4
GO:0016602	CCAAT-binding factor complex	8.79e-03	1.00e+00	6.825	1	1	4
GO:0003924	GTPase activity	1.00e-02	1.00e+00	2.744	3	9	203
GO:0051414	response to cortisol	1.10e-02	1.00e+00	6.503	1	1	5
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	1.10e-02	1.00e+00	6.503	1	2	5
GO:0001940	male pronucleus	1.10e-02	1.00e+00	6.503	1	1	5
GO:0001882	nucleoside binding	1.10e-02	1.00e+00	6.503	1	1	5
GO:0032407	MutSalpha complex binding	1.10e-02	1.00e+00	6.503	1	1	5
GO:0008622	epsilon DNA polymerase complex	1.10e-02	1.00e+00	6.503	1	1	5
GO:0097371	MDM2/MDM4 family protein binding	1.10e-02	1.00e+00	6.503	1	1	5
GO:0006269	DNA replication, synthesis of RNA primer	1.10e-02	1.00e+00	6.503	1	2	5
GO:0031461	cullin-RING ubiquitin ligase complex	1.10e-02	1.00e+00	6.503	1	1	5
GO:0071169	establishment of protein localization to chromatin	1.10e-02	1.00e+00	6.503	1	1	5
GO:0043248	proteasome assembly	1.10e-02	1.00e+00	6.503	1	1	5
GO:0030891	VCB complex	1.10e-02	1.00e+00	6.503	1	2	5
GO:0017108	5'-flap endonuclease activity	1.10e-02	1.00e+00	6.503	1	1	5
GO:0005827	polar microtubule	1.10e-02	1.00e+00	6.503	1	1	5
GO:0004523	RNA-DNA hybrid ribonuclease activity	1.10e-02	1.00e+00	6.503	1	1	5
GO:0055086	nucleobase-containing small molecule metabolic process	1.13e-02	1.00e+00	3.635	2	5	73
GO:0007265	Ras protein signal transduction	1.19e-02	1.00e+00	3.596	2	3	75
GO:0006184	GTP catabolic process	1.24e-02	1.00e+00	2.628	3	9	220
GO:0008584	male gonad development	1.25e-02	1.00e+00	3.558	2	2	77
GO:0071013	catalytic step 2 spliceosome	1.31e-02	1.00e+00	3.521	2	7	79
GO:0010666	positive regulation of cardiac muscle cell apoptotic process	1.32e-02	1.00e+00	6.240	1	1	6
GO:0001221	transcription cofactor binding	1.32e-02	1.00e+00	6.240	1	1	6
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	1.32e-02	1.00e+00	6.240	1	1	6
GO:0002309	T cell proliferation involved in immune response	1.32e-02	1.00e+00	6.240	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	1.32e-02	1.00e+00	6.240	1	1	6
GO:0030957	Tat protein binding	1.32e-02	1.00e+00	6.240	1	4	6
GO:0046134	pyrimidine nucleoside biosynthetic process	1.32e-02	1.00e+00	6.240	1	1	6
GO:0070245	positive regulation of thymocyte apoptotic process	1.32e-02	1.00e+00	6.240	1	1	6
GO:0007406	negative regulation of neuroblast proliferation	1.32e-02	1.00e+00	6.240	1	1	6
GO:0032405	MutLalpha complex binding	1.32e-02	1.00e+00	6.240	1	2	6
GO:0019083	viral transcription	1.37e-02	1.00e+00	3.485	2	8	81
GO:0007067	mitotic nuclear division	1.42e-02	1.00e+00	2.558	3	13	231
GO:0008380	RNA splicing	1.43e-02	1.00e+00	2.551	3	13	232
GO:0005681	spliceosomal complex	1.44e-02	1.00e+00	3.449	2	3	83
GO:0006412	translation	1.48e-02	1.00e+00	2.533	3	15	235
GO:0001939	female pronucleus	1.53e-02	1.00e+00	6.017	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	1.53e-02	1.00e+00	6.017	1	2	7
GO:0030157	pancreatic juice secretion	1.53e-02	1.00e+00	6.017	1	1	7
GO:0031497	chromatin assembly	1.53e-02	1.00e+00	6.017	1	1	7
GO:0000930	gamma-tubulin complex	1.53e-02	1.00e+00	6.017	1	1	7
GO:0006415	translational termination	1.57e-02	1.00e+00	3.382	2	8	87
GO:0003690	double-stranded DNA binding	1.71e-02	1.00e+00	3.317	2	4	91
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	1.75e-02	1.00e+00	5.825	1	2	8
GO:0000733	DNA strand renaturation	1.75e-02	1.00e+00	5.825	1	1	8
GO:0070688	MLL5-L complex	1.75e-02	1.00e+00	5.825	1	1	8
GO:0045116	protein neddylation	1.75e-02	1.00e+00	5.825	1	2	8
GO:0006414	translational elongation	1.78e-02	1.00e+00	3.285	2	11	93
GO:0005200	structural constituent of cytoskeleton	1.78e-02	1.00e+00	3.285	2	7	93
GO:0001649	osteoblast differentiation	1.86e-02	1.00e+00	3.255	2	6	95
GO:0008409	5'-3' exonuclease activity	1.97e-02	1.00e+00	5.655	1	1	9
GO:0014075	response to amine	1.97e-02	1.00e+00	5.655	1	1	9
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	1.97e-02	1.00e+00	5.655	1	1	9
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1.97e-02	1.00e+00	5.655	1	1	9
GO:0006228	UTP biosynthetic process	1.97e-02	1.00e+00	5.655	1	1	9
GO:0010389	regulation of G2/M transition of mitotic cell cycle	1.97e-02	1.00e+00	5.655	1	1	9
GO:0006983	ER overload response	1.97e-02	1.00e+00	5.655	1	2	9
GO:0071456	cellular response to hypoxia	1.97e-02	1.00e+00	3.210	2	4	98
GO:0031065	positive regulation of histone deacetylation	1.97e-02	1.00e+00	5.655	1	1	9
GO:0000075	cell cycle checkpoint	1.97e-02	1.00e+00	5.655	1	2	9
GO:0031000	response to caffeine	1.97e-02	1.00e+00	5.655	1	2	9
GO:0045893	positive regulation of transcription, DNA-templated	2.17e-02	1.00e+00	1.897	4	17	487
GO:0006379	mRNA cleavage	2.18e-02	1.00e+00	5.503	1	1	10
GO:0090399	replicative senescence	2.18e-02	1.00e+00	5.503	1	1	10
GO:2000648	positive regulation of stem cell proliferation	2.18e-02	1.00e+00	5.503	1	1	10
GO:0000731	DNA synthesis involved in DNA repair	2.18e-02	1.00e+00	5.503	1	1	10
GO:0000166	nucleotide binding	2.18e-02	1.00e+00	2.322	3	6	272
GO:0046902	regulation of mitochondrial membrane permeability	2.18e-02	1.00e+00	5.503	1	1	10
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	2.20e-02	1.00e+00	3.124	2	8	104
GO:0042802	identical protein binding	2.23e-02	1.00e+00	1.885	4	18	491
GO:0044267	cellular protein metabolic process	2.29e-02	1.00e+00	1.873	4	24	495
GO:0006098	pentose-phosphate shunt	2.40e-02	1.00e+00	5.365	1	3	11
GO:0021846	cell proliferation in forebrain	2.40e-02	1.00e+00	5.365	1	1	11
GO:0008340	determination of adult lifespan	2.40e-02	1.00e+00	5.365	1	1	11
GO:0071850	mitotic cell cycle arrest	2.40e-02	1.00e+00	5.365	1	1	11
GO:0031571	mitotic G1 DNA damage checkpoint	2.40e-02	1.00e+00	5.365	1	3	11
GO:0045120	pronucleus	2.40e-02	1.00e+00	5.365	1	1	11
GO:0033762	response to glucagon	2.40e-02	1.00e+00	5.365	1	1	11
GO:2000036	regulation of stem cell maintenance	2.40e-02	1.00e+00	5.365	1	2	11
GO:0035458	cellular response to interferon-beta	2.40e-02	1.00e+00	5.365	1	2	11
GO:0051290	protein heterotetramerization	2.40e-02	1.00e+00	5.365	1	2	11
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	2.61e-02	1.00e+00	2.992	2	10	114
GO:0019985	translesion synthesis	2.62e-02	1.00e+00	5.240	1	2	12
GO:0009650	UV protection	2.62e-02	1.00e+00	5.240	1	1	12
GO:0070935	3'-UTR-mediated mRNA stabilization	2.62e-02	1.00e+00	5.240	1	2	12
GO:0070266	necroptotic process	2.62e-02	1.00e+00	5.240	1	1	12
GO:0032461	positive regulation of protein oligomerization	2.62e-02	1.00e+00	5.240	1	1	12
GO:0009303	rRNA transcription	2.62e-02	1.00e+00	5.240	1	1	12
GO:0042273	ribosomal large subunit biogenesis	2.83e-02	1.00e+00	5.124	1	4	13
GO:0032479	regulation of type I interferon production	2.83e-02	1.00e+00	5.124	1	2	13
GO:0048205	COPI coating of Golgi vesicle	2.83e-02	1.00e+00	5.124	1	1	13
GO:0030234	enzyme regulator activity	2.83e-02	1.00e+00	5.124	1	3	13
GO:0030126	COPI vesicle coat	2.83e-02	1.00e+00	5.124	1	1	13
GO:0008266	poly(U) RNA binding	2.83e-02	1.00e+00	5.124	1	1	13
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	3.05e-02	1.00e+00	5.017	1	2	14
GO:2000378	negative regulation of reactive oxygen species metabolic process	3.05e-02	1.00e+00	5.017	1	1	14
GO:0004527	exonuclease activity	3.05e-02	1.00e+00	5.017	1	1	14
GO:0007020	microtubule nucleation	3.05e-02	1.00e+00	5.017	1	1	14
GO:0030330	DNA damage response, signal transduction by p53 class mediator	3.05e-02	1.00e+00	5.017	1	1	14
GO:0007095	mitotic G2 DNA damage checkpoint	3.05e-02	1.00e+00	5.017	1	1	14
GO:0009651	response to salt stress	3.05e-02	1.00e+00	5.017	1	2	14
GO:0048568	embryonic organ development	3.05e-02	1.00e+00	5.017	1	1	14
GO:0007219	Notch signaling pathway	3.09e-02	1.00e+00	2.859	2	4	125
GO:0035066	positive regulation of histone acetylation	3.26e-02	1.00e+00	4.918	1	1	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	3.26e-02	1.00e+00	4.918	1	1	15
GO:0042176	regulation of protein catabolic process	3.47e-02	1.00e+00	4.825	1	3	16
GO:0050998	nitric-oxide synthase binding	3.47e-02	1.00e+00	4.825	1	1	16
GO:0005525	GTP binding	3.52e-02	1.00e+00	2.052	3	11	328
GO:0000086	G2/M transition of mitotic cell cycle	3.66e-02	1.00e+00	2.726	2	7	137
GO:0010243	response to organonitrogen compound	3.69e-02	1.00e+00	4.737	1	2	17
GO:0042149	cellular response to glucose starvation	3.69e-02	1.00e+00	4.737	1	1	17
GO:0075733	intracellular transport of virus	3.69e-02	1.00e+00	4.737	1	2	17
GO:0003682	chromatin binding	3.69e-02	1.00e+00	2.026	3	12	334
GO:0003735	structural constituent of ribosome	3.86e-02	1.00e+00	2.685	2	8	141
GO:0071392	cellular response to estradiol stimulus	3.90e-02	1.00e+00	4.655	1	1	18
GO:0006541	glutamine metabolic process	3.90e-02	1.00e+00	4.655	1	1	18
GO:0031122	cytoplasmic microtubule organization	3.90e-02	1.00e+00	4.655	1	2	18
GO:0051721	protein phosphatase 2A binding	3.90e-02	1.00e+00	4.655	1	1	18
GO:0006303	double-strand break repair via nonhomologous end joining	3.90e-02	1.00e+00	4.655	1	3	18
GO:0015949	nucleobase-containing small molecule interconversion	3.90e-02	1.00e+00	4.655	1	2	18
GO:0005657	replication fork	3.90e-02	1.00e+00	4.655	1	3	18
GO:0016887	ATPase activity	4.01e-02	1.00e+00	2.655	2	7	144
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	4.11e-02	1.00e+00	4.577	1	1	19
GO:0048863	stem cell differentiation	4.11e-02	1.00e+00	4.577	1	1	19
GO:0035035	histone acetyltransferase binding	4.11e-02	1.00e+00	4.577	1	1	19
GO:0071158	positive regulation of cell cycle arrest	4.11e-02	1.00e+00	4.577	1	1	19
GO:0010165	response to X-ray	4.11e-02	1.00e+00	4.577	1	2	19
GO:0061024	membrane organization	4.11e-02	1.00e+00	2.635	2	5	146
GO:0006457	protein folding	4.26e-02	1.00e+00	2.605	2	8	149
GO:0005719	nuclear euchromatin	4.32e-02	1.00e+00	4.503	1	2	20
GO:0002931	response to ischemia	4.32e-02	1.00e+00	4.503	1	1	20
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	4.32e-02	1.00e+00	4.503	1	1	20
GO:0006298	mismatch repair	4.32e-02	1.00e+00	4.503	1	6	20
GO:0008156	negative regulation of DNA replication	4.53e-02	1.00e+00	4.432	1	1	21
GO:0007369	gastrulation	4.53e-02	1.00e+00	4.432	1	1	21
GO:0071364	cellular response to epidermal growth factor stimulus	4.53e-02	1.00e+00	4.432	1	1	21
GO:0005669	transcription factor TFIID complex	4.74e-02	1.00e+00	4.365	1	1	22
GO:0090200	positive regulation of release of cytochrome c from mitochondria	4.74e-02	1.00e+00	4.365	1	1	22
GO:0006297	nucleotide-excision repair, DNA gap filling	4.74e-02	1.00e+00	4.365	1	5	22
GO:0006378	mRNA polyadenylation	4.74e-02	1.00e+00	4.365	1	1	22
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	4.74e-02	1.00e+00	4.365	1	3	22
GO:0033574	response to testosterone	4.74e-02	1.00e+00	4.365	1	2	22
GO:0030863	cortical cytoskeleton	4.74e-02	1.00e+00	4.365	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	4.74e-02	1.00e+00	4.365	1	4	22
GO:0007052	mitotic spindle organization	4.74e-02	1.00e+00	4.365	1	2	22
GO:0031463	Cul3-RING ubiquitin ligase complex	4.96e-02	1.00e+00	4.301	1	2	23
GO:0006513	protein monoubiquitination	4.96e-02	1.00e+00	4.301	1	1	23
GO:0001836	release of cytochrome c from mitochondria	5.17e-02	1.00e+00	4.240	1	2	24
GO:0000794	condensed nuclear chromosome	5.17e-02	1.00e+00	4.240	1	2	24
GO:0048147	negative regulation of fibroblast proliferation	5.17e-02	1.00e+00	4.240	1	1	24
GO:0000060	protein import into nucleus, translocation	5.17e-02	1.00e+00	4.240	1	4	24
GO:2000379	positive regulation of reactive oxygen species metabolic process	5.17e-02	1.00e+00	4.240	1	1	24
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	5.28e-02	1.00e+00	2.432	2	5	168
GO:0006611	protein export from nucleus	5.37e-02	1.00e+00	4.181	1	4	25
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	5.37e-02	1.00e+00	4.181	1	1	25
GO:0007569	cell aging	5.37e-02	1.00e+00	4.181	1	2	25
GO:0071479	cellular response to ionizing radiation	5.37e-02	1.00e+00	4.181	1	1	25
GO:0017144	drug metabolic process	5.37e-02	1.00e+00	4.181	1	1	25
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	5.58e-02	1.00e+00	4.124	1	3	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	5.58e-02	1.00e+00	4.124	1	2	26
GO:0004519	endonuclease activity	5.58e-02	1.00e+00	4.124	1	1	26
GO:0046982	protein heterodimerization activity	5.72e-02	1.00e+00	1.769	3	11	399
GO:0004003	ATP-dependent DNA helicase activity	5.79e-02	1.00e+00	4.070	1	3	27
GO:0034080	CENP-A containing nucleosome assembly	5.79e-02	1.00e+00	4.070	1	2	27
GO:0019843	rRNA binding	5.79e-02	1.00e+00	4.070	1	3	27
GO:0031625	ubiquitin protein ligase binding	5.97e-02	1.00e+00	2.333	2	13	180
GO:0001046	core promoter sequence-specific DNA binding	6.00e-02	1.00e+00	4.017	1	1	28
GO:0019894	kinesin binding	6.00e-02	1.00e+00	4.017	1	1	28
GO:0019005	SCF ubiquitin ligase complex	6.21e-02	1.00e+00	3.967	1	1	29
GO:0010332	response to gamma radiation	6.21e-02	1.00e+00	3.967	1	2	29
GO:0003730	mRNA 3'-UTR binding	6.21e-02	1.00e+00	3.967	1	2	29
GO:0071897	DNA biosynthetic process	6.21e-02	1.00e+00	3.967	1	2	29
GO:0051262	protein tetramerization	6.42e-02	1.00e+00	3.918	1	3	30
GO:0021549	cerebellum development	6.42e-02	1.00e+00	3.918	1	1	30
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	6.42e-02	1.00e+00	3.918	1	2	30
GO:0046677	response to antibiotic	6.62e-02	1.00e+00	3.870	1	2	31
GO:0016604	nuclear body	6.62e-02	1.00e+00	3.870	1	2	31
GO:0050661	NADP binding	6.83e-02	1.00e+00	3.825	1	1	32
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	6.83e-02	1.00e+00	3.825	1	1	32
GO:0030971	receptor tyrosine kinase binding	7.03e-02	1.00e+00	3.780	1	2	33
GO:0033077	T cell differentiation in thymus	7.03e-02	1.00e+00	3.780	1	2	33
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	7.03e-02	1.00e+00	3.780	1	1	33
GO:0001085	RNA polymerase II transcription factor binding	7.24e-02	1.00e+00	3.737	1	2	34
GO:0034332	adherens junction organization	7.65e-02	1.00e+00	3.655	1	1	36
GO:0051402	neuron apoptotic process	7.65e-02	1.00e+00	3.655	1	2	36
GO:0001895	retina homeostasis	7.65e-02	1.00e+00	3.655	1	1	36
GO:0006446	regulation of translational initiation	7.65e-02	1.00e+00	3.655	1	1	36
GO:0001701	in utero embryonic development	7.81e-02	1.00e+00	2.110	2	6	210
GO:0051084	'de novo' posttranslational protein folding	7.85e-02	1.00e+00	3.615	1	4	37
GO:0018107	peptidyl-threonine phosphorylation	7.85e-02	1.00e+00	3.615	1	1	37
GO:0051539	4 iron, 4 sulfur cluster binding	7.85e-02	1.00e+00	3.615	1	3	37
GO:0001756	somitogenesis	8.06e-02	1.00e+00	3.577	1	1	38
GO:0070527	platelet aggregation	8.06e-02	1.00e+00	3.577	1	2	38
GO:0050681	androgen receptor binding	8.06e-02	1.00e+00	3.577	1	4	38
GO:0000737	DNA catabolic process, endonucleolytic	8.26e-02	1.00e+00	3.539	1	2	39
GO:0031490	chromatin DNA binding	8.26e-02	1.00e+00	3.539	1	2	39
GO:0032092	positive regulation of protein binding	8.26e-02	1.00e+00	3.539	1	3	39
GO:0007595	lactation	8.26e-02	1.00e+00	3.539	1	2	39
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	8.46e-02	1.00e+00	3.503	1	2	40
GO:0030145	manganese ion binding	8.67e-02	1.00e+00	3.467	1	1	41
GO:0043195	terminal bouton	8.67e-02	1.00e+00	3.467	1	1	41
GO:0030521	androgen receptor signaling pathway	8.67e-02	1.00e+00	3.467	1	2	41
GO:0031124	mRNA 3'-end processing	8.87e-02	1.00e+00	3.432	1	2	42
GO:0014070	response to organic cyclic compound	9.07e-02	1.00e+00	3.398	1	3	43
GO:0010212	response to ionizing radiation	9.07e-02	1.00e+00	3.398	1	1	43
GO:0048146	positive regulation of fibroblast proliferation	9.27e-02	1.00e+00	3.365	1	2	44
GO:0007286	spermatid development	9.27e-02	1.00e+00	3.365	1	1	44
GO:0034613	cellular protein localization	9.27e-02	1.00e+00	3.365	1	1	44
GO:0015030	Cajal body	9.47e-02	1.00e+00	3.333	1	2	45
GO:0043966	histone H3 acetylation	9.47e-02	1.00e+00	3.333	1	2	45
GO:0006369	termination of RNA polymerase II transcription	9.47e-02	1.00e+00	3.333	1	2	45
GO:0021762	substantia nigra development	9.67e-02	1.00e+00	3.301	1	1	46
GO:0043525	positive regulation of neuron apoptotic process	9.67e-02	1.00e+00	3.301	1	2	46
GO:0048511	rhythmic process	9.87e-02	1.00e+00	3.270	1	2	47
GO:0006950	response to stress	1.01e-01	1.00e+00	3.240	1	3	48
GO:0019003	GDP binding	1.01e-01	1.00e+00	3.240	1	2	48
GO:0005507	copper ion binding	1.01e-01	1.00e+00	3.240	1	2	48
GO:0043025	neuronal cell body	1.08e-01	1.00e+00	1.836	2	4	254
GO:0060041	retina development in camera-type eye	1.11e-01	1.00e+00	3.097	1	3	53
GO:0000226	microtubule cytoskeleton organization	1.15e-01	1.00e+00	3.043	1	3	55
GO:0097193	intrinsic apoptotic signaling pathway	1.15e-01	1.00e+00	3.043	1	4	55
GO:0002039	p53 binding	1.15e-01	1.00e+00	3.043	1	7	55
GO:0000932	cytoplasmic mRNA processing body	1.17e-01	1.00e+00	3.017	1	3	56
GO:0008104	protein localization	1.17e-01	1.00e+00	3.017	1	3	56
GO:0007613	memory	1.17e-01	1.00e+00	3.017	1	2	56
GO:0051087	chaperone binding	1.22e-01	1.00e+00	2.942	1	6	59
GO:0045216	cell-cell junction organization	1.22e-01	1.00e+00	2.942	1	2	59
GO:0005643	nuclear pore	1.22e-01	1.00e+00	2.942	1	4	59
GO:0032481	positive regulation of type I interferon production	1.26e-01	1.00e+00	2.894	1	6	61
GO:0019903	protein phosphatase binding	1.30e-01	1.00e+00	2.847	1	4	63
GO:0019899	enzyme binding	1.32e-01	1.00e+00	1.655	2	11	288
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	1.32e-01	1.00e+00	2.825	1	1	64
GO:0006338	chromatin remodeling	1.40e-01	1.00e+00	2.737	1	4	68
GO:0006289	nucleotide-excision repair	1.42e-01	1.00e+00	2.716	1	12	69
GO:0003697	single-stranded DNA binding	1.42e-01	1.00e+00	2.716	1	9	69
GO:0035264	multicellular organism growth	1.43e-01	1.00e+00	2.695	1	1	70
GO:0034329	cell junction assembly	1.45e-01	1.00e+00	2.675	1	1	71
GO:0032355	response to estradiol	1.49e-01	1.00e+00	2.635	1	5	73
GO:0002020	protease binding	1.51e-01	1.00e+00	2.615	1	4	74
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	1.53e-01	1.00e+00	2.596	1	1	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	1.55e-01	1.00e+00	2.577	1	3	76
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	1.57e-01	1.00e+00	2.558	1	5	77
GO:0006334	nucleosome assembly	1.60e-01	1.00e+00	2.521	1	4	79
GO:0007565	female pregnancy	1.62e-01	1.00e+00	2.503	1	2	80
GO:0051301	cell division	1.64e-01	1.00e+00	2.485	1	6	81
GO:0008283	cell proliferation	1.65e-01	1.00e+00	1.454	2	12	331
GO:0001889	liver development	1.66e-01	1.00e+00	2.467	1	3	82
GO:0005179	hormone activity	1.70e-01	1.00e+00	2.432	1	1	84
GO:0047485	protein N-terminus binding	1.73e-01	1.00e+00	2.398	1	4	86
GO:0016605	PML body	1.84e-01	1.00e+00	2.301	1	5	92
GO:0042470	melanosome	1.84e-01	1.00e+00	2.301	1	10	92
GO:0006928	cellular component movement	1.84e-01	1.00e+00	2.301	1	7	92
GO:0051082	unfolded protein binding	1.90e-01	1.00e+00	2.255	1	6	95
GO:0006364	rRNA processing	1.92e-01	1.00e+00	2.240	1	5	96
GO:0005925	focal adhesion	1.96e-01	1.00e+00	1.293	2	18	370
GO:0005739	mitochondrion	1.97e-01	1.00e+00	0.794	4	24	1046
GO:0014069	postsynaptic density	2.09e-01	1.00e+00	2.097	1	1	106
GO:0005815	microtubule organizing center	2.16e-01	1.00e+00	2.043	1	4	110
GO:0006461	protein complex assembly	2.18e-01	1.00e+00	2.030	1	6	111
GO:0015630	microtubule cytoskeleton	2.20e-01	1.00e+00	2.017	1	5	112
GO:0030308	negative regulation of cell growth	2.21e-01	1.00e+00	2.004	1	6	113
GO:0072562	blood microparticle	2.27e-01	1.00e+00	1.967	1	4	116
GO:0006366	transcription from RNA polymerase II promoter	2.41e-01	1.00e+00	1.093	2	12	425
GO:0007050	cell cycle arrest	2.44e-01	1.00e+00	1.847	1	7	126
GO:0006511	ubiquitin-dependent protein catabolic process	2.45e-01	1.00e+00	1.836	1	5	127
GO:0007179	transforming growth factor beta receptor signaling pathway	2.50e-01	1.00e+00	1.802	1	3	130
GO:0009615	response to virus	2.54e-01	1.00e+00	1.780	1	6	132
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.65e-01	1.00e+00	0.746	3	19	811
GO:0044255	cellular lipid metabolic process	2.67e-01	1.00e+00	1.695	1	4	140
GO:0007507	heart development	2.69e-01	1.00e+00	1.685	1	5	141
GO:0007596	blood coagulation	2.73e-01	1.00e+00	0.967	2	14	464
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	2.85e-01	1.00e+00	1.586	1	2	151
GO:0055114	oxidation-reduction process	2.87e-01	1.00e+00	0.915	2	11	481
GO:0006974	cellular response to DNA damage stimulus	2.96e-01	1.00e+00	1.521	1	8	158
GO:0046777	protein autophosphorylation	2.96e-01	1.00e+00	1.521	1	3	158
GO:0005198	structural molecule activity	2.97e-01	1.00e+00	1.512	1	4	159
GO:0006397	mRNA processing	3.13e-01	1.00e+00	1.424	1	3	169
GO:0044212	transcription regulatory region DNA binding	3.16e-01	1.00e+00	1.407	1	6	171
GO:0030424	axon	3.17e-01	1.00e+00	1.398	1	3	172
GO:0006886	intracellular protein transport	3.19e-01	1.00e+00	1.390	1	4	173
GO:0000287	magnesium ion binding	3.20e-01	1.00e+00	1.382	1	5	174
GO:0016607	nuclear speck	3.22e-01	1.00e+00	1.373	1	4	175
GO:0004672	protein kinase activity	3.26e-01	1.00e+00	1.349	1	2	178
GO:0019904	protein domain specific binding	3.31e-01	1.00e+00	1.325	1	6	181
GO:0015629	actin cytoskeleton	3.34e-01	1.00e+00	1.309	1	5	183
GO:0032403	protein complex binding	3.37e-01	1.00e+00	1.293	1	7	185
GO:0003677	DNA binding	3.48e-01	1.00e+00	0.425	4	26	1351
GO:0005622	intracellular	3.95e-01	1.00e+00	1.004	1	5	226
GO:0045087	innate immune response	3.96e-01	1.00e+00	0.558	2	20	616
GO:0005759	mitochondrial matrix	4.04e-01	1.00e+00	0.960	1	12	233
GO:0003713	transcription coactivator activity	4.12e-01	1.00e+00	0.924	1	10	239
GO:0008270	zinc ion binding	4.21e-01	1.00e+00	0.350	3	12	1067
GO:0008134	transcription factor binding	4.22e-01	1.00e+00	0.882	1	8	246
GO:0005794	Golgi apparatus	4.23e-01	1.00e+00	0.480	2	14	650
GO:0004842	ubiquitin-protein transferase activity	4.34e-01	1.00e+00	0.825	1	4	256
GO:0005975	carbohydrate metabolic process	4.57e-01	1.00e+00	0.726	1	5	274
GO:0043065	positive regulation of apoptotic process	4.57e-01	1.00e+00	0.726	1	8	274
GO:0006357	regulation of transcription from RNA polymerase II promoter	4.58e-01	1.00e+00	0.721	1	6	275
GO:0007283	spermatogenesis	4.59e-01	1.00e+00	0.716	1	6	276
GO:0007264	small GTPase mediated signal transduction	4.76e-01	1.00e+00	0.645	1	3	290
GO:0016567	protein ubiquitination	4.86e-01	1.00e+00	0.601	1	5	299
GO:0006200	ATP catabolic process	4.91e-01	1.00e+00	0.581	1	14	303
GO:0003700	sequence-specific DNA binding transcription factor activity	4.96e-01	1.00e+00	0.278	2	11	748
GO:0005856	cytoskeleton	5.00e-01	1.00e+00	0.544	1	8	311
GO:0030154	cell differentiation	5.16e-01	1.00e+00	0.480	1	5	325
GO:0007411	axon guidance	5.18e-01	1.00e+00	0.471	1	9	327
GO:0043231	intracellular membrane-bounded organelle	5.23e-01	1.00e+00	0.449	1	8	332
GO:0005813	centrosome	5.31e-01	1.00e+00	0.419	1	12	339
GO:0007275	multicellular organismal development	5.36e-01	1.00e+00	0.398	1	5	344
GO:0043565	sequence-specific DNA binding	5.57e-01	1.00e+00	0.313	1	4	365
GO:0008285	negative regulation of cell proliferation	5.59e-01	1.00e+00	0.305	1	11	367
GO:0045892	negative regulation of transcription, DNA-templated	6.13e-01	1.00e+00	0.097	1	14	424
GO:0046872	metal ion binding	6.39e-01	1.00e+00	-0.107	3	24	1465
GO:0005615	extracellular space	6.62e-01	1.00e+00	-0.156	2	17	1010
GO:0006355	regulation of transcription, DNA-templated	7.10e-01	1.00e+00	-0.284	2	17	1104
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	7.34e-01	1.00e+00	-0.378	1	12	589
GO:0005783	endoplasmic reticulum	7.47e-01	1.00e+00	-0.428	1	9	610
GO:0042803	protein homodimerization activity	7.51e-01	1.00e+00	-0.445	1	11	617
GO:0005789	endoplasmic reticulum membrane	7.61e-01	1.00e+00	-0.488	1	10	636
GO:0006351	transcription, DNA-templated	8.77e-01	1.00e+00	-0.806	2	25	1585
GO:0007165	signal transduction	8.85e-01	1.00e+00	-1.067	1	17	950

Wolf-ratios-Mammosphere-Adherent

meta-int-snw-10209

Interacting subnets

Genes (36)

Interactions (139)

Related GO terms (462)