reg-snw-11277

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.882	1.09e-07	9.11e-04	1.96e-03

wolf-screen-ratio-mammosphere-adherent-reg-snw-11277 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	Transcription factor	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CAD	790	25	0.807	0.973	67	-	-	-
PSMB1	5689	5	0.688	0.901	28	-	Yes	-
RBX1	9978	8	1.185	0.934	9	TF	Yes	-
PSMB7	5695	10	0.982	0.934	33	-	Yes	-
HNRNPC	3183	40	1.812	0.973	62	-	Yes	-
PSMB2	5690	23	0.877	0.956	52	-	Yes	-
PSMD11	5717	15	1.095	0.940	35	TF	Yes	-
[ TREX1 ]	11277	1	-0.051	0.882	91	TF	Yes	-
RAN	5901	8	0.632	0.899	83	-	Yes	-
RUVBL2	10856	20	0.693	0.956	187	TF	Yes	-

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RAN	5901	TREX1	11277	pd	<	reg.ITFP.txt: no annot
RUVBL2	10856	TREX1	11277	pd	<>	reg.ITFP.txt: no annot
PSMB2	5690	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
CAD	790	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
HNRNPC	3183	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
PSMB7	5695	RBX1	9978	pd	<	reg.ITFP.txt: no annot
PSMB1	5689	RUVBL2	10856	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	PSMD11	5717	pd	<	reg.ITFP.txt: no annot
CAD	790	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMB2	5690	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMB7	5695	TREX1	11277	pd	<	reg.ITFP.txt: no annot
PSMB1	5689	TREX1	11277	pd	<	reg.ITFP.txt: no annot

Related GO terms (193)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	5.52e-08	5.39e-04	6.574	4	16	41
GO:0000502	proteasome complex	9.69e-08	9.46e-04	6.377	4	17	47
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.47e-07	1.43e-03	6.231	4	17	52
GO:0005654	nucleoplasm	1.55e-07	1.52e-03	3.157	8	55	876
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.59e-07	1.55e-03	6.204	4	17	53
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.99e-07	1.94e-03	6.124	4	17	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	2.13e-07	2.08e-03	6.099	4	16	57
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.63e-07	2.57e-03	6.025	4	17	60
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.81e-07	2.75e-03	6.001	4	16	61
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.64e-07	3.56e-03	5.909	4	17	65
GO:0005839	proteasome core complex	4.30e-07	4.20e-03	7.516	3	9	16
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.92e-07	4.81e-03	5.802	4	16	70
GO:0004298	threonine-type endopeptidase activity	5.22e-07	5.10e-03	7.429	3	9	17
GO:0016032	viral process	1.24e-06	1.21e-02	3.775	6	32	428
GO:0000209	protein polyubiquitination	1.48e-06	1.45e-02	5.408	4	16	92
GO:0005829	cytosol	1.89e-06	1.85e-02	2.298	9	58	1787
GO:0034641	cellular nitrogen compound metabolic process	2.52e-06	2.46e-02	5.217	4	18	105
GO:0042981	regulation of apoptotic process	3.27e-06	3.19e-02	5.124	4	18	112
GO:0010467	gene expression	4.57e-06	4.47e-02	3.453	6	31	535
GO:0000082	G1/S transition of mitotic cell cycle	5.06e-06	4.94e-02	4.966	4	24	125
GO:0016071	mRNA metabolic process	1.72e-05	1.68e-01	4.522	4	21	170
GO:0070062	extracellular vesicular exosome	2.05e-05	2.00e-01	2.251	8	43	1641
GO:0016070	RNA metabolic process	2.55e-05	2.49e-01	4.377	4	21	188
GO:0044281	small molecule metabolic process	6.35e-05	6.20e-01	2.795	6	32	844
GO:0006259	DNA metabolic process	8.53e-05	8.33e-01	7.124	2	3	14
GO:0000278	mitotic cell cycle	1.89e-04	1.00e+00	3.637	4	35	314
GO:0043066	negative regulation of apoptotic process	2.08e-04	1.00e+00	3.601	4	20	322
GO:0005634	nucleus	3.45e-04	1.00e+00	1.437	9	67	3246
GO:0016020	membrane	4.75e-04	1.00e+00	2.279	6	38	1207
GO:0006915	apoptotic process	5.31e-04	1.00e+00	3.248	4	21	411
GO:0006281	DNA repair	9.54e-04	1.00e+00	3.851	3	19	203
GO:0032558	adenyl deoxyribonucleotide binding	1.02e-03	1.00e+00	9.931	1	1	1
GO:0004151	dihydroorotase activity	1.02e-03	1.00e+00	9.931	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	1.02e-03	1.00e+00	9.931	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.02e-03	1.00e+00	9.931	1	1	1
GO:0070335	aspartate binding	1.02e-03	1.00e+00	9.931	1	1	1
GO:0070409	carbamoyl phosphate biosynthetic process	1.02e-03	1.00e+00	9.931	1	1	1
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	1.08e-03	1.00e+00	5.317	2	3	49
GO:0006310	DNA recombination	1.13e-03	1.00e+00	5.288	2	6	50
GO:0030891	VCB complex	2.05e-03	1.00e+00	8.931	1	1	2
GO:0031467	Cul7-RING ubiquitin ligase complex	2.05e-03	1.00e+00	8.931	1	1	2
GO:0008296	3'-5'-exodeoxyribonuclease activity	2.05e-03	1.00e+00	8.931	1	1	2
GO:0032407	MutSalpha complex binding	2.05e-03	1.00e+00	8.931	1	1	2
GO:0016363	nuclear matrix	2.39e-03	1.00e+00	4.742	2	7	73
GO:0071733	transcriptional activation by promoter-enhancer looping	3.07e-03	1.00e+00	8.347	1	1	3
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	3.07e-03	1.00e+00	8.347	1	1	3
GO:0000056	ribosomal small subunit export from nucleus	3.07e-03	1.00e+00	8.347	1	1	3
GO:0006543	glutamine catabolic process	3.07e-03	1.00e+00	8.347	1	1	3
GO:0044205	'de novo' UMP biosynthetic process	3.07e-03	1.00e+00	8.347	1	1	3
GO:0071899	negative regulation of estrogen receptor binding	3.07e-03	1.00e+00	8.347	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	3.07e-03	1.00e+00	8.347	1	1	3
GO:0051414	response to cortisol	4.09e-03	1.00e+00	7.931	1	1	4
GO:0031461	cullin-RING ubiquitin ligase complex	4.09e-03	1.00e+00	7.931	1	2	4
GO:0071169	establishment of protein localization to chromatin	4.09e-03	1.00e+00	7.931	1	1	4
GO:0006228	UTP biosynthetic process	4.09e-03	1.00e+00	7.931	1	1	4
GO:0043248	proteasome assembly	4.09e-03	1.00e+00	7.931	1	1	4
GO:0019788	NEDD8 ligase activity	4.09e-03	1.00e+00	7.931	1	1	4
GO:0000055	ribosomal large subunit export from nucleus	4.09e-03	1.00e+00	7.931	1	1	4
GO:0008853	exodeoxyribonuclease III activity	4.09e-03	1.00e+00	7.931	1	1	4
GO:0032405	MutLalpha complex binding	4.09e-03	1.00e+00	7.931	1	1	4
GO:0005730	nucleolus	4.37e-03	1.00e+00	2.004	5	41	1217
GO:0042802	identical protein binding	4.69e-03	1.00e+00	3.049	3	7	354
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	5.11e-03	1.00e+00	7.610	1	2	5
GO:0014075	response to amine	5.11e-03	1.00e+00	7.610	1	1	5
GO:0046134	pyrimidine nucleoside biosynthetic process	6.13e-03	1.00e+00	7.347	1	1	6
GO:0031000	response to caffeine	6.13e-03	1.00e+00	7.347	1	1	6
GO:0031462	Cul2-RING ubiquitin ligase complex	6.13e-03	1.00e+00	7.347	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	6.13e-03	1.00e+00	7.347	1	1	6
GO:0075733	intracellular transport of virus	7.15e-03	1.00e+00	7.124	1	1	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	7.15e-03	1.00e+00	7.124	1	2	7
GO:0000812	Swr1 complex	7.15e-03	1.00e+00	7.124	1	2	7
GO:0045116	protein neddylation	7.15e-03	1.00e+00	7.124	1	1	7
GO:0031011	Ino80 complex	8.17e-03	1.00e+00	6.931	1	2	8
GO:0032479	regulation of type I interferon production	9.18e-03	1.00e+00	6.762	1	2	9
GO:0008266	poly(U) RNA binding	9.18e-03	1.00e+00	6.762	1	1	9
GO:0006541	glutamine metabolic process	1.02e-02	1.00e+00	6.610	1	1	10
GO:0035458	cellular response to interferon-beta	1.02e-02	1.00e+00	6.610	1	2	10
GO:0043968	histone H2A acetylation	1.02e-02	1.00e+00	6.610	1	2	10
GO:0005838	proteasome regulatory particle	1.02e-02	1.00e+00	6.610	1	4	10
GO:0070935	3'-UTR-mediated mRNA stabilization	1.12e-02	1.00e+00	6.472	1	2	11
GO:0008408	3'-5' exonuclease activity	1.12e-02	1.00e+00	6.472	1	2	11
GO:0045120	pronucleus	1.12e-02	1.00e+00	6.472	1	1	11
GO:0035267	NuA4 histone acetyltransferase complex	1.22e-02	1.00e+00	6.347	1	3	12
GO:0048863	stem cell differentiation	1.22e-02	1.00e+00	6.347	1	1	12
GO:0071392	cellular response to estradiol stimulus	1.32e-02	1.00e+00	6.231	1	1	13
GO:0035066	positive regulation of histone acetylation	1.32e-02	1.00e+00	6.231	1	1	13
GO:0000738	DNA catabolic process, exonucleolytic	1.32e-02	1.00e+00	6.231	1	3	13
GO:0010243	response to organonitrogen compound	1.43e-02	1.00e+00	6.124	1	1	14
GO:0022624	proteasome accessory complex	1.43e-02	1.00e+00	6.124	1	7	14
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.63e-02	1.00e+00	5.931	1	1	16
GO:0031463	Cul3-RING ubiquitin ligase complex	1.63e-02	1.00e+00	5.931	1	1	16
GO:0005719	nuclear euchromatin	1.63e-02	1.00e+00	5.931	1	1	16
GO:0006206	pyrimidine nucleobase metabolic process	1.73e-02	1.00e+00	5.844	1	2	17
GO:0006513	protein monoubiquitination	1.73e-02	1.00e+00	5.844	1	1	17
GO:0006298	mismatch repair	1.73e-02	1.00e+00	5.844	1	4	17
GO:0007052	mitotic spindle organization	1.73e-02	1.00e+00	5.844	1	2	17
GO:0005515	protein binding	1.78e-02	1.00e+00	0.922	8	76	4124
GO:0006611	protein export from nucleus	1.83e-02	1.00e+00	5.762	1	2	18
GO:0071364	cellular response to epidermal growth factor stimulus	1.83e-02	1.00e+00	5.762	1	1	18
GO:0003678	DNA helicase activity	1.83e-02	1.00e+00	5.762	1	3	18
GO:0071339	MLL1 complex	1.83e-02	1.00e+00	5.762	1	2	18
GO:0033574	response to testosterone	1.83e-02	1.00e+00	5.762	1	1	18
GO:0043234	protein complex	1.85e-02	1.00e+00	3.217	2	8	210
GO:0043044	ATP-dependent chromatin remodeling	2.03e-02	1.00e+00	5.610	1	2	20
GO:0019005	SCF ubiquitin ligase complex	2.03e-02	1.00e+00	5.610	1	1	20
GO:0017144	drug metabolic process	2.13e-02	1.00e+00	5.539	1	1	21
GO:0043967	histone H4 acetylation	2.23e-02	1.00e+00	5.472	1	2	22
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.23e-02	1.00e+00	5.472	1	1	22
GO:0007286	spermatid development	2.33e-02	1.00e+00	5.408	1	1	23
GO:0004003	ATP-dependent DNA helicase activity	2.53e-02	1.00e+00	5.288	1	2	25
GO:0003730	mRNA 3'-UTR binding	2.53e-02	1.00e+00	5.288	1	2	25
GO:0031492	nucleosomal DNA binding	2.53e-02	1.00e+00	5.288	1	2	25
GO:0034644	cellular response to UV	2.83e-02	1.00e+00	5.124	1	2	28
GO:0018107	peptidyl-threonine phosphorylation	2.93e-02	1.00e+00	5.073	1	2	29
GO:0050681	androgen receptor binding	3.03e-02	1.00e+00	5.025	1	2	30
GO:0090305	nucleic acid phosphodiester bond hydrolysis	3.13e-02	1.00e+00	4.977	1	2	31
GO:0043195	terminal bouton	3.13e-02	1.00e+00	4.977	1	1	31
GO:0031490	chromatin DNA binding	3.13e-02	1.00e+00	4.977	1	1	31
GO:0007595	lactation	3.23e-02	1.00e+00	4.931	1	2	32
GO:0019003	GDP binding	3.43e-02	1.00e+00	4.844	1	1	34
GO:0014070	response to organic cyclic compound	3.43e-02	1.00e+00	4.844	1	1	34
GO:0032092	positive regulation of protein binding	3.43e-02	1.00e+00	4.844	1	1	34
GO:0030521	androgen receptor signaling pathway	3.53e-02	1.00e+00	4.802	1	2	35
GO:0040008	regulation of growth	3.73e-02	1.00e+00	4.722	1	2	37
GO:0035690	cellular response to drug	3.83e-02	1.00e+00	4.684	1	2	38
GO:0032508	DNA duplex unwinding	3.83e-02	1.00e+00	4.684	1	5	38
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	4.02e-02	1.00e+00	4.610	1	2	40
GO:0042995	cell projection	4.12e-02	1.00e+00	4.574	1	2	41
GO:0003684	damaged DNA binding	4.12e-02	1.00e+00	4.574	1	9	41
GO:0031100	organ regeneration	4.42e-02	1.00e+00	4.472	1	2	44
GO:0032481	positive regulation of type I interferon production	4.81e-02	1.00e+00	4.347	1	5	48
GO:0005643	nuclear pore	5.10e-02	1.00e+00	4.259	1	2	51
GO:0055086	nucleobase-containing small molecule metabolic process	5.10e-02	1.00e+00	4.259	1	5	51
GO:0006338	chromatin remodeling	5.49e-02	1.00e+00	4.150	1	2	55
GO:0005681	spliceosomal complex	5.49e-02	1.00e+00	4.150	1	2	55
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.59e-02	1.00e+00	4.124	1	3	56
GO:0003697	single-stranded DNA binding	5.69e-02	1.00e+00	4.099	1	6	57
GO:0000785	chromatin	5.88e-02	1.00e+00	4.049	1	5	59
GO:0071013	catalytic step 2 spliceosome	6.08e-02	1.00e+00	4.001	1	5	61
GO:0007565	female pregnancy	6.37e-02	1.00e+00	3.931	1	2	64
GO:0042470	melanosome	6.37e-02	1.00e+00	3.931	1	2	64
GO:0006325	chromatin organization	6.94e-02	1.00e+00	3.802	1	3	70
GO:0051082	unfolded protein binding	6.94e-02	1.00e+00	3.802	1	4	70
GO:0001889	liver development	7.04e-02	1.00e+00	3.782	1	1	71
GO:0001649	osteoblast differentiation	7.33e-02	1.00e+00	3.722	1	2	74
GO:0015630	microtubule cytoskeleton	7.42e-02	1.00e+00	3.703	1	2	75
GO:0071456	cellular response to hypoxia	7.52e-02	1.00e+00	3.684	1	2	76
GO:0019058	viral life cycle	7.71e-02	1.00e+00	3.646	1	3	78
GO:0030529	ribonucleoprotein complex	8.09e-02	1.00e+00	3.574	1	4	82
GO:0003690	double-stranded DNA binding	8.19e-02	1.00e+00	3.556	1	3	83
GO:0005635	nuclear envelope	8.19e-02	1.00e+00	3.556	1	4	83
GO:0006511	ubiquitin-dependent protein catabolic process	9.04e-02	1.00e+00	3.408	1	2	92
GO:0006260	DNA replication	9.22e-02	1.00e+00	3.377	1	11	94
GO:0007219	Notch signaling pathway	9.32e-02	1.00e+00	3.362	1	4	95
GO:0006457	protein folding	9.51e-02	1.00e+00	3.332	1	4	97
GO:0016887	ATPase activity	9.79e-02	1.00e+00	3.288	1	6	100
GO:0007507	heart development	1.03e-01	1.00e+00	3.204	1	1	106
GO:0046777	protein autophosphorylation	1.03e-01	1.00e+00	3.204	1	2	106
GO:0000790	nuclear chromatin	1.06e-01	1.00e+00	3.163	1	3	109
GO:0003924	GTPase activity	1.15e-01	1.00e+00	3.037	1	3	119
GO:0004672	protein kinase activity	1.21e-01	1.00e+00	2.966	1	2	125
GO:0000398	mRNA splicing, via spliceosome	1.24e-01	1.00e+00	2.931	1	8	128
GO:0006184	GTP catabolic process	1.25e-01	1.00e+00	2.909	1	3	130
GO:0032403	protein complex binding	1.25e-01	1.00e+00	2.909	1	2	130
GO:0019904	protein domain specific binding	1.25e-01	1.00e+00	2.909	1	2	130
GO:0031625	ubiquitin protein ligase binding	1.33e-01	1.00e+00	2.823	1	5	138
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.36e-01	1.00e+00	2.782	1	2	142
GO:0005622	intracellular	1.39e-01	1.00e+00	2.752	1	1	145
GO:0008380	RNA splicing	1.57e-01	1.00e+00	2.565	1	7	165
GO:0007067	mitotic nuclear division	1.57e-01	1.00e+00	2.565	1	8	165
GO:0043025	neuronal cell body	1.62e-01	1.00e+00	2.514	1	3	171
GO:0007264	small GTPase mediated signal transduction	1.65e-01	1.00e+00	2.489	1	1	174
GO:0000166	nucleotide binding	1.66e-01	1.00e+00	2.472	1	6	176
GO:0008270	zinc ion binding	1.68e-01	1.00e+00	1.426	2	7	727
GO:0004842	ubiquitin-protein transferase activity	1.69e-01	1.00e+00	2.448	1	2	179
GO:0003713	transcription coactivator activity	1.73e-01	1.00e+00	2.408	1	5	184
GO:0016567	protein ubiquitination	1.77e-01	1.00e+00	2.377	1	3	188
GO:0005525	GTP binding	1.84e-01	1.00e+00	2.309	1	5	197
GO:0044822	poly(A) RNA binding	1.95e-01	1.00e+00	1.289	2	25	799
GO:0019899	enzyme binding	1.95e-01	1.00e+00	2.217	1	4	210
GO:0006200	ATP catabolic process	2.03e-01	1.00e+00	2.157	1	8	219
GO:0003723	RNA binding	2.26e-01	1.00e+00	1.983	1	11	247
GO:0003682	chromatin binding	2.30e-01	1.00e+00	1.954	1	6	252
GO:0005524	ATP binding	2.31e-01	1.00e+00	1.131	2	23	892
GO:0045893	positive regulation of transcription, DNA-templated	3.26e-01	1.00e+00	1.373	1	10	377
GO:0005789	endoplasmic reticulum membrane	3.33e-01	1.00e+00	1.335	1	1	387
GO:0042803	protein homodimerization activity	3.61e-01	1.00e+00	1.190	1	5	428
GO:0045087	innate immune response	3.78e-01	1.00e+00	1.111	1	7	452
GO:0007165	signal transduction	4.80e-01	1.00e+00	0.660	1	5	618
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.95e-01	1.00e+00	0.601	1	8	644
GO:0046872	metal ion binding	6.34e-01	1.00e+00	0.064	1	10	934
GO:0006351	transcription, DNA-templated	6.89e-01	1.00e+00	-0.140	1	9	1076
GO:0005737	cytoplasm	7.98e-01	1.00e+00	-0.431	2	50	2633

Wolf-ratios-Mammosphere-Adherent

reg-snw-11277

Statistics

Genes (10)

Interactions (12)

Related GO terms (193)