int-snw-10209

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.936	1.51e-15	2.42e-03	3.95e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-10209 subnetwork

Genes (14)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
PSMD2	5708	3	0.463	0.961	386	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
PSMA3	5684	12	0.533	1.026	218	Yes	-
IARS	3376	1	0.399	0.936	175	Yes	-
PSMD13	5719	16	0.848	1.029	104	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
[ EIF1 ]	10209	1	-0.215	0.936	64	-	-
HNRNPC	3183	20	1.812	1.026	119	Yes	-
RPL8	6132	9	0.778	0.967	218	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (28)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMD13	5719	EIF1	10209	pp	--	int.I2D: IntAct_Yeast, BioGrid_Yeast, BIND_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMD2	5708	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
IARS	3376	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
RPL8	6132	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
PSMA3	5684	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD13	5719	pp	--	int.I2D: YeastLow
RPL8	6132	EIF1	10209	pp	--	int.I2D: YeastMedium
HNRNPC	3183	PSMA3	5684	pp	--	int.I2D: BioGrid
ACTB	60	PSMD13	5719	pp	--	int.I2D: BioGrid_Yeast
PSMA2	5683	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
PSMA3	5684	EIF1	10209	pp	--	int.I2D: BioGrid_Yeast, BIND_Yeast, IntAct_Yeast
PSMA2	5683	PSMA3	5684	pp	--	int.Intact: MI:0915(physical association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BIND_Yeast, HPRD; int.HPRD: yeast 2-hybrid
PSMD2	5708	EIF1	10209	pp	--	int.I2D: IntAct_Yeast, BioGrid_Yeast, BIND_Yeast
PSMA3	5684	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid
PSMD2	5708	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastLow, BioGrid, Krogan_Core
IARS	3376	PGD	5226	pp	--	int.I2D: YeastLow
PSMD2	5708	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
IARS	3376	EIF1	10209	pp	--	int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA3	5684	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	PSMD13	5719	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMA3	5684	pp	--	int.I2D: BioGrid, BioGrid_Yeast
PSMD2	5708	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastLow
EIF2S2	8894	EIF1	10209	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (154)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0010467	gene expression	3.65e-11	5.27e-07	3.945	10	59	669
GO:0016071	mRNA metabolic process	6.02e-10	8.68e-06	5.015	7	31	223
GO:0006521	regulation of cellular amino acid metabolic process	7.97e-10	1.15e-05	6.687	5	17	50
GO:0016070	RNA metabolic process	1.23e-09	1.77e-05	4.868	7	32	247
GO:0005829	cytosol	1.43e-09	2.06e-05	2.424	13	132	2496
GO:0000502	proteasome complex	1.72e-09	2.48e-05	6.473	5	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	2.85e-09	4.11e-05	6.331	5	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.08e-09	4.45e-05	6.308	5	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.51e-09	6.50e-05	6.201	5	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.20e-09	7.51e-05	6.161	5	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.99e-09	8.63e-05	6.121	5	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.41e-09	9.25e-05	6.102	5	20	75
GO:0016032	viral process	8.27e-09	1.19e-04	3.948	8	55	534
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.35e-09	1.20e-04	6.027	5	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.81e-08	2.61e-04	5.807	5	21	92
GO:0000209	protein polyubiquitination	5.83e-08	8.41e-04	5.473	5	20	116
GO:0005838	proteasome regulatory particle	1.59e-07	2.30e-03	8.009	3	7	12
GO:0000082	G1/S transition of mitotic cell cycle	2.04e-07	2.95e-03	5.111	5	32	149
GO:0042981	regulation of apoptotic process	2.11e-07	3.05e-03	5.102	5	24	150
GO:0034641	cellular nitrogen compound metabolic process	4.06e-07	5.85e-03	4.913	5	20	171
GO:0022624	proteasome accessory complex	4.91e-07	7.08e-03	7.506	3	8	17
GO:0005654	nucleoplasm	1.95e-06	2.81e-02	2.929	8	76	1082
GO:0006413	translational initiation	6.06e-06	8.75e-02	4.975	4	17	131
GO:0070062	extracellular vesicular exosome	8.36e-06	1.21e-01	2.102	10	104	2400
GO:0000278	mitotic cell cycle	2.33e-05	3.37e-01	3.720	5	48	391
GO:0019773	proteasome core complex, alpha-subunit complex	2.44e-05	3.52e-01	8.009	2	4	8
GO:0043066	negative regulation of apoptotic process	3.45e-05	4.97e-01	3.603	5	31	424
GO:0016020	membrane	5.26e-05	7.58e-01	2.294	8	90	1681
GO:0006915	apoptotic process	1.24e-04	1.00e+00	3.214	5	33	555
GO:0005839	proteasome core complex	1.33e-04	1.00e+00	6.839	2	8	18
GO:0004298	threonine-type endopeptidase activity	1.48e-04	1.00e+00	6.761	2	8	19
GO:0043044	ATP-dependent chromatin remodeling	2.19e-04	1.00e+00	6.485	2	4	23
GO:0008135	translation factor activity, nucleic acid binding	2.39e-04	1.00e+00	6.424	2	7	24
GO:0003723	RNA binding	2.58e-04	1.00e+00	3.591	4	20	342
GO:0031492	nucleosomal DNA binding	3.03e-04	1.00e+00	6.254	2	4	27
GO:0044281	small molecule metabolic process	5.76e-04	1.00e+00	2.352	6	58	1211
GO:0044267	cellular protein metabolic process	8.87e-04	1.00e+00	3.120	4	29	474
GO:0019521	D-gluconate metabolic process	9.71e-04	1.00e+00	10.009	1	1	1
GO:0022625	cytosolic large ribosomal subunit	1.00e-03	1.00e+00	5.394	2	6	49
GO:0003743	translation initiation factor activity	1.00e-03	1.00e+00	5.394	2	8	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	1.17e-03	1.00e+00	5.281	2	5	53
GO:0006412	translation	1.28e-03	1.00e+00	3.748	3	20	230
GO:0004822	isoleucine-tRNA ligase activity	1.94e-03	1.00e+00	9.009	1	1	2
GO:0006428	isoleucyl-tRNA aminoacylation	1.94e-03	1.00e+00	9.009	1	1	2
GO:0002176	male germ cell proliferation	1.94e-03	1.00e+00	9.009	1	1	2
GO:0019322	pentose biosynthetic process	1.94e-03	1.00e+00	9.009	1	2	2
GO:0007127	meiosis I	1.94e-03	1.00e+00	9.009	1	1	2
GO:0044822	poly(A) RNA binding	2.39e-03	1.00e+00	2.286	5	49	1056
GO:0019083	viral transcription	2.71e-03	1.00e+00	4.669	2	10	81
GO:0005850	eukaryotic translation initiation factor 2 complex	2.91e-03	1.00e+00	8.424	1	1	3
GO:0009048	dosage compensation by inactivation of X chromosome	2.91e-03	1.00e+00	8.424	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.91e-03	1.00e+00	8.424	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.91e-03	1.00e+00	8.424	1	1	3
GO:0006415	translational termination	3.12e-03	1.00e+00	4.566	2	10	87
GO:0001649	osteoblast differentiation	3.48e-03	1.00e+00	4.485	2	6	92
GO:0006414	translational elongation	3.56e-03	1.00e+00	4.470	2	13	93
GO:0031467	Cul7-RING ubiquitin ligase complex	3.88e-03	1.00e+00	8.009	1	1	4
GO:0019788	NEDD8 ligase activity	3.88e-03	1.00e+00	8.009	1	1	4
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.43e-03	1.00e+00	4.308	2	10	104
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	4.84e-03	1.00e+00	7.687	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	4.84e-03	1.00e+00	7.687	1	1	5
GO:0043248	proteasome assembly	4.84e-03	1.00e+00	7.687	1	1	5
GO:0030891	VCB complex	4.84e-03	1.00e+00	7.687	1	2	5
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.30e-03	1.00e+00	4.176	2	11	114
GO:0019058	viral life cycle	5.39e-03	1.00e+00	4.163	2	13	115
GO:0030957	Tat protein binding	5.81e-03	1.00e+00	7.424	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	5.81e-03	1.00e+00	7.424	1	1	6
GO:0000790	nuclear chromatin	6.73e-03	1.00e+00	3.998	2	9	129
GO:0002161	aminoacyl-tRNA editing activity	6.78e-03	1.00e+00	7.201	1	2	7
GO:0031462	Cul2-RING ubiquitin ligase complex	6.78e-03	1.00e+00	7.201	1	2	7
GO:0003735	structural constituent of ribosome	7.56e-03	1.00e+00	3.911	2	10	137
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	7.74e-03	1.00e+00	7.009	1	2	8
GO:0070688	MLL5-L complex	7.74e-03	1.00e+00	7.009	1	1	8
GO:0045116	protein neddylation	7.74e-03	1.00e+00	7.009	1	2	8
GO:0006450	regulation of translational fidelity	8.70e-03	1.00e+00	6.839	1	2	9
GO:0006098	pentose-phosphate shunt	9.67e-03	1.00e+00	6.687	1	4	10
GO:0045120	pronucleus	1.06e-02	1.00e+00	6.549	1	2	11
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.08e-02	1.00e+00	3.642	2	7	165
GO:0070935	3'-UTR-mediated mRNA stabilization	1.16e-02	1.00e+00	6.424	1	2	12
GO:0042273	ribosomal large subunit biogenesis	1.26e-02	1.00e+00	6.308	1	4	13
GO:0030234	enzyme regulator activity	1.26e-02	1.00e+00	6.308	1	3	13
GO:0008266	poly(U) RNA binding	1.26e-02	1.00e+00	6.308	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	1.35e-02	1.00e+00	6.201	1	4	14
GO:0050998	nitric-oxide synthase binding	1.54e-02	1.00e+00	6.009	1	1	16
GO:0042176	regulation of protein catabolic process	1.54e-02	1.00e+00	6.009	1	3	16
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.83e-02	1.00e+00	5.761	1	1	19
GO:0048863	stem cell differentiation	1.83e-02	1.00e+00	5.761	1	1	19
GO:0030863	cortical cytoskeleton	2.12e-02	1.00e+00	5.549	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	2.12e-02	1.00e+00	5.549	1	4	22
GO:0031463	Cul3-RING ubiquitin ligase complex	2.21e-02	1.00e+00	5.485	1	3	23
GO:0006513	protein monoubiquitination	2.21e-02	1.00e+00	5.485	1	1	23
GO:0005515	protein binding	2.44e-02	1.00e+00	0.774	10	184	6024
GO:0003730	mRNA 3'-UTR binding	2.50e-02	1.00e+00	5.308	1	2	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.50e-02	1.00e+00	5.308	1	3	26
GO:0019843	rRNA binding	2.59e-02	1.00e+00	5.254	1	3	27
GO:0050661	NADP binding	2.59e-02	1.00e+00	5.254	1	2	27
GO:0019894	kinesin binding	2.69e-02	1.00e+00	5.201	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.78e-02	1.00e+00	5.151	1	1	29
GO:0043234	protein complex	3.23e-02	1.00e+00	2.804	2	18	295
GO:0001895	retina homeostasis	3.25e-02	1.00e+00	4.921	1	1	34
GO:0034332	adherens junction organization	3.44e-02	1.00e+00	4.839	1	1	36
GO:0006446	regulation of translational initiation	3.44e-02	1.00e+00	4.839	1	4	36
GO:0051084	'de novo' posttranslational protein folding	3.53e-02	1.00e+00	4.799	1	4	37
GO:0070527	platelet aggregation	3.63e-02	1.00e+00	4.761	1	2	38
GO:0006418	tRNA aminoacylation for protein translation	4.00e-02	1.00e+00	4.616	1	9	42
GO:0021762	substantia nigra development	4.19e-02	1.00e+00	4.549	1	2	44
GO:0006950	response to stress	4.38e-02	1.00e+00	4.485	1	2	46
GO:0005925	focal adhesion	4.78e-02	1.00e+00	2.493	2	19	366
GO:0045216	cell-cell junction organization	5.12e-02	1.00e+00	4.254	1	2	54
GO:0000932	cytoplasmic mRNA processing body	5.12e-02	1.00e+00	4.254	1	3	54
GO:0034329	cell junction assembly	6.40e-02	1.00e+00	3.921	1	1	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	6.95e-02	1.00e+00	3.799	1	6	74
GO:0008584	male gonad development	7.04e-02	1.00e+00	3.780	1	3	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	7.04e-02	1.00e+00	3.780	1	2	75
GO:0071013	catalytic step 2 spliceosome	7.31e-02	1.00e+00	3.723	1	4	78
GO:0005681	spliceosomal complex	7.77e-02	1.00e+00	3.634	1	4	83
GO:0006928	cellular component movement	8.48e-02	1.00e+00	3.501	1	7	91
GO:0005200	structural constituent of cytoskeleton	8.48e-02	1.00e+00	3.501	1	8	91
GO:0071456	cellular response to hypoxia	8.57e-02	1.00e+00	3.485	1	6	92
GO:0006364	rRNA processing	8.75e-02	1.00e+00	3.454	1	6	94
GO:0014069	postsynaptic density	9.73e-02	1.00e+00	3.294	1	3	105
GO:0030529	ribonucleoprotein complex	1.03e-01	1.00e+00	3.201	1	8	112
GO:0072562	blood microparticle	1.03e-01	1.00e+00	3.214	1	3	111
GO:0006325	chromatin organization	1.09e-01	1.00e+00	3.126	1	5	118
GO:0007219	Notch signaling pathway	1.10e-01	1.00e+00	3.102	1	5	120
GO:0006511	ubiquitin-dependent protein catabolic process	1.16e-01	1.00e+00	3.031	1	5	126
GO:0009615	response to virus	1.16e-01	1.00e+00	3.031	1	5	126
GO:0006457	protein folding	1.30e-01	1.00e+00	2.849	1	7	143
GO:0061024	membrane organization	1.32e-01	1.00e+00	2.829	1	7	145
GO:0000398	mRNA splicing, via spliceosome	1.48e-01	1.00e+00	2.651	1	8	164
GO:0030424	axon	1.50e-01	1.00e+00	2.634	1	4	166
GO:0031625	ubiquitin protein ligase binding	1.60e-01	1.00e+00	2.533	1	14	178
GO:0032403	protein complex binding	1.64e-01	1.00e+00	2.493	1	10	183
GO:0001701	in utero embryonic development	1.78e-01	1.00e+00	2.358	1	8	201
GO:0008380	RNA splicing	2.00e-01	1.00e+00	2.176	1	11	228
GO:0005975	carbohydrate metabolic process	2.20e-01	1.00e+00	2.026	1	9	253
GO:0004842	ubiquitin-protein transferase activity	2.21e-01	1.00e+00	2.014	1	6	255
GO:0000166	nucleotide binding	2.24e-01	1.00e+00	1.992	1	5	259
GO:0006281	DNA repair	2.26e-01	1.00e+00	1.981	1	18	261
GO:0005856	cytoskeleton	2.48e-01	1.00e+00	1.824	1	12	291
GO:0016567	protein ubiquitination	2.51e-01	1.00e+00	1.804	1	5	295
GO:0005634	nucleus	2.62e-01	1.00e+00	0.439	6	136	4559
GO:0019901	protein kinase binding	2.67e-01	1.00e+00	1.700	1	21	317
GO:0007411	axon guidance	2.69e-01	1.00e+00	1.691	1	13	319
GO:0005737	cytoplasm	2.92e-01	1.00e+00	0.451	5	110	3767
GO:0055114	oxidation-reduction process	3.39e-01	1.00e+00	1.294	1	12	420
GO:0007596	blood coagulation	3.62e-01	1.00e+00	1.179	1	18	455
GO:0005524	ATP binding	3.63e-01	1.00e+00	0.667	2	60	1298
GO:0042802	identical protein binding	3.80e-01	1.00e+00	1.090	1	20	484
GO:0045087	innate immune response	4.46e-01	1.00e+00	0.790	1	24	596
GO:0005615	extracellular space	6.18e-01	1.00e+00	0.106	1	17	957
GO:0008270	zinc ion binding	6.33e-01	1.00e+00	0.047	1	12	997
GO:0046872	metal ion binding	7.36e-01	1.00e+00	-0.343	1	25	1307
GO:0005730	nucleolus	8.16e-01	1.00e+00	-0.672	1	69	1641

Wolf-ratios-Mammosphere-Adherent

int-snw-10209

Statistics

Genes (14)

Interactions (28)

Related GO terms (154)