int-snw-90019

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.833 1.75e-15 4.97e-04 3.45e-03
chia-screen-data-Fav-int-snw-90019 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
TPR 7175 18-2.6383.07228YesYes
SYNCRIP 10492 9-2.4013.197103YesYes
PHB 5245 15-2.7433.004127YesYes
HNRNPD 3184 5-2.1533.117123Yes-
YAP1 10413 94-4.2563.53853Yes-
APC 324 13-2.2933.004353Yes-
SRSF3 6428 73-2.9923.53854Yes-
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
[ SYT8 ] 90019 1-1.3822.8331--
ULK2 9706 9-2.2923.197312YesYes
DDIT3 1649 60-2.8253.504343YesYes

Interactions (16)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HNRNPU 3192 SYNCRIP 10492 pp -- int.Mint: MI:0915(physical association)
SRSF3 6428 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3 1649 HNRNPD 3184 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
HNRNPD 3184 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPD 3184 SYNCRIP 10492 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
HNRNPD 3184 HNRNPU 3192 pp -- int.Mint: MI:0915(physical association)
APC 324 SYNCRIP 10492 pp -- int.I2D: Jorgensen_EphR
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
APC 324 PHB 5245 pp -- int.I2D: Jorgensen_EphR
HNRNPU 3192 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
SYNCRIP 10492 SYT8 90019 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vitro, in vivo
ULK2 9706 SYNCRIP 10492 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
APC 324 TPR 7175 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct, SOURAV_MAPK_HIGH

Related GO terms (255)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm1.30e-081.88e-043.3229641082
GO:0070934CRD-mediated mRNA stabilization6.34e-069.14e-028.909225
GO:0000398mRNA splicing, via spliceosome7.43e-061.07e-014.874415164
GO:0044212transcription regulatory region DNA binding8.17e-061.18e-014.839417168
GO:0070937CRD-mediated mRNA stability complex9.50e-061.37e-018.646236
GO:0006396RNA processing1.39e-052.01e-015.9333559
GO:0008380RNA splicing2.73e-053.93e-014.398422228
GO:0042789mRNA transcription from RNA polymerase II promoter4.92e-057.10e-017.5312213
GO:0001649osteoblast differentiation5.30e-057.64e-015.2933592
GO:0030529ribonucleoprotein complex9.53e-051.00e+005.00935112
GO:0044822poly(A) RNA binding9.55e-051.00e+002.7726501056
GO:0003723RNA binding1.32e-041.00e+003.813418342
GO:0006974cellular response to DNA damage stimulus2.31e-041.00e+004.57837151
GO:0007094mitotic spindle assembly checkpoint2.91e-041.00e+006.2772331
GO:0042594response to starvation2.91e-041.00e+006.2772431
GO:0035019somatic stem cell maintenance4.86e-041.00e+005.9092640
GO:0005515protein binding4.97e-041.00e+001.134111986024
GO:0006355regulation of transcription, DNA-templated8.21e-041.00e+002.592543997
GO:0060795cell fate commitment involved in formation of primary germ layer8.32e-041.00e+0010.231111
GO:1901673regulation of spindle assembly involved in mitosis8.32e-041.00e+0010.231111
GO:0043578nuclear matrix organization8.32e-041.00e+0010.231111
GO:2000016negative regulation of determination of dorsal identity8.32e-041.00e+0010.231111
GO:0051171regulation of nitrogen compound metabolic process8.32e-041.00e+0010.231111
GO:0010965regulation of mitotic sister chromatid separation8.32e-041.00e+0010.231111
GO:0006404RNA import into nucleus8.32e-041.00e+0010.231111
GO:0090308regulation of methylation-dependent chromatin silencing8.32e-041.00e+0010.231111
GO:0031453positive regulation of heterochromatin assembly8.32e-041.00e+0010.231111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway8.32e-041.00e+0010.231111
GO:0060965negative regulation of gene silencing by miRNA8.32e-041.00e+0010.231111
GO:0042483negative regulation of odontogenesis8.32e-041.00e+0010.231111
GO:0000166nucleotide binding1.12e-031.00e+003.799313259
GO:0000776kinetochore1.20e-031.00e+005.2542563
GO:0000189MAPK import into nucleus1.66e-031.00e+009.231112
GO:0060242contact inhibition1.66e-031.00e+009.231112
GO:0031990mRNA export from nucleus in response to heat stress1.66e-031.00e+009.231122
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process1.66e-031.00e+009.231112
GO:0009786regulation of asymmetric cell division1.66e-031.00e+009.231112
GO:0070840dynein complex binding1.66e-031.00e+009.231112
GO:0046832negative regulation of RNA export from nucleus1.66e-031.00e+009.231112
GO:0009798axis specification1.66e-031.00e+009.231112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.66e-031.00e+009.231112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.66e-031.00e+009.231112
GO:0010467gene expression1.68e-031.00e+002.845445669
GO:0071013catalytic step 2 spliceosome1.84e-031.00e+004.9462778
GO:0090090negative regulation of canonical Wnt signaling pathway2.23e-031.00e+004.8052886
GO:0006405RNA export from nucleus2.49e-031.00e+008.646123
GO:0042306regulation of protein import into nucleus2.49e-031.00e+008.646123
GO:0060913cardiac cell fate determination2.49e-031.00e+008.646113
GO:0003130BMP signaling pathway involved in heart induction2.49e-031.00e+008.646113
GO:0005634nucleus2.54e-031.00e+001.24791594559
GO:0097167circadian regulation of translation3.32e-031.00e+008.231114
GO:0097452GAIT complex3.32e-031.00e+008.231114
GO:0034273ATG1/UKL1 signaling complex3.32e-031.00e+008.231114
GO:0006999nuclear pore organization3.32e-031.00e+008.231114
GO:0044615nuclear pore nuclear basket3.32e-031.00e+008.231114
GO:0019887protein kinase regulator activity3.32e-031.00e+008.231114
GO:0001714endodermal cell fate specification4.15e-031.00e+007.909115
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint4.15e-031.00e+007.909115
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process4.15e-031.00e+007.909125
GO:0043620regulation of DNA-templated transcription in response to stress4.15e-031.00e+007.909115
GO:0010793regulation of mRNA export from nucleus4.15e-031.00e+007.909115
GO:0048671negative regulation of collateral sprouting4.15e-031.00e+007.909115
GO:0070849response to epidermal growth factor4.15e-031.00e+007.909115
GO:0007050cell cycle arrest4.57e-031.00e+004.27725124
GO:0030858positive regulation of epithelial cell differentiation4.98e-031.00e+007.646116
GO:0050847progesterone receptor signaling pathway4.98e-031.00e+007.646126
GO:2000323negative regulation of glucocorticoid receptor signaling pathway4.98e-031.00e+007.646116
GO:0071204histone pre-mRNA 3'end processing complex4.98e-031.00e+007.646116
GO:0005215transporter activity5.02e-031.00e+004.20923130
GO:0007091metaphase/anaphase transition of mitotic cell cycle5.81e-031.00e+007.424127
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development5.81e-031.00e+007.424117
GO:0046825regulation of protein export from nucleus5.81e-031.00e+007.424127
GO:0071354cellular response to interleukin-65.81e-031.00e+007.424127
GO:0051988regulation of attachment of spindle microtubules to kinetochore5.81e-031.00e+007.424127
GO:0045893positive regulation of transcription, DNA-templated6.36e-031.00e+002.915324478
GO:0045670regulation of osteoclast differentiation6.64e-031.00e+007.231128
GO:0051292nuclear pore complex assembly6.64e-031.00e+007.231148
GO:0001955blood vessel maturation6.64e-031.00e+007.231118
GO:0035457cellular response to interferon-alpha6.64e-031.00e+007.231118
GO:0045667regulation of osteoblast differentiation7.47e-031.00e+007.061119
GO:0042405nuclear inclusion body7.47e-031.00e+007.061129
GO:0006983ER overload response7.47e-031.00e+007.061119
GO:0043495protein anchor7.47e-031.00e+007.061119
GO:0010944negative regulation of transcription by competitive promoter binding7.47e-031.00e+007.061119
GO:0035413positive regulation of catenin import into nucleus8.29e-031.00e+006.9091210
GO:0031274positive regulation of pseudopodium assembly8.29e-031.00e+006.9091210
GO:0007340acrosome reaction8.29e-031.00e+006.9091110
GO:0030877beta-catenin destruction complex8.29e-031.00e+006.9091210
GO:0031116positive regulation of microtubule polymerization9.12e-031.00e+006.7721111
GO:0051010microtubule plus-end binding9.12e-031.00e+006.7721111
GO:0042162telomeric DNA binding9.12e-031.00e+006.7721111
GO:0045662negative regulation of myoblast differentiation9.12e-031.00e+006.7721311
GO:0060391positive regulation of SMAD protein import into nucleus9.12e-031.00e+006.7721411
GO:0003714transcription corepressor activity9.22e-031.00e+003.755211178
GO:0005829cytosol9.54e-031.00e+001.5316862496
GO:0045295gamma-catenin binding9.94e-031.00e+006.6461112
GO:0032886regulation of microtubule-based process9.94e-031.00e+006.6461112
GO:0045947negative regulation of translational initiation9.94e-031.00e+006.6461212
GO:0034045pre-autophagosomal structure membrane9.94e-031.00e+006.6461212
GO:0008143poly(A) binding9.94e-031.00e+006.6461212
GO:0034399nuclear periphery9.94e-031.00e+006.6461512
GO:0035198miRNA binding9.94e-031.00e+006.6461112
GO:0060766negative regulation of androgen receptor signaling pathway1.08e-021.00e+006.5311313
GO:0044295axonal growth cone1.08e-021.00e+006.5311113
GO:0071480cellular response to gamma radiation1.08e-021.00e+006.5311113
GO:0051019mitogen-activated protein kinase binding1.08e-021.00e+006.5311213
GO:0043409negative regulation of MAPK cascade1.08e-021.00e+006.5311213
GO:0005868cytoplasmic dynein complex1.08e-021.00e+006.5311113
GO:0043488regulation of mRNA stability1.08e-021.00e+006.5311113
GO:0046827positive regulation of protein export from nucleus1.08e-021.00e+006.5311113
GO:0035371microtubule plus-end1.16e-021.00e+006.4241114
GO:0006401RNA catabolic process1.16e-021.00e+006.4241114
GO:0005487nucleocytoplasmic transporter activity1.16e-021.00e+006.4241314
GO:0042307positive regulation of protein import into nucleus1.24e-021.00e+006.3241415
GO:0001824blastocyst development1.24e-021.00e+006.3241215
GO:0007026negative regulation of microtubule depolymerization1.32e-021.00e+006.2311116
GO:0046716muscle cell cellular homeostasis1.32e-021.00e+006.2311116
GO:0043274phospholipase binding1.32e-021.00e+006.2311116
GO:0051276chromosome organization1.32e-021.00e+006.2311216
GO:0090316positive regulation of intracellular protein transport1.41e-021.00e+006.1441217
GO:0031122cytoplasmic microtubule organization1.49e-021.00e+006.0611118
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity1.57e-021.00e+005.9831219
GO:0032757positive regulation of interleukin-8 production1.65e-021.00e+005.9091120
GO:0008134transcription factor binding1.66e-021.00e+003.312218242
GO:0009954proximal/distal pattern formation1.73e-021.00e+005.8391121
GO:0048675axon extension1.73e-021.00e+005.8391221
GO:0016575histone deacetylation1.73e-021.00e+005.8391321
GO:0000281mitotic cytokinesis1.73e-021.00e+005.8391221
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721222
GO:0010506regulation of autophagy1.90e-021.00e+005.7081223
GO:0071346cellular response to interferon-gamma1.90e-021.00e+005.7081123
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.90e-021.00e+005.7081123
GO:0045296cadherin binding1.98e-021.00e+005.6461324
GO:0006611protein export from nucleus2.06e-021.00e+005.5871325
GO:0035329hippo signaling2.14e-021.00e+005.5311526
GO:0000045autophagic vacuole assembly2.14e-021.00e+005.5311226
GO:0051209release of sequestered calcium ion into cytosol2.14e-021.00e+005.5311126
GO:0015631tubulin binding2.22e-021.00e+005.4761227
GO:0034605cellular response to heat2.31e-021.00e+005.4241128
GO:0070830tight junction assembly2.31e-021.00e+005.4241128
GO:0071897DNA biosynthetic process2.31e-021.00e+005.4241128
GO:0005913cell-cell adherens junction2.39e-021.00e+005.3731329
GO:0072686mitotic spindle2.39e-021.00e+005.3731329
GO:0006606protein import into nucleus2.47e-021.00e+005.3241230
GO:0031647regulation of protein stability2.47e-021.00e+005.3241430
GO:0010827regulation of glucose transport2.47e-021.00e+005.3241430
GO:0009953dorsal/ventral pattern formation2.55e-021.00e+005.2771231
GO:1903507negative regulation of nucleic acid-templated transcription2.63e-021.00e+005.2311232
GO:0031072heat shock protein binding2.71e-021.00e+005.1871233
GO:0033077T cell differentiation in thymus2.71e-021.00e+005.1871133
GO:0001942hair follicle development2.87e-021.00e+005.1021235
GO:0007077mitotic nuclear envelope disassembly2.96e-021.00e+005.0611436
GO:0048538thymus development2.96e-021.00e+005.0611236
GO:0042752regulation of circadian rhythm3.04e-021.00e+005.0221337
GO:0008645hexose transport3.20e-021.00e+004.9461439
GO:0051781positive regulation of cell division3.20e-021.00e+004.9461139
GO:0043565sequence-specific DNA binding3.23e-021.00e+002.796211346
GO:0005881cytoplasmic microtubule3.28e-021.00e+004.9091140
GO:0017148negative regulation of translation3.28e-021.00e+004.9091240
GO:0045785positive regulation of cell adhesion3.28e-021.00e+004.9091240
GO:0008285negative regulation of cell proliferation3.35e-021.00e+002.768210353
GO:0019898extrinsic component of membrane3.44e-021.00e+004.8391242
GO:0031124mRNA 3'-end processing3.44e-021.00e+004.8391242
GO:0045727positive regulation of translation3.60e-021.00e+004.7721244
GO:0006369termination of RNA polymerase II transcription3.68e-021.00e+004.7391245
GO:0043525positive regulation of neuron apoptotic process3.76e-021.00e+004.7081446
GO:0016328lateral plasma membrane3.76e-021.00e+004.7081346
GO:0006921cellular component disassembly involved in execution phase of apoptosis3.84e-021.00e+004.6771247
GO:0001669acrosomal vesicle4.00e-021.00e+004.6161249
GO:0006986response to unfolded protein4.08e-021.00e+004.5871450
GO:0045732positive regulation of protein catabolic process4.08e-021.00e+004.5871150
GO:0034976response to endoplasmic reticulum stress4.16e-021.00e+004.5591251
GO:0045454cell redox homeostasis4.16e-021.00e+004.5591151
GO:0060041retina development in camera-type eye4.16e-021.00e+004.5591251
GO:0009611response to wounding4.24e-021.00e+004.5311552
GO:0045892negative regulation of transcription, DNA-templated4.47e-021.00e+002.541224413
GO:0015758glucose transport4.48e-021.00e+004.4501455
GO:0048306calcium-dependent protein binding4.56e-021.00e+004.4241256
GO:0006366transcription from RNA polymerase II promoter4.58e-021.00e+002.520230419
GO:0005643nuclear pore4.64e-021.00e+004.39811157
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.80e-021.00e+004.3481659
GO:0008013beta-catenin binding4.88e-021.00e+004.3241960
GO:0006406mRNA export from nucleus4.96e-021.00e+004.3001461
GO:0006987activation of signaling protein activity involved in unfolded protein response4.96e-021.00e+004.3001261
GO:0007409axonogenesis5.28e-021.00e+004.2091265
GO:0010468regulation of gene expression5.52e-021.00e+004.1441268
GO:0032587ruffle membrane5.67e-021.00e+004.1021370
GO:0042826histone deacetylase binding5.83e-021.00e+004.0611472
GO:0003729mRNA binding5.83e-021.00e+004.0611472
GO:0008021synaptic vesicle5.91e-021.00e+004.0411273
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.99e-021.00e+004.0221474
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021175
GO:0060070canonical Wnt signaling pathway6.07e-021.00e+004.0021475
GO:0001822kidney development6.30e-021.00e+003.9461378
GO:0030968endoplasmic reticulum unfolded protein response6.38e-021.00e+003.9271279
GO:0005737cytoplasm6.58e-021.00e+000.93761243767
GO:0009653anatomical structure morphogenesis6.69e-021.00e+003.8561283
GO:0009952anterior/posterior pattern specification6.69e-021.00e+003.8561483
GO:0005923tight junction6.93e-021.00e+003.8051286
GO:0016032viral process7.07e-021.00e+002.170226534
GO:0003677DNA binding7.43e-021.00e+001.5663491218
GO:0005770late endosome7.47e-021.00e+003.6921293
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.92e-021.00e+002.076237570
GO:0030659cytoplasmic vesicle membrane8.09e-021.00e+003.57312101
GO:0030308negative regulation of cell growth8.78e-021.00e+003.45016110
GO:0006461protein complex assembly8.86e-021.00e+003.43714111
GO:0005635nuclear envelope9.01e-021.00e+003.41115113
GO:0030027lamellipodium9.92e-021.00e+003.26517125
GO:0030335positive regulation of cell migration1.01e-011.00e+003.24215127
GO:0016477cell migration1.01e-011.00e+003.23114128
GO:0016055Wnt signaling pathway1.09e-011.00e+003.12314138
GO:0003700sequence-specific DNA binding transcription factor activity1.12e-011.00e+001.782239699
GO:0008017microtubule binding1.16e-011.00e+003.03112147
GO:0042981regulation of apoptotic process1.18e-011.00e+003.00214150
GO:0046777protein autophosphorylation1.24e-011.00e+002.92714158
GO:0031965nuclear membrane1.31e-011.00e+002.839110168
GO:0016607nuclear speck1.34e-011.00e+002.805112172
GO:0005667transcription factor complex1.36e-011.00e+002.780117175
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.37e-011.00e+001.607241789
GO:0031625ubiquitin protein ligase binding1.38e-011.00e+002.75515178
GO:0006367transcription initiation from RNA polymerase II promoter1.43e-011.00e+002.708122184
GO:0016020membrane1.56e-011.00e+001.1013461681
GO:0019221cytokine-mediated signaling pathway1.69e-011.00e+002.44318221
GO:0016071mRNA metabolic process1.71e-011.00e+002.43018223
GO:0007165signal transduction1.72e-011.00e+001.406213907
GO:0007067mitotic nuclear division1.73e-011.00e+002.40516227
GO:0003713transcription coactivator activity1.80e-011.00e+002.342124237
GO:0016070RNA metabolic process1.87e-011.00e+002.28318247
GO:0005975carbohydrate metabolic process1.91e-011.00e+002.24818253
GO:0043065positive regulation of apoptotic process2.02e-011.00e+002.16517268
GO:0005743mitochondrial inner membrane2.08e-011.00e+002.11716277
GO:0019899enzyme binding2.08e-011.00e+002.11719277
GO:0004674protein serine/threonine kinase activity2.28e-011.00e+001.96416308
GO:0019901protein kinase binding2.34e-011.00e+001.923118317
GO:0005813centrosome2.40e-011.00e+001.88217326
GO:0003682chromatin binding2.41e-011.00e+001.878119327
GO:0008283cell proliferation2.41e-011.00e+001.874114328
GO:0007155cell adhesion2.67e-011.00e+001.70415369
GO:0046982protein heterodimerization activity2.74e-011.00e+001.66118380
GO:0000278mitotic cell cycle2.81e-011.00e+001.620115391
GO:0009986cell surface2.88e-011.00e+001.58019402
GO:0005524ATP binding2.95e-011.00e+000.8892311298
GO:0055085transmembrane transport3.08e-011.00e+001.46618435
GO:0044267cellular protein metabolic process3.30e-011.00e+001.342120474
GO:0006915apoptotic process3.76e-011.00e+001.115112555
GO:0005783endoplasmic reticulum3.76e-011.00e+001.112113556
GO:0042803protein homodimerization activity3.97e-011.00e+001.014119595
GO:0005887integral component of plasma membrane5.34e-011.00e+000.437110888
GO:0005739mitochondrion5.77e-011.00e+000.268123998
GO:0070062extracellular vesicular exosome6.18e-011.00e+000.0022572400
GO:0044281small molecule metabolic process6.51e-011.00e+00-0.0111201211
GO:0005886plasma membrane6.61e-011.00e+00-0.1032492582
GO:0006351transcription, DNA-templated7.19e-011.00e+00-0.2671571446
GO:0005730nucleolus7.65e-011.00e+00-0.4491661641
GO:0016021integral component of membrane8.30e-011.00e+00-0.7221171982