int-snw-79711

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.842 1.39e-15 4.44e-04 3.19e-03
chia-screen-data-Fav-int-snw-79711 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
PSMD2 5708 47-4.1723.157386YesYes
MED19 219541 30-2.6573.449115Yes-
EIF2S2 8894 9-2.9992.96881YesYes
TMED10 10972 3-1.9923.104106--
LUC7L3 51747 33-3.5233.44918Yes-
TADA2B 93624 11-3.0613.08219Yes-
EIF2B2 8892 8-2.4622.96895YesYes
ETF1 2107 3-2.8292.95971YesYes
KDM5C 8242 2-2.0402.84245Yes-
SRSF3 6428 73-2.9923.53854Yes-
POU5F1 5460 133-5.1483.538179YesYes
HSPD1 3329 3-1.8522.870286--
ACSS1 84532 2-2.3262.842148Yes-
[ IPO4 ] 79711 2-1.7392.842177--

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
EIF2B2 8892 TADA2B 93624 pp -- int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
TMED10 10972 IPO4 79711 pp -- int.I2D: IntAct_Yeast, YeastLow
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
EIF2B2 8892 IPO4 79711 pp -- int.I2D: IntAct_Yeast
HSPD1 3329 ACSS1 84532 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ETF1 2107 IPO4 79711 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
IPO4 79711 ACSS1 84532 pp -- int.I2D: IntAct_Yeast
PSMD2 5708 IPO4 79711 pp -- int.I2D: BioGrid_Yeast
PSMD2 5708 TMED10 10972 pp -- int.I2D: IntAct_Yeast
IPO4 79711 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
PSMD2 5708 EIF2B2 8892 pp -- int.I2D: IntAct_Yeast
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
PSMD2 5708 ACSS1 84532 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
KDM5C 8242 IPO4 79711 pp -- int.I2D: YeastLow
HSPD1 3329 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
EIF2B2 8892 EIF2S2 8894 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
HSPD1 3329 IPO4 79711 pp -- int.I2D: YeastLow
ETF1 2107 EIF2S2 8894 pp -- int.I2D: BioGrid_Yeast, YeastLow

Related GO terms (214)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0044822poly(A) RNA binding2.73e-041.00e+002.5496501056
GO:0010467gene expression2.98e-041.00e+002.945545669
GO:0060795cell fate commitment involved in formation of primary germ layer9.71e-041.00e+0010.009111
GO:0048199vesicle targeting, to, from or within Golgi9.71e-041.00e+0010.009111
GO:0002842positive regulation of T cell mediated immune response to tumor cell9.71e-041.00e+0010.009111
GO:0035964COPI-coated vesicle budding9.71e-041.00e+0010.009111
GO:0006085acetyl-CoA biosynthetic process9.71e-041.00e+0010.009111
GO:0008079translation termination factor activity9.71e-041.00e+0010.009111
GO:0048291isotype switching to IgG isotypes9.71e-041.00e+0010.009111
GO:0090308regulation of methylation-dependent chromatin silencing9.71e-041.00e+0010.009111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway9.71e-041.00e+0010.009111
GO:1902003regulation of beta-amyloid formation9.71e-041.00e+0010.009111
GO:0060965negative regulation of gene silencing by miRNA9.71e-041.00e+0010.009111
GO:0002368B cell cytokine production9.71e-041.00e+0010.009111
GO:0003743translation initiation factor activity1.00e-031.00e+005.3942749
GO:0006412translation1.28e-031.00e+003.74838230
GO:0070765gamma-secretase complex1.94e-031.00e+009.009112
GO:0019542propionate biosynthetic process1.94e-031.00e+009.009112
GO:0002176male germ cell proliferation1.94e-031.00e+009.009112
GO:0009786regulation of asymmetric cell division1.94e-031.00e+009.009112
GO:0019427acetyl-CoA biosynthetic process from acetate1.94e-031.00e+009.009112
GO:0019413acetate biosynthetic process1.94e-031.00e+009.009112
GO:0005850eukaryotic translation initiation factor 2 complex2.91e-031.00e+008.424113
GO:0006458'de novo' protein folding2.91e-031.00e+008.424113
GO:0016149translation release factor activity, codon specific2.91e-031.00e+008.424113
GO:0003987acetate-CoA ligase activity2.91e-031.00e+008.424113
GO:0060913cardiac cell fate determination2.91e-031.00e+008.424113
GO:0003130BMP signaling pathway involved in heart induction2.91e-031.00e+008.424113
GO:0030135coated vesicle2.91e-031.00e+008.424113
GO:0035459cargo loading into vesicle3.88e-031.00e+008.009114
GO:0051716cellular response to stimulus3.88e-031.00e+008.009144
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity3.88e-031.00e+008.009134
GO:0030137COPI-coated vesicle3.88e-031.00e+008.009114
GO:0003747translation release factor activity3.88e-031.00e+008.009124
GO:0032453histone demethylase activity (H3-K4 specific)3.88e-031.00e+008.009114
GO:0003723RNA binding3.96e-031.00e+003.176318342
GO:0070461SAGA-type complex4.84e-031.00e+007.687125
GO:0001714endodermal cell fate specification4.84e-031.00e+007.687115
GO:0046696lipopolysaccharide receptor complex4.84e-031.00e+007.687115
GO:0043279response to alkaloid4.84e-031.00e+007.687125
GO:0006449regulation of translational termination4.84e-031.00e+007.687115
GO:0003688DNA replication origin binding5.81e-031.00e+007.424116
GO:0034720histone H3-K4 demethylation5.81e-031.00e+007.424116
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex5.81e-031.00e+007.424116
GO:0005851eukaryotic translation initiation factor 2B complex5.81e-031.00e+007.424146
GO:0006413translational initiation6.94e-031.00e+003.97527131
GO:0006366transcription from RNA polymerase II promoter6.98e-031.00e+002.883330419
GO:0051604protein maturation7.74e-031.00e+007.009128
GO:0016208AMP binding8.70e-031.00e+006.839119
GO:0019509L-methionine biosynthetic process from methylthioadenosine8.70e-031.00e+006.839139
GO:0035413positive regulation of catenin import into nucleus9.67e-031.00e+006.6871210
GO:0045055regulated secretory pathway9.67e-031.00e+006.6871110
GO:0042589zymogen granule membrane9.67e-031.00e+006.6871110
GO:0006069ethanol oxidation9.67e-031.00e+006.6871110
GO:0043032positive regulation of macrophage activation9.67e-031.00e+006.6871110
GO:0044267cellular protein metabolic process9.80e-031.00e+002.705320474
GO:0032727positive regulation of interferon-alpha production1.06e-021.00e+006.5491111
GO:0060391positive regulation of SMAD protein import into nucleus1.06e-021.00e+006.5491411
GO:0030667secretory granule membrane1.16e-021.00e+006.4241212
GO:0030140trans-Golgi network transport vesicle1.16e-021.00e+006.4241112
GO:0005838proteasome regulatory particle1.16e-021.00e+006.4241112
GO:0006886intracellular protein transport1.16e-021.00e+003.59124171
GO:0035198miRNA binding1.16e-021.00e+006.4241112
GO:0016607nuclear speck1.17e-021.00e+003.582212172
GO:0048205COPI coating of Golgi vesicle1.26e-021.00e+006.3081113
GO:0042789mRNA transcription from RNA polymerase II promoter1.26e-021.00e+006.3081213
GO:0030914STAGA complex1.26e-021.00e+006.3081313
GO:0030234enzyme regulator activity1.26e-021.00e+006.3081213
GO:0001530lipopolysaccharide binding1.26e-021.00e+006.3081113
GO:0051131chaperone-mediated protein complex assembly1.26e-021.00e+006.3081113
GO:0006479protein methylation1.35e-021.00e+006.2011214
GO:0005685U1 snRNP1.35e-021.00e+006.2011114
GO:0048208COPII vesicle coating1.45e-021.00e+006.1021115
GO:0001824blastocyst development1.45e-021.00e+006.1021215
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors1.45e-021.00e+006.1021115
GO:0042026protein refolding1.45e-021.00e+006.1021115
GO:0006376mRNA splice site selection1.45e-021.00e+006.1021115
GO:0043274phospholipase binding1.54e-021.00e+006.0091116
GO:0042176regulation of protein catabolic process1.54e-021.00e+006.0091216
GO:0006336DNA replication-independent nucleosome assembly1.54e-021.00e+006.0091216
GO:0050870positive regulation of T cell activation1.64e-021.00e+005.9211117
GO:0022624proteasome accessory complex1.64e-021.00e+005.9211117
GO:0006335DNA replication-dependent nucleosome assembly1.64e-021.00e+005.9211217
GO:0032733positive regulation of interleukin-10 production1.83e-021.00e+005.7611219
GO:0016071mRNA metabolic process1.92e-021.00e+003.20828223
GO:0014003oligodendrocyte development1.92e-021.00e+005.6871520
GO:0008380RNA splicing2.00e-021.00e+003.176222228
GO:0005759mitochondrial matrix2.00e-021.00e+003.17624228
GO:0042100B cell proliferation2.02e-021.00e+005.6161121
GO:0005829cytosol2.27e-021.00e+001.3086862496
GO:0008135translation factor activity, nucleic acid binding2.31e-021.00e+005.4241324
GO:0016070RNA metabolic process2.32e-021.00e+003.06028247
GO:0008536Ran GTPase binding2.40e-021.00e+005.3651225
GO:0042113B cell activation2.40e-021.00e+005.3651225
GO:0032735positive regulation of interleukin-12 production2.40e-021.00e+005.3651225
GO:0006890retrograde vesicle-mediated transport, Golgi to ER2.40e-021.00e+005.3651125
GO:0005515protein binding2.44e-021.00e+000.774101986024
GO:0003677DNA binding2.55e-021.00e+001.7584491218
GO:0043022ribosome binding2.59e-021.00e+005.2541127
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane2.59e-021.00e+005.2541127
GO:0030658transport vesicle membrane3.06e-021.00e+005.0091132
GO:0019905syntaxin binding3.16e-021.00e+004.9641233
GO:0001104RNA polymerase II transcription cofactor activity3.16e-021.00e+004.9641833
GO:0005801cis-Golgi network3.16e-021.00e+004.9641133
GO:0043234protein complex3.23e-021.00e+002.804211295
GO:0042552myelination3.35e-021.00e+004.8791435
GO:0016592mediator complex3.35e-021.00e+004.87911035
GO:0032755positive regulation of interleukin-6 production3.44e-021.00e+004.8391236
GO:0006446regulation of translational initiation3.44e-021.00e+004.8391436
GO:0001541ovarian follicle development3.53e-021.00e+004.7991237
GO:0032729positive regulation of interferon-gamma production3.72e-021.00e+004.7231139
GO:0051259protein oligomerization3.72e-021.00e+004.7231239
GO:0009408response to heat3.82e-021.00e+004.6871640
GO:0035019somatic stem cell maintenance3.82e-021.00e+004.6871640
GO:0042110T cell activation4.00e-021.00e+004.6161142
GO:0031124mRNA 3'-end processing4.00e-021.00e+004.6161242
GO:0043434response to peptide hormone4.28e-021.00e+004.5171545
GO:0006369termination of RNA polymerase II transcription4.28e-021.00e+004.5171245
GO:0048511rhythmic process4.28e-021.00e+004.5171445
GO:0007030Golgi organization4.65e-021.00e+004.3941349
GO:0006521regulation of cellular amino acid metabolic process4.75e-021.00e+004.3651150
GO:0006986response to unfolded protein4.75e-021.00e+004.3651450
GO:0005905coated pit4.75e-021.00e+004.3651650
GO:0003725double-stranded RNA binding4.93e-021.00e+004.3081152
GO:0009611response to wounding4.93e-021.00e+004.3081552
GO:0006888ER to Golgi vesicle-mediated transport5.03e-021.00e+004.2811153
GO:0002039p53 binding5.21e-021.00e+004.2271455
GO:0005793endoplasmic reticulum-Golgi intermediate compartment5.30e-021.00e+004.2011256
GO:0005643nuclear pore5.40e-021.00e+004.17611157
GO:0000502proteasome complex5.49e-021.00e+004.1511358
GO:0051087chaperone binding5.58e-021.00e+004.1261359
GO:0006406mRNA export from nucleus5.76e-021.00e+004.0781461
GO:0030141secretory granule5.86e-021.00e+004.0551462
GO:0009749response to glucose6.04e-021.00e+004.0091764
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.04e-021.00e+004.0091164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.13e-021.00e+003.9861265
GO:0043066negative regulation of apoptotic process6.21e-021.00e+002.281216424
GO:0010468regulation of gene expression6.40e-021.00e+003.9211268
GO:0003697single-stranded DNA binding6.40e-021.00e+003.9211568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.59e-021.00e+003.8791270
GO:0005085guanyl-nucleotide exchange factor activity6.68e-021.00e+003.8591571
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.77e-021.00e+003.8391172
GO:0003729mRNA binding6.77e-021.00e+003.8391472
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity6.95e-021.00e+003.7991474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.95e-021.00e+003.7991274
GO:0008584male gonad development7.04e-021.00e+003.7801375
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.04e-021.00e+003.7801175
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process7.22e-021.00e+003.7421377
GO:0001822kidney development7.31e-021.00e+003.7231378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process7.40e-021.00e+003.7051279
GO:0002755MyD88-dependent toll-like receptor signaling pathway7.49e-021.00e+003.6871580
GO:0009653anatomical structure morphogenesis7.77e-021.00e+003.6341283
GO:0006415translational termination8.13e-021.00e+003.5661287
GO:0050821protein stabilization8.21e-021.00e+003.5491388
GO:0005654nucleoplasm8.23e-021.00e+001.5143641082
GO:0042470melanosome8.48e-021.00e+003.5011291
GO:0002474antigen processing and presentation of peptide antigen via MHC class I8.57e-021.00e+003.4851192
GO:0051082unfolded protein binding8.66e-021.00e+003.4701793
GO:0007417central nervous system development8.93e-021.00e+003.4241596
GO:0016032viral process9.28e-021.00e+001.948226534
GO:0006805xenobiotic metabolic process9.55e-021.00e+003.32212103
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.05e-011.00e+003.17614114
GO:0000209protein polyubiquitination1.07e-011.00e+003.15113116
GO:0006325chromatin organization1.09e-011.00e+003.126112118
GO:0000790nuclear chromatin1.18e-011.00e+002.99816129
GO:0005524ATP binding1.25e-011.00e+001.2523311298
GO:0016887ATPase activity1.28e-011.00e+002.87911140
GO:0005737cytoplasm1.32e-011.00e+000.71461243767
GO:0000082G1/S transition of mitotic cell cycle1.35e-011.00e+002.79013149
GO:0042981regulation of apoptotic process1.36e-011.00e+002.78014150
GO:0005769early endosome1.38e-011.00e+002.76111152
GO:0000398mRNA splicing, via spliceosome1.48e-011.00e+002.651115164
GO:0044212transcription regulatory region DNA binding1.51e-011.00e+002.616117168
GO:0034641cellular nitrogen compound metabolic process1.54e-011.00e+002.59112171
GO:0005667transcription factor complex1.57e-011.00e+002.558117175
GO:0031625ubiquitin protein ligase binding1.60e-011.00e+002.53315178
GO:0043547positive regulation of GTPase activity1.61e-011.00e+002.51719180
GO:0032403protein complex binding1.64e-011.00e+002.49316183
GO:0001701in utero embryonic development1.78e-011.00e+002.35818201
GO:0008134transcription factor binding2.11e-011.00e+002.090118242
GO:0016020membrane2.18e-011.00e+000.8793461681
GO:0000166nucleotide binding2.24e-011.00e+001.992113259
GO:0006357regulation of transcription from RNA polymerase II promoter2.28e-011.00e+001.964123264
GO:0043065positive regulation of apoptotic process2.31e-011.00e+001.94317268
GO:0005743mitochondrial inner membrane2.38e-011.00e+001.89516277
GO:0006200ATP catabolic process2.49e-011.00e+001.81912292
GO:0006355regulation of transcription, DNA-templated2.52e-011.00e+001.047243997
GO:0008270zinc ion binding2.52e-011.00e+001.047227997
GO:0005525GTP binding2.62e-011.00e+001.733112310
GO:0003682chromatin binding2.75e-011.00e+001.656119327
GO:0015031protein transport2.85e-011.00e+001.595111341
GO:0043565sequence-specific DNA binding2.88e-011.00e+001.574111346
GO:0000139Golgi membrane2.99e-011.00e+001.51317361
GO:0005925focal adhesion3.02e-011.00e+001.49319366
GO:0000278mitotic cell cycle3.20e-011.00e+001.398115391
GO:0009986cell surface3.27e-011.00e+001.35819402
GO:0044281small molecule metabolic process3.31e-011.00e+000.7672201211
GO:0045892negative regulation of transcription, DNA-templated3.34e-011.00e+001.319124413
GO:0055114oxidation-reduction process3.39e-011.00e+001.294110420
GO:0006351transcription, DNA-templated4.17e-011.00e+000.5112571446
GO:0070062extracellular vesicular exosome4.19e-011.00e+000.3653572400
GO:0006915apoptotic process4.23e-011.00e+000.892112555
GO:0005783endoplasmic reticulum4.23e-011.00e+000.890113556
GO:0005789endoplasmic reticulum membrane4.32e-011.00e+000.85419570
GO:0005794Golgi apparatus4.54e-011.00e+000.75619610
GO:0005886plasma membrane4.71e-011.00e+000.2593492582
GO:0003700sequence-specific DNA binding transcription factor activity5.01e-011.00e+000.560139699
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.45e-011.00e+000.385141789
GO:0005615extracellular space6.18e-011.00e+000.106120957
GO:0005739mitochondrion6.34e-011.00e+000.046123998
GO:0005634nucleus6.92e-011.00e+00-0.14641594559
GO:0046872metal ion binding7.36e-011.00e+00-0.3431291307
GO:0005730nucleolus8.16e-011.00e+00-0.6721661641
GO:0016021integral component of membrane8.74e-011.00e+00-0.9441171982