int-snw-7727

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.937	1.27e-16	1.35e-04	1.37e-03

chia-screen-data-Fav-int-snw-7727 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
TPR	7175	18	-2.638	3.072	28	Yes	Yes
ZC3H18	124245	3	-2.426	2.937	6	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
MED12	9968	14	-2.465	3.206	65	Yes	-
ZSCAN32	54925	1	-2.840	2.937	5	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
SON	6651	9	-3.844	3.108	9	Yes	Yes
CDK12	51755	6	-2.714	2.944	15	Yes	-
[ ZNF174 ]	7727	1	-1.410	2.937	6	-	-
SUMO1	7341	7	-1.696	3.050	439	-	-

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SON	6651	SUMO1	7341	pp	--	int.I2D: BioGrid
SUMO1	7341	ZC3H18	124245	pp	--	int.I2D: BioGrid
SUMO1	7341	CDK12	51755	pp	--	int.I2D: BioGrid
HNRNPU	3192	SUMO1	7341	pp	--	int.I2D: BioGrid
SUMO1	7341	MED12	9968	pp	--	int.I2D: BioGrid
SUMO1	7341	ZNF174	7727	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
POU5F1	5460	SUMO1	7341	pp	--	int.I2D: BioGrid, BioGrid_Mouse
ZNF174	7727	ZSCAN32	54925	pp	--	int.I2D: BioGrid; int.Ravasi: -
TPR	7175	SUMO1	7341	pp	--	int.I2D: BioGrid

Related GO terms (181)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005634	nucleus	3.12e-06	4.50e-02	1.662	11	159	4559
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	2.08e-05	3.00e-01	5.732	3	4	74
GO:0044822	poly(A) RNA binding	5.09e-05	7.35e-01	2.897	6	50	1056
GO:0005654	nucleoplasm	5.85e-05	8.43e-01	2.862	6	64	1082
GO:0044212	transcription regulatory region DNA binding	2.39e-04	1.00e+00	4.549	3	17	168
GO:0016607	nuclear speck	2.56e-04	1.00e+00	4.515	3	12	172
GO:0008380	RNA splicing	5.86e-04	1.00e+00	4.109	3	22	228
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:1901673	regulation of spindle assembly involved in mitosis	7.63e-04	1.00e+00	10.357	1	1	1
GO:0043578	nuclear matrix organization	7.63e-04	1.00e+00	10.357	1	1	1
GO:0010965	regulation of mitotic sister chromatid separation	7.63e-04	1.00e+00	10.357	1	1	1
GO:0006404	RNA import into nucleus	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0031453	positive regulation of heterochromatin assembly	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0005643	nuclear pore	8.25e-04	1.00e+00	5.524	2	11	57
GO:0000189	MAPK import into nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0031990	mRNA export from nucleus in response to heat stress	1.52e-03	1.00e+00	9.357	1	2	2
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	1.52e-03	1.00e+00	9.357	1	1	2
GO:0090204	protein localization to nuclear pore	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0070840	dynein complex binding	1.52e-03	1.00e+00	9.357	1	1	2
GO:0002944	cyclin K-CDK12 complex	1.52e-03	1.00e+00	9.357	1	1	2
GO:0046832	negative regulation of RNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	2.29e-03	1.00e+00	8.772	1	1	3
GO:0006405	RNA export from nucleus	2.29e-03	1.00e+00	8.772	1	2	3
GO:0042306	regulation of protein import into nucleus	2.29e-03	1.00e+00	8.772	1	2	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0001650	fibrillar center	2.29e-03	1.00e+00	8.772	1	1	3
GO:0090245	axis elongation involved in somitogenesis	2.29e-03	1.00e+00	8.772	1	1	3
GO:0051726	regulation of cell cycle	2.37e-03	1.00e+00	4.757	2	5	97
GO:0014044	Schwann cell development	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030578	PML body organization	3.05e-03	1.00e+00	8.357	1	1	4
GO:0006999	nuclear pore organization	3.05e-03	1.00e+00	8.357	1	1	4
GO:0044615	nuclear pore nuclear basket	3.05e-03	1.00e+00	8.357	1	1	4
GO:0006366	transcription from RNA polymerase II promoter	3.38e-03	1.00e+00	3.231	3	30	419
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:0010793	regulation of mRNA export from nucleus	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043405	regulation of MAP kinase activity	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070849	response to epidermal growth factor	3.81e-03	1.00e+00	8.035	1	1	5
GO:0050733	RS domain binding	4.57e-03	1.00e+00	7.772	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0005730	nucleolus	4.85e-03	1.00e+00	1.998	5	66	1641
GO:0046825	regulation of protein export from nucleus	5.33e-03	1.00e+00	7.549	1	2	7
GO:0051292	nuclear pore complex assembly	6.09e-03	1.00e+00	7.357	1	4	8
GO:0035457	cellular response to interferon-alpha	6.09e-03	1.00e+00	7.357	1	1	8
GO:0006397	mRNA processing	6.30e-03	1.00e+00	4.035	2	10	160
GO:0042405	nuclear inclusion body	6.85e-03	1.00e+00	7.187	1	2	9
GO:0043495	protein anchor	6.85e-03	1.00e+00	7.187	1	1	9
GO:0031965	nuclear membrane	6.92e-03	1.00e+00	3.964	2	10	168
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	7.60e-03	1.00e+00	7.035	1	1	10
GO:0031625	ubiquitin protein ligase binding	7.74e-03	1.00e+00	3.881	2	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	8.25e-03	1.00e+00	3.833	2	22	184
GO:0005515	protein binding	8.30e-03	1.00e+00	0.970	9	198	6024
GO:0019789	SUMO ligase activity	8.36e-03	1.00e+00	6.897	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0045947	negative regulation of translational initiation	9.12e-03	1.00e+00	6.772	1	2	12
GO:0034399	nuclear periphery	9.12e-03	1.00e+00	6.772	1	5	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	9.87e-03	1.00e+00	6.656	1	2	13
GO:0051019	mitogen-activated protein kinase binding	9.87e-03	1.00e+00	6.656	1	2	13
GO:0031334	positive regulation of protein complex assembly	9.87e-03	1.00e+00	6.656	1	2	13
GO:0005868	cytoplasmic dynein complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0046827	positive regulation of protein export from nucleus	9.87e-03	1.00e+00	6.656	1	1	13
GO:0003677	DNA binding	1.03e-02	1.00e+00	2.106	4	49	1218
GO:0030518	intracellular steroid hormone receptor signaling pathway	1.06e-02	1.00e+00	6.549	1	6	14
GO:0005487	nucleocytoplasmic transporter activity	1.06e-02	1.00e+00	6.549	1	3	14
GO:0042809	vitamin D receptor binding	1.14e-02	1.00e+00	6.450	1	6	15
GO:0042307	positive regulation of protein import into nucleus	1.14e-02	1.00e+00	6.450	1	4	15
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0019221	cytokine-mediated signaling pathway	1.17e-02	1.00e+00	3.569	2	8	221
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	1.21e-02	1.00e+00	6.357	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	1.21e-02	1.00e+00	6.357	1	2	16
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	1.21e-02	1.00e+00	6.357	1	1	16
GO:0010467	gene expression	1.24e-02	1.00e+00	2.556	3	45	669
GO:0090316	positive regulation of intracellular protein transport	1.29e-02	1.00e+00	6.269	1	2	17
GO:0003713	transcription coactivator activity	1.34e-02	1.00e+00	3.468	2	24	237
GO:0030332	cyclin binding	1.36e-02	1.00e+00	6.187	1	1	18
GO:0008134	transcription factor binding	1.40e-02	1.00e+00	3.438	2	18	242
GO:0014003	oligodendrocyte development	1.52e-02	1.00e+00	6.035	1	5	20
GO:0043484	regulation of RNA splicing	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0006611	protein export from nucleus	1.89e-02	1.00e+00	5.713	1	3	25
GO:0016925	protein sumoylation	1.89e-02	1.00e+00	5.713	1	2	25
GO:0043392	negative regulation of DNA binding	1.97e-02	1.00e+00	5.656	1	4	26
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0046966	thyroid hormone receptor binding	1.97e-02	1.00e+00	5.656	1	6	26
GO:0015631	tubulin binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0034605	cellular response to heat	2.12e-02	1.00e+00	5.549	1	1	28
GO:0072686	mitotic spindle	2.19e-02	1.00e+00	5.499	1	3	29
GO:0006606	protein import into nucleus	2.27e-02	1.00e+00	5.450	1	2	30
GO:0031647	regulation of protein stability	2.27e-02	1.00e+00	5.450	1	4	30
GO:0010827	regulation of glucose transport	2.27e-02	1.00e+00	5.450	1	4	30
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2.34e-02	1.00e+00	5.402	1	1	31
GO:0007094	mitotic spindle assembly checkpoint	2.34e-02	1.00e+00	5.402	1	3	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0003682	chromatin binding	2.46e-02	1.00e+00	3.004	2	19	327
GO:0031072	heat shock protein binding	2.49e-02	1.00e+00	5.312	1	2	33
GO:0001104	RNA polymerase II transcription cofactor activity	2.49e-02	1.00e+00	5.312	1	8	33
GO:0016592	mediator complex	2.64e-02	1.00e+00	5.227	1	10	35
GO:0030178	negative regulation of Wnt signaling pathway	2.64e-02	1.00e+00	5.227	1	4	35
GO:0003723	RNA binding	2.68e-02	1.00e+00	2.939	2	18	342
GO:0007077	mitotic nuclear envelope disassembly	2.71e-02	1.00e+00	5.187	1	4	36
GO:0032880	regulation of protein localization	2.79e-02	1.00e+00	5.147	1	2	37
GO:0008645	hexose transport	2.94e-02	1.00e+00	5.071	1	4	39
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0030521	androgen receptor signaling pathway	3.08e-02	1.00e+00	4.999	1	5	41
GO:0019898	extrinsic component of membrane	3.16e-02	1.00e+00	4.964	1	2	42
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	3.23e-02	1.00e+00	4.930	1	7	43
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	3.31e-02	1.00e+00	4.897	1	3	44
GO:0003712	transcription cofactor activity	3.31e-02	1.00e+00	4.897	1	8	44
GO:0019827	stem cell maintenance	3.53e-02	1.00e+00	4.802	1	7	47
GO:0045892	negative regulation of transcription, DNA-templated	3.79e-02	1.00e+00	2.667	2	24	413
GO:0000910	cytokinesis	3.82e-02	1.00e+00	4.684	1	2	51
GO:0000226	microtubule cytoskeleton organization	3.90e-02	1.00e+00	4.656	1	2	52
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0015758	glucose transport	4.12e-02	1.00e+00	4.575	1	4	55
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.41e-02	1.00e+00	4.474	1	6	59
GO:0008013	beta-catenin binding	4.48e-02	1.00e+00	4.450	1	9	60
GO:0060333	interferon-gamma-mediated signaling pathway	4.63e-02	1.00e+00	4.402	1	3	62
GO:0000776	kinetochore	4.70e-02	1.00e+00	4.379	1	5	63
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0060021	palate development	5.36e-02	1.00e+00	4.187	1	1	72
GO:0003729	mRNA binding	5.36e-02	1.00e+00	4.187	1	4	72
GO:0001843	neural tube closure	5.50e-02	1.00e+00	4.147	1	2	74
GO:0060070	canonical Wnt signaling pathway	5.58e-02	1.00e+00	4.128	1	4	75
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0016605	PML body	6.51e-02	1.00e+00	3.897	1	3	88
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	6.77e-02	1.00e+00	2.202	2	37	570
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	5	92
GO:0046872	metal ion binding	7.06e-02	1.00e+00	1.590	3	29	1307
GO:0042803	protein homodimerization activity	7.30e-02	1.00e+00	2.140	2	19	595
GO:0003676	nucleic acid binding	7.87e-02	1.00e+00	3.615	1	2	107
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	5	112
GO:0005635	nuclear envelope	8.29e-02	1.00e+00	3.536	1	5	113
GO:0005215	transporter activity	9.48e-02	1.00e+00	3.334	1	3	130
GO:0003700	sequence-specific DNA binding transcription factor activity	9.66e-02	1.00e+00	1.908	2	39	699
GO:0045202	synapse	9.90e-02	1.00e+00	3.269	1	5	136
GO:0007507	heart development	1.01e-01	1.00e+00	3.238	1	7	139
GO:0006974	cellular response to DNA damage stimulus	1.09e-01	1.00e+00	3.118	1	7	151
GO:0046777	protein autophosphorylation	1.14e-01	1.00e+00	3.053	1	4	158
GO:0008022	protein C-terminus binding	1.16e-01	1.00e+00	3.026	1	8	161
GO:0043687	post-translational protein modification	1.17e-01	1.00e+00	3.017	1	5	162
GO:0000398	mRNA splicing, via spliceosome	1.18e-01	1.00e+00	2.999	1	15	164
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.19e-01	1.00e+00	1.733	2	41	789
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0004672	protein kinase activity	1.27e-01	1.00e+00	2.889	1	3	177
GO:0015629	actin cytoskeleton	1.27e-01	1.00e+00	2.889	1	5	177
GO:0003714	transcription corepressor activity	1.28e-01	1.00e+00	2.881	1	11	178
GO:0019904	protein domain specific binding	1.28e-01	1.00e+00	2.873	1	8	179
GO:0005737	cytoplasm	1.33e-01	1.00e+00	0.799	5	124	3767
GO:0004872	receptor activity	1.35e-01	1.00e+00	2.794	1	8	189
GO:0007067	mitotic nuclear division	1.60e-01	1.00e+00	2.530	1	6	227
GO:0030425	dendrite	1.62e-01	1.00e+00	2.511	1	6	230
GO:0006355	regulation of transcription, DNA-templated	1.74e-01	1.00e+00	1.395	2	43	997
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	8	253
GO:0006281	DNA repair	1.82e-01	1.00e+00	2.329	1	14	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.84e-01	1.00e+00	2.312	1	23	264
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0043565	sequence-specific DNA binding	2.34e-01	1.00e+00	1.922	1	11	346
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	31	1298
GO:0000278	mitotic cell cycle	2.61e-01	1.00e+00	1.746	1	15	391
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0043066	negative regulation of apoptotic process	2.80e-01	1.00e+00	1.629	1	16	424
GO:0055085	transmembrane transport	2.86e-01	1.00e+00	1.592	1	8	435
GO:0044267	cellular protein metabolic process	3.08e-01	1.00e+00	1.468	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	3.10e-01	1.00e+00	1.456	1	24	478
GO:0016032	viral process	3.40e-01	1.00e+00	1.296	1	26	534
GO:0016020	membrane	3.73e-01	1.00e+00	0.642	2	46	1681
GO:0005829	cytosol	5.92e-01	1.00e+00	0.071	2	86	2496
GO:0044281	small molecule metabolic process	6.19e-01	1.00e+00	0.115	1	20	1211

chia-Fav

int-snw-7727

Statistics

Genes (11)

Interactions (11)

Related GO terms (181)