int-snw-7004

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.171	2.38e-19	4.75e-06	1.28e-04

chia-screen-data-Fav-int-snw-7004 subnetwork

Genes (5)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
YAP1	10413	94	-4.256	3.538	53	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
WWTR1	25937	2	-1.886	3.171	40	-	-
[ TEAD4 ]	7004	1	-1.693	3.171	14	-	-

Interactions (5)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
TEAD4	7004	WWTR1	25937	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, BioGrid_Mouse, HPRD, VidalHuman_core, IntAct; int.Ravasi: -; int.HPRD: yeast 2-hybrid
YAP1	10413	WWTR1	25937	pp	--	int.I2D: IntAct_Mouse
TEAD4	7004	YAP1	10413	pp	--	int.I2D: HPRD, BioGrid_Mouse; int.Transfac: -; int.HPRD: in vitro, in vivo
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo

Related GO terms (77)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0035329	hippo signaling	5.19e-08	7.48e-04	8.379	3	5	26
GO:0005654	nucleoplasm	2.36e-06	3.40e-02	3.737	5	64	1082
GO:0006367	transcription initiation from RNA polymerase II promoter	2.00e-05	2.89e-01	5.556	3	22	184
GO:0010467	gene expression	2.21e-05	3.19e-01	4.108	4	45	669
GO:0060795	cell fate commitment involved in formation of primary germ layer	3.47e-04	1.00e+00	11.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	3.47e-04	1.00e+00	11.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	3.47e-04	1.00e+00	11.494	1	1	1
GO:0060390	regulation of SMAD protein import into nucleus	3.47e-04	1.00e+00	11.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	3.47e-04	1.00e+00	11.494	1	1	1
GO:0001649	osteoblast differentiation	3.97e-04	1.00e+00	5.971	2	5	92
GO:0009786	regulation of asymmetric cell division	6.93e-04	1.00e+00	10.494	1	1	2
GO:0060242	contact inhibition	6.93e-04	1.00e+00	10.494	1	1	2
GO:0060913	cardiac cell fate determination	1.04e-03	1.00e+00	9.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.04e-03	1.00e+00	9.909	1	1	3
GO:0044212	transcription regulatory region DNA binding	1.32e-03	1.00e+00	5.102	2	17	168
GO:0005667	transcription factor complex	1.43e-03	1.00e+00	5.043	2	17	175
GO:0003714	transcription corepressor activity	1.48e-03	1.00e+00	5.018	2	11	178
GO:0001714	endodermal cell fate specification	1.73e-03	1.00e+00	9.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	1.73e-03	1.00e+00	9.172	1	2	5
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	1.73e-03	1.00e+00	9.172	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	2.08e-03	1.00e+00	8.909	1	3	6
GO:0017145	stem cell division	2.42e-03	1.00e+00	8.687	1	1	7
GO:0003713	transcription coactivator activity	2.60e-03	1.00e+00	4.605	2	24	237
GO:0006355	regulation of transcription, DNA-templated	2.96e-03	1.00e+00	3.118	3	43	997
GO:0032835	glomerulus development	3.12e-03	1.00e+00	8.324	1	1	9
GO:0035414	negative regulation of catenin import into nucleus	3.12e-03	1.00e+00	8.324	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	3.46e-03	1.00e+00	8.172	1	2	10
GO:0060391	positive regulation of SMAD protein import into nucleus	3.81e-03	1.00e+00	8.035	1	4	11
GO:0035198	miRNA binding	4.15e-03	1.00e+00	7.909	1	1	12
GO:0071480	cellular response to gamma radiation	4.50e-03	1.00e+00	7.794	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	4.50e-03	1.00e+00	7.794	1	2	13
GO:0001824	blastocyst development	5.19e-03	1.00e+00	7.587	1	2	15
GO:0003677	DNA binding	5.28e-03	1.00e+00	2.829	3	49	1218
GO:0036464	cytoplasmic ribonucleoprotein granule	7.60e-03	1.00e+00	7.035	1	2	22
GO:0010718	positive regulation of epithelial to mesenchymal transition	8.64e-03	1.00e+00	6.850	1	4	25
GO:1903507	negative regulation of nucleic acid-templated transcription	1.10e-02	1.00e+00	6.494	1	2	32
GO:0045599	negative regulation of fat cell differentiation	1.21e-02	1.00e+00	6.365	1	2	35
GO:0001933	negative regulation of protein phosphorylation	1.24e-02	1.00e+00	6.324	1	2	36
GO:0005515	protein binding	1.27e-02	1.00e+00	1.260	5	198	6024
GO:0060271	cilium morphogenesis	1.28e-02	1.00e+00	6.285	1	3	37
GO:0035019	somatic stem cell maintenance	1.38e-02	1.00e+00	6.172	1	6	40
GO:0009611	response to wounding	1.79e-02	1.00e+00	5.794	1	5	52
GO:0006396	RNA processing	2.03e-02	1.00e+00	5.612	1	5	59
GO:0003700	sequence-specific DNA binding transcription factor activity	2.13e-02	1.00e+00	3.045	2	39	699
GO:0006469	negative regulation of protein kinase activity	2.23e-02	1.00e+00	5.472	1	4	65
GO:0010468	regulation of gene expression	2.34e-02	1.00e+00	5.407	1	2	68
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	2.54e-02	1.00e+00	5.285	1	4	74
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.68e-02	1.00e+00	2.870	2	41	789
GO:0071013	catalytic step 2 spliceosome	2.68e-02	1.00e+00	5.209	1	7	78
GO:0007517	muscle organ development	2.84e-02	1.00e+00	5.119	1	4	83
GO:0009653	anatomical structure morphogenesis	2.84e-02	1.00e+00	5.119	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	2.95e-02	1.00e+00	5.068	1	8	86
GO:0005634	nucleus	3.73e-02	1.00e+00	1.340	4	159	4559
GO:0030529	ribonucleoprotein complex	3.82e-02	1.00e+00	4.687	1	5	112
GO:0005829	cytosol	3.93e-02	1.00e+00	1.794	3	86	2496
GO:0001501	skeletal system development	4.06e-02	1.00e+00	4.599	1	2	119
GO:0007179	transforming growth factor beta receptor signaling pathway	4.36e-02	1.00e+00	4.494	1	11	128
GO:0044822	poly(A) RNA binding	4.62e-02	1.00e+00	2.450	2	50	1056
GO:0006974	cellular response to DNA damage stimulus	5.13e-02	1.00e+00	4.256	1	7	151
GO:0000398	mRNA splicing, via spliceosome	5.56e-02	1.00e+00	4.137	1	15	164
GO:0031625	ubiquitin protein ligase binding	6.02e-02	1.00e+00	4.018	1	5	178
GO:0008380	RNA splicing	7.66e-02	1.00e+00	3.661	1	22	228
GO:0008134	transcription factor binding	8.11e-02	1.00e+00	3.575	1	18	242
GO:0006357	regulation of transcription from RNA polymerase II promoter	8.82e-02	1.00e+00	3.450	1	23	264
GO:0008283	cell proliferation	1.09e-01	1.00e+00	3.137	1	14	328
GO:0003723	RNA binding	1.13e-01	1.00e+00	3.076	1	18	342
GO:0043565	sequence-specific DNA binding	1.14e-01	1.00e+00	3.060	1	11	346
GO:0005737	cytoplasm	1.16e-01	1.00e+00	1.200	3	124	3767
GO:0008284	positive regulation of cell proliferation	1.26e-01	1.00e+00	2.917	1	10	382
GO:0009986	cell surface	1.32e-01	1.00e+00	2.843	1	9	402
GO:0006366	transcription from RNA polymerase II promoter	1.37e-01	1.00e+00	2.783	1	30	419
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	1.83e-01	1.00e+00	2.339	1	37	570
GO:0042803	protein homodimerization activity	1.90e-01	1.00e+00	2.277	1	19	595
GO:0005524	ATP binding	3.76e-01	1.00e+00	1.152	1	31	1298
GO:0006351	transcription, DNA-templated	4.10e-01	1.00e+00	0.996	1	57	1446
GO:0005730	nucleolus	4.53e-01	1.00e+00	0.814	1	66	1641
GO:0016020	membrane	4.62e-01	1.00e+00	0.779	1	46	1681

chia-Fav

int-snw-7004

Statistics

Genes (5)

Interactions (5)

Related GO terms (77)