int-snw-6905

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.836	1.62e-15	4.79e-04	3.36e-03

chia-screen-data-Fav-int-snw-6905 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
LARS	51520	14	-2.574	3.157	105	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
VBP1	7411	1	-1.686	2.836	161	-	-
MED13L	23389	12	-2.550	3.159	21	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
NAP1L4	4676	4	-1.947	3.119	187	-	-
USP14	9097	2	-1.714	2.974	167	-	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ TBCE ]	6905	1	-1.454	2.836	26	-	-

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
TBCE	6905	VBP1	7411	pp	--	int.I2D: BioGrid_Yeast
NAP1L4	4676	TBCE	6905	pp	--	int.I2D: BioGrid_Yeast
DDIT3	1649	NAP1L4	4676	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
VBP1	7411	MED13L	23389	pp	--	int.I2D: BioGrid_Fly, FlyLow, IntAct_Fly
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
PSMD2	5708	USP14	9097	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast
PSMD2	5708	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
PSMD2	5708	TBCE	6905	pp	--	int.I2D: IntAct_Yeast, YeastLow, BioGrid_Yeast, MINT_Yeast
TBCE	6905	USP14	9097	pp	--	int.I2D: Krogan_NonCore
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (148)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	4.11e-05	5.92e-01	7.656	2	2	13
GO:0044212	transcription regulatory region DNA binding	2.39e-04	1.00e+00	4.549	3	17	168
GO:0051084	'de novo' posttranslational protein folding	3.47e-04	1.00e+00	6.147	2	5	37
GO:0005654	nucleoplasm	7.42e-04	1.00e+00	2.599	5	64	1082
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:0014889	muscle atrophy	7.63e-04	1.00e+00	10.357	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0000502	proteasome complex	8.54e-04	1.00e+00	5.499	2	3	58
GO:0010467	gene expression	1.17e-03	1.00e+00	2.971	4	45	669
GO:0006429	leucyl-tRNA aminoacylation	1.52e-03	1.00e+00	9.357	1	1	2
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0008193	tRNA guanylyltransferase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0004823	leucine-tRNA ligase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.52e-03	1.00e+00	9.357	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.52e-03	1.00e+00	9.357	1	1	2
GO:0051082	unfolded protein binding	2.18e-03	1.00e+00	4.817	2	7	93
GO:0048936	peripheral nervous system neuron axonogenesis	2.29e-03	1.00e+00	8.772	1	1	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:0007023	post-chaperonin tubulin folding pathway	3.81e-03	1.00e+00	8.035	1	2	5
GO:0050920	regulation of chemotaxis	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0044267	cellular protein metabolic process	4.78e-03	1.00e+00	3.053	3	20	474
GO:0006457	protein folding	5.06e-03	1.00e+00	4.197	2	7	143
GO:0002161	aminoacyl-tRNA editing activity	5.33e-03	1.00e+00	7.549	1	2	7
GO:0006974	cellular response to DNA damage stimulus	5.63e-03	1.00e+00	4.118	2	7	151
GO:0001955	blood vessel maturation	6.09e-03	1.00e+00	7.357	1	1	8
GO:0016272	prefoldin complex	6.85e-03	1.00e+00	7.187	1	1	9
GO:0006983	ER overload response	6.85e-03	1.00e+00	7.187	1	1	9
GO:0006450	regulation of translational fidelity	6.85e-03	1.00e+00	7.187	1	2	9
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0070628	proteasome binding	7.60e-03	1.00e+00	7.035	1	1	10
GO:0003714	transcription corepressor activity	7.74e-03	1.00e+00	3.881	2	11	178
GO:0005515	protein binding	8.30e-03	1.00e+00	0.970	9	198	6024
GO:0045662	negative regulation of myoblast differentiation	8.36e-03	1.00e+00	6.897	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0061136	regulation of proteasomal protein catabolic process	9.12e-03	1.00e+00	6.772	1	1	12
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	1	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0005737	cytoplasm	9.75e-03	1.00e+00	1.285	7	124	3767
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0030234	enzyme regulator activity	9.87e-03	1.00e+00	6.656	1	2	13
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0042176	regulation of protein catabolic process	1.21e-02	1.00e+00	6.357	1	2	16
GO:0022624	proteasome accessory complex	1.29e-02	1.00e+00	6.269	1	1	17
GO:0008134	transcription factor binding	1.40e-02	1.00e+00	3.438	2	18	242
GO:0032757	positive regulation of interleukin-8 production	1.52e-02	1.00e+00	6.035	1	1	20
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.74e-02	1.00e+00	5.833	1	1	23
GO:0048589	developmental growth	1.89e-02	1.00e+00	5.713	1	2	25
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.97e-02	1.00e+00	5.656	1	1	26
GO:0004866	endopeptidase inhibitor activity	2.19e-02	1.00e+00	5.499	1	3	29
GO:0042594	response to starvation	2.34e-02	1.00e+00	5.402	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0001104	RNA polymerase II transcription cofactor activity	2.49e-02	1.00e+00	5.312	1	8	33
GO:0016592	mediator complex	2.64e-02	1.00e+00	5.227	1	10	35
GO:0004221	ubiquitin thiolesterase activity	2.71e-02	1.00e+00	5.187	1	1	36
GO:0043565	sequence-specific DNA binding	2.74e-02	1.00e+00	2.922	2	11	346
GO:0005829	cytosol	2.85e-02	1.00e+00	1.393	5	86	2496
GO:0005634	nucleus	2.89e-02	1.00e+00	1.010	7	159	4559
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0006418	tRNA aminoacylation for protein translation	3.16e-02	1.00e+00	4.964	1	3	42
GO:0016579	protein deubiquitination	3.16e-02	1.00e+00	4.964	1	1	42
GO:0008344	adult locomotory behavior	3.31e-02	1.00e+00	4.897	1	2	44
GO:0043525	positive regulation of neuron apoptotic process	3.45e-02	1.00e+00	4.833	1	4	46
GO:0006355	regulation of transcription, DNA-templated	3.57e-02	1.00e+00	1.980	3	43	997
GO:0009986	cell surface	3.61e-02	1.00e+00	2.706	2	9	402
GO:0004197	cysteine-type endopeptidase activity	3.75e-02	1.00e+00	4.713	1	1	50
GO:0006521	regulation of cellular amino acid metabolic process	3.75e-02	1.00e+00	4.713	1	1	50
GO:0006986	response to unfolded protein	3.75e-02	1.00e+00	4.713	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.82e-02	1.00e+00	4.684	1	2	51
GO:0045454	cell redox homeostasis	3.82e-02	1.00e+00	4.684	1	1	51
GO:0006366	transcription from RNA polymerase II promoter	3.89e-02	1.00e+00	2.646	2	30	419
GO:0000226	microtubule cytoskeleton organization	3.90e-02	1.00e+00	4.656	1	2	52
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0044822	poly(A) RNA binding	4.14e-02	1.00e+00	1.897	3	50	1056
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0051087	chaperone binding	4.41e-02	1.00e+00	4.474	1	3	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.41e-02	1.00e+00	4.474	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.56e-02	1.00e+00	4.426	1	2	61
GO:0004843	ubiquitin-specific protease activity	4.78e-02	1.00e+00	4.357	1	1	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.78e-02	1.00e+00	4.357	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.85e-02	1.00e+00	4.334	1	2	65
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.21e-02	1.00e+00	4.227	1	2	70
GO:0006334	nucleosome assembly	5.36e-02	1.00e+00	4.187	1	3	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.36e-02	1.00e+00	4.187	1	1	72
GO:0009791	post-embryonic development	5.43e-02	1.00e+00	4.167	1	3	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-02	1.00e+00	4.147	1	2	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.58e-02	1.00e+00	4.128	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.86e-02	1.00e+00	4.053	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	5.86e-02	1.00e+00	4.053	1	2	79
GO:0003677	DNA binding	5.93e-02	1.00e+00	1.691	3	49	1218
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	6.37e-02	1.00e+00	3.930	1	8	86
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.80e-02	1.00e+00	3.833	1	1	92
GO:0005770	late endosome	6.87e-02	1.00e+00	3.817	1	2	93
GO:0010951	negative regulation of endopeptidase activity	7.65e-02	1.00e+00	3.656	1	6	104
GO:0016023	cytoplasmic membrane-bounded vesicle	7.73e-02	1.00e+00	3.642	1	8	105
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	5	112
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	3	116
GO:0007050	cell cycle arrest	9.06e-02	1.00e+00	3.402	1	5	124
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0003700	sequence-specific DNA binding transcription factor activity	9.66e-02	1.00e+00	1.908	2	39	699
GO:0045202	synapse	9.90e-02	1.00e+00	3.269	1	5	136
GO:0016055	Wnt signaling pathway	1.00e-01	1.00e+00	3.248	1	4	138
GO:0000082	G1/S transition of mitotic cell cycle	1.08e-01	1.00e+00	3.137	1	3	149
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	4	150
GO:0000398	mRNA splicing, via spliceosome	1.18e-01	1.00e+00	2.999	1	15	164
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.19e-01	1.00e+00	1.733	2	41	789
GO:0034641	cellular nitrogen compound metabolic process	1.23e-01	1.00e+00	2.939	1	2	171
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0016071	mRNA metabolic process	1.58e-01	1.00e+00	2.556	1	8	223
GO:0008380	RNA splicing	1.61e-01	1.00e+00	2.524	1	22	228
GO:0003713	transcription coactivator activity	1.67e-01	1.00e+00	2.468	1	24	237
GO:0016070	RNA metabolic process	1.73e-01	1.00e+00	2.408	1	8	247
GO:0005874	microtubule	1.74e-01	1.00e+00	2.397	1	7	249
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.84e-01	1.00e+00	2.312	1	23	264
GO:0043231	intracellular membrane-bounded organelle	2.18e-01	1.00e+00	2.044	1	6	318
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0007268	synaptic transmission	2.26e-01	1.00e+00	1.982	1	5	332
GO:0003723	RNA binding	2.32e-01	1.00e+00	1.939	1	18	342
GO:0046982	protein heterodimerization activity	2.55e-01	1.00e+00	1.787	1	8	380
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	31	1298
GO:0000278	mitotic cell cycle	2.61e-01	1.00e+00	1.746	1	15	391
GO:0045892	negative regulation of transcription, DNA-templated	2.74e-01	1.00e+00	1.667	1	24	413
GO:0043066	negative regulation of apoptotic process	2.80e-01	1.00e+00	1.629	1	16	424
GO:0045893	positive regulation of transcription, DNA-templated	3.10e-01	1.00e+00	1.456	1	24	478
GO:0016032	viral process	3.40e-01	1.00e+00	1.296	1	26	534
GO:0006915	apoptotic process	3.51e-01	1.00e+00	1.240	1	12	555
GO:0016020	membrane	3.73e-01	1.00e+00	0.642	2	46	1681
GO:0070062	extracellular vesicular exosome	5.68e-01	1.00e+00	0.128	2	57	2400
GO:0044281	small molecule metabolic process	6.19e-01	1.00e+00	0.115	1	20	1211
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	49	2582

chia-Fav

int-snw-6905

Statistics

Genes (11)

Interactions (11)

Related GO terms (148)