int-snw-6789

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.110	1.28e-18	1.20e-05	2.46e-04

chia-screen-data-Fav-int-snw-6789 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
TCP1	6950	10	-2.383	3.119	241	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
HNRNPD	3184	5	-2.153	3.117	123	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
CSTB	1476	2	-2.252	3.110	34	Yes	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ STK4 ]	6789	3	-2.048	3.110	228	Yes	-

Interactions (13)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
HNRNPD	3184	STK4	6789	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPD	3184	HNRNPU	3192	pp	--	int.Mint: MI:0915(physical association)
DDIT3	1649	TCP1	6950	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
PSMD2	5708	TCP1	6950	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
SRSF3	6428	STK4	6789	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3	1649	HNRNPD	3184	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
HNRNPU	3192	STK4	6789	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
CSTB	1476	STK4	6789	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
STK4	6789	TCP1	6950	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (173)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	1.29e-06	1.86e-02	3.222	7	64	1082
GO:0044822	poly(A) RNA binding	2.47e-05	3.56e-01	3.035	6	50	1056
GO:0042789	mRNA transcription from RNA polymerase II promoter	3.36e-05	4.85e-01	7.794	2	2	13
GO:0010467	gene expression	4.39e-05	6.33e-01	3.430	5	45	669
GO:0035329	hippo signaling	1.39e-04	1.00e+00	6.794	2	5	26
GO:0000398	mRNA splicing, via spliceosome	1.63e-04	1.00e+00	4.722	3	15	164
GO:0044212	transcription regulatory region DNA binding	1.75e-04	1.00e+00	4.687	3	17	168
GO:0005829	cytosol	3.39e-04	1.00e+00	2.016	7	86	2496
GO:0008380	RNA splicing	4.31e-04	1.00e+00	4.246	3	22	228
GO:0008134	transcription factor binding	5.13e-04	1.00e+00	4.160	3	18	242
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0006396	RNA processing	7.25e-04	1.00e+00	5.612	2	5	59
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.39e-03	1.00e+00	9.494	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.39e-03	1.00e+00	9.494	1	1	2
GO:0003723	RNA binding	1.40e-03	1.00e+00	3.661	3	18	342
GO:0090090	negative regulation of canonical Wnt signaling pathway	1.53e-03	1.00e+00	5.068	2	8	86
GO:0003157	endocardium development	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060215	primitive hemopoiesis	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	198	6024
GO:0030529	ribonucleoprotein complex	2.58e-03	1.00e+00	4.687	2	5	112
GO:0007021	tubulin complex assembly	2.77e-03	1.00e+00	8.494	1	1	4
GO:0097167	circadian regulation of translation	2.77e-03	1.00e+00	8.494	1	1	4
GO:0006355	regulation of transcription, DNA-templated	3.40e-03	1.00e+00	2.533	4	43	997
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.46e-03	1.00e+00	8.172	1	2	5
GO:0060706	cell differentiation involved in embryonic placenta development	4.15e-03	1.00e+00	7.909	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.15e-03	1.00e+00	7.909	1	3	6
GO:0042981	regulation of apoptotic process	4.58e-03	1.00e+00	4.265	2	4	150
GO:0006974	cellular response to DNA damage stimulus	4.64e-03	1.00e+00	4.256	2	7	151
GO:0010466	negative regulation of peptidase activity	5.53e-03	1.00e+00	7.494	1	2	8
GO:0001955	blood vessel maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0097284	hepatocyte apoptotic process	6.22e-03	1.00e+00	7.324	1	1	9
GO:0006983	ER overload response	6.22e-03	1.00e+00	7.324	1	1	9
GO:0005832	chaperonin-containing T-complex	6.22e-03	1.00e+00	7.324	1	2	9
GO:0003714	transcription corepressor activity	6.39e-03	1.00e+00	4.018	2	11	178
GO:0002199	zona pellucida receptor complex	6.91e-03	1.00e+00	7.172	1	2	10
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0001841	neural tube formation	6.91e-03	1.00e+00	7.172	1	1	10
GO:0046621	negative regulation of organ growth	7.60e-03	1.00e+00	7.035	1	1	11
GO:0042162	telomeric DNA binding	7.60e-03	1.00e+00	7.035	1	1	11
GO:0045662	negative regulation of myoblast differentiation	7.60e-03	1.00e+00	7.035	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	1	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0030234	enzyme regulator activity	8.98e-03	1.00e+00	6.794	1	2	13
GO:0043488	regulation of mRNA stability	8.98e-03	1.00e+00	6.794	1	1	13
GO:0006401	RNA catabolic process	9.67e-03	1.00e+00	6.687	1	1	14
GO:0000242	pericentriolar material	9.67e-03	1.00e+00	6.687	1	1	14
GO:0043539	protein serine/threonine kinase activator activity	9.67e-03	1.00e+00	6.687	1	1	14
GO:0016071	mRNA metabolic process	9.87e-03	1.00e+00	3.693	2	8	223
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	1.04e-02	1.00e+00	6.587	1	1	15
GO:0043274	phospholipase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0042176	regulation of protein catabolic process	1.10e-02	1.00e+00	6.494	1	2	16
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	1	17
GO:0016070	RNA metabolic process	1.20e-02	1.00e+00	3.546	2	8	247
GO:0045861	negative regulation of proteolysis	1.24e-02	1.00e+00	6.324	1	4	18
GO:0000166	nucleotide binding	1.31e-02	1.00e+00	3.477	2	13	259
GO:0032757	positive regulation of interleukin-8 production	1.38e-02	1.00e+00	6.172	1	1	20
GO:0005720	nuclear heterochromatin	1.52e-02	1.00e+00	6.035	1	2	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	2	22
GO:0004869	cysteine-type endopeptidase inhibitor activity	1.58e-02	1.00e+00	5.971	1	2	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.58e-02	1.00e+00	5.971	1	1	23
GO:0007339	binding of sperm to zona pellucida	1.72e-02	1.00e+00	5.850	1	2	25
GO:0071902	positive regulation of protein serine/threonine kinase activity	1.79e-02	1.00e+00	5.794	1	2	26
GO:0051209	release of sequestered calcium ion into cytosol	1.79e-02	1.00e+00	5.794	1	1	26
GO:0004866	endopeptidase inhibitor activity	1.99e-02	1.00e+00	5.636	1	3	29
GO:0001569	patterning of blood vessels	2.13e-02	1.00e+00	5.540	1	1	31
GO:0042594	response to starvation	2.13e-02	1.00e+00	5.540	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0045600	positive regulation of fat cell differentiation	2.20e-02	1.00e+00	5.494	1	2	32
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0051084	'de novo' posttranslational protein folding	2.54e-02	1.00e+00	5.285	1	5	37
GO:0042752	regulation of circadian rhythm	2.54e-02	1.00e+00	5.285	1	3	37
GO:0032092	positive regulation of protein binding	2.60e-02	1.00e+00	5.246	1	2	38
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0031124	mRNA 3'-end processing	2.88e-02	1.00e+00	5.102	1	2	42
GO:0045727	positive regulation of translation	3.01e-02	1.00e+00	5.035	1	2	44
GO:0008344	adult locomotory behavior	3.01e-02	1.00e+00	5.035	1	2	44
GO:0006369	termination of RNA polymerase II transcription	3.08e-02	1.00e+00	5.002	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	4	46
GO:0044297	cell body	3.14e-02	1.00e+00	4.971	1	2	46
GO:0030216	keratinocyte differentiation	3.21e-02	1.00e+00	4.940	1	2	47
GO:0006366	transcription from RNA polymerase II promoter	3.25e-02	1.00e+00	2.783	2	30	419
GO:0000902	cell morphogenesis	3.35e-02	1.00e+00	4.879	1	4	49
GO:0001669	acrosomal vesicle	3.35e-02	1.00e+00	4.879	1	2	49
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	1	50
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.48e-02	1.00e+00	4.822	1	2	51
GO:0045454	cell redox homeostasis	3.48e-02	1.00e+00	4.822	1	1	51
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	3	58
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.02e-02	1.00e+00	4.612	1	6	59
GO:0044267	cellular protein metabolic process	4.07e-02	1.00e+00	2.605	2	20	474
GO:0045893	positive regulation of transcription, DNA-templated	4.14e-02	1.00e+00	2.593	2	24	478
GO:0006406	mRNA export from nucleus	4.15e-02	1.00e+00	4.563	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.15e-02	1.00e+00	4.563	1	2	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	2	65
GO:0003677	DNA binding	4.60e-02	1.00e+00	1.829	3	49	1218
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0018105	peptidyl-serine phosphorylation	4.68e-02	1.00e+00	4.386	1	2	69
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	2	74
GO:0002020	protease binding	5.02e-02	1.00e+00	4.285	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	5.35e-02	1.00e+00	4.190	1	2	79
GO:0005524	ATP binding	5.40e-02	1.00e+00	1.737	3	31	1298
GO:0006915	apoptotic process	5.42e-02	1.00e+00	2.378	2	12	555
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0005634	nucleus	6.02e-02	1.00e+00	0.925	6	159	4559
GO:0001649	osteoblast differentiation	6.20e-02	1.00e+00	3.971	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	1	92
GO:0005770	late endosome	6.27e-02	1.00e+00	3.955	1	2	93
GO:0051082	unfolded protein binding	6.27e-02	1.00e+00	3.955	1	7	93
GO:0007417	central nervous system development	6.46e-02	1.00e+00	3.909	1	5	96
GO:0070062	extracellular vesicular exosome	6.93e-02	1.00e+00	1.265	4	57	2400
GO:0010951	negative regulation of endopeptidase activity	6.98e-02	1.00e+00	3.794	1	6	104
GO:0000209	protein polyubiquitination	7.76e-02	1.00e+00	3.636	1	3	116
GO:0046983	protein dimerization activity	7.89e-02	1.00e+00	3.612	1	5	118
GO:0003700	sequence-specific DNA binding transcription factor activity	8.15e-02	1.00e+00	2.045	2	39	699
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0016055	Wnt signaling pathway	9.17e-02	1.00e+00	3.386	1	4	138
GO:0005737	cytoplasm	9.18e-02	1.00e+00	0.937	5	124	3767
GO:0006457	protein folding	9.49e-02	1.00e+00	3.334	1	7	143
GO:0000082	G1/S transition of mitotic cell cycle	9.87e-02	1.00e+00	3.275	1	3	149
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.00e-01	1.00e+00	1.870	2	41	789
GO:0046777	protein autophosphorylation	1.04e-01	1.00e+00	3.190	1	4	158
GO:0000287	magnesium ion binding	1.08e-01	1.00e+00	3.137	1	4	164
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	2	171
GO:0016607	nuclear speck	1.13e-01	1.00e+00	3.068	1	12	172
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.21e-01	1.00e+00	2.971	1	22	184
GO:0003713	transcription coactivator activity	1.53e-01	1.00e+00	2.605	1	24	237
GO:0005874	microtubule	1.60e-01	1.00e+00	2.534	1	7	249
GO:0043065	positive regulation of apoptotic process	1.71e-01	1.00e+00	2.428	1	7	268
GO:0035556	intracellular signal transduction	1.91e-01	1.00e+00	2.251	1	9	303
GO:0004674	protein serine/threonine kinase activity	1.94e-01	1.00e+00	2.227	1	6	308
GO:0005813	centrosome	2.04e-01	1.00e+00	2.145	1	7	326
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0008285	negative regulation of cell proliferation	2.20e-01	1.00e+00	2.031	1	10	353
GO:0046982	protein heterodimerization activity	2.34e-01	1.00e+00	1.924	1	8	380
GO:0000278	mitotic cell cycle	2.40e-01	1.00e+00	1.883	1	15	391
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.52e-01	1.00e+00	1.804	1	24	413
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	16	424
GO:0006468	protein phosphorylation	2.77e-01	1.00e+00	1.649	1	10	460
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	19	484
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0005730	nucleolus	3.18e-01	1.00e+00	0.814	2	66	1641
GO:0016020	membrane	3.28e-01	1.00e+00	0.779	2	46	1681
GO:0042803	protein homodimerization activity	3.44e-01	1.00e+00	1.277	1	19	595
GO:0005794	Golgi apparatus	3.51e-01	1.00e+00	1.241	1	9	610
GO:0007165	signal transduction	4.78e-01	1.00e+00	0.669	1	13	907
GO:0005615	extracellular space	4.97e-01	1.00e+00	0.592	1	20	957
GO:0044281	small molecule metabolic process	5.84e-01	1.00e+00	0.252	1	20	1211
GO:0006351	transcription, DNA-templated	6.52e-01	1.00e+00	-0.004	1	57	1446

chia-Fav

int-snw-6789

Statistics

Genes (10)

Interactions (13)

Related GO terms (173)