int-snw-6663

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.050	6.57e-18	2.89e-05	4.60e-04

chia-screen-data-Fav-int-snw-6663 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
[ SOX10 ]	6663	2	-1.490	3.050	33	-	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
SON	6651	9	-3.844	3.108	9	Yes	Yes
SUMO1	7341	7	-1.696	3.050	439	-	-

Interactions (6)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
SOX10	6663	SUMO1	7341	pp	--	int.I2D: BCI, HPRD, MINT; int.Mint: MI:0566(sumoylation reaction); int.HPRD: in vivo
POU5F1	5460	SOX10	6663	pp	--	int.I2D: HPRD, BCI; int.Ravasi: -; int.HPRD: in vitro
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
SON	6651	SUMO1	7341	pp	--	int.I2D: BioGrid
POU5F1	5460	SUMO1	7341	pp	--	int.I2D: BioGrid, BioGrid_Mouse

Related GO terms (101)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006366	transcription from RNA polymerase II promoter	1.01e-05	1.45e-01	4.520	4	30	419
GO:0016607	nuclear speck	3.25e-05	4.68e-01	5.390	3	12	172
GO:0008134	transcription factor binding	8.99e-05	1.00e+00	4.897	3	18	242
GO:0044822	poly(A) RNA binding	3.80e-04	1.00e+00	3.187	4	50	1056
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.16e-04	1.00e+00	11.231	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.16e-04	1.00e+00	11.231	1	1	1
GO:0009653	anatomical structure morphogenesis	4.83e-04	1.00e+00	5.856	2	2	83
GO:0090204	protein localization to nuclear pore	8.32e-04	1.00e+00	10.231	1	1	2
GO:0031315	extrinsic component of mitochondrial outer membrane	8.32e-04	1.00e+00	10.231	1	1	2
GO:0009786	regulation of asymmetric cell division	8.32e-04	1.00e+00	10.231	1	1	2
GO:0014015	positive regulation of gliogenesis	8.32e-04	1.00e+00	10.231	1	1	2
GO:0060913	cardiac cell fate determination	1.25e-03	1.00e+00	9.646	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.25e-03	1.00e+00	9.646	1	1	3
GO:0001650	fibrillar center	1.25e-03	1.00e+00	9.646	1	1	3
GO:0030578	PML body organization	1.66e-03	1.00e+00	9.231	1	1	4
GO:0001714	endodermal cell fate specification	2.08e-03	1.00e+00	8.909	1	1	5
GO:0031625	ubiquitin protein ligase binding	2.20e-03	1.00e+00	4.755	2	5	178
GO:0050733	RS domain binding	2.49e-03	1.00e+00	8.646	1	1	6
GO:0008380	RNA splicing	3.58e-03	1.00e+00	4.398	2	22	228
GO:0035413	positive regulation of catenin import into nucleus	4.15e-03	1.00e+00	7.909	1	2	10
GO:0048484	enteric nervous system development	4.15e-03	1.00e+00	7.909	1	1	10
GO:0019789	SUMO ligase activity	4.57e-03	1.00e+00	7.772	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	4.57e-03	1.00e+00	7.772	1	4	11
GO:0006281	DNA repair	4.66e-03	1.00e+00	4.203	2	14	261
GO:0035198	miRNA binding	4.98e-03	1.00e+00	7.646	1	1	12
GO:0005515	protein binding	5.30e-03	1.00e+00	1.260	6	198	6024
GO:0031334	positive regulation of protein complex assembly	5.40e-03	1.00e+00	7.531	1	2	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	5.40e-03	1.00e+00	7.531	1	2	13
GO:0031011	Ino80 complex	5.81e-03	1.00e+00	7.424	1	6	14
GO:0048546	digestive tract morphogenesis	5.81e-03	1.00e+00	7.424	1	1	14
GO:0001824	blastocyst development	6.22e-03	1.00e+00	7.324	1	2	15
GO:0043274	phospholipase binding	6.64e-03	1.00e+00	7.231	1	1	16
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	6.64e-03	1.00e+00	7.231	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	6.64e-03	1.00e+00	7.231	1	2	16
GO:0005654	nucleoplasm	7.09e-03	1.00e+00	2.737	3	64	1082
GO:0002052	positive regulation of neuroblast proliferation	7.47e-03	1.00e+00	7.061	1	1	18
GO:0030318	melanocyte differentiation	7.88e-03	1.00e+00	6.983	1	3	19
GO:0003723	RNA binding	7.89e-03	1.00e+00	3.813	2	18	342
GO:0043484	regulation of RNA splicing	9.12e-03	1.00e+00	6.772	1	1	22
GO:0048709	oligodendrocyte differentiation	9.53e-03	1.00e+00	6.708	1	2	23
GO:0003677	DNA binding	9.89e-03	1.00e+00	2.566	3	49	1218
GO:0007422	peripheral nervous system development	1.04e-02	1.00e+00	6.587	1	2	25
GO:0016925	protein sumoylation	1.04e-02	1.00e+00	6.587	1	2	25
GO:0048589	developmental growth	1.04e-02	1.00e+00	6.587	1	2	25
GO:0043392	negative regulation of DNA binding	1.08e-02	1.00e+00	6.531	1	4	26
GO:0045892	negative regulation of transcription, DNA-templated	1.14e-02	1.00e+00	3.541	2	24	413
GO:0001755	neural crest cell migration	1.16e-02	1.00e+00	6.424	1	1	28
GO:0043066	negative regulation of apoptotic process	1.20e-02	1.00e+00	3.503	2	16	424
GO:0005634	nucleus	1.39e-02	1.00e+00	1.399	5	159	4559
GO:0032880	regulation of protein localization	1.53e-02	1.00e+00	6.022	1	2	37
GO:0048469	cell maturation	1.57e-02	1.00e+00	5.983	1	1	38
GO:0035019	somatic stem cell maintenance	1.65e-02	1.00e+00	5.909	1	6	40
GO:0031124	mRNA 3'-end processing	1.73e-02	1.00e+00	5.839	1	2	42
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	1.82e-02	1.00e+00	5.772	1	3	44
GO:0006369	termination of RNA polymerase II transcription	1.86e-02	1.00e+00	5.739	1	2	45
GO:0000910	cytokinesis	2.10e-02	1.00e+00	5.559	1	2	51
GO:0009611	response to wounding	2.14e-02	1.00e+00	5.531	1	5	52
GO:0000226	microtubule cytoskeleton organization	2.14e-02	1.00e+00	5.531	1	2	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.19e-02	1.00e+00	5.503	1	5	53
GO:0005730	nucleolus	2.26e-02	1.00e+00	2.136	3	66	1641
GO:0005643	nuclear pore	2.35e-02	1.00e+00	5.398	1	11	57
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	2.43e-02	1.00e+00	5.348	1	6	59
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	2.51e-02	1.00e+00	5.300	1	4	61
GO:0006406	mRNA export from nucleus	2.51e-02	1.00e+00	5.300	1	4	61
GO:0060333	interferon-gamma-mediated signaling pathway	2.55e-02	1.00e+00	5.277	1	3	62
GO:0006310	DNA recombination	2.67e-02	1.00e+00	5.209	1	7	65
GO:0010468	regulation of gene expression	2.80e-02	1.00e+00	5.144	1	2	68
GO:0060021	palate development	2.96e-02	1.00e+00	5.061	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.04e-02	1.00e+00	5.022	1	4	74
GO:0002020	protease binding	3.04e-02	1.00e+00	5.022	1	6	74
GO:0090090	negative regulation of canonical Wnt signaling pathway	3.53e-02	1.00e+00	4.805	1	8	86
GO:0016605	PML body	3.61e-02	1.00e+00	4.772	1	3	88
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.87e-02	1.00e+00	2.607	2	41	789
GO:0051726	regulation of cell cycle	3.97e-02	1.00e+00	4.631	1	5	97
GO:0003676	nucleic acid binding	4.37e-02	1.00e+00	4.490	1	2	107
GO:0045202	synapse	5.53e-02	1.00e+00	4.144	1	5	136
GO:0006355	regulation of transcription, DNA-templated	5.94e-02	1.00e+00	2.270	2	43	997
GO:0006397	mRNA processing	6.48e-02	1.00e+00	3.909	1	10	160
GO:0043687	post-translational protein modification	6.55e-02	1.00e+00	3.891	1	5	162
GO:0000398	mRNA splicing, via spliceosome	6.63e-02	1.00e+00	3.874	1	15	164
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	6.67e-02	1.00e+00	3.865	1	12	165
GO:0031965	nuclear membrane	6.79e-02	1.00e+00	3.839	1	10	168
GO:0044212	transcription regulatory region DNA binding	6.79e-02	1.00e+00	3.839	1	17	168
GO:0005667	transcription factor complex	7.06e-02	1.00e+00	3.780	1	17	175
GO:0001701	in utero embryonic development	8.08e-02	1.00e+00	3.580	1	8	201
GO:0019221	cytokine-mediated signaling pathway	8.85e-02	1.00e+00	3.443	1	8	221
GO:0030425	dendrite	9.20e-02	1.00e+00	3.386	1	6	230
GO:0003713	transcription coactivator activity	9.46e-02	1.00e+00	3.342	1	24	237
GO:0000166	nucleotide binding	1.03e-01	1.00e+00	3.214	1	13	259
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.05e-01	1.00e+00	3.187	1	23	264
GO:0006954	inflammatory response	1.10e-01	1.00e+00	3.117	1	6	277
GO:0003682	chromatin binding	1.29e-01	1.00e+00	2.878	1	19	327
GO:0043565	sequence-specific DNA binding	1.36e-01	1.00e+00	2.796	1	11	346
GO:0044267	cellular protein metabolic process	1.82e-01	1.00e+00	2.342	1	20	474
GO:0042802	identical protein binding	1.85e-01	1.00e+00	2.312	1	19	484
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.937	3	124	3767
GO:0010467	gene expression	2.48e-01	1.00e+00	1.845	1	45	669
GO:0003700	sequence-specific DNA binding transcription factor activity	2.58e-01	1.00e+00	1.782	1	39	699
GO:0005829	cytosol	6.80e-01	1.00e+00	-0.054	1	86	2496

chia-Fav

int-snw-6663

Statistics

Genes (6)

Interactions (6)

Related GO terms (101)