int-snw-6421

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.193	1.27e-19	3.35e-06	9.95e-05

chia-screen-data-Fav-int-snw-6421 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PXN	5829	19	-2.554	3.193	206	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
MVP	9961	16	-2.846	3.193	20	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ SFPQ ]	6421	1	-2.051	3.193	111	Yes	-

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
PXN	5829	SFPQ	6421	pp	--	int.I2D: BIND
DDIT3	1649	SFPQ	6421	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (151)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0044212	transcription regulatory region DNA binding	1.20e-06	1.73e-02	5.424	4	17	168
GO:0005654	nucleoplasm	4.32e-06	6.23e-02	3.322	6	64	1082
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0008380	RNA splicing	2.06e-04	1.00e+00	4.568	3	22	228
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0023057	negative regulation of signaling	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0072376	protein activation cascade	5.55e-04	1.00e+00	10.816	1	1	1
GO:0051435	BH4 domain binding	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0005515	protein binding	9.24e-04	1.00e+00	1.260	8	198	6024
GO:0060242	contact inhibition	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044822	poly(A) RNA binding	1.57e-03	1.00e+00	2.772	4	50	1056
GO:0030529	ribonucleoprotein complex	1.62e-03	1.00e+00	5.009	2	5	112
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	1.66e-03	1.00e+00	9.231	1	1	3
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0005634	nucleus	1.82e-03	1.00e+00	1.469	7	159	4559
GO:0038127	ERBB signaling pathway	2.22e-03	1.00e+00	8.816	1	1	4
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	2.77e-03	1.00e+00	8.494	1	2	5
GO:0006974	cellular response to DNA damage stimulus	2.93e-03	1.00e+00	4.578	2	7	151
GO:0070937	CRD-mediated mRNA stability complex	3.32e-03	1.00e+00	8.231	1	3	6
GO:0042382	paraspeckles	3.32e-03	1.00e+00	8.231	1	2	6
GO:0000398	mRNA splicing, via spliceosome	3.44e-03	1.00e+00	4.459	2	15	164
GO:0061099	negative regulation of protein tyrosine kinase activity	3.88e-03	1.00e+00	8.009	1	1	7
GO:0003714	transcription corepressor activity	4.04e-03	1.00e+00	4.340	2	11	178
GO:0042754	negative regulation of circadian rhythm	4.43e-03	1.00e+00	7.816	1	1	8
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0007172	signal complex assembly	4.43e-03	1.00e+00	7.816	1	1	8
GO:0060396	growth hormone receptor signaling pathway	4.43e-03	1.00e+00	7.816	1	1	8
GO:0010467	gene expression	4.67e-03	1.00e+00	3.015	3	45	669
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	4.98e-03	1.00e+00	7.646	1	1	9
GO:0005737	cytoplasm	5.35e-03	1.00e+00	1.522	6	124	3767
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0017166	vinculin binding	6.09e-03	1.00e+00	7.357	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0000380	alternative mRNA splicing, via spliceosome	6.09e-03	1.00e+00	7.357	1	2	11
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0071480	cellular response to gamma radiation	7.19e-03	1.00e+00	7.116	1	1	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0034614	cellular response to reactive oxygen species	7.74e-03	1.00e+00	7.009	1	2	14
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0000166	nucleotide binding	8.37e-03	1.00e+00	3.799	2	13	259
GO:0043274	phospholipase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0048041	focal adhesion assembly	1.16e-02	1.00e+00	6.424	1	1	21
GO:0070932	histone H3 deacetylation	1.16e-02	1.00e+00	6.424	1	2	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	2	22
GO:0019901	protein kinase binding	1.24e-02	1.00e+00	3.508	2	18	317
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:0008283	cell proliferation	1.32e-02	1.00e+00	3.459	2	14	328
GO:0006355	regulation of transcription, DNA-templated	1.42e-02	1.00e+00	2.440	3	43	997
GO:0035329	hippo signaling	1.43e-02	1.00e+00	6.116	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0003723	RNA binding	1.43e-02	1.00e+00	3.398	2	18	342
GO:0000976	transcription regulatory region sequence-specific DNA binding	1.43e-02	1.00e+00	6.116	1	3	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0048754	branching morphogenesis of an epithelial tube	1.49e-02	1.00e+00	6.061	1	1	27
GO:0005875	microtubule associated complex	1.54e-02	1.00e+00	6.009	1	1	28
GO:0030032	lamellipodium assembly	1.60e-02	1.00e+00	5.958	1	1	29
GO:0042594	response to starvation	1.71e-02	1.00e+00	5.862	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.76e-02	1.00e+00	5.816	1	2	32
GO:0034446	substrate adhesion-dependent cell spreading	1.98e-02	1.00e+00	5.646	1	2	36
GO:0042752	regulation of circadian rhythm	2.03e-02	1.00e+00	5.607	1	3	37
GO:0045892	negative regulation of transcription, DNA-templated	2.04e-02	1.00e+00	3.126	2	24	413
GO:0006366	transcription from RNA polymerase II promoter	2.10e-02	1.00e+00	3.105	2	30	419
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0031124	mRNA 3'-end processing	2.31e-02	1.00e+00	5.424	1	2	42
GO:0003677	DNA binding	2.44e-02	1.00e+00	2.151	3	49	1218
GO:0001047	core promoter binding	2.47e-02	1.00e+00	5.324	1	5	45
GO:0006369	termination of RNA polymerase II transcription	2.47e-02	1.00e+00	5.324	1	2	45
GO:0048511	rhythmic process	2.47e-02	1.00e+00	5.324	1	4	45
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0051028	mRNA transport	2.85e-02	1.00e+00	5.116	1	4	52
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0001725	stress fiber	3.01e-02	1.00e+00	5.035	1	4	55
GO:0005643	nuclear pore	3.12e-02	1.00e+00	4.983	1	11	57
GO:0006396	RNA processing	3.23e-02	1.00e+00	4.933	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0008013	beta-catenin binding	3.28e-02	1.00e+00	4.909	1	9	60
GO:0006406	mRNA export from nucleus	3.33e-02	1.00e+00	4.885	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0019903	protein phosphatase binding	3.39e-02	1.00e+00	4.862	1	2	62
GO:0006310	DNA recombination	3.55e-02	1.00e+00	4.794	1	7	65
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	3	68
GO:0042826	histone deacetylase binding	3.93e-02	1.00e+00	4.646	1	4	72
GO:0000785	chromatin	3.98e-02	1.00e+00	4.626	1	6	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0071013	catalytic step 2 spliceosome	4.25e-02	1.00e+00	4.531	1	7	78
GO:0007229	integrin-mediated signaling pathway	4.25e-02	1.00e+00	4.531	1	3	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0006936	muscle contraction	4.73e-02	1.00e+00	4.373	1	3	87
GO:0000187	activation of MAPK activity	4.89e-02	1.00e+00	4.324	1	3	90
GO:0007010	cytoskeleton organization	4.94e-02	1.00e+00	4.308	1	4	91
GO:0016363	nuclear matrix	4.94e-02	1.00e+00	4.308	1	6	91
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	3	91
GO:0001649	osteoblast differentiation	4.99e-02	1.00e+00	4.293	1	5	92
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0005178	integrin binding	5.20e-02	1.00e+00	4.231	1	4	96
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0008360	regulation of cell shape	5.57e-02	1.00e+00	4.130	1	4	103
GO:0005938	cell cortex	5.63e-02	1.00e+00	4.116	1	5	104
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.72e-02	1.00e+00	2.192	2	41	789
GO:0030027	lamellipodium	6.73e-02	1.00e+00	3.850	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	6.88e-02	1.00e+00	3.816	1	11	128
GO:0018108	peptidyl-tyrosine phosphorylation	7.09e-02	1.00e+00	3.772	1	4	132
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0006397	mRNA processing	8.54e-02	1.00e+00	3.494	1	10	160
GO:0016607	nuclear speck	9.15e-02	1.00e+00	3.390	1	12	172
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	9.76e-02	1.00e+00	3.293	1	22	184
GO:0007173	epidermal growth factor receptor signaling pathway	1.00e-01	1.00e+00	3.254	1	5	189
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	24	237
GO:0006281	DNA repair	1.36e-01	1.00e+00	2.788	1	14	261
GO:0005829	cytosol	1.47e-01	1.00e+00	1.116	3	86	2496
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	9	291
GO:0015031	protein transport	1.74e-01	1.00e+00	2.402	1	11	341
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	9	366
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	5	369
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	9	402
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0016020	membrane	2.37e-01	1.00e+00	1.101	2	46	1681
GO:0048471	perinuclear region of cytoplasm	2.47e-01	1.00e+00	1.845	1	8	502
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.76e-01	1.00e+00	1.661	1	37	570
GO:0007165	signal transduction	4.05e-01	1.00e+00	0.991	1	13	907
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	27	997
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	31	1298
GO:0006351	transcription, DNA-templated	5.71e-01	1.00e+00	0.318	1	57	1446
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	66	1641
GO:0070062	extracellular vesicular exosome	7.67e-01	1.00e+00	-0.413	1	57	2400
GO:0005886	plasma membrane	7.94e-01	1.00e+00	-0.518	1	49	2582

chia-Fav

int-snw-6421

Statistics

Genes (8)

Interactions (8)

Related GO terms (151)