Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.915 | 2.22e-16 | 1.79e-04 | 1.68e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
[ BLK ] | 640 | 1 | -1.359 | 2.915 | 17 | - | - |
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
PXN | 5829 | 19 | -2.554 | 3.193 | 206 | Yes | Yes |
MS4A2 | 2206 | 2 | -2.182 | 3.067 | 9 | Yes | - |
TNFRSF1A | 7132 | 2 | -1.846 | 2.915 | 166 | - | - |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
SRSF3 | 6428 | 73 | -2.992 | 3.538 | 54 | Yes | - |
MVP | 9961 | 16 | -2.846 | 3.193 | 20 | Yes | Yes |
HNRNPU | 3192 | 76 | -2.869 | 3.538 | 139 | Yes | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
SYK | 6850 | 2 | -1.934 | 3.067 | 115 | - | - |
DDIT3 | 1649 | 60 | -2.825 | 3.504 | 343 | Yes | Yes |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
BLK | 640 | SYK | 6850 | pp | -- | int.I2D: INNATEDB_Mouse |
PXN | 5829 | SRSF3 | 6428 | pp | -- | int.I2D: BIND |
HNRNPU | 3192 | YAP1 | 10413 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo |
HNRNPU | 3192 | SYK | 6850 | pp | -- | int.I2D: BCI, HPRD; int.HPRD: in vitro |
SYK | 6850 | TNFRSF1A | 7132 | pp | -- | int.I2D: HPRD; int.HPRD: in vivo |
POU5F1 | 5460 | SRSF3 | 6428 | pp | -- | int.I2D: BioGrid |
HNRNPU | 3192 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
PXN | 5829 | MVP | 9961 | pp | -- | int.I2D: BIND |
PXN | 5829 | SYK | 6850 | pp | -- | int.I2D: BioGrid, BCI, HPRD; int.HPRD: in vitro, in vivo |
PSMD2 | 5708 | TNFRSF1A | 7132 | pp | -- | int.I2D: BioGrid, BCI, HPRD; int.HPRD: in vitro, yeast 2-hybrid |
DDIT3 | 1649 | HNRNPU | 3192 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
MS4A2 | 2206 | SYK | 6850 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0043306 | positive regulation of mast cell degranulation | 2.28e-05 | 3.28e-01 | 8.061 | 2 | 2 | 9 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 4.92e-05 | 7.10e-01 | 7.531 | 2 | 2 | 13 |
GO:0019901 | protein kinase binding | 9.86e-05 | 1.00e+00 | 3.923 | 4 | 18 | 317 |
GO:0005654 | nucleoplasm | 1.10e-04 | 1.00e+00 | 2.737 | 6 | 64 | 1082 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 1.55e-04 | 1.00e+00 | 4.772 | 3 | 4 | 132 |
GO:0050853 | B cell receptor signaling pathway | 2.54e-04 | 1.00e+00 | 6.373 | 2 | 2 | 29 |
GO:0044212 | transcription regulatory region DNA binding | 3.16e-04 | 1.00e+00 | 4.424 | 3 | 17 | 168 |
GO:0005515 | protein binding | 4.97e-04 | 1.00e+00 | 1.134 | 11 | 198 | 6024 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 5.36e-04 | 1.00e+00 | 5.839 | 2 | 3 | 42 |
GO:0043525 | positive regulation of neuron apoptotic process | 6.44e-04 | 1.00e+00 | 5.708 | 2 | 4 | 46 |
GO:0009611 | response to wounding | 8.22e-04 | 1.00e+00 | 5.531 | 2 | 5 | 52 |
GO:2000016 | negative regulation of determination of dorsal identity | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0023057 | negative regulation of signaling | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0051435 | BH4 domain binding | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0071226 | cellular response to molecule of fungal origin | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0032928 | regulation of superoxide anion generation | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0042991 | transcription factor import into nucleus | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0072376 | protein activation cascade | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090237 | regulation of arachidonic acid secretion | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0033013 | tetrapyrrole metabolic process | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0042742 | defense response to bacterium | 1.09e-03 | 1.00e+00 | 5.324 | 2 | 5 | 60 |
GO:0060242 | contact inhibition | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0032998 | Fc-epsilon receptor I complex | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0045401 | positive regulation of interleukin-3 biosynthetic process | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0043366 | beta selection | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0002366 | leukocyte activation involved in immune response | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0043120 | tumor necrosis factor binding | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0044324 | regulation of transcription involved in anterior/posterior axis specification | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0043313 | regulation of neutrophil degranulation | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0010467 | gene expression | 1.68e-03 | 1.00e+00 | 2.845 | 4 | 45 | 669 |
GO:0007229 | integrin-mediated signaling pathway | 1.84e-03 | 1.00e+00 | 4.946 | 2 | 3 | 78 |
GO:0004713 | protein tyrosine kinase activity | 2.03e-03 | 1.00e+00 | 4.874 | 2 | 3 | 82 |
GO:0008283 | cell proliferation | 2.20e-03 | 1.00e+00 | 3.459 | 3 | 14 | 328 |
GO:0002554 | serotonin secretion by platelet | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0019767 | IgE receptor activity | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0002283 | neutrophil activation involved in immune response | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0019815 | B cell receptor complex | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0005178 | integrin binding | 2.77e-03 | 1.00e+00 | 4.646 | 2 | 4 | 96 |
GO:0010543 | regulation of platelet activation | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0032009 | early phagosome | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0038127 | ERBB signaling pathway | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0090330 | regulation of platelet aggregation | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0030529 | ribonucleoprotein complex | 3.75e-03 | 1.00e+00 | 4.424 | 2 | 5 | 112 |
GO:0001714 | endodermal cell fate specification | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0019863 | IgE binding | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0070934 | CRD-mediated mRNA stabilization | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 2 | 5 |
GO:0043279 | response to alkaloid | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 2 | 5 |
GO:0045588 | positive regulation of gamma-delta T cell differentiation | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0070937 | CRD-mediated mRNA stability complex | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 3 | 6 |
GO:0001945 | lymph vessel development | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 6 |
GO:0050764 | regulation of phagocytosis | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 6 |
GO:0002281 | macrophage activation involved in immune response | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 6 |
GO:0061099 | negative regulation of protein tyrosine kinase activity | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0050663 | cytokine secretion | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0001955 | blood vessel maturation | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0007172 | signal complex assembly | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0060396 | growth hormone receptor signaling pathway | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0006974 | cellular response to DNA damage stimulus | 6.71e-03 | 1.00e+00 | 3.993 | 2 | 7 | 151 |
GO:0045121 | membrane raft | 7.15e-03 | 1.00e+00 | 3.946 | 2 | 3 | 156 |
GO:0031953 | negative regulation of protein autophosphorylation | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0006693 | prostaglandin metabolic process | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0004716 | receptor signaling protein tyrosine kinase activity | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0046638 | positive regulation of alpha-beta T cell differentiation | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0042511 | positive regulation of tyrosine phosphorylation of Stat1 protein | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0006983 | ER overload response | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0005031 | tumor necrosis factor-activated receptor activity | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0000398 | mRNA splicing, via spliceosome | 7.87e-03 | 1.00e+00 | 3.874 | 2 | 15 | 164 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 8.24e-03 | 1.00e+00 | 3.839 | 2 | 5 | 168 |
GO:0045579 | positive regulation of B cell differentiation | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0035413 | positive regulation of catenin import into nucleus | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 10 |
GO:0046641 | positive regulation of alpha-beta T cell proliferation | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0016032 | viral process | 8.65e-03 | 1.00e+00 | 2.755 | 3 | 26 | 534 |
GO:0045662 | negative regulation of myoblast differentiation | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 3 | 11 |
GO:0017166 | vinculin binding | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 1 | 11 |
GO:0033630 | positive regulation of cell adhesion mediated by integrin | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 1 | 11 |
GO:0045780 | positive regulation of bone resorption | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 1 | 11 |
GO:0033160 | positive regulation of protein import into nucleus, translocation | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 3 | 11 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 4 | 11 |
GO:0003714 | transcription corepressor activity | 9.22e-03 | 1.00e+00 | 3.755 | 2 | 11 | 178 |
GO:0005829 | cytosol | 9.54e-03 | 1.00e+00 | 1.531 | 6 | 86 | 2496 |
GO:0005838 | proteasome regulatory particle | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0071480 | cellular response to gamma radiation | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0042101 | T cell receptor complex | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0019370 | leukotriene biosynthetic process | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0030234 | enzyme regulator activity | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
GO:0034614 | cellular response to reactive oxygen species | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 2 | 14 |
GO:0001824 | blastocyst development | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 15 |
GO:0042176 | regulation of protein catabolic process | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 2 | 16 |
GO:0043274 | phospholipase binding | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 16 |
GO:0005634 | nucleus | 1.33e-02 | 1.00e+00 | 1.077 | 8 | 159 | 4559 |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 2 | 17 |
GO:0048514 | blood vessel morphogenesis | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 17 |
GO:0008380 | RNA splicing | 1.48e-02 | 1.00e+00 | 3.398 | 2 | 22 | 228 |
GO:0071392 | cellular response to estradiol stimulus | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 2 | 18 |
GO:0050850 | positive regulation of calcium-mediated signaling | 1.57e-02 | 1.00e+00 | 5.983 | 1 | 1 | 19 |
GO:0032757 | positive regulation of interleukin-8 production | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 3 | 20 |
GO:0032715 | negative regulation of interleukin-6 production | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0008134 | transcription factor binding | 1.66e-02 | 1.00e+00 | 3.312 | 2 | 18 | 242 |
GO:0048041 | focal adhesion assembly | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 1 | 21 |
GO:0050715 | positive regulation of cytokine secretion | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 2 | 22 |
GO:0043200 | response to amino acid | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 1 | 23 |
GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 1 | 23 |
GO:0035329 | hippo signaling | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 5 | 26 |
GO:0006954 | inflammatory response | 2.14e-02 | 1.00e+00 | 3.117 | 2 | 6 | 277 |
GO:0051209 | release of sequestered calcium ion into cytosol | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 1 | 26 |
GO:0048754 | branching morphogenesis of an epithelial tube | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 27 |
GO:0007159 | leukocyte cell-cell adhesion | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 27 |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 1 | 28 |
GO:0005875 | microtubule associated complex | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 1 | 28 |
GO:0002250 | adaptive immune response | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 1 | 28 |
GO:0030032 | lamellipodium assembly | 2.39e-02 | 1.00e+00 | 5.373 | 1 | 1 | 29 |
GO:0042169 | SH2 domain binding | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 2 | 30 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 2.48e-02 | 1.00e+00 | 2.192 | 3 | 41 | 789 |
GO:0042594 | response to starvation | 2.55e-02 | 1.00e+00 | 5.277 | 1 | 4 | 31 |
GO:0051219 | phosphoprotein binding | 2.63e-02 | 1.00e+00 | 5.231 | 1 | 1 | 32 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 2.63e-02 | 1.00e+00 | 5.231 | 1 | 2 | 32 |
GO:0032024 | positive regulation of insulin secretion | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 3 | 33 |
GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 1 | 34 |
GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 2 | 35 |
GO:0007257 | activation of JUN kinase activity | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 5 | 36 |
GO:0034446 | substrate adhesion-dependent cell spreading | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 2 | 36 |
GO:0032760 | positive regulation of tumor necrosis factor production | 3.04e-02 | 1.00e+00 | 5.022 | 1 | 2 | 37 |
GO:0003723 | RNA binding | 3.16e-02 | 1.00e+00 | 2.813 | 2 | 18 | 342 |
GO:0043565 | sequence-specific DNA binding | 3.23e-02 | 1.00e+00 | 2.796 | 2 | 11 | 346 |
GO:0035019 | somatic stem cell maintenance | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 6 | 40 |
GO:0030593 | neutrophil chemotaxis | 3.36e-02 | 1.00e+00 | 4.874 | 1 | 2 | 41 |
GO:0031124 | mRNA 3'-end processing | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 2 | 42 |
GO:0006369 | termination of RNA polymerase II transcription | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 2 | 45 |
GO:0050729 | positive regulation of inflammatory response | 3.92e-02 | 1.00e+00 | 4.646 | 1 | 2 | 48 |
GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 4.00e-02 | 1.00e+00 | 4.616 | 1 | 2 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 1 | 50 |
GO:0006986 | response to unfolded protein | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 4 | 50 |
GO:0034976 | response to endoplasmic reticulum stress | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 2 | 51 |
GO:0045454 | cell redox homeostasis | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 1 | 51 |
GO:0051028 | mRNA transport | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 4 | 52 |
GO:0009986 | cell surface | 4.25e-02 | 1.00e+00 | 2.580 | 2 | 9 | 402 |
GO:0007202 | activation of phospholipase C activity | 4.48e-02 | 1.00e+00 | 4.450 | 1 | 1 | 55 |
GO:0001725 | stress fiber | 4.48e-02 | 1.00e+00 | 4.450 | 1 | 4 | 55 |
GO:0006355 | regulation of transcription, DNA-templated | 4.53e-02 | 1.00e+00 | 1.855 | 3 | 43 | 997 |
GO:0051291 | protein heterooligomerization | 4.56e-02 | 1.00e+00 | 4.424 | 1 | 4 | 56 |
GO:0050728 | negative regulation of inflammatory response | 4.56e-02 | 1.00e+00 | 4.424 | 1 | 3 | 56 |
GO:0006366 | transcription from RNA polymerase II promoter | 4.58e-02 | 1.00e+00 | 2.520 | 2 | 30 | 419 |
GO:0005643 | nuclear pore | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 11 | 57 |
GO:0043066 | negative regulation of apoptotic process | 4.68e-02 | 1.00e+00 | 2.503 | 2 | 16 | 424 |
GO:0000502 | proteasome complex | 4.72e-02 | 1.00e+00 | 4.373 | 1 | 3 | 58 |
GO:0005886 | plasma membrane | 4.78e-02 | 1.00e+00 | 1.219 | 5 | 49 | 2582 |
GO:0006396 | RNA processing | 4.80e-02 | 1.00e+00 | 4.348 | 1 | 5 | 59 |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 4.80e-02 | 1.00e+00 | 4.348 | 1 | 6 | 59 |
GO:0008013 | beta-catenin binding | 4.88e-02 | 1.00e+00 | 4.324 | 1 | 9 | 60 |
GO:0006987 | activation of signaling protein activity involved in unfolded protein response | 4.96e-02 | 1.00e+00 | 4.300 | 1 | 2 | 61 |
GO:0006406 | mRNA export from nucleus | 4.96e-02 | 1.00e+00 | 4.300 | 1 | 4 | 61 |
GO:0019903 | protein phosphatase binding | 5.04e-02 | 1.00e+00 | 4.277 | 1 | 2 | 62 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 5.20e-02 | 1.00e+00 | 4.231 | 1 | 1 | 64 |
GO:0044822 | poly(A) RNA binding | 5.23e-02 | 1.00e+00 | 1.772 | 3 | 50 | 1056 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 2 | 65 |
GO:0071260 | cellular response to mechanical stimulus | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 4 | 65 |
GO:0010468 | regulation of gene expression | 5.52e-02 | 1.00e+00 | 4.144 | 1 | 2 | 68 |
GO:0034329 | cell junction assembly | 5.52e-02 | 1.00e+00 | 4.144 | 1 | 3 | 68 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.67e-02 | 1.00e+00 | 4.102 | 1 | 2 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 5.83e-02 | 1.00e+00 | 4.061 | 1 | 1 | 72 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0002020 | protease binding | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 6 | 74 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 1 | 75 |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 2 | 75 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 1 | 75 |
GO:0010629 | negative regulation of gene expression | 6.22e-02 | 1.00e+00 | 3.964 | 1 | 4 | 77 |
GO:0071013 | catalytic step 2 spliceosome | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 7 | 78 |
GO:0030968 | endoplasmic reticulum unfolded protein response | 6.38e-02 | 1.00e+00 | 3.927 | 1 | 2 | 79 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 6.38e-02 | 1.00e+00 | 3.927 | 1 | 2 | 79 |
GO:0005737 | cytoplasm | 6.58e-02 | 1.00e+00 | 0.937 | 6 | 124 | 3767 |
GO:0009653 | anatomical structure morphogenesis | 6.69e-02 | 1.00e+00 | 3.856 | 1 | 2 | 83 |
GO:0009887 | organ morphogenesis | 6.93e-02 | 1.00e+00 | 3.805 | 1 | 5 | 86 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 6.93e-02 | 1.00e+00 | 3.805 | 1 | 8 | 86 |
GO:0045471 | response to ethanol | 6.93e-02 | 1.00e+00 | 3.805 | 1 | 3 | 86 |
GO:0006936 | muscle contraction | 7.01e-02 | 1.00e+00 | 3.788 | 1 | 3 | 87 |
GO:0045766 | positive regulation of angiogenesis | 7.08e-02 | 1.00e+00 | 3.772 | 1 | 2 | 88 |
GO:0000187 | activation of MAPK activity | 7.24e-02 | 1.00e+00 | 3.739 | 1 | 3 | 90 |
GO:0007010 | cytoskeleton organization | 7.32e-02 | 1.00e+00 | 3.723 | 1 | 4 | 91 |
GO:0006928 | cellular component movement | 7.32e-02 | 1.00e+00 | 3.723 | 1 | 3 | 91 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 1 | 92 |
GO:0001649 | osteoblast differentiation | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 5 | 92 |
GO:0003677 | DNA binding | 7.43e-02 | 1.00e+00 | 1.566 | 3 | 49 | 1218 |
GO:0005770 | late endosome | 7.47e-02 | 1.00e+00 | 3.692 | 1 | 2 | 93 |
GO:0006915 | apoptotic process | 7.56e-02 | 1.00e+00 | 2.115 | 2 | 12 | 555 |
GO:0043235 | receptor complex | 7.94e-02 | 1.00e+00 | 3.602 | 1 | 2 | 99 |
GO:0008360 | regulation of cell shape | 8.24e-02 | 1.00e+00 | 3.545 | 1 | 4 | 103 |
GO:0005938 | cell cortex | 8.32e-02 | 1.00e+00 | 3.531 | 1 | 5 | 104 |
GO:0045087 | innate immune response | 8.56e-02 | 1.00e+00 | 2.012 | 2 | 15 | 596 |
GO:0005524 | ATP binding | 8.65e-02 | 1.00e+00 | 1.474 | 3 | 31 | 1298 |
GO:0097190 | apoptotic signaling pathway | 9.01e-02 | 1.00e+00 | 3.411 | 1 | 3 | 113 |
GO:0000209 | protein polyubiquitination | 9.24e-02 | 1.00e+00 | 3.373 | 1 | 3 | 116 |
GO:0032496 | response to lipopolysaccharide | 9.62e-02 | 1.00e+00 | 3.312 | 1 | 4 | 121 |
GO:0007050 | cell cycle arrest | 9.85e-02 | 1.00e+00 | 3.277 | 1 | 5 | 124 |
GO:0030027 | lamellipodium | 9.92e-02 | 1.00e+00 | 3.265 | 1 | 7 | 125 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.01e-01 | 1.00e+00 | 3.231 | 1 | 11 | 128 |
GO:0045202 | synapse | 1.08e-01 | 1.00e+00 | 3.144 | 1 | 5 | 136 |
GO:0016055 | Wnt signaling pathway | 1.09e-01 | 1.00e+00 | 3.123 | 1 | 4 | 138 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 1.12e-01 | 1.00e+00 | 1.782 | 2 | 39 | 699 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 1.14e-01 | 1.00e+00 | 3.051 | 1 | 4 | 145 |
GO:0001666 | response to hypoxia | 1.17e-01 | 1.00e+00 | 3.012 | 1 | 7 | 149 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.17e-01 | 1.00e+00 | 3.012 | 1 | 3 | 149 |
GO:0042981 | regulation of apoptotic process | 1.18e-01 | 1.00e+00 | 3.002 | 1 | 4 | 150 |
GO:0046777 | protein autophosphorylation | 1.24e-01 | 1.00e+00 | 2.927 | 1 | 4 | 158 |
GO:0030424 | axon | 1.30e-01 | 1.00e+00 | 2.856 | 1 | 4 | 166 |
GO:0005768 | endosome | 1.32e-01 | 1.00e+00 | 2.830 | 1 | 3 | 169 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.33e-01 | 1.00e+00 | 2.813 | 1 | 2 | 171 |
GO:0016607 | nuclear speck | 1.34e-01 | 1.00e+00 | 2.805 | 1 | 12 | 172 |
GO:0005667 | transcription factor complex | 1.36e-01 | 1.00e+00 | 2.780 | 1 | 17 | 175 |
GO:0009897 | external side of plasma membrane | 1.38e-01 | 1.00e+00 | 2.764 | 1 | 3 | 177 |
GO:0004672 | protein kinase activity | 1.38e-01 | 1.00e+00 | 2.764 | 1 | 3 | 177 |
GO:0031625 | ubiquitin protein ligase binding | 1.38e-01 | 1.00e+00 | 2.755 | 1 | 5 | 178 |
GO:0032403 | protein complex binding | 1.42e-01 | 1.00e+00 | 2.715 | 1 | 6 | 183 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.43e-01 | 1.00e+00 | 2.708 | 1 | 22 | 184 |
GO:0007173 | epidermal growth factor receptor signaling pathway | 1.46e-01 | 1.00e+00 | 2.669 | 1 | 5 | 189 |
GO:0001525 | angiogenesis | 1.48e-01 | 1.00e+00 | 2.654 | 1 | 7 | 191 |
GO:0016020 | membrane | 1.56e-01 | 1.00e+00 | 1.101 | 3 | 46 | 1681 |
GO:0030168 | platelet activation | 1.58e-01 | 1.00e+00 | 2.552 | 1 | 6 | 205 |
GO:0005887 | integral component of plasma membrane | 1.66e-01 | 1.00e+00 | 1.437 | 2 | 10 | 888 |
GO:0019221 | cytokine-mediated signaling pathway | 1.69e-01 | 1.00e+00 | 2.443 | 1 | 8 | 221 |
GO:0016071 | mRNA metabolic process | 1.71e-01 | 1.00e+00 | 2.430 | 1 | 8 | 223 |
GO:0003713 | transcription coactivator activity | 1.80e-01 | 1.00e+00 | 2.342 | 1 | 24 | 237 |
GO:0016070 | RNA metabolic process | 1.87e-01 | 1.00e+00 | 2.283 | 1 | 8 | 247 |
GO:0000166 | nucleotide binding | 1.95e-01 | 1.00e+00 | 2.214 | 1 | 13 | 259 |
GO:0006955 | immune response | 2.15e-01 | 1.00e+00 | 2.061 | 1 | 1 | 288 |
GO:0005856 | cytoskeleton | 2.17e-01 | 1.00e+00 | 2.046 | 1 | 9 | 291 |
GO:0043234 | protein complex | 2.20e-01 | 1.00e+00 | 2.027 | 1 | 11 | 295 |
GO:0035556 | intracellular signal transduction | 2.25e-01 | 1.00e+00 | 1.988 | 1 | 9 | 303 |
GO:0004674 | protein serine/threonine kinase activity | 2.28e-01 | 1.00e+00 | 1.964 | 1 | 6 | 308 |
GO:0015031 | protein transport | 2.50e-01 | 1.00e+00 | 1.817 | 1 | 11 | 341 |
GO:0000139 | Golgi membrane | 2.62e-01 | 1.00e+00 | 1.735 | 1 | 7 | 361 |
GO:0005925 | focal adhesion | 2.65e-01 | 1.00e+00 | 1.715 | 1 | 9 | 366 |
GO:0007155 | cell adhesion | 2.67e-01 | 1.00e+00 | 1.704 | 1 | 5 | 369 |
GO:0046982 | protein heterodimerization activity | 2.74e-01 | 1.00e+00 | 1.661 | 1 | 8 | 380 |
GO:0000278 | mitotic cell cycle | 2.81e-01 | 1.00e+00 | 1.620 | 1 | 15 | 391 |
GO:0045892 | negative regulation of transcription, DNA-templated | 2.94e-01 | 1.00e+00 | 1.541 | 1 | 24 | 413 |
GO:0007596 | blood coagulation | 3.19e-01 | 1.00e+00 | 1.401 | 1 | 11 | 455 |
GO:0006468 | protein phosphorylation | 3.22e-01 | 1.00e+00 | 1.386 | 1 | 10 | 460 |
GO:0044267 | cellular protein metabolic process | 3.30e-01 | 1.00e+00 | 1.342 | 1 | 20 | 474 |
GO:0045893 | positive regulation of transcription, DNA-templated | 3.33e-01 | 1.00e+00 | 1.330 | 1 | 24 | 478 |
GO:0048471 | perinuclear region of cytoplasm | 3.46e-01 | 1.00e+00 | 1.260 | 1 | 8 | 502 |
GO:0007165 | signal transduction | 5.41e-01 | 1.00e+00 | 0.406 | 1 | 13 | 907 |
GO:0005576 | extracellular region | 5.56e-01 | 1.00e+00 | 0.352 | 1 | 13 | 942 |
GO:0005615 | extracellular space | 5.61e-01 | 1.00e+00 | 0.329 | 1 | 20 | 957 |
GO:0008270 | zinc ion binding | 5.77e-01 | 1.00e+00 | 0.270 | 1 | 27 | 997 |
GO:0005739 | mitochondrion | 5.77e-01 | 1.00e+00 | 0.268 | 1 | 23 | 998 |
GO:0070062 | extracellular vesicular exosome | 6.18e-01 | 1.00e+00 | 0.002 | 2 | 57 | 2400 |
GO:0044281 | small molecule metabolic process | 6.51e-01 | 1.00e+00 | -0.011 | 1 | 20 | 1211 |
GO:0005730 | nucleolus | 7.65e-01 | 1.00e+00 | -0.449 | 1 | 66 | 1641 |