int-snw-640

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.915 2.22e-16 1.79e-04 1.68e-03
chia-screen-data-Fav-int-snw-640 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
[ BLK ] 640 1-1.3592.91517--
PSMD2 5708 47-4.1723.157386YesYes
PXN 5829 19-2.5543.193206YesYes
MS4A2 2206 2-2.1823.0679Yes-
TNFRSF1A 7132 2-1.8462.915166--
YAP1 10413 94-4.2563.53853Yes-
SRSF3 6428 73-2.9923.53854Yes-
MVP 9961 16-2.8463.19320YesYes
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
SYK 6850 2-1.9343.067115--
DDIT3 1649 60-2.8253.504343YesYes

Interactions (12)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
BLK 640 SYK 6850 pp -- int.I2D: INNATEDB_Mouse
PXN 5829 SRSF3 6428 pp -- int.I2D: BIND
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
HNRNPU 3192 SYK 6850 pp -- int.I2D: BCI, HPRD;
int.HPRD: in vitro
SYK 6850 TNFRSF1A 7132 pp -- int.I2D: HPRD;
int.HPRD: in vivo
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
PXN 5829 MVP 9961 pp -- int.I2D: BIND
PXN 5829 SYK 6850 pp -- int.I2D: BioGrid, BCI, HPRD;
int.HPRD: in vitro, in vivo
PSMD2 5708 TNFRSF1A 7132 pp -- int.I2D: BioGrid, BCI, HPRD;
int.HPRD: in vitro, yeast 2-hybrid
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
MS4A2 2206 SYK 6850 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vitro, in vivo

Related GO terms (266)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0043306positive regulation of mast cell degranulation2.28e-053.28e-018.061229
GO:0042789mRNA transcription from RNA polymerase II promoter4.92e-057.10e-017.5312213
GO:0019901protein kinase binding9.86e-051.00e+003.923418317
GO:0005654nucleoplasm1.10e-041.00e+002.7376641082
GO:0018108peptidyl-tyrosine phosphorylation1.55e-041.00e+004.77234132
GO:0050853B cell receptor signaling pathway2.54e-041.00e+006.3732229
GO:0044212transcription regulatory region DNA binding3.16e-041.00e+004.424317168
GO:0005515protein binding4.97e-041.00e+001.134111986024
GO:0004715non-membrane spanning protein tyrosine kinase activity5.36e-041.00e+005.8392342
GO:0043525positive regulation of neuron apoptotic process6.44e-041.00e+005.7082446
GO:0009611response to wounding8.22e-041.00e+005.5312552
GO:2000016negative regulation of determination of dorsal identity8.32e-041.00e+0010.231111
GO:0023057negative regulation of signaling8.32e-041.00e+0010.231111
GO:0051435BH4 domain binding8.32e-041.00e+0010.231111
GO:0090308regulation of methylation-dependent chromatin silencing8.32e-041.00e+0010.231111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway8.32e-041.00e+0010.231111
GO:0060965negative regulation of gene silencing by miRNA8.32e-041.00e+0010.231111
GO:0071226cellular response to molecule of fungal origin8.32e-041.00e+0010.231111
GO:0060795cell fate commitment involved in formation of primary germ layer8.32e-041.00e+0010.231111
GO:0032928regulation of superoxide anion generation8.32e-041.00e+0010.231111
GO:0042991transcription factor import into nucleus8.32e-041.00e+0010.231111
GO:0072376protein activation cascade8.32e-041.00e+0010.231111
GO:0090237regulation of arachidonic acid secretion8.32e-041.00e+0010.231111
GO:0033013tetrapyrrole metabolic process8.32e-041.00e+0010.231111
GO:0042742defense response to bacterium1.09e-031.00e+005.3242560
GO:0060242contact inhibition1.66e-031.00e+009.231112
GO:0032998Fc-epsilon receptor I complex1.66e-031.00e+009.231112
GO:0009786regulation of asymmetric cell division1.66e-031.00e+009.231112
GO:0045401positive regulation of interleukin-3 biosynthetic process1.66e-031.00e+009.231112
GO:0043366beta selection1.66e-031.00e+009.231112
GO:0002366leukocyte activation involved in immune response1.66e-031.00e+009.231112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.66e-031.00e+009.231112
GO:0043120tumor necrosis factor binding1.66e-031.00e+009.231112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.66e-031.00e+009.231112
GO:0043313regulation of neutrophil degranulation1.66e-031.00e+009.231112
GO:0010467gene expression1.68e-031.00e+002.845445669
GO:0007229integrin-mediated signaling pathway1.84e-031.00e+004.9462378
GO:0004713protein tyrosine kinase activity2.03e-031.00e+004.8742382
GO:0008283cell proliferation2.20e-031.00e+003.459314328
GO:0002554serotonin secretion by platelet2.49e-031.00e+008.646113
GO:0019767IgE receptor activity2.49e-031.00e+008.646113
GO:0060913cardiac cell fate determination2.49e-031.00e+008.646113
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process2.49e-031.00e+008.646113
GO:0002283neutrophil activation involved in immune response2.49e-031.00e+008.646113
GO:0019815B cell receptor complex2.49e-031.00e+008.646113
GO:0003130BMP signaling pathway involved in heart induction2.49e-031.00e+008.646113
GO:0005178integrin binding2.77e-031.00e+004.6462496
GO:0010543regulation of platelet activation3.32e-031.00e+008.231114
GO:0032009early phagosome3.32e-031.00e+008.231114
GO:0038127ERBB signaling pathway3.32e-031.00e+008.231114
GO:0090330regulation of platelet aggregation3.32e-031.00e+008.231114
GO:0030529ribonucleoprotein complex3.75e-031.00e+004.42425112
GO:0001714endodermal cell fate specification4.15e-031.00e+007.909115
GO:0019863IgE binding4.15e-031.00e+007.909115
GO:0043620regulation of DNA-templated transcription in response to stress4.15e-031.00e+007.909115
GO:0070934CRD-mediated mRNA stabilization4.15e-031.00e+007.909125
GO:0043279response to alkaloid4.15e-031.00e+007.909125
GO:0045588positive regulation of gamma-delta T cell differentiation4.15e-031.00e+007.909115
GO:0070937CRD-mediated mRNA stability complex4.98e-031.00e+007.646136
GO:0001945lymph vessel development4.98e-031.00e+007.646116
GO:0050764regulation of phagocytosis4.98e-031.00e+007.646116
GO:0002281macrophage activation involved in immune response4.98e-031.00e+007.646116
GO:0061099negative regulation of protein tyrosine kinase activity5.81e-031.00e+007.424117
GO:0050663cytokine secretion5.81e-031.00e+007.424117
GO:0001955blood vessel maturation6.64e-031.00e+007.231118
GO:0051279regulation of release of sequestered calcium ion into cytosol6.64e-031.00e+007.231118
GO:0007172signal complex assembly6.64e-031.00e+007.231118
GO:0060396growth hormone receptor signaling pathway6.64e-031.00e+007.231118
GO:0006974cellular response to DNA damage stimulus6.71e-031.00e+003.99327151
GO:0045121membrane raft7.15e-031.00e+003.94623156
GO:0031953negative regulation of protein autophosphorylation7.47e-031.00e+007.061119
GO:0006693prostaglandin metabolic process7.47e-031.00e+007.061119
GO:0004716receptor signaling protein tyrosine kinase activity7.47e-031.00e+007.061119
GO:0046638positive regulation of alpha-beta T cell differentiation7.47e-031.00e+007.061119
GO:0042511positive regulation of tyrosine phosphorylation of Stat1 protein7.47e-031.00e+007.061119
GO:0006983ER overload response7.47e-031.00e+007.061119
GO:0007167enzyme linked receptor protein signaling pathway7.47e-031.00e+007.061119
GO:0005031tumor necrosis factor-activated receptor activity7.47e-031.00e+007.061119
GO:0000398mRNA splicing, via spliceosome7.87e-031.00e+003.874215164
GO:0038095Fc-epsilon receptor signaling pathway8.24e-031.00e+003.83925168
GO:0045579positive regulation of B cell differentiation8.29e-031.00e+006.9091110
GO:0035413positive regulation of catenin import into nucleus8.29e-031.00e+006.9091210
GO:0046641positive regulation of alpha-beta T cell proliferation8.29e-031.00e+006.9091110
GO:0016032viral process8.65e-031.00e+002.755326534
GO:0045662negative regulation of myoblast differentiation9.12e-031.00e+006.7721311
GO:0017166vinculin binding9.12e-031.00e+006.7721111
GO:0033630positive regulation of cell adhesion mediated by integrin9.12e-031.00e+006.7721111
GO:0045780positive regulation of bone resorption9.12e-031.00e+006.7721111
GO:0033160positive regulation of protein import into nucleus, translocation9.12e-031.00e+006.7721311
GO:0060391positive regulation of SMAD protein import into nucleus9.12e-031.00e+006.7721411
GO:0003714transcription corepressor activity9.22e-031.00e+003.755211178
GO:0005829cytosol9.54e-031.00e+001.5316862496
GO:0005838proteasome regulatory particle9.94e-031.00e+006.6461112
GO:0035198miRNA binding9.94e-031.00e+006.6461112
GO:0071480cellular response to gamma radiation1.08e-021.00e+006.5311113
GO:0042101T cell receptor complex1.08e-021.00e+006.5311113
GO:0019370leukotriene biosynthetic process1.08e-021.00e+006.5311113
GO:0030234enzyme regulator activity1.08e-021.00e+006.5311213
GO:0034614cellular response to reactive oxygen species1.16e-021.00e+006.4241214
GO:0001824blastocyst development1.24e-021.00e+006.3241215
GO:0042176regulation of protein catabolic process1.32e-021.00e+006.2311216
GO:0043274phospholipase binding1.32e-021.00e+006.2311116
GO:0005634nucleus1.33e-021.00e+001.07781594559
GO:0070372regulation of ERK1 and ERK2 cascade1.41e-021.00e+006.1441217
GO:0048514blood vessel morphogenesis1.41e-021.00e+006.1441117
GO:0022624proteasome accessory complex1.41e-021.00e+006.1441117
GO:0008380RNA splicing1.48e-021.00e+003.398222228
GO:0071392cellular response to estradiol stimulus1.49e-021.00e+006.0611218
GO:0050850positive regulation of calcium-mediated signaling1.57e-021.00e+005.9831119
GO:0032757positive regulation of interleukin-8 production1.65e-021.00e+005.9091120
GO:0051090regulation of sequence-specific DNA binding transcription factor activity1.65e-021.00e+005.9091320
GO:0032715negative regulation of interleukin-6 production1.65e-021.00e+005.9091120
GO:0008134transcription factor binding1.66e-021.00e+003.312218242
GO:0048041focal adhesion assembly1.73e-021.00e+005.8391121
GO:0050715positive regulation of cytokine secretion1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721222
GO:0043200response to amino acid1.90e-021.00e+005.7081123
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.90e-021.00e+005.7081123
GO:0035329hippo signaling2.14e-021.00e+005.5311526
GO:0006954inflammatory response2.14e-021.00e+003.11726277
GO:0051209release of sequestered calcium ion into cytosol2.14e-021.00e+005.5311126
GO:0048754branching morphogenesis of an epithelial tube2.22e-021.00e+005.4761127
GO:0007159leukocyte cell-cell adhesion2.22e-021.00e+005.4761127
GO:0033209tumor necrosis factor-mediated signaling pathway2.31e-021.00e+005.4241128
GO:0005875microtubule associated complex2.31e-021.00e+005.4241128
GO:0002250adaptive immune response2.31e-021.00e+005.4241128
GO:0030032lamellipodium assembly2.39e-021.00e+005.3731129
GO:0042169SH2 domain binding2.47e-021.00e+005.3241230
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.48e-021.00e+002.192341789
GO:0042594response to starvation2.55e-021.00e+005.2771431
GO:0051219phosphoprotein binding2.63e-021.00e+005.2311132
GO:1903507negative regulation of nucleic acid-templated transcription2.63e-021.00e+005.2311232
GO:0032024positive regulation of insulin secretion2.71e-021.00e+005.1871333
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors2.79e-021.00e+005.1441134
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway2.87e-021.00e+005.1021235
GO:0007257activation of JUN kinase activity2.96e-021.00e+005.0611536
GO:0034446substrate adhesion-dependent cell spreading2.96e-021.00e+005.0611236
GO:0032760positive regulation of tumor necrosis factor production3.04e-021.00e+005.0221237
GO:0003723RNA binding3.16e-021.00e+002.813218342
GO:0043565sequence-specific DNA binding3.23e-021.00e+002.796211346
GO:0035019somatic stem cell maintenance3.28e-021.00e+004.9091640
GO:0030593neutrophil chemotaxis3.36e-021.00e+004.8741241
GO:0031124mRNA 3'-end processing3.44e-021.00e+004.8391242
GO:0006369termination of RNA polymerase II transcription3.68e-021.00e+004.7391245
GO:0050729positive regulation of inflammatory response3.92e-021.00e+004.6461248
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage4.00e-021.00e+004.6161249
GO:0006521regulation of cellular amino acid metabolic process4.08e-021.00e+004.5871150
GO:0006986response to unfolded protein4.08e-021.00e+004.5871450
GO:0034976response to endoplasmic reticulum stress4.16e-021.00e+004.5591251
GO:0045454cell redox homeostasis4.16e-021.00e+004.5591151
GO:0051028mRNA transport4.24e-021.00e+004.5311452
GO:0009986cell surface4.25e-021.00e+002.58029402
GO:0007202activation of phospholipase C activity4.48e-021.00e+004.4501155
GO:0001725stress fiber4.48e-021.00e+004.4501455
GO:0006355regulation of transcription, DNA-templated4.53e-021.00e+001.855343997
GO:0051291protein heterooligomerization4.56e-021.00e+004.4241456
GO:0050728negative regulation of inflammatory response4.56e-021.00e+004.4241356
GO:0006366transcription from RNA polymerase II promoter4.58e-021.00e+002.520230419
GO:0005643nuclear pore4.64e-021.00e+004.39811157
GO:0043066negative regulation of apoptotic process4.68e-021.00e+002.503216424
GO:0000502proteasome complex4.72e-021.00e+004.3731358
GO:0005886plasma membrane4.78e-021.00e+001.2195492582
GO:0006396RNA processing4.80e-021.00e+004.3481559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.80e-021.00e+004.3481659
GO:0008013beta-catenin binding4.88e-021.00e+004.3241960
GO:0006987activation of signaling protein activity involved in unfolded protein response4.96e-021.00e+004.3001261
GO:0006406mRNA export from nucleus4.96e-021.00e+004.3001461
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771262
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.20e-021.00e+004.2311164
GO:0044822poly(A) RNA binding5.23e-021.00e+001.7723501056
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.28e-021.00e+004.2091265
GO:0071260cellular response to mechanical stimulus5.28e-021.00e+004.2091465
GO:0010468regulation of gene expression5.52e-021.00e+004.1441268
GO:0034329cell junction assembly5.52e-021.00e+004.1441368
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.67e-021.00e+004.1021270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.83e-021.00e+004.0611172
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221274
GO:0002020protease binding5.99e-021.00e+004.0221674
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.99e-021.00e+004.0221474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.99e-021.00e+004.0221274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021175
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation6.07e-021.00e+004.0021275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.07e-021.00e+004.0021175
GO:0010629negative regulation of gene expression6.22e-021.00e+003.9641477
GO:0071013catalytic step 2 spliceosome6.30e-021.00e+003.9461778
GO:0030968endoplasmic reticulum unfolded protein response6.38e-021.00e+003.9271279
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.38e-021.00e+003.9271279
GO:0005737cytoplasm6.58e-021.00e+000.93761243767
GO:0009653anatomical structure morphogenesis6.69e-021.00e+003.8561283
GO:0009887organ morphogenesis6.93e-021.00e+003.8051586
GO:0090090negative regulation of canonical Wnt signaling pathway6.93e-021.00e+003.8051886
GO:0045471response to ethanol6.93e-021.00e+003.8051386
GO:0006936muscle contraction7.01e-021.00e+003.7881387
GO:0045766positive regulation of angiogenesis7.08e-021.00e+003.7721288
GO:0000187activation of MAPK activity7.24e-021.00e+003.7391390
GO:0007010cytoskeleton organization7.32e-021.00e+003.7231491
GO:0006928cellular component movement7.32e-021.00e+003.7231391
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.39e-021.00e+003.7081192
GO:0001649osteoblast differentiation7.39e-021.00e+003.7081592
GO:0003677DNA binding7.43e-021.00e+001.5663491218
GO:0005770late endosome7.47e-021.00e+003.6921293
GO:0006915apoptotic process7.56e-021.00e+002.115212555
GO:0043235receptor complex7.94e-021.00e+003.6021299
GO:0008360regulation of cell shape8.24e-021.00e+003.54514103
GO:0005938cell cortex8.32e-021.00e+003.53115104
GO:0045087innate immune response8.56e-021.00e+002.012215596
GO:0005524ATP binding8.65e-021.00e+001.4743311298
GO:0097190apoptotic signaling pathway9.01e-021.00e+003.41113113
GO:0000209protein polyubiquitination9.24e-021.00e+003.37313116
GO:0032496response to lipopolysaccharide9.62e-021.00e+003.31214121
GO:0007050cell cycle arrest9.85e-021.00e+003.27715124
GO:0030027lamellipodium9.92e-021.00e+003.26517125
GO:0007179transforming growth factor beta receptor signaling pathway1.01e-011.00e+003.231111128
GO:0045202synapse1.08e-011.00e+003.14415136
GO:0016055Wnt signaling pathway1.09e-011.00e+003.12314138
GO:0003700sequence-specific DNA binding transcription factor activity1.12e-011.00e+001.782239699
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling1.14e-011.00e+003.05114145
GO:0001666response to hypoxia1.17e-011.00e+003.01217149
GO:0000082G1/S transition of mitotic cell cycle1.17e-011.00e+003.01213149
GO:0042981regulation of apoptotic process1.18e-011.00e+003.00214150
GO:0046777protein autophosphorylation1.24e-011.00e+002.92714158
GO:0030424axon1.30e-011.00e+002.85614166
GO:0005768endosome1.32e-011.00e+002.83013169
GO:0034641cellular nitrogen compound metabolic process1.33e-011.00e+002.81312171
GO:0016607nuclear speck1.34e-011.00e+002.805112172
GO:0005667transcription factor complex1.36e-011.00e+002.780117175
GO:0009897external side of plasma membrane1.38e-011.00e+002.76413177
GO:0004672protein kinase activity1.38e-011.00e+002.76413177
GO:0031625ubiquitin protein ligase binding1.38e-011.00e+002.75515178
GO:0032403protein complex binding1.42e-011.00e+002.71516183
GO:0006367transcription initiation from RNA polymerase II promoter1.43e-011.00e+002.708122184
GO:0007173epidermal growth factor receptor signaling pathway1.46e-011.00e+002.66915189
GO:0001525angiogenesis1.48e-011.00e+002.65417191
GO:0016020membrane1.56e-011.00e+001.1013461681
GO:0030168platelet activation1.58e-011.00e+002.55216205
GO:0005887integral component of plasma membrane1.66e-011.00e+001.437210888
GO:0019221cytokine-mediated signaling pathway1.69e-011.00e+002.44318221
GO:0016071mRNA metabolic process1.71e-011.00e+002.43018223
GO:0003713transcription coactivator activity1.80e-011.00e+002.342124237
GO:0016070RNA metabolic process1.87e-011.00e+002.28318247
GO:0000166nucleotide binding1.95e-011.00e+002.214113259
GO:0006955immune response2.15e-011.00e+002.06111288
GO:0005856cytoskeleton2.17e-011.00e+002.04619291
GO:0043234protein complex2.20e-011.00e+002.027111295
GO:0035556intracellular signal transduction2.25e-011.00e+001.98819303
GO:0004674protein serine/threonine kinase activity2.28e-011.00e+001.96416308
GO:0015031protein transport2.50e-011.00e+001.817111341
GO:0000139Golgi membrane2.62e-011.00e+001.73517361
GO:0005925focal adhesion2.65e-011.00e+001.71519366
GO:0007155cell adhesion2.67e-011.00e+001.70415369
GO:0046982protein heterodimerization activity2.74e-011.00e+001.66118380
GO:0000278mitotic cell cycle2.81e-011.00e+001.620115391
GO:0045892negative regulation of transcription, DNA-templated2.94e-011.00e+001.541124413
GO:0007596blood coagulation3.19e-011.00e+001.401111455
GO:0006468protein phosphorylation3.22e-011.00e+001.386110460
GO:0044267cellular protein metabolic process3.30e-011.00e+001.342120474
GO:0045893positive regulation of transcription, DNA-templated3.33e-011.00e+001.330124478
GO:0048471perinuclear region of cytoplasm3.46e-011.00e+001.26018502
GO:0007165signal transduction5.41e-011.00e+000.406113907
GO:0005576extracellular region5.56e-011.00e+000.352113942
GO:0005615extracellular space5.61e-011.00e+000.329120957
GO:0008270zinc ion binding5.77e-011.00e+000.270127997
GO:0005739mitochondrion5.77e-011.00e+000.268123998
GO:0070062extracellular vesicular exosome6.18e-011.00e+000.0022572400
GO:0044281small molecule metabolic process6.51e-011.00e+00-0.0111201211
GO:0005730nucleolus7.65e-011.00e+00-0.4491661641