int-snw-58

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.062	4.78e-18	2.43e-05	4.08e-04

chia-screen-data-Fav-int-snw-58 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
YAP1	10413	94	-4.256	3.538	53	Yes	-
EP300	2033	22	-2.274	3.120	415	Yes	Yes
ACTR1B	10120	2	-2.320	3.062	19	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
ANXA4	307	7	-2.478	3.062	15	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ ACTA1 ]	58	3	-2.128	3.062	180	Yes	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTA1	58	POU5F1	5460	pp	--	int.I2D: BioGrid
EP300	2033	YAP1	10413	pp	--	int.I2D: BioGrid
ACTA1	58	ACTR1B	10120	pp	--	int.I2D: HPRD; int.HPRD: in vitro
ACTA1	58	EP300	2033	pp	--	int.I2D: BioGrid
ACTA1	58	ANXA4	307	pp	--	int.I2D: IntAct_Mouse
DDIT3	1649	EP300	2033	pp	--	int.Intact: MI:0915(physical association)
ACTA1	58	DDIT3	1649	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (212)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.57e-05	2.27e-01	8.308	2	2	13
GO:0044212	transcription regulatory region DNA binding	5.25e-05	7.57e-01	5.201	3	17	168
GO:0051059	NF-kappaB binding	6.03e-05	8.69e-01	7.365	2	3	25
GO:0008134	transcription factor binding	1.55e-04	1.00e+00	4.675	3	18	242
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060177	regulation of angiotensin metabolic process	4.85e-04	1.00e+00	11.009	1	1	1
GO:1901985	positive regulation of protein acetylation	4.85e-04	1.00e+00	11.009	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0043969	histone H2B acetylation	4.85e-04	1.00e+00	11.009	1	1	1
GO:2000629	negative regulation of miRNA metabolic process	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0006355	regulation of transcription, DNA-templated	6.71e-04	1.00e+00	3.047	4	43	997
GO:0005654	nucleoplasm	9.17e-04	1.00e+00	2.929	4	64	1082
GO:0060242	contact inhibition	9.70e-04	1.00e+00	10.009	1	1	2
GO:0014737	positive regulation of muscle atrophy	9.70e-04	1.00e+00	10.009	1	1	2
GO:2000483	negative regulation of interleukin-8 secretion	9.70e-04	1.00e+00	10.009	1	1	2
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0090043	regulation of tubulin deacetylation	9.70e-04	1.00e+00	10.009	1	2	2
GO:0035984	cellular response to trichostatin A	9.70e-04	1.00e+00	10.009	1	1	2
GO:0071389	cellular response to mineralocorticoid stimulus	9.70e-04	1.00e+00	10.009	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	9.70e-04	1.00e+00	10.009	1	1	2
GO:0043503	skeletal muscle fiber adaptation	9.70e-04	1.00e+00	10.009	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	9.70e-04	1.00e+00	10.009	1	1	2
GO:0018076	N-terminal peptidyl-lysine acetylation	1.46e-03	1.00e+00	9.424	1	1	3
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0010560	positive regulation of glycoprotein biosynthetic process	1.46e-03	1.00e+00	9.424	1	1	3
GO:0097157	pre-mRNA intronic binding	1.94e-03	1.00e+00	9.009	1	1	4
GO:0018393	internal peptidyl-lysine acetylation	1.94e-03	1.00e+00	9.009	1	1	4
GO:0009991	response to extracellular stimulus	1.94e-03	1.00e+00	9.009	1	1	4
GO:0006974	cellular response to DNA damage stimulus	2.21e-03	1.00e+00	4.770	2	7	151
GO:0005829	cytosol	2.38e-03	1.00e+00	2.045	5	86	2496
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0030240	skeletal muscle thin filament assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:0065004	protein-DNA complex assembly	2.42e-03	1.00e+00	8.687	1	1	5
GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	2.42e-03	1.00e+00	8.687	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.42e-03	1.00e+00	8.687	1	1	5
GO:0060298	positive regulation of sarcomere organization	2.42e-03	1.00e+00	8.687	1	1	5
GO:0032025	response to cobalt ion	2.42e-03	1.00e+00	8.687	1	1	5
GO:0004859	phospholipase inhibitor activity	2.91e-03	1.00e+00	8.424	1	1	6
GO:0005865	striated muscle thin filament	2.91e-03	1.00e+00	8.424	1	1	6
GO:0005667	transcription factor complex	2.95e-03	1.00e+00	4.558	2	17	175
GO:0003714	transcription corepressor activity	3.05e-03	1.00e+00	4.533	2	11	178
GO:0006475	internal protein amino acid acetylation	3.39e-03	1.00e+00	8.201	1	1	7
GO:0003700	sequence-specific DNA binding transcription factor activity	3.43e-03	1.00e+00	3.145	3	39	699
GO:0001955	blood vessel maturation	3.88e-03	1.00e+00	8.009	1	1	8
GO:0005869	dynactin complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0060765	regulation of androgen receptor signaling pathway	4.36e-03	1.00e+00	7.839	1	1	9
GO:0006983	ER overload response	4.36e-03	1.00e+00	7.839	1	1	9
GO:0035259	glucocorticoid receptor binding	4.36e-03	1.00e+00	7.839	1	1	9
GO:0045793	positive regulation of cell size	4.36e-03	1.00e+00	7.839	1	2	9
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.83e-03	1.00e+00	2.970	3	41	789
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0016407	acetyltransferase activity	4.84e-03	1.00e+00	7.687	1	2	10
GO:0010226	response to lithium ion	4.84e-03	1.00e+00	7.687	1	2	10
GO:0043923	positive regulation by host of viral transcription	5.33e-03	1.00e+00	7.549	1	1	11
GO:0033160	positive regulation of protein import into nucleus, translocation	5.33e-03	1.00e+00	7.549	1	3	11
GO:0045662	negative regulation of myoblast differentiation	5.33e-03	1.00e+00	7.549	1	3	11
GO:0042975	peroxisome proliferator activated receptor binding	5.33e-03	1.00e+00	7.549	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0003713	transcription coactivator activity	5.35e-03	1.00e+00	4.120	2	24	237
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0048545	response to steroid hormone	6.29e-03	1.00e+00	7.308	1	1	13
GO:0071480	cellular response to gamma radiation	6.29e-03	1.00e+00	7.308	1	1	13
GO:0051019	mitogen-activated protein kinase binding	6.29e-03	1.00e+00	7.308	1	2	13
GO:0016746	transferase activity, transferring acyl groups	6.29e-03	1.00e+00	7.308	1	1	13
GO:0070542	response to fatty acid	6.78e-03	1.00e+00	7.201	1	1	14
GO:0032993	protein-DNA complex	6.78e-03	1.00e+00	7.201	1	2	14
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:1990090	cellular response to nerve growth factor stimulus	7.26e-03	1.00e+00	7.102	1	1	15
GO:0048741	skeletal muscle fiber development	7.74e-03	1.00e+00	7.009	1	1	16
GO:0017022	myosin binding	8.22e-03	1.00e+00	6.921	1	2	17
GO:0012506	vesicle membrane	8.22e-03	1.00e+00	6.921	1	1	17
GO:0045773	positive regulation of axon extension	8.71e-03	1.00e+00	6.839	1	1	18
GO:0033613	activating transcription factor binding	8.71e-03	1.00e+00	6.839	1	3	18
GO:0035257	nuclear hormone receptor binding	9.19e-03	1.00e+00	6.761	1	1	19
GO:0071549	cellular response to dexamethasone stimulus	9.67e-03	1.00e+00	6.687	1	3	20
GO:0010942	positive regulation of cell death	9.67e-03	1.00e+00	6.687	1	1	20
GO:0032757	positive regulation of interleukin-8 production	9.67e-03	1.00e+00	6.687	1	1	20
GO:0000123	histone acetyltransferase complex	1.01e-02	1.00e+00	6.616	1	6	21
GO:0032967	positive regulation of collagen biosynthetic process	1.01e-02	1.00e+00	6.616	1	3	21
GO:0045862	positive regulation of proteolysis	1.01e-02	1.00e+00	6.616	1	2	21
GO:0003823	antigen binding	1.06e-02	1.00e+00	6.549	1	2	22
GO:0043565	sequence-specific DNA binding	1.11e-02	1.00e+00	3.574	2	11	346
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.11e-02	1.00e+00	6.485	1	1	23
GO:0043388	positive regulation of DNA binding	1.16e-02	1.00e+00	6.424	1	2	24
GO:0043425	bHLH transcription factor binding	1.16e-02	1.00e+00	6.424	1	1	24
GO:0035329	hippo signaling	1.26e-02	1.00e+00	6.308	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.26e-02	1.00e+00	6.308	1	1	26
GO:0048565	digestive tract development	1.26e-02	1.00e+00	6.308	1	2	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.26e-02	1.00e+00	6.308	1	1	26
GO:0034612	response to tumor necrosis factor	1.30e-02	1.00e+00	6.254	1	2	27
GO:0043967	histone H4 acetylation	1.30e-02	1.00e+00	6.254	1	1	27
GO:0043531	ADP binding	1.35e-02	1.00e+00	6.201	1	3	28
GO:0050714	positive regulation of protein secretion	1.35e-02	1.00e+00	6.201	1	3	28
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	1.45e-02	1.00e+00	6.102	1	1	30
GO:0005544	calcium-dependent phospholipid binding	1.45e-02	1.00e+00	6.102	1	1	30
GO:0042594	response to starvation	1.50e-02	1.00e+00	6.055	1	4	31
GO:0043491	protein kinase B signaling	1.54e-02	1.00e+00	6.009	1	2	32
GO:1903507	negative regulation of nucleic acid-templated transcription	1.54e-02	1.00e+00	6.009	1	2	32
GO:0005737	cytoplasm	1.56e-02	1.00e+00	1.451	5	124	3767
GO:0071333	cellular response to glucose stimulus	1.59e-02	1.00e+00	5.964	1	1	33
GO:0001756	somitogenesis	1.59e-02	1.00e+00	5.964	1	1	33
GO:0003677	DNA binding	1.62e-02	1.00e+00	2.343	3	49	1218
GO:0030017	sarcomere	1.64e-02	1.00e+00	5.921	1	2	34
GO:0001102	RNA polymerase II activating transcription factor binding	1.73e-02	1.00e+00	5.839	1	1	36
GO:0030049	muscle filament sliding	1.83e-02	1.00e+00	5.761	1	3	38
GO:0032092	positive regulation of protein binding	1.83e-02	1.00e+00	5.761	1	2	38
GO:0031490	chromatin DNA binding	1.83e-02	1.00e+00	5.761	1	2	38
GO:0050681	androgen receptor binding	1.83e-02	1.00e+00	5.761	1	1	38
GO:0035019	somatic stem cell maintenance	1.93e-02	1.00e+00	5.687	1	6	40
GO:0007519	skeletal muscle tissue development	1.93e-02	1.00e+00	5.687	1	2	40
GO:0046332	SMAD binding	1.93e-02	1.00e+00	5.687	1	2	40
GO:0071320	cellular response to cAMP	1.93e-02	1.00e+00	5.687	1	1	40
GO:0070301	cellular response to hydrogen peroxide	1.97e-02	1.00e+00	5.651	1	2	41
GO:0004402	histone acetyltransferase activity	2.07e-02	1.00e+00	5.582	1	6	43
GO:0045727	positive regulation of translation	2.12e-02	1.00e+00	5.549	1	2	44
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2.12e-02	1.00e+00	5.549	1	4	44
GO:0005884	actin filament	2.12e-02	1.00e+00	5.549	1	3	44
GO:0043966	histone H3 acetylation	2.16e-02	1.00e+00	5.517	1	5	45
GO:0001047	core promoter binding	2.16e-02	1.00e+00	5.517	1	5	45
GO:0043525	positive regulation of neuron apoptotic process	2.21e-02	1.00e+00	5.485	1	4	46
GO:0016049	cell growth	2.35e-02	1.00e+00	5.394	1	3	49
GO:0035690	cellular response to drug	2.35e-02	1.00e+00	5.394	1	3	49
GO:0005515	protein binding	2.38e-02	1.00e+00	1.037	6	198	6024
GO:0006986	response to unfolded protein	2.40e-02	1.00e+00	5.365	1	4	50
GO:0009612	response to mechanical stimulus	2.40e-02	1.00e+00	5.365	1	1	50
GO:0034976	response to endoplasmic reticulum stress	2.45e-02	1.00e+00	5.336	1	2	51
GO:0045454	cell redox homeostasis	2.45e-02	1.00e+00	5.336	1	1	51
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0007623	circadian rhythm	2.54e-02	1.00e+00	5.281	1	1	53
GO:0001725	stress fiber	2.64e-02	1.00e+00	5.227	1	4	55
GO:0071300	cellular response to retinoic acid	2.64e-02	1.00e+00	5.227	1	1	55
GO:0051592	response to calcium ion	2.64e-02	1.00e+00	5.227	1	1	55
GO:0002039	p53 binding	2.64e-02	1.00e+00	5.227	1	4	55
GO:0048306	calcium-dependent protein binding	2.69e-02	1.00e+00	5.201	1	2	56
GO:0043627	response to estrogen	2.69e-02	1.00e+00	5.201	1	5	56
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	2.83e-02	1.00e+00	5.126	1	6	59
GO:0008013	beta-catenin binding	2.88e-02	1.00e+00	5.102	1	9	60
GO:0032481	positive regulation of type I interferon production	2.92e-02	1.00e+00	5.078	1	6	61
GO:0030855	epithelial cell differentiation	2.92e-02	1.00e+00	5.078	1	1	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	2.92e-02	1.00e+00	5.078	1	2	61
GO:0032088	negative regulation of NF-kappaB transcription factor activity	3.02e-02	1.00e+00	5.031	1	3	63
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	3.02e-02	1.00e+00	5.031	1	4	63
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0043086	negative regulation of catalytic activity	3.44e-02	1.00e+00	4.839	1	2	72
GO:0030324	lung development	3.44e-02	1.00e+00	4.839	1	1	72
GO:0000785	chromatin	3.49e-02	1.00e+00	4.819	1	6	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	3.58e-02	1.00e+00	4.780	1	1	75
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	159	4559
GO:0001889	liver development	3.68e-02	1.00e+00	4.742	1	3	77
GO:0030968	endoplasmic reticulum unfolded protein response	3.77e-02	1.00e+00	4.705	1	2	79
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0009887	organ morphogenesis	4.10e-02	1.00e+00	4.582	1	5	86
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.10e-02	1.00e+00	4.582	1	8	86
GO:0045471	response to ethanol	4.10e-02	1.00e+00	4.582	1	3	86
GO:0006936	muscle contraction	4.15e-02	1.00e+00	4.566	1	3	87
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	4.29e-02	1.00e+00	4.517	1	1	90
GO:0005200	structural constituent of cytoskeleton	4.33e-02	1.00e+00	4.501	1	6	91
GO:0071456	cellular response to hypoxia	4.38e-02	1.00e+00	4.485	1	3	92
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	4.38e-02	1.00e+00	4.485	1	7	92
GO:0005770	late endosome	4.43e-02	1.00e+00	4.470	1	2	93
GO:0051726	regulation of cell cycle	4.61e-02	1.00e+00	4.409	1	5	97
GO:0001934	positive regulation of protein phosphorylation	4.94e-02	1.00e+00	4.308	1	5	104
GO:0072562	blood microparticle	5.27e-02	1.00e+00	4.214	1	3	111
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	12	118
GO:0007219	Notch signaling pathway	5.68e-02	1.00e+00	4.102	1	5	120
GO:0007050	cell cycle arrest	5.87e-02	1.00e+00	4.055	1	5	124
GO:0000086	G2/M transition of mitotic cell cycle	6.42e-02	1.00e+00	3.921	1	4	136
GO:0016055	Wnt signaling pathway	6.51e-02	1.00e+00	3.900	1	4	138
GO:0007507	heart development	6.56e-02	1.00e+00	3.890	1	7	139
GO:0001666	response to hypoxia	7.01e-02	1.00e+00	3.790	1	7	149
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	7.74e-02	1.00e+00	3.642	1	12	165
GO:0031965	nuclear membrane	7.88e-02	1.00e+00	3.616	1	10	168
GO:0015629	actin cytoskeleton	8.28e-02	1.00e+00	3.541	1	5	177
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0032403	protein complex binding	8.55e-02	1.00e+00	3.493	1	6	183
GO:0006367	transcription initiation from RNA polymerase II promoter	8.60e-02	1.00e+00	3.485	1	22	184
GO:0070062	extracellular vesicular exosome	9.54e-02	1.00e+00	1.365	3	57	2400
GO:0007399	nervous system development	1.07e-01	1.00e+00	3.157	1	6	231
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.21e-01	1.00e+00	2.964	1	23	264
GO:0005524	ATP binding	1.25e-01	1.00e+00	1.667	2	31	1298
GO:0003682	chromatin binding	1.48e-01	1.00e+00	2.656	1	19	327
GO:0005813	centrosome	1.48e-01	1.00e+00	2.660	1	7	326
GO:0008283	cell proliferation	1.49e-01	1.00e+00	2.651	1	14	328
GO:0046982	protein heterodimerization activity	1.71e-01	1.00e+00	2.439	1	8	380
GO:0000278	mitotic cell cycle	1.75e-01	1.00e+00	2.398	1	15	391
GO:0009986	cell surface	1.80e-01	1.00e+00	2.358	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	1.84e-01	1.00e+00	2.319	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	1.87e-01	1.00e+00	2.298	1	30	419
GO:0043066	negative regulation of apoptotic process	1.89e-01	1.00e+00	2.281	1	16	424
GO:0044267	cellular protein metabolic process	2.09e-01	1.00e+00	2.120	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.10e-01	1.00e+00	2.108	1	24	478
GO:0042802	identical protein binding	2.13e-01	1.00e+00	2.090	1	19	484
GO:0048471	perinuclear region of cytoplasm	2.20e-01	1.00e+00	2.037	1	8	502
GO:0005509	calcium ion binding	2.31e-01	1.00e+00	1.956	1	11	531
GO:0016032	viral process	2.32e-01	1.00e+00	1.948	1	26	534
GO:0006915	apoptotic process	2.40e-01	1.00e+00	1.892	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	37	570
GO:0045087	innate immune response	2.56e-01	1.00e+00	1.790	1	15	596
GO:0010467	gene expression	2.83e-01	1.00e+00	1.623	1	45	669
GO:0007165	signal transduction	3.65e-01	1.00e+00	1.184	1	13	907
GO:0005615	extracellular space	3.82e-01	1.00e+00	1.106	1	20	957
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	27	997
GO:0044822	poly(A) RNA binding	4.13e-01	1.00e+00	0.964	1	50	1056
GO:0006351	transcription, DNA-templated	5.23e-01	1.00e+00	0.511	1	57	1446
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	66	1641
GO:0016020	membrane	5.80e-01	1.00e+00	0.294	1	46	1681
GO:0005886	plasma membrane	7.49e-01	1.00e+00	-0.326	1	49	2582

chia-Fav

int-snw-58

Statistics

Genes (7)

Interactions (7)

Related GO terms (212)