int-snw-4722

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.797	4.21e-15	7.56e-04	4.65e-03

chia-screen-data-Fav-int-snw-4722 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
SQSTM1	8878	1	-1.719	2.797	488	-	-
SYNCRIP	10492	9	-2.401	3.197	103	Yes	Yes
ALDH1L2	160428	1	-2.422	2.797	4	Yes	-
PHB	5245	15	-2.743	3.004	127	Yes	Yes
ICT1	3396	2	-2.210	2.813	208	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
NXF1	10482	10	-2.426	3.538	65	Yes	Yes
[ NDUFS3 ]	4722	1	-1.581	2.797	28	-	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-

Interactions (13)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	NXF1	10482	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association)
ICT1	3396	ALDH1L2	160428	pp	--	int.I2D: BioGrid
NDUFS3	4722	PHB	5245	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HNRNPU	3192	SYNCRIP	10492	pp	--	int.Mint: MI:0915(physical association)
ICT1	3396	NDUFS3	4722	pp	--	int.I2D: BioGrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
ICT1	3396	PHB	5245	pp	--	int.I2D: BioGrid
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
SQSTM1	8878	NXF1	10482	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
SQSTM1	8878	SYNCRIP	10492	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	NXF1	10482	pp	--	int.Intact: MI:0914(association)
NDUFS3	4722	SQSTM1	8878	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (159)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	1.32e-07	1.90e-03	3.277	8	64	1082
GO:0070934	CRD-mediated mRNA stabilization	5.28e-06	7.62e-02	9.035	2	2	5
GO:0070937	CRD-mediated mRNA stability complex	7.92e-06	1.14e-01	8.772	2	3	6
GO:0001649	osteoblast differentiation	3.99e-05	5.76e-01	5.418	3	5	92
GO:0000398	mRNA splicing, via spliceosome	2.23e-04	1.00e+00	4.584	3	15	164
GO:0044212	transcription regulatory region DNA binding	2.39e-04	1.00e+00	4.549	3	17	168
GO:0008380	RNA splicing	5.86e-04	1.00e+00	4.109	3	22	228
GO:0044822	poly(A) RNA binding	6.63e-04	1.00e+00	2.634	5	50	1056
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:0070126	mitochondrial translational termination	7.63e-04	1.00e+00	10.357	1	1	1
GO:0016150	translation release factor activity, codon nonspecific	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0000166	nucleotide binding	8.49e-04	1.00e+00	3.925	3	13	259
GO:0006396	RNA processing	8.84e-04	1.00e+00	5.474	2	5	59
GO:0006406	mRNA export from nucleus	9.44e-04	1.00e+00	5.426	2	4	61
GO:0010467	gene expression	1.17e-03	1.00e+00	2.971	4	45	669
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0016155	formyltetrahydrofolate dehydrogenase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009258	10-formyltetrahydrofolate catabolic process	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0071013	catalytic step 2 spliceosome	1.54e-03	1.00e+00	5.071	2	7	78
GO:0003723	RNA binding	1.89e-03	1.00e+00	3.524	3	18	342
GO:0004045	aminoacyl-tRNA hydrolase activity	2.29e-03	1.00e+00	8.772	1	1	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0030308	negative regulation of cell growth	3.03e-03	1.00e+00	4.575	2	6	110
GO:0097452	GAIT complex	3.05e-03	1.00e+00	8.357	1	1	4
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030529	ribonucleoprotein complex	3.14e-03	1.00e+00	4.549	2	5	112
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0050847	progesterone receptor signaling pathway	4.57e-03	1.00e+00	7.772	1	2	6
GO:0003954	NADH dehydrogenase activity	4.57e-03	1.00e+00	7.772	1	1	6
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	4.57e-03	1.00e+00	7.772	1	1	6
GO:0016236	macroautophagy	4.57e-03	1.00e+00	7.772	1	1	6
GO:0071204	histone pre-mRNA 3'end processing complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0005739	mitochondrion	5.07e-03	1.00e+00	2.394	4	23	998
GO:0071354	cellular response to interleukin-6	5.33e-03	1.00e+00	7.549	1	2	7
GO:0046578	regulation of Ras protein signal transduction	5.33e-03	1.00e+00	7.549	1	1	7
GO:0016973	poly(A)+ mRNA export from nucleus	6.09e-03	1.00e+00	7.357	1	1	8
GO:0042405	nuclear inclusion body	6.85e-03	1.00e+00	7.187	1	2	9
GO:0010944	negative regulation of transcription by competitive promoter binding	6.85e-03	1.00e+00	7.187	1	1	9
GO:0016607	nuclear speck	7.25e-03	1.00e+00	3.930	2	12	172
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0009058	biosynthetic process	7.60e-03	1.00e+00	7.035	1	1	10
GO:0005515	protein binding	8.30e-03	1.00e+00	0.970	9	198	6024
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	8.36e-03	1.00e+00	6.897	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0070530	K63-linked polyubiquitin binding	8.36e-03	1.00e+00	6.897	1	2	11
GO:0016239	positive regulation of macroautophagy	9.12e-03	1.00e+00	6.772	1	1	12
GO:0008143	poly(A) binding	9.12e-03	1.00e+00	6.772	1	2	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0060766	negative regulation of androgen receptor signaling pathway	9.87e-03	1.00e+00	6.656	1	3	13
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	9.87e-03	1.00e+00	6.656	1	2	13
GO:0000407	pre-autophagosomal structure	9.87e-03	1.00e+00	6.656	1	2	13
GO:0000346	transcription export complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0005762	mitochondrial large ribosomal subunit	1.06e-02	1.00e+00	6.549	1	1	14
GO:0005487	nucleocytoplasmic transporter activity	1.06e-02	1.00e+00	6.549	1	3	14
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0043274	phospholipase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0016234	inclusion body	1.44e-02	1.00e+00	6.109	1	2	19
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	1.59e-02	1.00e+00	5.964	1	1	21
GO:0016575	histone deacetylation	1.59e-02	1.00e+00	5.964	1	3	21
GO:0016235	aggresome	1.59e-02	1.00e+00	5.964	1	1	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0071346	cellular response to interferon-gamma	1.74e-02	1.00e+00	5.833	1	1	23
GO:0006730	one-carbon metabolic process	1.74e-02	1.00e+00	5.833	1	1	23
GO:0005743	mitochondrial inner membrane	1.80e-02	1.00e+00	3.243	2	6	277
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0071897	DNA biosynthetic process	2.12e-02	1.00e+00	5.549	1	1	28
GO:0042169	SH2 domain binding	2.27e-02	1.00e+00	5.450	1	2	30
GO:0072593	reactive oxygen species metabolic process	2.34e-02	1.00e+00	5.402	1	2	31
GO:0002376	immune system process	2.41e-02	1.00e+00	5.357	1	3	32
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0005776	autophagic vacuole	2.41e-02	1.00e+00	5.357	1	1	32
GO:0030971	receptor tyrosine kinase binding	2.49e-02	1.00e+00	5.312	1	2	33
GO:0008137	NADH dehydrogenase (ubiquinone) activity	2.71e-02	1.00e+00	5.187	1	1	36
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	2.71e-02	1.00e+00	5.187	1	1	36
GO:0005747	mitochondrial respiratory chain complex I	2.94e-02	1.00e+00	5.071	1	1	39
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0017148	negative regulation of translation	3.01e-02	1.00e+00	5.035	1	2	40
GO:0008168	methyltransferase activity	3.08e-02	1.00e+00	4.999	1	2	41
GO:0031124	mRNA 3'-end processing	3.16e-02	1.00e+00	4.964	1	2	42
GO:0005080	protein kinase C binding	3.23e-02	1.00e+00	4.930	1	1	43
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	4	44
GO:0043130	ubiquitin binding	3.38e-02	1.00e+00	4.865	1	2	45
GO:0006369	termination of RNA polymerase II transcription	3.38e-02	1.00e+00	4.865	1	2	45
GO:0006950	response to stress	3.45e-02	1.00e+00	4.833	1	2	46
GO:0006355	regulation of transcription, DNA-templated	3.57e-02	1.00e+00	1.980	3	43	997
GO:0006366	transcription from RNA polymerase II promoter	3.89e-02	1.00e+00	2.646	2	30	419
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0000932	cytoplasmic mRNA processing body	4.04e-02	1.00e+00	4.602	1	4	54
GO:0031966	mitochondrial membrane	4.12e-02	1.00e+00	4.575	1	1	55
GO:0008104	protein localization	4.19e-02	1.00e+00	4.549	1	1	56
GO:0051291	protein heterooligomerization	4.19e-02	1.00e+00	4.549	1	4	56
GO:0032259	methylation	4.26e-02	1.00e+00	4.524	1	1	57
GO:0005643	nuclear pore	4.26e-02	1.00e+00	4.524	1	11	57
GO:0016197	endosomal transport	4.26e-02	1.00e+00	4.524	1	2	57
GO:0009055	electron carrier activity	4.85e-02	1.00e+00	4.334	1	2	65
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0042826	histone deacetylase binding	5.36e-02	1.00e+00	4.187	1	4	72
GO:0003729	mRNA binding	5.36e-02	1.00e+00	4.187	1	4	72
GO:0006914	autophagy	5.50e-02	1.00e+00	4.147	1	3	74
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0016032	viral process	6.03e-02	1.00e+00	2.296	2	26	534
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0022904	respiratory electron transport chain	6.30e-02	1.00e+00	3.947	1	1	85
GO:0005783	endoplasmic reticulum	6.48e-02	1.00e+00	2.238	2	13	556
GO:0016605	PML body	6.51e-02	1.00e+00	3.897	1	3	88
GO:0005770	late endosome	6.87e-02	1.00e+00	3.817	1	2	93
GO:0031410	cytoplasmic vesicle	7.58e-02	1.00e+00	3.670	1	4	103
GO:0001934	positive regulation of protein phosphorylation	7.65e-02	1.00e+00	3.656	1	5	104
GO:0097190	apoptotic signaling pathway	8.29e-02	1.00e+00	3.536	1	3	113
GO:0044237	cellular metabolic process	8.57e-02	1.00e+00	3.486	1	2	117
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0005634	nucleus	9.78e-02	1.00e+00	0.787	6	159	4559
GO:0005829	cytosol	1.07e-01	1.00e+00	1.071	4	86	2496
GO:0006974	cellular response to DNA damage stimulus	1.09e-01	1.00e+00	3.118	1	7	151
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	4	150
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.19e-01	1.00e+00	1.733	2	41	789
GO:0005764	lysosome	1.24e-01	1.00e+00	2.930	1	2	172
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	5	178
GO:0003714	transcription corepressor activity	1.28e-01	1.00e+00	2.881	1	11	178
GO:0016020	membrane	1.28e-01	1.00e+00	1.227	3	46	1681
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0005737	cytoplasm	1.33e-01	1.00e+00	0.799	5	124	3767
GO:0003713	transcription coactivator activity	1.67e-01	1.00e+00	2.468	1	24	237
GO:0008134	transcription factor binding	1.70e-01	1.00e+00	2.438	1	18	242
GO:0043065	positive regulation of apoptotic process	1.86e-01	1.00e+00	2.291	1	7	268
GO:0048011	neurotrophin TRK receptor signaling pathway	1.87e-01	1.00e+00	2.285	1	7	269
GO:0019899	enzyme binding	1.92e-01	1.00e+00	2.243	1	9	277
GO:0030154	cell differentiation	2.07e-01	1.00e+00	2.123	1	5	301
GO:0035556	intracellular signal transduction	2.08e-01	1.00e+00	2.113	1	9	303
GO:0004674	protein serine/threonine kinase activity	2.11e-01	1.00e+00	2.090	1	6	308
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	18	317
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0043565	sequence-specific DNA binding	2.34e-01	1.00e+00	1.922	1	11	346
GO:0003677	DNA binding	2.37e-01	1.00e+00	1.106	2	49	1218
GO:0008285	negative regulation of cell proliferation	2.39e-01	1.00e+00	1.893	1	10	353
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0070062	extracellular vesicular exosome	2.72e-01	1.00e+00	0.713	3	57	2400
GO:0045892	negative regulation of transcription, DNA-templated	2.74e-01	1.00e+00	1.667	1	24	413
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	10	420
GO:0043066	negative regulation of apoptotic process	2.80e-01	1.00e+00	1.629	1	16	424
GO:0006468	protein phosphorylation	3.00e-01	1.00e+00	1.511	1	10	460
GO:0045893	positive regulation of transcription, DNA-templated	3.10e-01	1.00e+00	1.456	1	24	478
GO:0042802	identical protein binding	3.13e-01	1.00e+00	1.438	1	19	484
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.58e-01	1.00e+00	1.202	1	37	570
GO:0042803	protein homodimerization activity	3.71e-01	1.00e+00	1.140	1	19	595
GO:0003700	sequence-specific DNA binding transcription factor activity	4.21e-01	1.00e+00	0.908	1	39	699
GO:0005887	integral component of plasma membrane	5.03e-01	1.00e+00	0.562	1	10	888
GO:0007165	signal transduction	5.11e-01	1.00e+00	0.532	1	13	907
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	27	997
GO:0044281	small molecule metabolic process	6.19e-01	1.00e+00	0.115	1	20	1211
GO:0005524	ATP binding	6.46e-01	1.00e+00	0.015	1	31	1298

chia-Fav

int-snw-4722

Statistics

Genes (11)

Interactions (13)

Related GO terms (159)