int-snw-29915

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.853	1.07e-15	3.90e-04	2.91e-03

chia-screen-data-Fav-int-snw-29915 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
ASH2L	9070	1	-1.756	2.853	65	-	-
WDR82	80335	7	-2.455	3.129	64	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
ANKRD1	27063	1	-2.448	2.853	15	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ HCFC2 ]	29915	1	-1.637	2.853	13	-	-

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ASH2L	9070	ANKRD1	27063	pp	--	int.Intact: MI:0915(physical association)
ASH2L	9070	WDR82	80335	pp	--	int.I2D: BioGrid
ASH2L	9070	HCFC2	29915	pp	--	int.I2D: BioGrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	ASH2L	9070	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BCI, IntAct, BioGrid; int.Ravasi: -
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HCFC1	3054	HCFC2	29915	pp	--	int.I2D: BioGrid
HCFC1	3054	WDR82	80335	pp	--	int.I2D: BioGrid

Related GO terms (116)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0048188	Set1C/COMPASS complex	1.41e-08	2.03e-04	9.061	3	4	9
GO:0006366	transcription from RNA polymerase II promoter	2.31e-06	3.33e-02	4.257	5	30	419
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2.69e-05	3.88e-01	7.946	2	3	13
GO:0051568	histone H3-K4 methylation	4.68e-05	6.76e-01	7.559	2	3	17
GO:0035097	histone methyltransferase complex	7.22e-05	1.00e+00	7.254	2	3	21
GO:0003677	DNA binding	4.02e-04	1.00e+00	2.718	5	49	1218
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0005634	nucleus	6.43e-04	1.00e+00	1.492	8	159	4559
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.97e-04	1.00e+00	3.022	4	41	789
GO:0019046	release from viral latency	1.25e-03	1.00e+00	9.646	1	2	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0035994	response to muscle stretch	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006355	regulation of transcription, DNA-templated	2.16e-03	1.00e+00	2.685	4	43	997
GO:0070461	SAGA-type complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.31e-03	1.00e+00	3.076	3	37	570
GO:0072357	PTW/PP1 phosphatase complex	4.36e-03	1.00e+00	7.839	1	2	7
GO:0044212	transcription regulatory region DNA binding	4.60e-03	1.00e+00	4.254	2	17	168
GO:2000279	negative regulation of DNA biosynthetic process	4.98e-03	1.00e+00	7.646	1	1	8
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0043254	regulation of protein complex assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0005667	transcription factor complex	4.98e-03	1.00e+00	4.195	2	17	175
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0055008	cardiac muscle tissue morphogenesis	7.47e-03	1.00e+00	7.061	1	1	12
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	7.47e-03	1.00e+00	7.061	1	2	12
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.09e-03	1.00e+00	6.946	1	2	13
GO:0005685	U1 snRNP	8.70e-03	1.00e+00	6.839	1	1	14
GO:0031011	Ino80 complex	8.70e-03	1.00e+00	6.839	1	6	14
GO:0031432	titin binding	8.70e-03	1.00e+00	6.839	1	1	14
GO:0003713	transcription coactivator activity	8.97e-03	1.00e+00	3.757	2	24	237
GO:0043981	histone H4-K5 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	9.32e-03	1.00e+00	6.739	1	3	15
GO:0006376	mRNA splice site selection	9.32e-03	1.00e+00	6.739	1	1	15
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0043982	histone H4-K8 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.10e-02	1.00e+00	3.602	2	23	264
GO:0031674	I band	1.12e-02	1.00e+00	6.476	1	1	18
GO:0043984	histone H4-K16 acetylation	1.18e-02	1.00e+00	6.398	1	5	19
GO:0000123	histone acetyltransferase complex	1.30e-02	1.00e+00	6.254	1	6	21
GO:0070412	R-SMAD binding	1.30e-02	1.00e+00	6.254	1	1	21
GO:0005730	nucleolus	1.31e-02	1.00e+00	1.966	4	66	1641
GO:0045787	positive regulation of cell cycle	1.36e-02	1.00e+00	6.187	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.36e-02	1.00e+00	6.187	1	4	22
GO:0001105	RNA polymerase II transcription coactivator activity	1.49e-02	1.00e+00	6.061	1	2	24
GO:0045214	sarcomere organization	1.61e-02	1.00e+00	5.946	1	2	26
GO:0003682	chromatin binding	1.66e-02	1.00e+00	3.293	2	19	327
GO:0071339	MLL1 complex	1.67e-02	1.00e+00	5.891	1	6	27
GO:0050714	positive regulation of protein secretion	1.73e-02	1.00e+00	5.839	1	3	28
GO:0071347	cellular response to interleukin-1	1.92e-02	1.00e+00	5.692	1	2	31
GO:0001085	RNA polymerase II transcription factor binding	2.04e-02	1.00e+00	5.602	1	2	33
GO:0001104	RNA polymerase II transcription cofactor activity	2.04e-02	1.00e+00	5.602	1	8	33
GO:0016592	mediator complex	2.16e-02	1.00e+00	5.517	1	10	35
GO:0071560	cellular response to transforming growth factor beta stimulus	2.22e-02	1.00e+00	5.476	1	3	36
GO:0071407	cellular response to organic cyclic compound	2.35e-02	1.00e+00	5.398	1	3	38
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0005654	nucleoplasm	2.51e-02	1.00e+00	2.152	3	64	1082
GO:0035914	skeletal muscle cell differentiation	2.53e-02	1.00e+00	5.289	1	2	41
GO:0035690	cellular response to drug	3.02e-02	1.00e+00	5.031	1	3	49
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0005515	protein binding	3.23e-02	1.00e+00	0.897	7	198	6024
GO:0002039	p53 binding	3.38e-02	1.00e+00	4.865	1	4	55
GO:0043627	response to estrogen	3.44e-02	1.00e+00	4.839	1	5	56
GO:0030097	hemopoiesis	3.44e-02	1.00e+00	4.839	1	1	56
GO:0071356	cellular response to tumor necrosis factor	3.50e-02	1.00e+00	4.813	1	1	57
GO:0010976	positive regulation of neuron projection development	3.56e-02	1.00e+00	4.788	1	1	58
GO:0006310	DNA recombination	3.98e-02	1.00e+00	4.624	1	7	65
GO:0071260	cellular response to mechanical stimulus	3.98e-02	1.00e+00	4.624	1	4	65
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0003729	mRNA binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0042826	histone deacetylase binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0000785	chromatin	4.47e-02	1.00e+00	4.456	1	6	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0002020	protease binding	4.53e-02	1.00e+00	4.437	1	6	74
GO:0071222	cellular response to lipopolysaccharide	4.94e-02	1.00e+00	4.306	1	4	81
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0050821	protein stabilization	5.36e-02	1.00e+00	4.187	1	3	88
GO:0071456	cellular response to hypoxia	5.60e-02	1.00e+00	4.123	1	3	92
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	12	118
GO:0044255	cellular lipid metabolic process	8.00e-02	1.00e+00	3.591	1	2	133
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	7	146
GO:0006974	cellular response to DNA damage stimulus	9.04e-02	1.00e+00	3.408	1	7	151
GO:0016607	nuclear speck	1.02e-01	1.00e+00	3.220	1	12	172
GO:0007049	cell cycle	1.04e-01	1.00e+00	3.203	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0003714	transcription corepressor activity	1.06e-01	1.00e+00	3.170	1	11	178
GO:0008380	RNA splicing	1.34e-01	1.00e+00	2.813	1	22	228
GO:0044822	poly(A) RNA binding	1.37e-01	1.00e+00	1.602	2	50	1056
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	18	242
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	14	261
GO:0043065	positive regulation of apoptotic process	1.55e-01	1.00e+00	2.580	1	7	268
GO:0006954	inflammatory response	1.60e-01	1.00e+00	2.532	1	6	277
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	124	3767
GO:0043565	sequence-specific DNA binding	1.96e-01	1.00e+00	2.212	1	11	346
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0008284	positive regulation of cell proliferation	2.15e-01	1.00e+00	2.069	1	10	382
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	19	484
GO:0016032	viral process	2.88e-01	1.00e+00	1.585	1	26	534
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	23	998
GO:0005829	cytosol	4.79e-01	1.00e+00	0.361	2	86	2496
GO:0005886	plasma membrane	4.98e-01	1.00e+00	0.312	2	49	2582
GO:0044281	small molecule metabolic process	5.46e-01	1.00e+00	0.404	1	20	1211
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	29	1307
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	57	1446
GO:0016020	membrane	6.72e-01	1.00e+00	-0.069	1	46	1681

chia-Fav

int-snw-29915

Statistics

Genes (9)

Interactions (10)

Related GO terms (116)