int-snw-25909

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.974	4.84e-17	8.23e-05	9.67e-04

chia-screen-data-Fav-int-snw-25909 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
TPR	7175	18	-2.638	3.072	28	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
[ AHCTF1 ]	25909	1	-2.069	2.974	9	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
NUP107	57122	1	-2.267	2.974	19	Yes	Yes
MED13L	23389	12	-2.550	3.159	21	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
AHCTF1	25909	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
AHCTF1	25909	NUP107	57122	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED13L	23389	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
TPR	7175	NUP107	57122	pp	--	int.I2D: BioGrid

Related GO terms (145)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0051292	nuclear pore complex assembly	9.39e-09	1.35e-04	9.231	3	4	8
GO:0006366	transcription from RNA polymerase II promoter	2.31e-06	3.33e-02	4.257	5	30	419
GO:0005643	nuclear pore	4.83e-06	6.97e-02	6.398	3	11	57
GO:0031080	nuclear pore outer ring	1.55e-05	2.24e-01	8.324	2	2	10
GO:0034399	nuclear periphery	2.28e-05	3.28e-01	8.061	2	5	12
GO:0005487	nucleocytoplasmic transporter activity	3.14e-05	4.53e-01	7.839	2	3	14
GO:0031965	nuclear membrane	1.24e-04	1.00e+00	4.839	3	10	168
GO:0010827	regulation of glucose transport	1.49e-04	1.00e+00	6.739	2	4	30
GO:0001104	RNA polymerase II transcription cofactor activity	1.81e-04	1.00e+00	6.602	2	8	33
GO:0016592	mediator complex	2.04e-04	1.00e+00	6.517	2	10	35
GO:0007077	mitotic nuclear envelope disassembly	2.16e-04	1.00e+00	6.476	2	4	36
GO:0005654	nucleoplasm	2.30e-04	1.00e+00	2.889	5	64	1082
GO:0008645	hexose transport	2.53e-04	1.00e+00	6.361	2	4	39
GO:0015758	glucose transport	5.05e-04	1.00e+00	5.865	2	4	55
GO:0006406	mRNA export from nucleus	6.21e-04	1.00e+00	5.715	2	4	61
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:1901673	regulation of spindle assembly involved in mitosis	6.24e-04	1.00e+00	10.646	1	1	1
GO:0043578	nuclear matrix organization	6.24e-04	1.00e+00	10.646	1	1	1
GO:0010965	regulation of mitotic sister chromatid separation	6.24e-04	1.00e+00	10.646	1	1	1
GO:0006404	RNA import into nucleus	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0031453	positive regulation of heterochromatin assembly	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0000776	kinetochore	6.63e-04	1.00e+00	5.669	2	5	63
GO:0000777	condensed chromosome kinetochore	7.72e-04	1.00e+00	5.559	2	3	68
GO:0003729	mRNA binding	8.65e-04	1.00e+00	5.476	2	4	72
GO:0000189	MAPK import into nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0031990	mRNA export from nucleus in response to heat stress	1.25e-03	1.00e+00	9.646	1	2	2
GO:0019046	release from viral latency	1.25e-03	1.00e+00	9.646	1	2	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0070840	dynein complex binding	1.25e-03	1.00e+00	9.646	1	1	2
GO:0046832	negative regulation of RNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0000278	mitotic cell cycle	1.47e-03	1.00e+00	3.620	3	15	391
GO:0006405	RNA export from nucleus	1.87e-03	1.00e+00	9.061	1	2	3
GO:0042306	regulation of protein import into nucleus	1.87e-03	1.00e+00	9.061	1	2	3
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0005635	nuclear envelope	2.11e-03	1.00e+00	4.826	2	5	113
GO:0006999	nuclear pore organization	2.49e-03	1.00e+00	8.646	1	1	4
GO:0044615	nuclear pore nuclear basket	2.49e-03	1.00e+00	8.646	1	1	4
GO:0044822	poly(A) RNA binding	2.67e-03	1.00e+00	2.602	4	50	1056
GO:0070461	SAGA-type complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	3.12e-03	1.00e+00	8.324	1	1	5
GO:0010793	regulation of mRNA export from nucleus	3.12e-03	1.00e+00	8.324	1	1	5
GO:0070849	response to epidermal growth factor	3.12e-03	1.00e+00	8.324	1	1	5
GO:0046825	regulation of protein export from nucleus	4.36e-03	1.00e+00	7.839	1	2	7
GO:0016607	nuclear speck	4.82e-03	1.00e+00	4.220	2	12	172
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0043254	regulation of protein complex assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0035457	cellular response to interferon-alpha	4.98e-03	1.00e+00	7.646	1	1	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0042405	nuclear inclusion body	5.60e-03	1.00e+00	7.476	1	2	9
GO:0048188	Set1C/COMPASS complex	5.60e-03	1.00e+00	7.476	1	4	9
GO:0043495	protein anchor	5.60e-03	1.00e+00	7.476	1	1	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0017056	structural constituent of nuclear pore	5.60e-03	1.00e+00	7.476	1	2	9
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	159	4559
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0045947	negative regulation of translational initiation	7.47e-03	1.00e+00	7.061	1	2	12
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0003700	sequence-specific DNA binding transcription factor activity	7.64e-03	1.00e+00	2.782	3	39	699
GO:0019221	cytokine-mediated signaling pathway	7.84e-03	1.00e+00	3.858	2	8	221
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.09e-03	1.00e+00	6.946	1	2	13
GO:0051019	mitogen-activated protein kinase binding	8.09e-03	1.00e+00	6.946	1	2	13
GO:0005868	cytoplasmic dynein complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0046827	positive regulation of protein export from nucleus	8.09e-03	1.00e+00	6.946	1	1	13
GO:0008380	RNA splicing	8.32e-03	1.00e+00	3.813	2	22	228
GO:0005685	U1 snRNP	8.70e-03	1.00e+00	6.839	1	1	14
GO:0043981	histone H4-K5 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	9.32e-03	1.00e+00	6.739	1	3	15
GO:0042307	positive regulation of protein import into nucleus	9.32e-03	1.00e+00	6.739	1	4	15
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0043982	histone H4-K8 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0006376	mRNA splice site selection	9.32e-03	1.00e+00	6.739	1	1	15
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0005975	carbohydrate metabolic process	1.02e-02	1.00e+00	3.663	2	8	253
GO:0090316	positive regulation of intracellular protein transport	1.06e-02	1.00e+00	6.559	1	2	17
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.10e-02	1.00e+00	3.602	2	23	264
GO:0043984	histone H4-K16 acetylation	1.18e-02	1.00e+00	6.398	1	5	19
GO:0000123	histone acetyltransferase complex	1.30e-02	1.00e+00	6.254	1	6	21
GO:0045787	positive regulation of cell cycle	1.36e-02	1.00e+00	6.187	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.36e-02	1.00e+00	6.187	1	4	22
GO:0006611	protein export from nucleus	1.55e-02	1.00e+00	6.002	1	3	25
GO:0003682	chromatin binding	1.66e-02	1.00e+00	3.293	2	19	327
GO:0015631	tubulin binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:0071339	MLL1 complex	1.67e-02	1.00e+00	5.891	1	6	27
GO:0034605	cellular response to heat	1.73e-02	1.00e+00	5.839	1	1	28
GO:0015031	protein transport	1.80e-02	1.00e+00	3.233	2	11	341
GO:0072686	mitotic spindle	1.80e-02	1.00e+00	5.788	1	3	29
GO:0006606	protein import into nucleus	1.86e-02	1.00e+00	5.739	1	2	30
GO:0031647	regulation of protein stability	1.86e-02	1.00e+00	5.739	1	4	30
GO:0007094	mitotic spindle assembly checkpoint	1.92e-02	1.00e+00	5.692	1	3	31
GO:0006355	regulation of transcription, DNA-templated	2.02e-02	1.00e+00	2.270	3	43	997
GO:0031072	heat shock protein binding	2.04e-02	1.00e+00	5.602	1	2	33
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0019898	extrinsic component of membrane	2.59e-02	1.00e+00	5.254	1	2	42
GO:0031124	mRNA 3'-end processing	2.59e-02	1.00e+00	5.254	1	2	42
GO:0006369	termination of RNA polymerase II transcription	2.77e-02	1.00e+00	5.154	1	2	45
GO:0055085	transmembrane transport	2.84e-02	1.00e+00	2.881	2	8	435
GO:0000910	cytokinesis	3.14e-02	1.00e+00	4.974	1	2	51
GO:0051028	mRNA transport	3.20e-02	1.00e+00	4.946	1	4	52
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0003677	DNA binding	3.43e-02	1.00e+00	1.981	3	49	1218
GO:0016032	viral process	4.14e-02	1.00e+00	2.585	2	26	534
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0000785	chromatin	4.47e-02	1.00e+00	4.456	1	6	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.67e-02	1.00e+00	2.491	2	37	570
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0050821	protein stabilization	5.36e-02	1.00e+00	4.187	1	3	88
GO:0016363	nuclear matrix	5.54e-02	1.00e+00	4.138	1	6	91
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	12	118
GO:0005730	nucleolus	7.30e-02	1.00e+00	1.551	3	66	1641
GO:0005215	transporter activity	7.83e-02	1.00e+00	3.624	1	3	130
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.33e-02	1.00e+00	2.022	2	41	789
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	7	146
GO:0000398	mRNA splicing, via spliceosome	9.78e-02	1.00e+00	3.289	1	15	164
GO:0044212	transcription regulatory region DNA binding	1.00e-01	1.00e+00	3.254	1	17	168
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0007049	cell cycle	1.04e-01	1.00e+00	3.203	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0005515	protein binding	1.20e-01	1.00e+00	0.675	6	198	6024
GO:0007067	mitotic nuclear division	1.33e-01	1.00e+00	2.820	1	6	227
GO:0003713	transcription coactivator activity	1.39e-01	1.00e+00	2.757	1	24	237
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	18	242
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0000166	nucleotide binding	1.51e-01	1.00e+00	2.629	1	13	259
GO:0044281	small molecule metabolic process	1.71e-01	1.00e+00	1.404	2	20	1211
GO:0005813	centrosome	1.86e-01	1.00e+00	2.297	1	7	326
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	124	3767
GO:0005829	cytosol	1.93e-01	1.00e+00	0.946	3	86	2496
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	18	342
GO:0043565	sequence-specific DNA binding	1.96e-01	1.00e+00	2.212	1	11	346
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	19	484
GO:0016020	membrane	2.83e-01	1.00e+00	0.931	2	46	1681
GO:0042803	protein homodimerization activity	3.16e-01	1.00e+00	1.429	1	19	595
GO:0010467	gene expression	3.48e-01	1.00e+00	1.260	1	45	669
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	23	998
GO:0070062	extracellular vesicular exosome	8.06e-01	1.00e+00	-0.583	1	57	2400
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	49	2582

chia-Fav

int-snw-25909

Statistics

Genes (9)

Interactions (9)

Related GO terms (145)