int-snw-2521

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 3.004 2.24e-17 5.51e-05 7.28e-04
chia-screen-data-Fav-int-snw-2521 subnetwork

Genes (10)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
TPR 7175 18-2.6383.07228YesYes
PHB 5245 15-2.7433.004127YesYes
YAP1 10413 94-4.2563.53853Yes-
APC 324 13-2.2933.004353Yes-
[ FUS ] 2521 2-1.9803.004136--
SRSF3 6428 73-2.9923.53854Yes-
POU5F1 5460 133-5.1483.538179YesYes
HNRNPU 3192 76-2.8693.538139Yes-
ULK2 9706 9-2.2923.197312YesYes
DDIT3 1649 60-2.8253.504343YesYes

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
APC 324 FUS 2521 pp -- int.I2D: Jorgensen_EphR
FUS 2521 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
APC 324 PHB 5245 pp -- int.I2D: Jorgensen_EphR
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
SRSF3 6428 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU 3192 ULK2 9706 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3 1649 FUS 2521 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
APC 324 TPR 7175 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct, SOURAV_MAPK_HIGH
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (237)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm3.84e-085.54e-043.4158641082
GO:0044212transcription regulatory region DNA binding3.53e-065.09e-025.102417168
GO:0042789mRNA transcription from RNA polymerase II promoter3.36e-054.85e-017.7942213
GO:0006974cellular response to DNA damage stimulus1.28e-041.00e+004.84137151
GO:0005515protein binding1.61e-041.00e+001.260101986024
GO:0000398mRNA splicing, via spliceosome1.63e-041.00e+004.722315164
GO:0007094mitotic spindle assembly checkpoint1.99e-041.00e+006.5402331
GO:0042594response to starvation1.99e-041.00e+006.5402431
GO:0035019somatic stem cell maintenance3.33e-041.00e+006.1722640
GO:0044822poly(A) RNA binding3.85e-041.00e+002.7725501056
GO:0008380RNA splicing4.31e-041.00e+004.246322228
GO:0060795cell fate commitment involved in formation of primary germ layer6.93e-041.00e+0010.494111
GO:1901673regulation of spindle assembly involved in mitosis6.93e-041.00e+0010.494111
GO:0043578nuclear matrix organization6.93e-041.00e+0010.494111
GO:2000016negative regulation of determination of dorsal identity6.93e-041.00e+0010.494111
GO:0051171regulation of nitrogen compound metabolic process6.93e-041.00e+0010.494111
GO:0010965regulation of mitotic sister chromatid separation6.93e-041.00e+0010.494111
GO:0006404RNA import into nucleus6.93e-041.00e+0010.494111
GO:0090308regulation of methylation-dependent chromatin silencing6.93e-041.00e+0010.494111
GO:0031453positive regulation of heterochromatin assembly6.93e-041.00e+0010.494111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway6.93e-041.00e+0010.494111
GO:0060965negative regulation of gene silencing by miRNA6.93e-041.00e+0010.494111
GO:0042483negative regulation of odontogenesis6.93e-041.00e+0010.494111
GO:0010467gene expression7.70e-041.00e+003.108445669
GO:0000776kinetochore8.26e-041.00e+005.5172563
GO:0000189MAPK import into nucleus1.39e-031.00e+009.494112
GO:0060242contact inhibition1.39e-031.00e+009.494112
GO:0031990mRNA export from nucleus in response to heat stress1.39e-031.00e+009.494122
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process1.39e-031.00e+009.494112
GO:0009786regulation of asymmetric cell division1.39e-031.00e+009.494112
GO:0070840dynein complex binding1.39e-031.00e+009.494112
GO:0009798axis specification1.39e-031.00e+009.494112
GO:0046832negative regulation of RNA export from nucleus1.39e-031.00e+009.494112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.39e-031.00e+009.494112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.39e-031.00e+009.494112
GO:0003723RNA binding1.40e-031.00e+003.661318342
GO:0090090negative regulation of canonical Wnt signaling pathway1.53e-031.00e+005.0682886
GO:0001649osteoblast differentiation1.75e-031.00e+004.9712592
GO:0006405RNA export from nucleus2.08e-031.00e+008.909123
GO:0042306regulation of protein import into nucleus2.08e-031.00e+008.909123
GO:0060913cardiac cell fate determination2.08e-031.00e+008.909113
GO:0003130BMP signaling pathway involved in heart induction2.08e-031.00e+008.909113
GO:0005634nucleus2.32e-031.00e+001.34081594559
GO:0034273ATG1/UKL1 signaling complex2.77e-031.00e+008.494114
GO:0006999nuclear pore organization2.77e-031.00e+008.494114
GO:0044615nuclear pore nuclear basket2.77e-031.00e+008.494114
GO:0019887protein kinase regulator activity2.77e-031.00e+008.494114
GO:0007050cell cycle arrest3.15e-031.00e+004.54025124
GO:0006355regulation of transcription, DNA-templated3.40e-031.00e+002.533443997
GO:0001714endodermal cell fate specification3.46e-031.00e+008.172115
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint3.46e-031.00e+008.172115
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process3.46e-031.00e+008.172125
GO:0043620regulation of DNA-templated transcription in response to stress3.46e-031.00e+008.172115
GO:0070934CRD-mediated mRNA stabilization3.46e-031.00e+008.172125
GO:0010793regulation of mRNA export from nucleus3.46e-031.00e+008.172115
GO:0048671negative regulation of collateral sprouting3.46e-031.00e+008.172115
GO:0070849response to epidermal growth factor3.46e-031.00e+008.172115
GO:0030858positive regulation of epithelial cell differentiation4.15e-031.00e+007.909116
GO:0050847progesterone receptor signaling pathway4.15e-031.00e+007.909126
GO:2000323negative regulation of glucocorticoid receptor signaling pathway4.15e-031.00e+007.909116
GO:0070937CRD-mediated mRNA stability complex4.15e-031.00e+007.909136
GO:0005737cytoplasm4.57e-031.00e+001.42271243767
GO:0007091metaphase/anaphase transition of mitotic cell cycle4.84e-031.00e+007.687127
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development4.84e-031.00e+007.687117
GO:0046825regulation of protein export from nucleus4.84e-031.00e+007.687127
GO:0071354cellular response to interleukin-64.84e-031.00e+007.687127
GO:0051988regulation of attachment of spindle microtubules to kinetochore4.84e-031.00e+007.687127
GO:0045670regulation of osteoclast differentiation5.53e-031.00e+007.494128
GO:0051292nuclear pore complex assembly5.53e-031.00e+007.494148
GO:0001955blood vessel maturation5.53e-031.00e+007.494118
GO:0035457cellular response to interferon-alpha5.53e-031.00e+007.494118
GO:0045667regulation of osteoblast differentiation6.22e-031.00e+007.324119
GO:0042405nuclear inclusion body6.22e-031.00e+007.324129
GO:0006983ER overload response6.22e-031.00e+007.324119
GO:0043495protein anchor6.22e-031.00e+007.324119
GO:0010944negative regulation of transcription by competitive promoter binding6.22e-031.00e+007.324119
GO:0003714transcription corepressor activity6.39e-031.00e+004.018211178
GO:0035413positive regulation of catenin import into nucleus6.91e-031.00e+007.1721210
GO:0031274positive regulation of pseudopodium assembly6.91e-031.00e+007.1721210
GO:0030877beta-catenin destruction complex6.91e-031.00e+007.1721210
GO:0003677DNA binding7.02e-031.00e+002.2444491218
GO:0031116positive regulation of microtubule polymerization7.60e-031.00e+007.0351111
GO:0051010microtubule plus-end binding7.60e-031.00e+007.0351111
GO:0045662negative regulation of myoblast differentiation7.60e-031.00e+007.0351311
GO:0060391positive regulation of SMAD protein import into nucleus7.60e-031.00e+007.0351411
GO:0045295gamma-catenin binding8.29e-031.00e+006.9091112
GO:0032886regulation of microtubule-based process8.29e-031.00e+006.9091112
GO:0045947negative regulation of translational initiation8.29e-031.00e+006.9091212
GO:0034045pre-autophagosomal structure membrane8.29e-031.00e+006.9091212
GO:0034399nuclear periphery8.29e-031.00e+006.9091512
GO:0035198miRNA binding8.29e-031.00e+006.9091112
GO:0060766negative regulation of androgen receptor signaling pathway8.98e-031.00e+006.7941313
GO:0044295axonal growth cone8.98e-031.00e+006.7941113
GO:0071480cellular response to gamma radiation8.98e-031.00e+006.7941113
GO:0051019mitogen-activated protein kinase binding8.98e-031.00e+006.7941213
GO:0043409negative regulation of MAPK cascade8.98e-031.00e+006.7941213
GO:0005868cytoplasmic dynein complex8.98e-031.00e+006.7941113
GO:0046827positive regulation of protein export from nucleus8.98e-031.00e+006.7941113
GO:0035371microtubule plus-end9.67e-031.00e+006.6871114
GO:0005487nucleocytoplasmic transporter activity9.67e-031.00e+006.6871314
GO:0042307positive regulation of protein import into nucleus1.04e-021.00e+006.5871415
GO:0001824blastocyst development1.04e-021.00e+006.5871215
GO:0007026negative regulation of microtubule depolymerization1.10e-021.00e+006.4941116
GO:0046716muscle cell cellular homeostasis1.10e-021.00e+006.4941116
GO:0043274phospholipase binding1.10e-021.00e+006.4941116
GO:0051276chromosome organization1.10e-021.00e+006.4941216
GO:0008134transcription factor binding1.15e-021.00e+003.575218242
GO:0090316positive regulation of intracellular protein transport1.17e-021.00e+006.4071217
GO:0031122cytoplasmic microtubule organization1.24e-021.00e+006.3241118
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity1.31e-021.00e+006.2461219
GO:0000166nucleotide binding1.31e-021.00e+003.477213259
GO:0032757positive regulation of interleukin-8 production1.38e-021.00e+006.1721120
GO:0009954proximal/distal pattern formation1.45e-021.00e+006.1021121
GO:0048675axon extension1.45e-021.00e+006.1021221
GO:0016575histone deacetylation1.45e-021.00e+006.1021321
GO:0000281mitotic cytokinesis1.45e-021.00e+006.1021221
GO:0036464cytoplasmic ribonucleoprotein granule1.52e-021.00e+006.0351222
GO:0010506regulation of autophagy1.58e-021.00e+005.9711223
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.58e-021.00e+005.9711123
GO:0045296cadherin binding1.65e-021.00e+005.9091324
GO:0006611protein export from nucleus1.72e-021.00e+005.8501325
GO:0035329hippo signaling1.79e-021.00e+005.7941526
GO:0000045autophagic vacuole assembly1.79e-021.00e+005.7941226
GO:0051209release of sequestered calcium ion into cytosol1.79e-021.00e+005.7941126
GO:0005829cytosol1.81e-021.00e+001.5315862496
GO:0015631tubulin binding1.86e-021.00e+005.7391227
GO:0034605cellular response to heat1.93e-021.00e+005.6871128
GO:0070830tight junction assembly1.93e-021.00e+005.6871128
GO:0071897DNA biosynthetic process1.93e-021.00e+005.6871128
GO:0005913cell-cell adherens junction1.99e-021.00e+005.6361329
GO:0072686mitotic spindle1.99e-021.00e+005.6361329
GO:0006606protein import into nucleus2.06e-021.00e+005.5871230
GO:0031647regulation of protein stability2.06e-021.00e+005.5871430
GO:0010827regulation of glucose transport2.06e-021.00e+005.5871430
GO:0009953dorsal/ventral pattern formation2.13e-021.00e+005.5401231
GO:1903507negative regulation of nucleic acid-templated transcription2.20e-021.00e+005.4941232
GO:0031072heat shock protein binding2.27e-021.00e+005.4501233
GO:0033077T cell differentiation in thymus2.27e-021.00e+005.4501133
GO:0043565sequence-specific DNA binding2.27e-021.00e+003.060211346
GO:0008285negative regulation of cell proliferation2.36e-021.00e+003.031210353
GO:0001942hair follicle development2.40e-021.00e+005.3651235
GO:0007077mitotic nuclear envelope disassembly2.47e-021.00e+005.3241436
GO:0048538thymus development2.47e-021.00e+005.3241236
GO:0008645hexose transport2.67e-021.00e+005.2091439
GO:0051781positive regulation of cell division2.67e-021.00e+005.2091139
GO:0005881cytoplasmic microtubule2.74e-021.00e+005.1721140
GO:0045785positive regulation of cell adhesion2.74e-021.00e+005.1721240
GO:0019898extrinsic component of membrane2.88e-021.00e+005.1021242
GO:0031124mRNA 3'-end processing2.88e-021.00e+005.1021242
GO:0006369termination of RNA polymerase II transcription3.08e-021.00e+005.0021245
GO:0043525positive regulation of neuron apoptotic process3.14e-021.00e+004.9711446
GO:0016328lateral plasma membrane3.14e-021.00e+004.9711346
GO:0045892negative regulation of transcription, DNA-templated3.16e-021.00e+002.804224413
GO:0006921cellular component disassembly involved in execution phase of apoptosis3.21e-021.00e+004.9401247
GO:0006366transcription from RNA polymerase II promoter3.25e-021.00e+002.783230419
GO:0006986response to unfolded protein3.41e-021.00e+004.8501450
GO:0045732positive regulation of protein catabolic process3.41e-021.00e+004.8501150
GO:0034976response to endoplasmic reticulum stress3.48e-021.00e+004.8221251
GO:0045454cell redox homeostasis3.48e-021.00e+004.8221151
GO:0060041retina development in camera-type eye3.48e-021.00e+004.8221251
GO:0009611response to wounding3.55e-021.00e+004.7941552
GO:0015758glucose transport3.75e-021.00e+004.7131455
GO:0005643nuclear pore3.88e-021.00e+004.66111157
GO:0006396RNA processing4.02e-021.00e+004.6121559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.02e-021.00e+004.6121659
GO:0008013beta-catenin binding4.08e-021.00e+004.5871960
GO:0045893positive regulation of transcription, DNA-templated4.14e-021.00e+002.593224478
GO:0006406mRNA export from nucleus4.15e-021.00e+004.5631461
GO:0006987activation of signaling protein activity involved in unfolded protein response4.15e-021.00e+004.5631261
GO:0007409axonogenesis4.42e-021.00e+004.4721265
GO:0010468regulation of gene expression4.62e-021.00e+004.4071268
GO:0032587ruffle membrane4.75e-021.00e+004.3651370
GO:0042826histone deacetylase binding4.88e-021.00e+004.3241472
GO:0003729mRNA binding4.88e-021.00e+004.3241472
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.02e-021.00e+004.2851474
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.08e-021.00e+004.2651175
GO:0060070canonical Wnt signaling pathway5.08e-021.00e+004.2651475
GO:0071013catalytic step 2 spliceosome5.28e-021.00e+004.2091778
GO:0001822kidney development5.28e-021.00e+004.2091378
GO:0030968endoplasmic reticulum unfolded protein response5.35e-021.00e+004.1901279
GO:0009653anatomical structure morphogenesis5.61e-021.00e+004.1191283
GO:0009952anterior/posterior pattern specification5.61e-021.00e+004.1191483
GO:0000122negative regulation of transcription from RNA polymerase II promoter5.69e-021.00e+002.339237570
GO:0005923tight junction5.81e-021.00e+004.0681286
GO:0005770late endosome6.27e-021.00e+003.9551293
GO:0030659cytoplasmic vesicle membrane6.79e-021.00e+003.83612101
GO:0030308negative regulation of cell growth7.37e-021.00e+003.71316110
GO:0006461protein complex assembly7.44e-021.00e+003.70014111
GO:0030529ribonucleoprotein complex7.50e-021.00e+003.68715112
GO:0005635nuclear envelope7.57e-021.00e+003.67415113
GO:0003700sequence-specific DNA binding transcription factor activity8.15e-021.00e+002.045239699
GO:0030027lamellipodium8.34e-021.00e+003.52817125
GO:0030335positive regulation of cell migration8.47e-021.00e+003.50515127
GO:0016477cell migration8.53e-021.00e+003.49414128
GO:0005215transporter activity8.66e-021.00e+003.47213130
GO:0016055Wnt signaling pathway9.17e-021.00e+003.38614138
GO:0008017microtubule binding9.74e-021.00e+003.29412147
GO:0042981regulation of apoptotic process9.93e-021.00e+003.26514150
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.00e-011.00e+001.870241789
GO:0046777protein autophosphorylation1.04e-011.00e+003.19014158
GO:0031965nuclear membrane1.11e-011.00e+003.102110168
GO:0016607nuclear speck1.13e-011.00e+003.068112172
GO:0005667transcription factor complex1.15e-011.00e+003.043117175
GO:0031625ubiquitin protein ligase binding1.17e-011.00e+003.01815178
GO:0006367transcription initiation from RNA polymerase II promoter1.21e-011.00e+002.971122184
GO:0007165signal transduction1.27e-011.00e+001.669213907
GO:0019221cytokine-mediated signaling pathway1.43e-011.00e+002.70618221
GO:0007067mitotic nuclear division1.47e-011.00e+002.66816227
GO:0003713transcription coactivator activity1.53e-011.00e+002.605124237
GO:0005975carbohydrate metabolic process1.62e-011.00e+002.51118253
GO:0043065positive regulation of apoptotic process1.71e-011.00e+002.42817268
GO:0005743mitochondrial inner membrane1.76e-011.00e+002.38016277
GO:0019899enzyme binding1.76e-011.00e+002.38019277
GO:0004674protein serine/threonine kinase activity1.94e-011.00e+002.22716308
GO:0019901protein kinase binding1.99e-011.00e+002.186118317
GO:0005813centrosome2.04e-011.00e+002.14517326
GO:0003682chromatin binding2.05e-011.00e+002.141119327
GO:0008283cell proliferation2.06e-011.00e+002.137114328
GO:0005524ATP binding2.25e-011.00e+001.1522311298
GO:0007155cell adhesion2.28e-011.00e+001.96715369
GO:0046982protein heterodimerization activity2.34e-011.00e+001.92418380
GO:0000278mitotic cell cycle2.40e-011.00e+001.883115391
GO:0009986cell surface2.46e-011.00e+001.84319402
GO:0055085transmembrane transport2.64e-011.00e+001.72918435
GO:0044267cellular protein metabolic process2.84e-011.00e+001.605120474
GO:0042802identical protein binding2.89e-011.00e+001.575119484
GO:0016032viral process3.14e-011.00e+001.433126534
GO:0006915apoptotic process3.25e-011.00e+001.378112555
GO:0016020membrane3.28e-011.00e+000.7792461681
GO:0042803protein homodimerization activity3.44e-011.00e+001.277119595
GO:0005887integral component of plasma membrane4.70e-011.00e+000.700110888
GO:0005739mitochondrion5.12e-011.00e+000.531123998
GO:0008270zinc ion binding5.12e-011.00e+000.533127997
GO:0044281small molecule metabolic process5.84e-011.00e+000.2521201211
GO:0005730nucleolus7.01e-011.00e+00-0.1861661641
GO:0070062extracellular vesicular exosome8.38e-011.00e+00-0.7351572400
GO:0005886plasma membrane8.61e-011.00e+00-0.8401492582