Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.804 | 3.53e-15 | 6.96e-04 | 4.38e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
CTNNBIP1 | 56998 | 1 | -2.034 | 2.804 | 19 | Yes | - |
APLP2 | 334 | 12 | -2.732 | 3.206 | 35 | Yes | Yes |
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
CCDC130 | 81576 | 1 | -2.761 | 2.804 | 9 | Yes | - |
RHOA | 387 | 5 | -2.408 | 2.845 | 151 | Yes | Yes |
JUP | 3728 | 1 | -1.370 | 2.804 | 104 | - | - |
TBC1D10A | 83874 | 8 | -2.544 | 2.989 | 26 | Yes | - |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
HNRNPU | 3192 | 76 | -2.869 | 3.538 | 139 | Yes | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
PROP1 | 5626 | 1 | -2.636 | 2.804 | 6 | Yes | Yes |
[ CTNNA2 ] | 1496 | 1 | -0.720 | 2.804 | 8 | - | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
JUP | 3728 | CCDC130 | 81576 | pp | -- | int.Mint: MI:0915(physical association) |
RHOA | 387 | CTNNA2 | 1496 | pp | -- | int.I2D: BioGrid_Fly, IntAct_Fly |
RHOA | 387 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
APLP2 | 334 | RHOA | 387 | pp | -- | int.I2D: IntAct_Mouse |
CTNNA2 | 1496 | JUP | 3728 | pp | -- | int.I2D: BIND_Worm, BioGrid_Worm |
HNRNPU | 3192 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
CTNNA2 | 1496 | CTNNBIP1 | 56998 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro |
HNRNPU | 3192 | YAP1 | 10413 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo |
JUP | 3728 | CTNNBIP1 | 56998 | pp | -- | int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid, HPRD, IntAct, MINT, VidalHuman_core, BIND; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
RHOA | 387 | TBC1D10A | 83874 | pp | -- | int.I2D: BioGrid_Yeast |
CTNNA2 | 1496 | YAP1 | 10413 | pp | -- | int.Intact: MI:0914(association) |
PROP1 | 5626 | CTNNBIP1 | 56998 | pp | -- | int.I2D: BioGrid_Mouse |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005515 | protein binding | 2.80e-05 | 4.04e-01 | 1.260 | 12 | 198 | 6024 |
GO:0045296 | cadherin binding | 1.73e-04 | 1.00e+00 | 6.646 | 2 | 3 | 24 |
GO:0005913 | cell-cell adherens junction | 2.54e-04 | 1.00e+00 | 6.373 | 2 | 3 | 29 |
GO:0005667 | transcription factor complex | 3.56e-04 | 1.00e+00 | 4.365 | 3 | 17 | 175 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0005199 | structural constituent of cell wall | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0061383 | trabecula morphogenesis | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0071665 | gamma-catenin-TCF7L2 complex | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 8.32e-04 | 1.00e+00 | 10.231 | 1 | 1 | 1 |
GO:0008013 | beta-catenin binding | 1.09e-03 | 1.00e+00 | 5.324 | 2 | 9 | 60 |
GO:0005829 | cytosol | 1.62e-03 | 1.00e+00 | 1.753 | 7 | 86 | 2496 |
GO:0002528 | regulation of vascular permeability involved in acute inflammatory response | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0048850 | hypophysis morphogenesis | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0021979 | hypothalamus cell differentiation | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0060242 | contact inhibition | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.66e-03 | 1.00e+00 | 9.231 | 1 | 1 | 2 |
GO:0016337 | single organismal cell-cell adhesion | 2.13e-03 | 1.00e+00 | 4.839 | 2 | 2 | 84 |
GO:0071603 | endothelial cell-cell adhesion | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0046914 | transition metal ion binding | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0003136 | negative regulation of heart induction by canonical Wnt signaling pathway | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0033688 | regulation of osteoblast proliferation | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0072201 | negative regulation of mesenchymal cell proliferation | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0060126 | somatotropin secreting cell differentiation | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0021942 | radial glia guided migration of Purkinje cell | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 3 |
GO:0038027 | apolipoprotein A-I-mediated signaling pathway | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0002159 | desmosome assembly | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0045657 | positive regulation of monocyte differentiation | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 4 |
GO:0001714 | endodermal cell fate specification | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0071681 | cellular response to indole-3-methanol | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0070934 | CRD-mediated mRNA stabilization | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 2 | 5 |
GO:0051823 | regulation of synapse structural plasticity | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0007176 | regulation of epidermal growth factor-activated receptor activity | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 5 |
GO:0030027 | lamellipodium | 4.65e-03 | 1.00e+00 | 4.265 | 2 | 7 | 125 |
GO:0016477 | cell migration | 4.87e-03 | 1.00e+00 | 4.231 | 2 | 4 | 128 |
GO:0036089 | cleavage furrow formation | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 2 | 6 |
GO:0070937 | CRD-mediated mRNA stability complex | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 3 | 6 |
GO:0016323 | basolateral plasma membrane | 5.40e-03 | 1.00e+00 | 4.154 | 2 | 3 | 135 |
GO:0050982 | detection of mechanical stimulus | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0043297 | apical junction assembly | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0043931 | ossification involved in bone maturation | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 7 |
GO:0097202 | activation of cysteine-type endopeptidase activity | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0048599 | oocyte development | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0007617 | mating behavior | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0086069 | bundle of His cell to Purkinje myocyte communication | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0045294 | alpha-catenin binding | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0003181 | atrioventricular valve morphogenesis | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0016342 | catenin complex | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 8 |
GO:0005915 | zonula adherens | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0030056 | hemidesmosome | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0043296 | apical junction complex | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 9 |
GO:0044212 | transcription regulatory region DNA binding | 8.24e-03 | 1.00e+00 | 3.839 | 2 | 17 | 168 |
GO:0035413 | positive regulation of catenin import into nucleus | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 10 |
GO:0090307 | spindle assembly involved in mitosis | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0016331 | morphogenesis of embryonic epithelium | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0070016 | armadillo repeat domain binding | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0030877 | beta-catenin destruction complex | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 10 |
GO:0016327 | apicolateral plasma membrane | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 10 |
GO:0015629 | actin cytoskeleton | 9.12e-03 | 1.00e+00 | 3.764 | 2 | 5 | 177 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 4 | 11 |
GO:0060134 | prepulse inhibition | 9.12e-03 | 1.00e+00 | 6.772 | 1 | 1 | 11 |
GO:0005654 | nucleoplasm | 9.57e-03 | 1.00e+00 | 2.152 | 4 | 64 | 1082 |
GO:0006878 | cellular copper ion homeostasis | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 12 |
GO:0071480 | cellular response to gamma radiation | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0007016 | cytoskeletal anchoring at plasma membrane | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0005916 | fascia adherens | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 13 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
GO:0030234 | enzyme regulator activity | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 13 |
GO:0001967 | suckling behavior | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 14 |
GO:0032993 | protein-DNA complex | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 2 | 14 |
GO:0042307 | positive regulation of protein import into nucleus | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 4 | 15 |
GO:0001824 | blastocyst development | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 15 |
GO:0048854 | brain morphogenesis | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 15 |
GO:0090002 | establishment of protein localization to plasma membrane | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 16 |
GO:0042176 | regulation of protein catabolic process | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 2 | 16 |
GO:0086005 | ventricular cardiac muscle cell action potential | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 16 |
GO:0007398 | ectoderm development | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 16 |
GO:0050919 | negative chemotaxis | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 17 |
GO:0017022 | myosin binding | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 2 | 17 |
GO:0022624 | proteasome accessory complex | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 17 |
GO:0050772 | positive regulation of axonogenesis | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 18 |
GO:0042346 | positive regulation of NF-kappaB import into nucleus | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 18 |
GO:0007369 | gastrulation | 1.57e-02 | 1.00e+00 | 5.983 | 1 | 1 | 19 |
GO:0086091 | regulation of heart rate by cardiac conduction | 1.57e-02 | 1.00e+00 | 5.983 | 1 | 1 | 19 |
GO:0003713 | transcription coactivator activity | 1.59e-02 | 1.00e+00 | 3.342 | 2 | 24 | 237 |
GO:0010467 | gene expression | 1.60e-02 | 1.00e+00 | 2.430 | 3 | 45 | 669 |
GO:0050771 | negative regulation of axonogenesis | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0043393 | regulation of protein binding | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 20 |
GO:0045862 | positive regulation of proteolysis | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 2 | 21 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.82e-02 | 1.00e+00 | 5.772 | 1 | 2 | 22 |
GO:0030057 | desmosome | 1.90e-02 | 1.00e+00 | 5.708 | 1 | 1 | 23 |
GO:1902017 | regulation of cilium assembly | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 2 | 24 |
GO:0043392 | negative regulation of DNA binding | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 4 | 26 |
GO:0035329 | hippo signaling | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 5 | 26 |
GO:0050770 | regulation of axonogenesis | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 2 | 26 |
GO:0051149 | positive regulation of muscle cell differentiation | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 4 | 27 |
GO:0032467 | positive regulation of cytokinesis | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 2 | 27 |
GO:0043588 | skin development | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 1 | 28 |
GO:0048662 | negative regulation of smooth muscle cell proliferation | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 2 | 28 |
GO:0005856 | cytoskeleton | 2.34e-02 | 1.00e+00 | 3.046 | 2 | 9 | 291 |
GO:0030901 | midbrain development | 2.39e-02 | 1.00e+00 | 5.373 | 1 | 1 | 29 |
GO:0048813 | dendrite morphogenesis | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 2 | 30 |
GO:0009953 | dorsal/ventral pattern formation | 2.55e-02 | 1.00e+00 | 5.277 | 1 | 2 | 31 |
GO:0032091 | negative regulation of protein binding | 2.63e-02 | 1.00e+00 | 5.231 | 1 | 3 | 32 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 2.63e-02 | 1.00e+00 | 5.231 | 1 | 2 | 32 |
GO:0005097 | Rab GTPase activator activity | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 1 | 34 |
GO:0042692 | muscle cell differentiation | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 4 | 34 |
GO:0001568 | blood vessel development | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 2 | 35 |
GO:0030178 | negative regulation of Wnt signaling pathway | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 4 | 35 |
GO:0005912 | adherens junction | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 1 | 35 |
GO:0014704 | intercalated disc | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 1 | 36 |
GO:0034332 | adherens junction organization | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 2 | 36 |
GO:0005902 | microvillus | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 3 | 38 |
GO:0051496 | positive regulation of stress fiber assembly | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 4 | 38 |
GO:0032154 | cleavage furrow | 3.12e-02 | 1.00e+00 | 4.983 | 1 | 1 | 38 |
GO:0043565 | sequence-specific DNA binding | 3.23e-02 | 1.00e+00 | 2.796 | 2 | 11 | 346 |
GO:0035019 | somatic stem cell maintenance | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 6 | 40 |
GO:0050885 | neuromuscular process controlling balance | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 2 | 40 |
GO:0042147 | retrograde transport, endosome to Golgi | 3.36e-02 | 1.00e+00 | 4.874 | 1 | 1 | 41 |
GO:0009898 | cytoplasmic side of plasma membrane | 3.36e-02 | 1.00e+00 | 4.874 | 1 | 2 | 41 |
GO:0001658 | branching involved in ureteric bud morphogenesis | 3.52e-02 | 1.00e+00 | 4.805 | 1 | 3 | 43 |
GO:0005925 | focal adhesion | 3.58e-02 | 1.00e+00 | 2.715 | 2 | 9 | 366 |
GO:0021762 | substantia nigra development | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 4 | 44 |
GO:0070062 | extracellular vesicular exosome | 3.61e-02 | 1.00e+00 | 1.324 | 5 | 57 | 2400 |
GO:0016328 | lateral plasma membrane | 3.76e-02 | 1.00e+00 | 4.708 | 1 | 3 | 46 |
GO:0007266 | Rho protein signal transduction | 3.84e-02 | 1.00e+00 | 4.677 | 1 | 1 | 47 |
GO:0090263 | positive regulation of canonical Wnt signaling pathway | 3.92e-02 | 1.00e+00 | 4.646 | 1 | 3 | 48 |
GO:0000902 | cell morphogenesis | 4.00e-02 | 1.00e+00 | 4.616 | 1 | 4 | 49 |
GO:0030900 | forebrain development | 4.00e-02 | 1.00e+00 | 4.616 | 1 | 1 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 1 | 50 |
GO:0030334 | regulation of cell migration | 4.08e-02 | 1.00e+00 | 4.587 | 1 | 5 | 50 |
GO:0009611 | response to wounding | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 5 | 52 |
GO:0032851 | positive regulation of Rab GTPase activity | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 2 | 53 |
GO:0045216 | cell-cell junction organization | 4.40e-02 | 1.00e+00 | 4.476 | 1 | 2 | 54 |
GO:0045669 | positive regulation of osteoblast differentiation | 4.48e-02 | 1.00e+00 | 4.450 | 1 | 1 | 55 |
GO:0051291 | protein heterooligomerization | 4.56e-02 | 1.00e+00 | 4.424 | 1 | 4 | 56 |
GO:0008203 | cholesterol metabolic process | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 2 | 57 |
GO:0043066 | negative regulation of apoptotic process | 4.68e-02 | 1.00e+00 | 2.503 | 2 | 16 | 424 |
GO:0000502 | proteasome complex | 4.72e-02 | 1.00e+00 | 4.373 | 1 | 3 | 58 |
GO:0006396 | RNA processing | 4.80e-02 | 1.00e+00 | 4.348 | 1 | 5 | 59 |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 4.80e-02 | 1.00e+00 | 4.348 | 1 | 6 | 59 |
GO:0005882 | intermediate filament | 4.96e-02 | 1.00e+00 | 4.300 | 1 | 2 | 61 |
GO:0019903 | protein phosphatase binding | 5.04e-02 | 1.00e+00 | 4.277 | 1 | 2 | 62 |
GO:0005634 | nucleus | 5.06e-02 | 1.00e+00 | 0.884 | 7 | 159 | 4559 |
GO:0004867 | serine-type endopeptidase inhibitor activity | 5.12e-02 | 1.00e+00 | 4.254 | 1 | 3 | 63 |
GO:0045666 | positive regulation of neuron differentiation | 5.12e-02 | 1.00e+00 | 4.254 | 1 | 3 | 63 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 5.20e-02 | 1.00e+00 | 4.231 | 1 | 1 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 2 | 65 |
GO:0007409 | axonogenesis | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 2 | 65 |
GO:0010468 | regulation of gene expression | 5.52e-02 | 1.00e+00 | 4.144 | 1 | 2 | 68 |
GO:0034329 | cell junction assembly | 5.52e-02 | 1.00e+00 | 4.144 | 1 | 3 | 68 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.67e-02 | 1.00e+00 | 4.102 | 1 | 2 | 70 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 5.75e-02 | 1.00e+00 | 4.081 | 1 | 5 | 71 |
GO:0007626 | locomotory behavior | 5.75e-02 | 1.00e+00 | 4.081 | 1 | 2 | 71 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 5.83e-02 | 1.00e+00 | 4.061 | 1 | 1 | 72 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.99e-02 | 1.00e+00 | 4.022 | 1 | 2 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 1 | 75 |
GO:0060070 | canonical Wnt signaling pathway | 6.07e-02 | 1.00e+00 | 4.002 | 1 | 4 | 75 |
GO:0071013 | catalytic step 2 spliceosome | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 7 | 78 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 6.38e-02 | 1.00e+00 | 3.927 | 1 | 2 | 79 |
GO:0009653 | anatomical structure morphogenesis | 6.69e-02 | 1.00e+00 | 3.856 | 1 | 2 | 83 |
GO:0009952 | anterior/posterior pattern specification | 6.69e-02 | 1.00e+00 | 3.856 | 1 | 4 | 83 |
GO:0016032 | viral process | 7.07e-02 | 1.00e+00 | 2.170 | 2 | 26 | 534 |
GO:0005200 | structural constituent of cytoskeleton | 7.32e-02 | 1.00e+00 | 3.723 | 1 | 6 | 91 |
GO:0001649 | osteoblast differentiation | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 5 | 92 |
GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 7 | 92 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 7.39e-02 | 1.00e+00 | 3.708 | 1 | 1 | 92 |
GO:0003677 | DNA binding | 7.43e-02 | 1.00e+00 | 1.566 | 3 | 49 | 1218 |
GO:0030165 | PDZ domain binding | 7.55e-02 | 1.00e+00 | 3.677 | 1 | 1 | 94 |
GO:0007417 | central nervous system development | 7.70e-02 | 1.00e+00 | 3.646 | 1 | 5 | 96 |
GO:0030018 | Z disc | 7.78e-02 | 1.00e+00 | 3.631 | 1 | 4 | 97 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 7.92e-02 | 1.00e+00 | 2.076 | 2 | 37 | 570 |
GO:0010951 | negative regulation of endopeptidase activity | 8.32e-02 | 1.00e+00 | 3.531 | 1 | 6 | 104 |
GO:0005938 | cell cortex | 8.32e-02 | 1.00e+00 | 3.531 | 1 | 5 | 104 |
GO:0030496 | midbody | 8.63e-02 | 1.00e+00 | 3.476 | 1 | 2 | 108 |
GO:0042127 | regulation of cell proliferation | 8.70e-02 | 1.00e+00 | 3.463 | 1 | 4 | 109 |
GO:0030529 | ribonucleoprotein complex | 8.93e-02 | 1.00e+00 | 3.424 | 1 | 5 | 112 |
GO:0048015 | phosphatidylinositol-mediated signaling | 9.09e-02 | 1.00e+00 | 3.398 | 1 | 2 | 114 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 9.16e-02 | 1.00e+00 | 3.386 | 1 | 3 | 115 |
GO:0000209 | protein polyubiquitination | 9.24e-02 | 1.00e+00 | 3.373 | 1 | 3 | 116 |
GO:0008201 | heparin binding | 9.69e-02 | 1.00e+00 | 3.300 | 1 | 1 | 122 |
GO:0030036 | actin cytoskeleton organization | 9.77e-02 | 1.00e+00 | 3.289 | 1 | 3 | 123 |
GO:0009615 | response to virus | 1.00e-01 | 1.00e+00 | 3.254 | 1 | 1 | 126 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.01e-01 | 1.00e+00 | 3.231 | 1 | 11 | 128 |
GO:0005911 | cell-cell junction | 1.08e-01 | 1.00e+00 | 3.144 | 1 | 2 | 136 |
GO:0016055 | Wnt signaling pathway | 1.09e-01 | 1.00e+00 | 3.123 | 1 | 4 | 138 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 1.14e-01 | 1.00e+00 | 3.051 | 1 | 4 | 145 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.17e-01 | 1.00e+00 | 3.012 | 1 | 3 | 149 |
GO:0005198 | structural molecule activity | 1.18e-01 | 1.00e+00 | 3.002 | 1 | 3 | 150 |
GO:0042981 | regulation of apoptotic process | 1.18e-01 | 1.00e+00 | 3.002 | 1 | 4 | 150 |
GO:0006974 | cellular response to DNA damage stimulus | 1.19e-01 | 1.00e+00 | 2.993 | 1 | 7 | 151 |
GO:0008022 | protein C-terminus binding | 1.26e-01 | 1.00e+00 | 2.900 | 1 | 8 | 161 |
GO:0000398 | mRNA splicing, via spliceosome | 1.28e-01 | 1.00e+00 | 2.874 | 1 | 15 | 164 |
GO:0030424 | axon | 1.30e-01 | 1.00e+00 | 2.856 | 1 | 4 | 166 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.33e-01 | 1.00e+00 | 2.813 | 1 | 2 | 171 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 1.37e-01 | 1.00e+00 | 1.607 | 2 | 41 | 789 |
GO:0031625 | ubiquitin protein ligase binding | 1.38e-01 | 1.00e+00 | 2.755 | 1 | 5 | 178 |
GO:0003714 | transcription corepressor activity | 1.38e-01 | 1.00e+00 | 2.755 | 1 | 11 | 178 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.43e-01 | 1.00e+00 | 2.708 | 1 | 22 | 184 |
GO:0003924 | GTPase activity | 1.52e-01 | 1.00e+00 | 2.609 | 1 | 7 | 197 |
GO:0005886 | plasma membrane | 1.53e-01 | 1.00e+00 | 0.897 | 4 | 49 | 2582 |
GO:0016020 | membrane | 1.56e-01 | 1.00e+00 | 1.101 | 3 | 46 | 1681 |
GO:0030168 | platelet activation | 1.58e-01 | 1.00e+00 | 2.552 | 1 | 6 | 205 |
GO:0006184 | GTP catabolic process | 1.64e-01 | 1.00e+00 | 2.490 | 1 | 7 | 214 |
GO:0016071 | mRNA metabolic process | 1.71e-01 | 1.00e+00 | 2.430 | 1 | 8 | 223 |
GO:0008380 | RNA splicing | 1.74e-01 | 1.00e+00 | 2.398 | 1 | 22 | 228 |
GO:0007399 | nervous system development | 1.76e-01 | 1.00e+00 | 2.379 | 1 | 6 | 231 |
GO:0005737 | cytoplasm | 1.81e-01 | 1.00e+00 | 0.674 | 5 | 124 | 3767 |
GO:0008134 | transcription factor binding | 1.84e-01 | 1.00e+00 | 2.312 | 1 | 18 | 242 |
GO:0016070 | RNA metabolic process | 1.87e-01 | 1.00e+00 | 2.283 | 1 | 8 | 247 |
GO:0006355 | regulation of transcription, DNA-templated | 1.99e-01 | 1.00e+00 | 1.270 | 2 | 43 | 997 |
GO:0048011 | neurotrophin TRK receptor signaling pathway | 2.02e-01 | 1.00e+00 | 2.160 | 1 | 7 | 269 |
GO:0007264 | small GTPase mediated signal transduction | 2.09e-01 | 1.00e+00 | 2.107 | 1 | 3 | 279 |
GO:0005575 | cellular_component | 2.09e-01 | 1.00e+00 | 2.107 | 1 | 2 | 279 |
GO:0030198 | extracellular matrix organization | 2.12e-01 | 1.00e+00 | 2.086 | 1 | 6 | 283 |
GO:0007186 | G-protein coupled receptor signaling pathway | 2.16e-01 | 1.00e+00 | 2.056 | 1 | 1 | 289 |
GO:0044822 | poly(A) RNA binding | 2.18e-01 | 1.00e+00 | 1.187 | 2 | 50 | 1056 |
GO:0005525 | GTP binding | 2.30e-01 | 1.00e+00 | 1.955 | 1 | 12 | 310 |
GO:0019901 | protein kinase binding | 2.34e-01 | 1.00e+00 | 1.923 | 1 | 18 | 317 |
GO:0007411 | axon guidance | 2.35e-01 | 1.00e+00 | 1.914 | 1 | 5 | 319 |
GO:0003682 | chromatin binding | 2.41e-01 | 1.00e+00 | 1.878 | 1 | 19 | 327 |
GO:0008283 | cell proliferation | 2.41e-01 | 1.00e+00 | 1.874 | 1 | 14 | 328 |
GO:0030054 | cell junction | 2.46e-01 | 1.00e+00 | 1.839 | 1 | 5 | 336 |
GO:0003723 | RNA binding | 2.50e-01 | 1.00e+00 | 1.813 | 1 | 18 | 342 |
GO:0000278 | mitotic cell cycle | 2.81e-01 | 1.00e+00 | 1.620 | 1 | 15 | 391 |
GO:0009986 | cell surface | 2.88e-01 | 1.00e+00 | 1.580 | 1 | 9 | 402 |
GO:0006366 | transcription from RNA polymerase II promoter | 2.98e-01 | 1.00e+00 | 1.520 | 1 | 30 | 419 |
GO:0007596 | blood coagulation | 3.19e-01 | 1.00e+00 | 1.401 | 1 | 11 | 455 |
GO:0042802 | identical protein binding | 3.36e-01 | 1.00e+00 | 1.312 | 1 | 19 | 484 |
GO:0006915 | apoptotic process | 3.76e-01 | 1.00e+00 | 1.115 | 1 | 12 | 555 |
GO:0042803 | protein homodimerization activity | 3.97e-01 | 1.00e+00 | 1.014 | 1 | 19 | 595 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 4.49e-01 | 1.00e+00 | 0.782 | 1 | 39 | 699 |
GO:0044281 | small molecule metabolic process | 6.51e-01 | 1.00e+00 | -0.011 | 1 | 20 | 1211 |
GO:0005524 | ATP binding | 6.78e-01 | 1.00e+00 | -0.111 | 1 | 31 | 1298 |
GO:0016021 | integral component of membrane | 8.30e-01 | 1.00e+00 | -0.722 | 1 | 17 | 1982 |