int-snw-1496

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.804 3.53e-15 6.96e-04 4.38e-03
chia-screen-data-Fav-int-snw-1496 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
CTNNBIP1 56998 1-2.0342.80419Yes-
APLP2 334 12-2.7323.20635YesYes
PSMD2 5708 47-4.1723.157386YesYes
CCDC130 81576 1-2.7612.8049Yes-
RHOA 387 5-2.4082.845151YesYes
JUP 3728 1-1.3702.804104--
TBC1D10A 83874 8-2.5442.98926Yes-
YAP1 10413 94-4.2563.53853Yes-
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
PROP1 5626 1-2.6362.8046YesYes
[ CTNNA2 ] 1496 1-0.7202.8048--

Interactions (12)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
JUP 3728 CCDC130 81576 pp -- int.Mint: MI:0915(physical association)
RHOA 387 CTNNA2 1496 pp -- int.I2D: BioGrid_Fly, IntAct_Fly
RHOA 387 PSMD2 5708 pp -- int.I2D: BioGrid_Yeast
APLP2 334 RHOA 387 pp -- int.I2D: IntAct_Mouse
CTNNA2 1496 JUP 3728 pp -- int.I2D: BIND_Worm, BioGrid_Worm
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
CTNNA2 1496 CTNNBIP1 56998 pp -- int.I2D: HPRD;
int.HPRD: in vitro
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
JUP 3728 CTNNBIP1 56998 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid, HPRD, IntAct, MINT, VidalHuman_core, BIND;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
RHOA 387 TBC1D10A 83874 pp -- int.I2D: BioGrid_Yeast
CTNNA2 1496 YAP1 10413 pp -- int.Intact: MI:0914(association)
PROP1 5626 CTNNBIP1 56998 pp -- int.I2D: BioGrid_Mouse

Related GO terms (243)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005515protein binding2.80e-054.04e-011.260121986024
GO:0045296cadherin binding1.73e-041.00e+006.6462324
GO:0005913cell-cell adherens junction2.54e-041.00e+006.3732329
GO:0005667transcription factor complex3.56e-041.00e+004.365317175
GO:0060795cell fate commitment involved in formation of primary germ layer8.32e-041.00e+0010.231111
GO:0005199structural constituent of cell wall8.32e-041.00e+0010.231111
GO:0061383trabecula morphogenesis8.32e-041.00e+0010.231111
GO:0090308regulation of methylation-dependent chromatin silencing8.32e-041.00e+0010.231111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway8.32e-041.00e+0010.231111
GO:0071665gamma-catenin-TCF7L2 complex8.32e-041.00e+0010.231111
GO:0060965negative regulation of gene silencing by miRNA8.32e-041.00e+0010.231111
GO:0008013beta-catenin binding1.09e-031.00e+005.3242960
GO:0005829cytosol1.62e-031.00e+001.7537862496
GO:0002528regulation of vascular permeability involved in acute inflammatory response1.66e-031.00e+009.231112
GO:0048850hypophysis morphogenesis1.66e-031.00e+009.231112
GO:0021979hypothalamus cell differentiation1.66e-031.00e+009.231112
GO:0060242contact inhibition1.66e-031.00e+009.231112
GO:0060633negative regulation of transcription initiation from RNA polymerase II promoter1.66e-031.00e+009.231112
GO:0009786regulation of asymmetric cell division1.66e-031.00e+009.231112
GO:0016337single organismal cell-cell adhesion2.13e-031.00e+004.8392284
GO:0071603endothelial cell-cell adhesion2.49e-031.00e+008.646113
GO:0003308negative regulation of Wnt signaling pathway involved in heart development2.49e-031.00e+008.646113
GO:0046914transition metal ion binding2.49e-031.00e+008.646113
GO:0003136negative regulation of heart induction by canonical Wnt signaling pathway2.49e-031.00e+008.646113
GO:0033688regulation of osteoblast proliferation2.49e-031.00e+008.646113
GO:0072201negative regulation of mesenchymal cell proliferation2.49e-031.00e+008.646113
GO:0060913cardiac cell fate determination2.49e-031.00e+008.646113
GO:0003130BMP signaling pathway involved in heart induction2.49e-031.00e+008.646113
GO:0060126somatotropin secreting cell differentiation2.49e-031.00e+008.646113
GO:0021942radial glia guided migration of Purkinje cell2.49e-031.00e+008.646113
GO:0038027apolipoprotein A-I-mediated signaling pathway3.32e-031.00e+008.231114
GO:0002159desmosome assembly3.32e-031.00e+008.231114
GO:0045657positive regulation of monocyte differentiation3.32e-031.00e+008.231114
GO:0001714endodermal cell fate specification4.15e-031.00e+007.909115
GO:0071681cellular response to indole-3-methanol4.15e-031.00e+007.909115
GO:0070934CRD-mediated mRNA stabilization4.15e-031.00e+007.909125
GO:0051823regulation of synapse structural plasticity4.15e-031.00e+007.909115
GO:0007176regulation of epidermal growth factor-activated receptor activity4.15e-031.00e+007.909115
GO:0030027lamellipodium4.65e-031.00e+004.26527125
GO:0016477cell migration4.87e-031.00e+004.23124128
GO:0036089cleavage furrow formation4.98e-031.00e+007.646126
GO:0070937CRD-mediated mRNA stability complex4.98e-031.00e+007.646136
GO:0016323basolateral plasma membrane5.40e-031.00e+004.15423135
GO:0050982detection of mechanical stimulus5.81e-031.00e+007.424117
GO:0043297apical junction assembly5.81e-031.00e+007.424117
GO:0043931ossification involved in bone maturation5.81e-031.00e+007.424117
GO:0097202activation of cysteine-type endopeptidase activity6.64e-031.00e+007.231118
GO:0048599oocyte development6.64e-031.00e+007.231118
GO:0007617mating behavior6.64e-031.00e+007.231118
GO:0086069bundle of His cell to Purkinje myocyte communication6.64e-031.00e+007.231118
GO:0045294alpha-catenin binding6.64e-031.00e+007.231118
GO:0003181atrioventricular valve morphogenesis6.64e-031.00e+007.231118
GO:0016342catenin complex6.64e-031.00e+007.231118
GO:0005915zonula adherens7.47e-031.00e+007.061119
GO:0030056hemidesmosome7.47e-031.00e+007.061119
GO:0043296apical junction complex7.47e-031.00e+007.061119
GO:0044212transcription regulatory region DNA binding8.24e-031.00e+003.839217168
GO:0035413positive regulation of catenin import into nucleus8.29e-031.00e+006.9091210
GO:0090307spindle assembly involved in mitosis8.29e-031.00e+006.9091110
GO:0016331morphogenesis of embryonic epithelium8.29e-031.00e+006.9091110
GO:0070016armadillo repeat domain binding8.29e-031.00e+006.9091110
GO:0030877beta-catenin destruction complex8.29e-031.00e+006.9091210
GO:0016327apicolateral plasma membrane8.29e-031.00e+006.9091110
GO:0015629actin cytoskeleton9.12e-031.00e+003.76425177
GO:0060391positive regulation of SMAD protein import into nucleus9.12e-031.00e+006.7721411
GO:0060134prepulse inhibition9.12e-031.00e+006.7721111
GO:0005654nucleoplasm9.57e-031.00e+002.1524641082
GO:0006878cellular copper ion homeostasis9.94e-031.00e+006.6461112
GO:0005838proteasome regulatory particle9.94e-031.00e+006.6461112
GO:0035198miRNA binding9.94e-031.00e+006.6461112
GO:0071480cellular response to gamma radiation1.08e-021.00e+006.5311113
GO:0007016cytoskeletal anchoring at plasma membrane1.08e-021.00e+006.5311113
GO:0005916fascia adherens1.08e-021.00e+006.5311113
GO:0042789mRNA transcription from RNA polymerase II promoter1.08e-021.00e+006.5311213
GO:0030234enzyme regulator activity1.08e-021.00e+006.5311213
GO:0001967suckling behavior1.16e-021.00e+006.4241114
GO:0032993protein-DNA complex1.16e-021.00e+006.4241214
GO:0042307positive regulation of protein import into nucleus1.24e-021.00e+006.3241415
GO:0001824blastocyst development1.24e-021.00e+006.3241215
GO:0048854brain morphogenesis1.24e-021.00e+006.3241215
GO:0090002establishment of protein localization to plasma membrane1.32e-021.00e+006.2311116
GO:0042176regulation of protein catabolic process1.32e-021.00e+006.2311216
GO:0086005ventricular cardiac muscle cell action potential1.32e-021.00e+006.2311116
GO:0007398ectoderm development1.32e-021.00e+006.2311116
GO:0050919negative chemotaxis1.41e-021.00e+006.1441117
GO:0017022myosin binding1.41e-021.00e+006.1441217
GO:0022624proteasome accessory complex1.41e-021.00e+006.1441117
GO:0050772positive regulation of axonogenesis1.49e-021.00e+006.0611118
GO:0042346positive regulation of NF-kappaB import into nucleus1.49e-021.00e+006.0611118
GO:0007369gastrulation1.57e-021.00e+005.9831119
GO:0086091regulation of heart rate by cardiac conduction1.57e-021.00e+005.9831119
GO:0003713transcription coactivator activity1.59e-021.00e+003.342224237
GO:0010467gene expression1.60e-021.00e+002.430345669
GO:0050771negative regulation of axonogenesis1.65e-021.00e+005.9091120
GO:0043393regulation of protein binding1.65e-021.00e+005.9091120
GO:0045862positive regulation of proteolysis1.73e-021.00e+005.8391221
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721222
GO:0030057desmosome1.90e-021.00e+005.7081123
GO:1902017regulation of cilium assembly1.98e-021.00e+005.6461224
GO:0043392negative regulation of DNA binding2.14e-021.00e+005.5311426
GO:0035329hippo signaling2.14e-021.00e+005.5311526
GO:0050770regulation of axonogenesis2.14e-021.00e+005.5311226
GO:0051149positive regulation of muscle cell differentiation2.22e-021.00e+005.4761427
GO:0032467positive regulation of cytokinesis2.22e-021.00e+005.4761227
GO:0043588skin development2.31e-021.00e+005.4241128
GO:0048662negative regulation of smooth muscle cell proliferation2.31e-021.00e+005.4241228
GO:0005856cytoskeleton2.34e-021.00e+003.04629291
GO:0030901midbrain development2.39e-021.00e+005.3731129
GO:0048813dendrite morphogenesis2.47e-021.00e+005.3241230
GO:0009953dorsal/ventral pattern formation2.55e-021.00e+005.2771231
GO:0032091negative regulation of protein binding2.63e-021.00e+005.2311332
GO:1903507negative regulation of nucleic acid-templated transcription2.63e-021.00e+005.2311232
GO:0005097Rab GTPase activator activity2.79e-021.00e+005.1441134
GO:0042692muscle cell differentiation2.79e-021.00e+005.1441434
GO:0001568blood vessel development2.87e-021.00e+005.1021235
GO:0030178negative regulation of Wnt signaling pathway2.87e-021.00e+005.1021435
GO:0005912adherens junction2.87e-021.00e+005.1021135
GO:0014704intercalated disc2.96e-021.00e+005.0611136
GO:0034332adherens junction organization2.96e-021.00e+005.0611236
GO:0005902microvillus3.12e-021.00e+004.9831338
GO:0051496positive regulation of stress fiber assembly3.12e-021.00e+004.9831438
GO:0032154cleavage furrow3.12e-021.00e+004.9831138
GO:0043565sequence-specific DNA binding3.23e-021.00e+002.796211346
GO:0035019somatic stem cell maintenance3.28e-021.00e+004.9091640
GO:0050885neuromuscular process controlling balance3.28e-021.00e+004.9091240
GO:0042147retrograde transport, endosome to Golgi3.36e-021.00e+004.8741141
GO:0009898cytoplasmic side of plasma membrane3.36e-021.00e+004.8741241
GO:0001658branching involved in ureteric bud morphogenesis3.52e-021.00e+004.8051343
GO:0005925focal adhesion3.58e-021.00e+002.71529366
GO:0021762substantia nigra development3.60e-021.00e+004.7721444
GO:0070062extracellular vesicular exosome3.61e-021.00e+001.3245572400
GO:0016328lateral plasma membrane3.76e-021.00e+004.7081346
GO:0007266Rho protein signal transduction3.84e-021.00e+004.6771147
GO:0090263positive regulation of canonical Wnt signaling pathway3.92e-021.00e+004.6461348
GO:0000902cell morphogenesis4.00e-021.00e+004.6161449
GO:0030900forebrain development4.00e-021.00e+004.6161149
GO:0006521regulation of cellular amino acid metabolic process4.08e-021.00e+004.5871150
GO:0030334regulation of cell migration4.08e-021.00e+004.5871550
GO:0009611response to wounding4.24e-021.00e+004.5311552
GO:0032851positive regulation of Rab GTPase activity4.32e-021.00e+004.5031253
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0045669positive regulation of osteoblast differentiation4.48e-021.00e+004.4501155
GO:0051291protein heterooligomerization4.56e-021.00e+004.4241456
GO:0008203cholesterol metabolic process4.64e-021.00e+004.3981257
GO:0043066negative regulation of apoptotic process4.68e-021.00e+002.503216424
GO:0000502proteasome complex4.72e-021.00e+004.3731358
GO:0006396RNA processing4.80e-021.00e+004.3481559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.80e-021.00e+004.3481659
GO:0005882intermediate filament4.96e-021.00e+004.3001261
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771262
GO:0005634nucleus5.06e-021.00e+000.88471594559
GO:0004867serine-type endopeptidase inhibitor activity5.12e-021.00e+004.2541363
GO:0045666positive regulation of neuron differentiation5.12e-021.00e+004.2541363
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.20e-021.00e+004.2311164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.28e-021.00e+004.2091265
GO:0007409axonogenesis5.28e-021.00e+004.2091265
GO:0010468regulation of gene expression5.52e-021.00e+004.1441268
GO:0034329cell junction assembly5.52e-021.00e+004.1441368
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.67e-021.00e+004.1021270
GO:0005085guanyl-nucleotide exchange factor activity5.75e-021.00e+004.0811571
GO:0007626locomotory behavior5.75e-021.00e+004.0811271
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.83e-021.00e+004.0611172
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.99e-021.00e+004.0221474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.99e-021.00e+004.0221274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.07e-021.00e+004.0021175
GO:0060070canonical Wnt signaling pathway6.07e-021.00e+004.0021475
GO:0071013catalytic step 2 spliceosome6.30e-021.00e+003.9461778
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.38e-021.00e+003.9271279
GO:0009653anatomical structure morphogenesis6.69e-021.00e+003.8561283
GO:0009952anterior/posterior pattern specification6.69e-021.00e+003.8561483
GO:0016032viral process7.07e-021.00e+002.170226534
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231691
GO:0001649osteoblast differentiation7.39e-021.00e+003.7081592
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity7.39e-021.00e+003.7081792
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.39e-021.00e+003.7081192
GO:0003677DNA binding7.43e-021.00e+001.5663491218
GO:0030165PDZ domain binding7.55e-021.00e+003.6771194
GO:0007417central nervous system development7.70e-021.00e+003.6461596
GO:0030018Z disc7.78e-021.00e+003.6311497
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.92e-021.00e+002.076237570
GO:0010951negative regulation of endopeptidase activity8.32e-021.00e+003.53116104
GO:0005938cell cortex8.32e-021.00e+003.53115104
GO:0030496midbody8.63e-021.00e+003.47612108
GO:0042127regulation of cell proliferation8.70e-021.00e+003.46314109
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42415112
GO:0048015phosphatidylinositol-mediated signaling9.09e-021.00e+003.39812114
GO:0051056regulation of small GTPase mediated signal transduction9.16e-021.00e+003.38613115
GO:0000209protein polyubiquitination9.24e-021.00e+003.37313116
GO:0008201heparin binding9.69e-021.00e+003.30011122
GO:0030036actin cytoskeleton organization9.77e-021.00e+003.28913123
GO:0009615response to virus1.00e-011.00e+003.25411126
GO:0007179transforming growth factor beta receptor signaling pathway1.01e-011.00e+003.231111128
GO:0005911cell-cell junction1.08e-011.00e+003.14412136
GO:0016055Wnt signaling pathway1.09e-011.00e+003.12314138
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling1.14e-011.00e+003.05114145
GO:0000082G1/S transition of mitotic cell cycle1.17e-011.00e+003.01213149
GO:0005198structural molecule activity1.18e-011.00e+003.00213150
GO:0042981regulation of apoptotic process1.18e-011.00e+003.00214150
GO:0006974cellular response to DNA damage stimulus1.19e-011.00e+002.99317151
GO:0008022protein C-terminus binding1.26e-011.00e+002.90018161
GO:0000398mRNA splicing, via spliceosome1.28e-011.00e+002.874115164
GO:0030424axon1.30e-011.00e+002.85614166
GO:0034641cellular nitrogen compound metabolic process1.33e-011.00e+002.81312171
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.37e-011.00e+001.607241789
GO:0031625ubiquitin protein ligase binding1.38e-011.00e+002.75515178
GO:0003714transcription corepressor activity1.38e-011.00e+002.755111178
GO:0006367transcription initiation from RNA polymerase II promoter1.43e-011.00e+002.708122184
GO:0003924GTPase activity1.52e-011.00e+002.60917197
GO:0005886plasma membrane1.53e-011.00e+000.8974492582
GO:0016020membrane1.56e-011.00e+001.1013461681
GO:0030168platelet activation1.58e-011.00e+002.55216205
GO:0006184GTP catabolic process1.64e-011.00e+002.49017214
GO:0016071mRNA metabolic process1.71e-011.00e+002.43018223
GO:0008380RNA splicing1.74e-011.00e+002.398122228
GO:0007399nervous system development1.76e-011.00e+002.37916231
GO:0005737cytoplasm1.81e-011.00e+000.67451243767
GO:0008134transcription factor binding1.84e-011.00e+002.312118242
GO:0016070RNA metabolic process1.87e-011.00e+002.28318247
GO:0006355regulation of transcription, DNA-templated1.99e-011.00e+001.270243997
GO:0048011neurotrophin TRK receptor signaling pathway2.02e-011.00e+002.16017269
GO:0007264small GTPase mediated signal transduction2.09e-011.00e+002.10713279
GO:0005575cellular_component2.09e-011.00e+002.10712279
GO:0030198extracellular matrix organization2.12e-011.00e+002.08616283
GO:0007186G-protein coupled receptor signaling pathway2.16e-011.00e+002.05611289
GO:0044822poly(A) RNA binding2.18e-011.00e+001.1872501056
GO:0005525GTP binding2.30e-011.00e+001.955112310
GO:0019901protein kinase binding2.34e-011.00e+001.923118317
GO:0007411axon guidance2.35e-011.00e+001.91415319
GO:0003682chromatin binding2.41e-011.00e+001.878119327
GO:0008283cell proliferation2.41e-011.00e+001.874114328
GO:0030054cell junction2.46e-011.00e+001.83915336
GO:0003723RNA binding2.50e-011.00e+001.813118342
GO:0000278mitotic cell cycle2.81e-011.00e+001.620115391
GO:0009986cell surface2.88e-011.00e+001.58019402
GO:0006366transcription from RNA polymerase II promoter2.98e-011.00e+001.520130419
GO:0007596blood coagulation3.19e-011.00e+001.401111455
GO:0042802identical protein binding3.36e-011.00e+001.312119484
GO:0006915apoptotic process3.76e-011.00e+001.115112555
GO:0042803protein homodimerization activity3.97e-011.00e+001.014119595
GO:0003700sequence-specific DNA binding transcription factor activity4.49e-011.00e+000.782139699
GO:0044281small molecule metabolic process6.51e-011.00e+00-0.0111201211
GO:0005524ATP binding6.78e-011.00e+00-0.1111311298
GO:0016021integral component of membrane8.30e-011.00e+00-0.7221171982