int-snw-9948

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.003 2.99e-18 5.14e-04 1.24e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-9948 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RSL24D1 51187 361.3001.02059Yes-
RUVBL1 8607 170.7201.013343Yes-
RBX1 9978 971.1851.151139Yes-
[ WDR1 ] 9948 10.4341.00338Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
RUVBL2 10856 50.6931.003345Yes-
RPSA 3921 1561.3271.151152Yes-
CFL1 1072 120.6741.020203Yes-
PGD 5226 751.2011.106138Yes-

Interactions (20)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
RUVBL1 8607 WDR1 9948 pp -- int.I2D: BioGrid_Mouse
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
WDR1 9948 RUVBL2 10856 pp -- int.I2D: BioGrid_Mouse
RPSA 3921 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
CFL1 1072 WDR1 9948 pp -- int.I2D: BioGrid_Yeast, HPRD, YeastLow, BCI, IntAct_Yeast, MINT_Yeast;
int.HPRD: in vitro, yeast 2-hybrid
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
RUVBL1 8607 RUVBL2 10856 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd;
int.Ravasi: -;
int.HPRD: in vitro, in vivo, yeast 2-hybrid;
int.DIP: MI:0915(physical association)
ACTB 60 WDR1 9948 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MIPS
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 RUVBL2 10856 pp -- int.I2D: YeastLow
CFL1 1072 RUVBL1 8607 pp -- int.I2D: YeastLow
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow

Related GO terms (219)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0035267NuA4 histone acetyltransferase complex1.20e-071.72e-038.1343414
GO:0000812Swr1 complex1.48e-052.13e-018.357238
GO:0006281DNA repair3.13e-054.51e-014.329418261
GO:0043968histone H2A acetylation3.48e-055.01e-017.7722312
GO:0016363nuclear matrix3.87e-055.57e-015.43431291
GO:0031011Ino80 complex4.79e-056.91e-017.5492314
GO:0005654nucleoplasm5.85e-058.43e-012.8626761082
GO:0070062extracellular vesicular exosome5.96e-058.59e-012.12881042400
GO:0003678DNA helicase activity7.15e-051.00e+007.2692317
GO:0030529ribonucleoprotein complex7.19e-051.00e+005.13438112
GO:0006325chromatin organization8.40e-051.00e+005.05935118
GO:0071339MLL1 complex1.84e-041.00e+006.6022327
GO:0043967histone H4 acetylation1.84e-041.00e+006.6022327
GO:0032508DNA duplex unwinding4.27e-041.00e+005.9992341
GO:0003684damaged DNA binding6.10e-041.00e+005.7422749
GO:0040008regulation of growth6.35e-041.00e+005.7132550
GO:0016020membrane6.82e-041.00e+002.2276901681
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding7.13e-041.00e+005.6292553
GO:0019521D-gluconate metabolic process7.63e-041.00e+0010.357111
GO:0006310DNA recombination1.07e-031.00e+005.3342265
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.39e-031.00e+005.1472674
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.52e-031.00e+009.357112
GO:0019322pentose biosynthetic process1.52e-031.00e+009.357122
GO:0005055laminin receptor activity1.52e-031.00e+009.357112
GO:0006407rRNA export from nucleus1.52e-031.00e+009.357112
GO:0002576platelet degranulation1.70e-031.00e+004.9992482
GO:0001842neural fold formation2.29e-031.00e+008.772113
GO:0071733transcriptional activation by promoter-enhancer looping2.29e-031.00e+008.772113
GO:0009051pentose-phosphate shunt, oxidative branch2.29e-031.00e+008.772123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.29e-031.00e+008.772113
GO:0071899negative regulation of estrogen receptor binding2.29e-031.00e+008.772113
GO:0043141ATP-dependent 5'-3' DNA helicase activity3.05e-031.00e+008.357114
GO:0048713regulation of oligodendrocyte differentiation3.05e-031.00e+008.357114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.05e-031.00e+008.357114
GO:003068690S preribosome3.05e-031.00e+008.357114
GO:0031467Cul7-RING ubiquitin ligase complex3.05e-031.00e+008.357114
GO:0019788NEDD8 ligase activity3.05e-031.00e+008.357114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.81e-031.00e+008.035135
GO:0031461cullin-RING ubiquitin ligase complex3.81e-031.00e+008.035115
GO:0071169establishment of protein localization to chromatin3.81e-031.00e+008.035115
GO:0043248proteasome assembly3.81e-031.00e+008.035115
GO:0030891VCB complex3.81e-031.00e+008.035125
GO:0000730DNA recombinase assembly3.81e-031.00e+008.035115
GO:2000001regulation of DNA damage checkpoint3.81e-031.00e+008.035115
GO:0007596blood coagulation4.26e-031.00e+003.112318455
GO:0030957Tat protein binding4.57e-031.00e+007.772136
GO:0030836positive regulation of actin filament depolymerization4.57e-031.00e+007.772126
GO:0031466Cul5-RING ubiquitin ligase complex4.57e-031.00e+007.772116
GO:0016887ATPase activity4.86e-031.00e+004.22727140
GO:0006457protein folding5.06e-031.00e+004.19727143
GO:0000028ribosomal small subunit assembly5.33e-031.00e+007.549117
GO:0031462Cul2-RING ubiquitin ligase complex5.33e-031.00e+007.549127
GO:0000082G1/S transition of mitotic cell cycle5.48e-031.00e+004.137232149
GO:0005829cytosol5.58e-031.00e+001.65661322496
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.09e-031.00e+007.357128
GO:0070688MLL5-L complex6.09e-031.00e+007.357118
GO:0030042actin filament depolymerization6.09e-031.00e+007.357128
GO:0045116protein neddylation6.09e-031.00e+007.357128
GO:0016032viral process6.67e-031.00e+002.881355534
GO:0006098pentose-phosphate shunt7.60e-031.00e+007.0351410
GO:0010569regulation of double-strand break repair via homologous recombination7.60e-031.00e+007.0351110
GO:0031625ubiquitin protein ligase binding7.74e-031.00e+003.881214178
GO:0031571mitotic G1 DNA damage checkpoint8.36e-031.00e+006.8971411
GO:0061001regulation of dendritic spine morphogenesis8.36e-031.00e+006.8971211
GO:0005838proteasome regulatory particle9.12e-031.00e+006.7721712
GO:0005662DNA replication factor A complex9.87e-031.00e+006.6561113
GO:0030168platelet activation1.02e-021.00e+003.677210205
GO:0035066positive regulation of histone acetylation1.14e-021.00e+006.4501115
GO:0016071mRNA metabolic process1.19e-021.00e+003.556231223
GO:0050998nitric-oxide synthase binding1.21e-021.00e+006.3571116
GO:0002102podosome1.21e-021.00e+006.3571216
GO:0031258lamellipodium membrane1.21e-021.00e+006.3571216
GO:0022604regulation of cell morphogenesis1.21e-021.00e+006.3571116
GO:0022624proteasome accessory complex1.29e-021.00e+006.2691817
GO:0071392cellular response to estradiol stimulus1.36e-021.00e+006.1871118
GO:0035861site of double-strand break1.36e-021.00e+006.1871118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.44e-021.00e+006.1091119
GO:0048863stem cell differentiation1.44e-021.00e+006.1091119
GO:0005719nuclear euchromatin1.44e-021.00e+006.1091219
GO:0016070RNA metabolic process1.45e-021.00e+003.408232247
GO:0006298mismatch repair1.52e-021.00e+006.0351320
GO:0032201telomere maintenance via semi-conservative replication1.59e-021.00e+005.9641521
GO:0030010establishment of cell polarity1.59e-021.00e+005.9641221
GO:0000281mitotic cytokinesis1.59e-021.00e+005.9641121
GO:0000718nucleotide-excision repair, DNA damage removal1.59e-021.00e+005.9641421
GO:0006297nucleotide-excision repair, DNA gap filling1.67e-021.00e+005.8971322
GO:0003779actin binding1.67e-021.00e+003.301212266
GO:0030863cortical cytoskeleton1.67e-021.00e+005.8971122
GO:0036464cytoplasmic ribonucleoprotein granule1.67e-021.00e+005.8971422
GO:0043044ATP-dependent chromatin remodeling1.74e-021.00e+005.8331423
GO:0030864cortical actin cytoskeleton1.74e-021.00e+005.8331123
GO:0031463Cul3-RING ubiquitin ligase complex1.74e-021.00e+005.8331323
GO:0043236laminin binding1.74e-021.00e+005.8331123
GO:0043200response to amino acid1.74e-021.00e+005.8331123
GO:0006513protein monoubiquitination1.74e-021.00e+005.8331123
GO:0034080CENP-A containing nucleosome assembly1.89e-021.00e+005.7131125
GO:0000722telomere maintenance via recombination1.89e-021.00e+005.7131525
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.97e-021.00e+005.6561326
GO:0004003ATP-dependent DNA helicase activity2.04e-021.00e+005.6021227
GO:0043022ribosome binding2.04e-021.00e+005.6021327
GO:0050661NADP binding2.04e-021.00e+005.6021227
GO:0031492nucleosomal DNA binding2.04e-021.00e+005.6021427
GO:0001755neural crest cell migration2.12e-021.00e+005.5491228
GO:0019894kinesin binding2.12e-021.00e+005.5491128
GO:0019005SCF ubiquitin ligase complex2.19e-021.00e+005.4991129
GO:0034644cellular response to UV2.27e-021.00e+005.4501530
GO:0042254ribosome biogenesis2.27e-021.00e+005.4501130
GO:0006271DNA strand elongation involved in DNA replication2.27e-021.00e+005.4501730
GO:0007411axon guidance2.35e-021.00e+003.039213319
GO:0001895retina homeostasis2.56e-021.00e+005.2691134
GO:0034332adherens junction organization2.71e-021.00e+005.1871136
GO:0051084'de novo' posttranslational protein folding2.79e-021.00e+005.1471437
GO:0006284base-excision repair2.79e-021.00e+005.1471337
GO:0005730nucleolus2.86e-021.00e+001.6764691641
GO:0070527platelet aggregation2.86e-021.00e+005.1091238
GO:0031490chromatin DNA binding2.86e-021.00e+005.1091338
GO:0005634nucleus2.89e-021.00e+001.01071364559
GO:0022627cytosolic small ribosomal subunit2.94e-021.00e+005.0711439
GO:0000781chromosome, telomeric region2.94e-021.00e+005.0711339
GO:0005925focal adhesion3.04e-021.00e+002.841219366
GO:0021762substantia nigra development3.31e-021.00e+004.8971244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.31e-021.00e+004.8971244
GO:0005884actin filament3.31e-021.00e+004.8971244
GO:0000278mitotic cell cycle3.43e-021.00e+002.746248391
GO:0006283transcription-coupled nucleotide-excision repair3.45e-021.00e+004.8331746
GO:0007266Rho protein signal transduction3.53e-021.00e+004.8021247
GO:0006521regulation of cellular amino acid metabolic process3.75e-021.00e+004.71311750
GO:0005515protein binding3.84e-021.00e+000.80081846024
GO:0043066negative regulation of apoptotic process3.98e-021.00e+002.629231424
GO:0045216cell-cell junction organization4.04e-021.00e+004.6021254
GO:0000724double-strand break repair via homologous recombination4.12e-021.00e+004.5751355
GO:0000723telomere maintenance4.19e-021.00e+004.5491656
GO:0005737cytoplasm4.20e-021.00e+001.06261103767
GO:0000502proteasome complex4.34e-021.00e+004.49911758
GO:0042995cell projection4.48e-021.00e+004.4501660
GO:0019903protein phosphatase binding4.63e-021.00e+004.4021462
GO:0006302double-strand break repair4.63e-021.00e+004.4021462
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.78e-021.00e+004.35711964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.85e-021.00e+004.33412265
GO:0044267cellular protein metabolic process4.87e-021.00e+002.468229474
GO:0006338chromatin remodeling4.92e-021.00e+004.3121566
GO:0006289nucleotide-excision repair5.07e-021.00e+004.26911168
GO:0034329cell junction assembly5.07e-021.00e+004.2691168
GO:0003697single-stranded DNA binding5.07e-021.00e+004.2691568
GO:0032587ruffle membrane5.21e-021.00e+004.2271370
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.21e-021.00e+004.22712270
GO:0006334nucleosome assembly5.36e-021.00e+004.1871272
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.36e-021.00e+004.18712072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.50e-021.00e+004.14712274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.58e-021.00e+004.1281275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I5.58e-021.00e+004.12812075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process5.86e-021.00e+004.05312379
GO:0019083viral transcription6.01e-021.00e+004.01711081
GO:0047485protein N-terminus binding6.37e-021.00e+003.9301586
GO:0006415translational termination6.44e-021.00e+003.91411087
GO:0016605PML body6.51e-021.00e+003.8971388
GO:0007010cytoskeleton organization6.73e-021.00e+003.8491191
GO:0006928cellular component movement6.73e-021.00e+003.8491791
GO:0005200structural constituent of cytoskeleton6.73e-021.00e+003.8491891
GO:0071456cellular response to hypoxia6.80e-021.00e+003.8331692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I6.80e-021.00e+003.83312192
GO:0006414translational elongation6.87e-021.00e+003.81711393
GO:0051082unfolded protein binding6.87e-021.00e+003.8171593
GO:0005524ATP binding6.94e-021.00e+001.6003601298
GO:0045087innate immune response7.32e-021.00e+002.137224596
GO:0006614SRP-dependent cotranslational protein targeting to membrane7.65e-021.00e+003.656110104
GO:0007605sensory perception of sound7.65e-021.00e+003.65611104
GO:0014069postsynaptic density7.73e-021.00e+003.64213105
GO:0005815microtubule organizing center8.01e-021.00e+003.58815109
GO:0072562blood microparticle8.15e-021.00e+003.56213111
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay8.36e-021.00e+003.524111114
GO:0019058viral life cycle8.43e-021.00e+003.511113115
GO:0000209protein polyubiquitination8.50e-021.00e+003.499120116
GO:0007219Notch signaling pathway8.78e-021.00e+003.45015120
GO:0006260DNA replication8.85e-021.00e+003.43819121
GO:0010467gene expression8.95e-021.00e+001.971259669
GO:0030036actin cytoskeleton organization8.99e-021.00e+003.41415123
GO:0006511ubiquitin-dependent protein catabolic process9.20e-021.00e+003.37915126
GO:0009615response to virus9.20e-021.00e+003.37915126
GO:0000790nuclear chromatin9.41e-021.00e+003.34519129
GO:0006413translational initiation9.55e-021.00e+003.323117131
GO:0031982vesicle9.55e-021.00e+003.32319131
GO:0005911cell-cell junction9.90e-021.00e+003.26914136
GO:0003735structural constituent of ribosome9.97e-021.00e+003.259110137
GO:0061024membrane organization1.05e-011.00e+003.17717145
GO:0042981regulation of apoptotic process1.09e-011.00e+003.128124150
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.19e-011.00e+002.99017165
GO:0030424axon1.20e-011.00e+002.98214166
GO:0034641cellular nitrogen compound metabolic process1.23e-011.00e+002.939120171
GO:0032403protein complex binding1.31e-011.00e+002.841110183
GO:0005622intracellular1.47e-011.00e+002.66316207
GO:0007067mitotic nuclear division1.60e-011.00e+002.530114227
GO:0006412translation1.62e-011.00e+002.511120230
GO:0005615extracellular space1.63e-011.00e+001.454217957
GO:0005975carbohydrate metabolic process1.77e-011.00e+002.37419253
GO:0004842ubiquitin-protein transferase activity1.78e-011.00e+002.36216255
GO:0007283spermatogenesis1.83e-011.00e+002.32318262
GO:0006357regulation of transcription from RNA polymerase II promoter1.84e-011.00e+002.31218264
GO:0019899enzyme binding1.92e-011.00e+002.243112277
GO:0005856cytoskeleton2.01e-011.00e+002.172112291
GO:0006200ATP catabolic process2.02e-011.00e+002.167115292
GO:0043234protein complex2.03e-011.00e+002.152118295
GO:0016567protein ubiquitination2.03e-011.00e+002.15215295
GO:0019901protein kinase binding2.17e-011.00e+002.048121317
GO:0043231intracellular membrane-bounded organelle2.18e-011.00e+002.04419318
GO:0030054cell junction2.28e-011.00e+001.96415336
GO:0044281small molecule metabolic process2.35e-011.00e+001.1152581211
GO:0007155cell adhesion2.48e-011.00e+001.82916369
GO:0055114oxidation-reduction process2.78e-011.00e+001.642112420
GO:0006468protein phosphorylation3.00e-011.00e+001.511118460
GO:0006351transcription, DNA-templated3.04e-011.00e+000.8592311446
GO:0042802identical protein binding3.13e-011.00e+001.438120484
GO:0006915apoptotic process3.51e-011.00e+001.240133555
GO:0005794Golgi apparatus3.78e-011.00e+001.104115610
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.62e-011.00e+000.733119789
GO:0005576extracellular region5.24e-011.00e+000.47714942
GO:0008270zinc ion binding5.45e-011.00e+000.395112997
GO:0044822poly(A) RNA binding5.67e-011.00e+000.3121491056
GO:0005886plasma membrane8.86e-011.00e+00-0.9781452582