int-snw-8295

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.013	1.13e-18	4.02e-04	1.03e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-8295 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
[ TRRAP ]	8295	1	0.551	1.013	127	Yes	-
RUVBL1	8607	17	0.720	1.013	343	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
DDX18	8886	9	0.660	1.013	173	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (20)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RUVBL1	8607	DDX18	8886	pp	--	int.I2D: YeastLow
PGD	5226	DDX18	8886	pp	--	int.I2D: YeastLow
EIF6	3692	RUVBL1	8607	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMD11	5717	DDX18	8886	pp	--	int.I2D: YeastLow
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
TRRAP	8295	DDX18	8886	pp	--	int.I2D: YeastLow
EIF6	3692	DDX18	8886	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
DDX18	8886	RSL24D1	51187	pp	--	int.I2D: YeastLow, BioGrid_Yeast
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
TRRAP	8295	RUVBL1	8607	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
ACTB	60	RUVBL1	8607	pp	--	int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11	5717	RUVBL1	8607	pp	--	int.I2D: YeastLow
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	TRRAP	8295	pp	--	int.I2D: IntAct_Yeast, YeastLow
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	TRRAP	8295	pp	--	int.I2D: YeastLow

Related GO terms (191)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0035267	NuA4 histone acetyltransferase complex	1.20e-07	1.72e-03	8.134	3	4	14
GO:0000812	Swr1 complex	1.48e-05	2.13e-01	8.357	2	3	8
GO:0043968	histone H2A acetylation	3.48e-05	5.01e-01	7.772	2	3	12
GO:0005654	nucleoplasm	5.85e-05	8.43e-01	2.862	6	76	1082
GO:0006325	chromatin organization	8.40e-05	1.00e+00	5.059	3	5	118
GO:0043022	ribosome binding	1.84e-04	1.00e+00	6.602	2	3	27
GO:0043967	histone H4 acetylation	1.84e-04	1.00e+00	6.602	2	3	27
GO:0000054	ribosomal subunit export from nucleus	7.63e-04	1.00e+00	10.357	1	1	1
GO:0019521	D-gluconate metabolic process	7.63e-04	1.00e+00	10.357	1	1	1
GO:0006281	DNA repair	8.68e-04	1.00e+00	3.914	3	18	261
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019322	pentose biosynthetic process	1.52e-03	1.00e+00	9.357	1	2	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009051	pentose-phosphate shunt, oxidative branch	2.29e-03	1.00e+00	8.772	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.29e-03	1.00e+00	8.772	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.05e-03	1.00e+00	8.357	1	1	4
GO:0019788	NEDD8 ligase activity	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030529	ribonucleoprotein complex	3.14e-03	1.00e+00	4.549	2	8	112
GO:0016773	phosphotransferase activity, alcohol group as acceptor	3.81e-03	1.00e+00	8.035	1	1	5
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0042256	mature ribosome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043248	proteasome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0030891	VCB complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0000730	DNA recombinase assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.81e-03	1.00e+00	8.035	1	1	5
GO:0005638	lamin filament	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043023	ribosomal large subunit binding	3.81e-03	1.00e+00	8.035	1	1	5
GO:0006413	translational initiation	4.27e-03	1.00e+00	4.323	2	17	131
GO:0070062	extracellular vesicular exosome	4.55e-03	1.00e+00	1.713	6	104	2400
GO:0030957	Tat protein binding	4.57e-03	1.00e+00	7.772	1	3	6
GO:0000125	PCAF complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0005730	nucleolus	4.85e-03	1.00e+00	1.998	5	69	1641
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.33e-03	1.00e+00	7.549	1	2	7
GO:0016020	membrane	5.39e-03	1.00e+00	1.963	5	90	1681
GO:0000082	G1/S transition of mitotic cell cycle	5.48e-03	1.00e+00	4.137	2	32	149
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.09e-03	1.00e+00	7.357	1	2	8
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0045116	protein neddylation	6.09e-03	1.00e+00	7.357	1	2	8
GO:0016032	viral process	6.67e-03	1.00e+00	2.881	3	55	534
GO:0006098	pentose-phosphate shunt	7.60e-03	1.00e+00	7.035	1	4	10
GO:0010569	regulation of double-strand break repair via homologous recombination	7.60e-03	1.00e+00	7.035	1	1	10
GO:0031625	ubiquitin protein ligase binding	7.74e-03	1.00e+00	3.881	2	14	178
GO:0005515	protein binding	8.30e-03	1.00e+00	0.970	9	184	6024
GO:0016578	histone deubiquitination	8.36e-03	1.00e+00	6.897	1	1	11
GO:0031571	mitotic G1 DNA damage checkpoint	8.36e-03	1.00e+00	6.897	1	4	11
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	7	12
GO:0042273	ribosomal large subunit biogenesis	9.87e-03	1.00e+00	6.656	1	4	13
GO:0005662	DNA replication factor A complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0030914	STAGA complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0033276	transcription factor TFTC complex	1.06e-02	1.00e+00	6.549	1	1	14
GO:0031011	Ino80 complex	1.06e-02	1.00e+00	6.549	1	3	14
GO:0016071	mRNA metabolic process	1.19e-02	1.00e+00	3.556	2	31	223
GO:0050998	nitric-oxide synthase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0003678	DNA helicase activity	1.29e-02	1.00e+00	6.269	1	3	17
GO:0022624	proteasome accessory complex	1.29e-02	1.00e+00	6.269	1	8	17
GO:0035861	site of double-strand break	1.36e-02	1.00e+00	6.187	1	1	18
GO:0004004	ATP-dependent RNA helicase activity	1.36e-02	1.00e+00	6.187	1	2	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.44e-02	1.00e+00	6.109	1	1	19
GO:0048863	stem cell differentiation	1.44e-02	1.00e+00	6.109	1	1	19
GO:0016070	RNA metabolic process	1.45e-02	1.00e+00	3.408	2	32	247
GO:0006298	mismatch repair	1.52e-02	1.00e+00	6.035	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.59e-02	1.00e+00	5.964	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.59e-02	1.00e+00	5.964	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.67e-02	1.00e+00	5.897	1	3	22
GO:0030863	cortical cytoskeleton	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.74e-02	1.00e+00	5.833	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.74e-02	1.00e+00	5.833	1	3	23
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0006513	protein monoubiquitination	1.74e-02	1.00e+00	5.833	1	1	23
GO:0016573	histone acetylation	1.74e-02	1.00e+00	5.833	1	1	23
GO:0034080	CENP-A containing nucleosome assembly	1.89e-02	1.00e+00	5.713	1	1	25
GO:0000722	telomere maintenance via recombination	1.89e-02	1.00e+00	5.713	1	5	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.97e-02	1.00e+00	5.656	1	3	26
GO:0050661	NADP binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0071339	MLL1 complex	2.04e-02	1.00e+00	5.602	1	3	27
GO:0031492	nucleosomal DNA binding	2.04e-02	1.00e+00	5.602	1	4	27
GO:0019894	kinesin binding	2.12e-02	1.00e+00	5.549	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.19e-02	1.00e+00	5.499	1	1	29
GO:0042254	ribosome biogenesis	2.27e-02	1.00e+00	5.450	1	1	30
GO:0006271	DNA strand elongation involved in DNA replication	2.27e-02	1.00e+00	5.450	1	7	30
GO:0007093	mitotic cell cycle checkpoint	2.34e-02	1.00e+00	5.402	1	2	31
GO:0001895	retina homeostasis	2.56e-02	1.00e+00	5.269	1	1	34
GO:0034332	adherens junction organization	2.71e-02	1.00e+00	5.187	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.79e-02	1.00e+00	5.147	1	4	37
GO:0006284	base-excision repair	2.79e-02	1.00e+00	5.147	1	3	37
GO:0005829	cytosol	2.85e-02	1.00e+00	1.393	5	132	2496
GO:0070527	platelet aggregation	2.86e-02	1.00e+00	5.109	1	2	38
GO:0005634	nucleus	2.89e-02	1.00e+00	1.010	7	136	4559
GO:0022627	cytosolic small ribosomal subunit	2.94e-02	1.00e+00	5.071	1	4	39
GO:0000781	chromosome, telomeric region	2.94e-02	1.00e+00	5.071	1	3	39
GO:0032508	DNA duplex unwinding	3.08e-02	1.00e+00	4.999	1	3	41
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	2	44
GO:0003712	transcription cofactor activity	3.31e-02	1.00e+00	4.897	1	1	44
GO:0000278	mitotic cell cycle	3.43e-02	1.00e+00	2.746	2	48	391
GO:0006283	transcription-coupled nucleotide-excision repair	3.45e-02	1.00e+00	4.833	1	7	46
GO:0003743	translation initiation factor activity	3.68e-02	1.00e+00	4.742	1	8	49
GO:0003684	damaged DNA binding	3.68e-02	1.00e+00	4.742	1	7	49
GO:0006521	regulation of cellular amino acid metabolic process	3.75e-02	1.00e+00	4.713	1	17	50
GO:0040008	regulation of growth	3.75e-02	1.00e+00	4.713	1	5	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0045216	cell-cell junction organization	4.04e-02	1.00e+00	4.602	1	2	54
GO:0000724	double-strand break repair via homologous recombination	4.12e-02	1.00e+00	4.575	1	3	55
GO:0000723	telomere maintenance	4.19e-02	1.00e+00	4.549	1	6	56
GO:0000502	proteasome complex	4.34e-02	1.00e+00	4.499	1	17	58
GO:0019903	protein phosphatase binding	4.63e-02	1.00e+00	4.402	1	4	62
GO:0006302	double-strand break repair	4.63e-02	1.00e+00	4.402	1	4	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.78e-02	1.00e+00	4.357	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.85e-02	1.00e+00	4.334	1	22	65
GO:0006310	DNA recombination	4.85e-02	1.00e+00	4.334	1	2	65
GO:0044267	cellular protein metabolic process	4.87e-02	1.00e+00	2.468	2	29	474
GO:0006289	nucleotide-excision repair	5.07e-02	1.00e+00	4.269	1	11	68
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	1	68
GO:0003697	single-stranded DNA binding	5.07e-02	1.00e+00	4.269	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.21e-02	1.00e+00	4.227	1	22	70
GO:0006334	nucleosome assembly	5.36e-02	1.00e+00	4.187	1	2	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.36e-02	1.00e+00	4.187	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.50e-02	1.00e+00	4.147	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-02	1.00e+00	4.147	1	22	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	2	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.58e-02	1.00e+00	4.128	1	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.86e-02	1.00e+00	4.053	1	23	79
GO:0019083	viral transcription	6.01e-02	1.00e+00	4.017	1	10	81
GO:0047485	protein N-terminus binding	6.37e-02	1.00e+00	3.930	1	5	86
GO:0006415	translational termination	6.44e-02	1.00e+00	3.914	1	10	87
GO:0016605	PML body	6.51e-02	1.00e+00	3.897	1	3	88
GO:0016363	nuclear matrix	6.73e-02	1.00e+00	3.849	1	12	91
GO:0006928	cellular component movement	6.73e-02	1.00e+00	3.849	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.73e-02	1.00e+00	3.849	1	8	91
GO:0071456	cellular response to hypoxia	6.80e-02	1.00e+00	3.833	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.80e-02	1.00e+00	3.833	1	21	92
GO:0006414	translational elongation	6.87e-02	1.00e+00	3.817	1	13	93
GO:0005524	ATP binding	6.94e-02	1.00e+00	1.600	3	60	1298
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7.65e-02	1.00e+00	3.656	1	10	104
GO:0014069	postsynaptic density	7.73e-02	1.00e+00	3.642	1	3	105
GO:0005815	microtubule organizing center	8.01e-02	1.00e+00	3.588	1	5	109
GO:0072562	blood microparticle	8.15e-02	1.00e+00	3.562	1	3	111
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	8.36e-02	1.00e+00	3.524	1	11	114
GO:0019058	viral life cycle	8.43e-02	1.00e+00	3.511	1	13	115
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	20	116
GO:0007219	Notch signaling pathway	8.78e-02	1.00e+00	3.450	1	5	120
GO:0006260	DNA replication	8.85e-02	1.00e+00	3.438	1	9	121
GO:0010467	gene expression	8.95e-02	1.00e+00	1.971	2	59	669
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0000790	nuclear chromatin	9.41e-02	1.00e+00	3.345	1	9	129
GO:0003735	structural constituent of ribosome	9.97e-02	1.00e+00	3.259	1	10	137
GO:0016887	ATPase activity	1.02e-01	1.00e+00	3.227	1	7	140
GO:0006457	protein folding	1.04e-01	1.00e+00	3.197	1	7	143
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	7	145
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	24	150
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	7	165
GO:0030424	axon	1.20e-01	1.00e+00	2.982	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	1.23e-01	1.00e+00	2.939	1	20	171
GO:0032403	protein complex binding	1.31e-01	1.00e+00	2.841	1	10	183
GO:0007067	mitotic nuclear division	1.60e-01	1.00e+00	2.530	1	14	227
GO:0006412	translation	1.62e-01	1.00e+00	2.511	1	20	230
GO:0003713	transcription coactivator activity	1.67e-01	1.00e+00	2.468	1	10	237
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	9	253
GO:0004842	ubiquitin-protein transferase activity	1.78e-01	1.00e+00	2.362	1	6	255
GO:0007283	spermatogenesis	1.83e-01	1.00e+00	2.323	1	8	262
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.84e-01	1.00e+00	2.312	1	8	264
GO:0044822	poly(A) RNA binding	1.90e-01	1.00e+00	1.312	2	49	1056
GO:0019899	enzyme binding	1.92e-01	1.00e+00	2.243	1	12	277
GO:0005856	cytoskeleton	2.01e-01	1.00e+00	2.172	1	12	291
GO:0006200	ATP catabolic process	2.02e-01	1.00e+00	2.167	1	15	292
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	18	295
GO:0016567	protein ubiquitination	2.03e-01	1.00e+00	2.152	1	5	295
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	21	317
GO:0043231	intracellular membrane-bounded organelle	2.18e-01	1.00e+00	2.044	1	9	318
GO:0007411	axon guidance	2.18e-01	1.00e+00	2.039	1	13	319
GO:0044281	small molecule metabolic process	2.35e-01	1.00e+00	1.115	2	58	1211
GO:0005925	focal adhesion	2.46e-01	1.00e+00	1.841	1	19	366
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	12	420
GO:0043066	negative regulation of apoptotic process	2.80e-01	1.00e+00	1.629	1	31	424
GO:0007596	blood coagulation	2.97e-01	1.00e+00	1.527	1	18	455
GO:0006351	transcription, DNA-templated	3.04e-01	1.00e+00	0.859	2	31	1446
GO:0005737	cytoplasm	3.18e-01	1.00e+00	0.477	4	110	3767
GO:0006915	apoptotic process	3.51e-01	1.00e+00	1.240	1	33	555
GO:0045087	innate immune response	3.71e-01	1.00e+00	1.137	1	24	596
GO:0005794	Golgi apparatus	3.78e-01	1.00e+00	1.104	1	15	610
GO:0005615	extracellular space	5.30e-01	1.00e+00	0.454	1	17	957
GO:0006355	regulation of transcription, DNA-templated	5.45e-01	1.00e+00	0.395	1	18	997
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	12	997
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-8295

Statistics

Genes (11)

Interactions (20)

Related GO terms (191)