int-snw-10093

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.958 2.06e-16 1.49e-03 2.77e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-10093 subnetwork

Genes (15)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
ACACB 32 50.6561.002184Yes-
ACO2 50 501.0001.076191Yes-
RUVBL1 8607 170.7201.013343Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
PSMD3 5709 570.9861.106146Yes-
PSMB7 5695 480.9821.05257Yes-
PSMD7 5713 50.6400.958133Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
[ ARPC4 ] 10093 1-0.0850.95854--
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (41)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACO2 50 RUVBL1 8607 pp -- int.I2D: YeastLow
ACO2 50 PSMD7 5713 pp -- int.I2D: YeastLow
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA2 5683 PSMD7 5713 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PSMD7 5713 RUVBL1 8607 pp -- int.I2D: YeastLow
PSMD7 5713 ARPC4 10093 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
PSMD7 5713 PSMD11 5717 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, IntAct
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACACB 32 PSMD3 5709 pp -- int.I2D: YeastLow
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD7 5713 pp -- int.I2D: BioGrid_Yeast, YeastMedium, IntAct_Yeast, MINT_Yeast
RUVBL1 8607 ARPC4 10093 pp -- int.I2D: YeastLow
PSMB7 5695 PSMD7 5713 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD7 5713 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACACB 32 ARPC4 10093 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD7 5713 RBX1 9978 pp -- int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
ACACB 32 PGD 5226 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMD3 5709 PSMD7 5713 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BioGrid, IntAct
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ACACB 32 RPSA 3921 pp -- int.I2D: IntAct_Yeast, YeastMedium
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 ARPC4 10093 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow

Related GO terms (221)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006521regulation of cellular amino acid metabolic process6.22e-128.97e-086.85061750
GO:0000502proteasome complex1.58e-112.28e-076.63661758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.91e-114.20e-076.49461964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.21e-114.63e-076.47262265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.08e-117.32e-076.36562270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.04e-118.72e-076.32462072
GO:0000082G1/S transition of mitotic cell cycle6.55e-119.44e-075.497732149
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.16e-111.03e-066.28562274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.78e-111.12e-066.26562075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.07e-101.54e-066.19062379
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.73e-103.94e-065.97162192
GO:0016071mRNA metabolic process1.11e-091.61e-054.916731223
GO:0000209protein polyubiquitination1.12e-091.62e-055.636620116
GO:0016070RNA metabolic process2.27e-093.28e-054.768732247
GO:0042981regulation of apoptotic process5.30e-097.65e-055.265624150
GO:0005654nucleoplasm1.15e-081.66e-043.15210761082
GO:0034641cellular nitrogen compound metabolic process1.17e-081.68e-045.076620171
GO:0016032viral process1.72e-082.47e-043.848855534
GO:0000278mitotic cell cycle5.44e-087.85e-044.106748391
GO:0005829cytosol1.91e-072.76e-032.209121322496
GO:0005838proteasome regulatory particle1.99e-072.87e-037.9093712
GO:0044281small molecule metabolic process6.33e-079.13e-032.8379581211
GO:0005839proteasome core complex7.36e-071.06e-027.3243818
GO:0004298threonine-type endopeptidase activity8.73e-071.26e-027.2463819
GO:0070062extracellular vesicular exosome1.88e-062.71e-022.140111042400
GO:0010467gene expression2.08e-063.00e-023.331759669
GO:0043066negative regulation of apoptotic process2.49e-063.59e-023.766631424
GO:0006915apoptotic process1.18e-051.70e-013.378633555
GO:0019773proteasome core complex, alpha-subunit complex2.82e-054.06e-017.909248
GO:0035267NuA4 histone acetyltransferase complex9.12e-051.00e+007.1022414
GO:0022624proteasome accessory complex1.36e-041.00e+006.8222817
GO:0005634nucleus1.60e-041.00e+001.340121364559
GO:0019521D-gluconate metabolic process1.04e-031.00e+009.909111
GO:2001295malonyl-CoA biosynthetic process2.08e-031.00e+008.909112
GO:00515383 iron, 4 sulfur cluster binding2.08e-031.00e+008.909112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.08e-031.00e+008.909112
GO:0003989acetyl-CoA carboxylase activity2.08e-031.00e+008.909112
GO:0019322pentose biosynthetic process2.08e-031.00e+008.909122
GO:0003994aconitate hydratase activity2.08e-031.00e+008.909112
GO:0005055laminin receptor activity2.08e-031.00e+008.909112
GO:0006407rRNA export from nucleus2.08e-031.00e+008.909112
GO:0006281DNA repair2.27e-031.00e+003.466318261
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis2.61e-031.00e+004.7002674
GO:0005515protein binding2.98e-031.00e+000.938121846024
GO:0006084acetyl-CoA metabolic process3.12e-031.00e+008.324113
GO:0009051pentose-phosphate shunt, oxidative branch3.12e-031.00e+008.324123
GO:0045010actin nucleation3.12e-031.00e+008.324113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity3.12e-031.00e+008.324113
GO:0005200structural constituent of cytoskeleton3.92e-031.00e+004.4012891
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.15e-031.00e+007.909114
GO:003068690S preribosome4.15e-031.00e+007.909114
GO:0031467Cul7-RING ubiquitin ligase complex4.15e-031.00e+007.909114
GO:0019788NEDD8 ligase activity4.15e-031.00e+007.909114
GO:0005730nucleolus4.33e-031.00e+001.8146691641
GO:0016020membrane4.89e-031.00e+001.7796901681
GO:0031465Cul4B-RING E3 ubiquitin ligase complex5.19e-031.00e+007.587135
GO:0031461cullin-RING ubiquitin ligase complex5.19e-031.00e+007.587115
GO:0043248proteasome assembly5.19e-031.00e+007.587115
GO:0006102isocitrate metabolic process5.19e-031.00e+007.587115
GO:0030891VCB complex5.19e-031.00e+007.587125
GO:0000730DNA recombinase assembly5.19e-031.00e+007.587115
GO:0004075biotin carboxylase activity5.19e-031.00e+007.587115
GO:2000001regulation of DNA damage checkpoint5.19e-031.00e+007.587115
GO:0009374biotin binding5.19e-031.00e+007.587115
GO:0030529ribonucleoprotein complex5.87e-031.00e+004.10228112
GO:0030957Tat protein binding6.22e-031.00e+007.324136
GO:0006101citrate metabolic process6.22e-031.00e+007.324116
GO:0031466Cul5-RING ubiquitin ligase complex6.22e-031.00e+007.324116
GO:0006325chromatin organization6.50e-031.00e+004.02725118
GO:0000028ribosomal small subunit assembly7.26e-031.00e+007.102117
GO:0005885Arp2/3 protein complex7.26e-031.00e+007.102117
GO:0031462Cul2-RING ubiquitin ligase complex7.26e-031.00e+007.102127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex8.29e-031.00e+006.909128
GO:0006853carnitine shuttle8.29e-031.00e+006.909118
GO:0031325positive regulation of cellular metabolic process8.29e-031.00e+006.909118
GO:0070688MLL5-L complex8.29e-031.00e+006.909118
GO:0000812Swr1 complex8.29e-031.00e+006.909138
GO:0045116protein neddylation8.29e-031.00e+006.909128
GO:0006768biotin metabolic process9.32e-031.00e+006.739119
GO:0006098pentose-phosphate shunt1.04e-021.00e+006.5871410
GO:0010569regulation of double-strand break repair via homologous recombination1.04e-021.00e+006.5871110
GO:0034314Arp2/3 complex-mediated actin nucleation1.14e-021.00e+006.4501111
GO:0031571mitotic G1 DNA damage checkpoint1.14e-021.00e+006.4501411
GO:0043968histone H2A acetylation1.24e-021.00e+006.3241312
GO:0005662DNA replication factor A complex1.34e-021.00e+006.2091113
GO:0030234enzyme regulator activity1.34e-021.00e+006.2091313
GO:0031625ubiquitin protein ligase binding1.43e-021.00e+003.433214178
GO:0031011Ino80 complex1.45e-021.00e+006.1021314
GO:0050998nitric-oxide synthase binding1.65e-021.00e+005.9091116
GO:0042176regulation of protein catabolic process1.65e-021.00e+005.9091316
GO:0003678DNA helicase activity1.75e-021.00e+005.8221317
GO:0035861site of double-strand break1.86e-021.00e+005.7391118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.96e-021.00e+005.6611119
GO:0048863stem cell differentiation1.96e-021.00e+005.6611119
GO:0006298mismatch repair2.06e-021.00e+005.5871320
GO:0030041actin filament polymerization2.16e-021.00e+005.5171321
GO:0032201telomere maintenance via semi-conservative replication2.16e-021.00e+005.5171521
GO:0000718nucleotide-excision repair, DNA damage removal2.16e-021.00e+005.5171421
GO:0006297nucleotide-excision repair, DNA gap filling2.26e-021.00e+005.4501322
GO:0030863cortical cytoskeleton2.26e-021.00e+005.4501122
GO:0036464cytoplasmic ribonucleoprotein granule2.26e-021.00e+005.4501422
GO:0043044ATP-dependent chromatin remodeling2.37e-021.00e+005.3861423
GO:0005844polysome2.37e-021.00e+005.3861423
GO:0031463Cul3-RING ubiquitin ligase complex2.37e-021.00e+005.3861323
GO:0043236laminin binding2.37e-021.00e+005.3861123
GO:0006513protein monoubiquitination2.37e-021.00e+005.3861123
GO:0034080CENP-A containing nucleosome assembly2.57e-021.00e+005.2651125
GO:0000722telomere maintenance via recombination2.57e-021.00e+005.2651525
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.67e-021.00e+005.2091326
GO:0043022ribosome binding2.77e-021.00e+005.1541327
GO:0050661NADP binding2.77e-021.00e+005.1541227
GO:0071339MLL1 complex2.77e-021.00e+005.1541327
GO:0043967histone H4 acetylation2.77e-021.00e+005.1541327
GO:0031492nucleosomal DNA binding2.77e-021.00e+005.1541427
GO:0006099tricarboxylic acid cycle2.87e-021.00e+005.1021428
GO:0019894kinesin binding2.87e-021.00e+005.1021128
GO:0019005SCF ubiquitin ligase complex2.98e-021.00e+005.0511129
GO:0006271DNA strand elongation involved in DNA replication3.08e-021.00e+005.0021730
GO:0019899enzyme binding3.27e-021.00e+002.795212277
GO:0006633fatty acid biosynthetic process3.28e-021.00e+004.9091332
GO:0001895retina homeostasis3.48e-021.00e+004.8221134
GO:00515394 iron, 4 sulfur cluster binding3.58e-021.00e+004.7801335
GO:0034332adherens junction organization3.68e-021.00e+004.7391136
GO:0051084'de novo' posttranslational protein folding3.78e-021.00e+004.7001437
GO:0006284base-excision repair3.78e-021.00e+004.7001337
GO:0070527platelet aggregation3.88e-021.00e+004.6611238
GO:0022627cytosolic small ribosomal subunit3.98e-021.00e+004.6241439
GO:0000781chromosome, telomeric region3.98e-021.00e+004.6241339
GO:0032508DNA duplex unwinding4.18e-021.00e+004.5521341
GO:0014070response to organic cyclic compound4.38e-021.00e+004.4831443
GO:0021762substantia nigra development4.48e-021.00e+004.4501244
GO:0006283transcription-coupled nucleotide-excision repair4.68e-021.00e+004.3861746
GO:0003684damaged DNA binding4.98e-021.00e+004.2941749
GO:0006091generation of precursor metabolites and energy5.08e-021.00e+004.2651350
GO:0040008regulation of growth5.08e-021.00e+004.2651550
GO:0051289protein homotetramerization5.18e-021.00e+004.2371151
GO:0030674protein binding, bridging5.18e-021.00e+004.2371151
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.38e-021.00e+004.1811553
GO:0045216cell-cell junction organization5.47e-021.00e+004.1541254
GO:0000932cytoplasmic mRNA processing body5.47e-021.00e+004.1541354
GO:0000724double-strand break repair via homologous recombination5.57e-021.00e+004.1281355
GO:0000723telomere maintenance5.67e-021.00e+004.1021656
GO:0012505endomembrane system5.67e-021.00e+004.1021256
GO:0042995cell projection6.06e-021.00e+004.0021660
GO:0019903protein phosphatase binding6.26e-021.00e+003.9551462
GO:0006302double-strand break repair6.26e-021.00e+003.9551462
GO:0006310DNA recombination6.55e-021.00e+003.8871265
GO:0006289nucleotide-excision repair6.85e-021.00e+003.82211168
GO:0006767water-soluble vitamin metabolic process6.85e-021.00e+003.8221168
GO:0034329cell junction assembly6.85e-021.00e+003.8221168
GO:0003697single-stranded DNA binding6.85e-021.00e+003.8221568
GO:0006766vitamin metabolic process7.14e-021.00e+003.7591171
GO:0006334nucleosome assembly7.24e-021.00e+003.7391272
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process7.53e-021.00e+003.6801275
GO:0019083viral transcription8.10e-021.00e+003.56911081
GO:0044267cellular protein metabolic process8.54e-021.00e+002.020229474
GO:0047485protein N-terminus binding8.58e-021.00e+003.4831586
GO:0006415translational termination8.68e-021.00e+003.46611087
GO:0016605PML body8.78e-021.00e+003.4501388
GO:0016363nuclear matrix9.06e-021.00e+003.40111291
GO:0006928cellular component movement9.06e-021.00e+003.4011791
GO:0051015actin filament binding9.16e-021.00e+003.3861292
GO:0071456cellular response to hypoxia9.16e-021.00e+003.3861692
GO:0006414translational elongation9.25e-021.00e+003.37011393
GO:0006112energy reserve metabolic process9.44e-021.00e+003.3391395
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.03e-011.00e+003.209110104
GO:0014069postsynaptic density1.04e-011.00e+003.19513105
GO:0005506iron ion binding1.04e-011.00e+003.19514105
GO:0005741mitochondrial outer membrane1.04e-011.00e+003.19517105
GO:0005815microtubule organizing center1.08e-011.00e+003.14115109
GO:0072562blood microparticle1.09e-011.00e+003.11513111
GO:0015630microtubule cytoskeleton1.09e-011.00e+003.12814110
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.12e-011.00e+003.076111114
GO:0019058viral life cycle1.13e-011.00e+003.064113115
GO:0044237cellular metabolic process1.15e-011.00e+003.03915117
GO:0007219Notch signaling pathway1.18e-011.00e+003.00215120
GO:0006260DNA replication1.19e-011.00e+002.99019121
GO:0006511ubiquitin-dependent protein catabolic process1.23e-011.00e+002.93215126
GO:0009615response to virus1.23e-011.00e+002.93215126
GO:0000790nuclear chromatin1.26e-011.00e+002.89819129
GO:0045087innate immune response1.26e-011.00e+001.690224596
GO:0006413translational initiation1.28e-011.00e+002.876117131
GO:0044255cellular lipid metabolic process1.30e-011.00e+002.85416133
GO:0003735structural constituent of ribosome1.33e-011.00e+002.811110137
GO:0016887ATPase activity1.36e-011.00e+002.78017140
GO:0006457protein folding1.39e-011.00e+002.74917143
GO:0061024membrane organization1.41e-011.00e+002.72917145
GO:0005524ATP binding1.47e-011.00e+001.1523601298
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.59e-011.00e+002.54317165
GO:0030424axon1.59e-011.00e+002.53414166
GO:0032403protein complex binding1.74e-011.00e+002.393110183
GO:0007067mitotic nuclear division2.12e-011.00e+002.083114227
GO:0005759mitochondrial matrix2.13e-011.00e+002.076114228
GO:0006412translation2.14e-011.00e+002.064120230
GO:0005975carbohydrate metabolic process2.33e-011.00e+001.92619253
GO:0004842ubiquitin-protein transferase activity2.35e-011.00e+001.91516255
GO:0007283spermatogenesis2.41e-011.00e+001.87618262
GO:0006357regulation of transcription from RNA polymerase II promoter2.42e-011.00e+001.86518264
GO:0042493response to drug2.58e-011.00e+001.759113284
GO:0005856cytoskeleton2.64e-011.00e+001.724112291
GO:0043234protein complex2.67e-011.00e+001.705118295
GO:0016567protein ubiquitination2.67e-011.00e+001.70515295
GO:0005739mitochondrion2.79e-011.00e+000.946228998
GO:0019901protein kinase binding2.84e-011.00e+001.601121317
GO:0043231intracellular membrane-bounded organelle2.84e-011.00e+001.59619318
GO:0007411axon guidance2.85e-011.00e+001.592113319
GO:0005813centrosome2.90e-011.00e+001.560114326
GO:0003723RNA binding3.02e-011.00e+001.491120342
GO:0005925focal adhesion3.20e-011.00e+001.393119366
GO:0007155cell adhesion3.22e-011.00e+001.38216369
GO:0055114oxidation-reduction process3.58e-011.00e+001.195112420
GO:0007596blood coagulation3.82e-011.00e+001.079118455
GO:0042803protein homodimerization activity4.69e-011.00e+000.692112595
GO:0005794Golgi apparatus4.77e-011.00e+000.657115610
GO:0005737cytoplasm5.78e-011.00e+000.03041103767
GO:0005615extracellular space6.43e-011.00e+000.007117957
GO:0008270zinc ion binding6.59e-011.00e+00-0.052112997
GO:0044822poly(A) RNA binding6.81e-011.00e+00-0.1351491056
GO:0046872metal ion binding7.60e-011.00e+00-0.4431251307
GO:0006351transcription, DNA-templated7.95e-011.00e+00-0.5891311446
GO:0005886plasma membrane9.48e-011.00e+00-1.4251452582