meta-reg-snw-55869

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-56848 tai-screen-luciferase 6.375 2.94e-136 3.59e-07 2.58e-03 24 19
reg-snw-55869 tai-screen-luciferase 4.752 5.69e-25 4.24e-04 6.99e-04 8 5
int-snw-10296 tai-screen-luciferase 6.413 3.70e-138 2.79e-07 2.32e-03 18 15
int-snw-4831 tai-screen-luciferase 6.314 3.38e-133 5.36e-07 3.08e-03 24 20
int-snw-51382 tai-screen-luciferase 7.286 3.65e-186 4.21e-10 1.27e-04 13 12
int-snw-51741 tai-screen-luciferase 6.174 2.67e-126 1.32e-06 4.54e-03 24 19
tai-screen-luciferase-meta-reg-snw-55869 subnetwork

Genes (48)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree List-Gonzales GI Tai-Hits
RPS20 6224 22-4.7576.314153Yes-
RPS8 6202 33-5.5457.555234--
MAPK8 5599 28-4.4036.468153--
CHMP2A 27243 33-9.0377.55541YesYes
RPS15 6209 30-5.0407.011116Yes-
COPA 1314 48-9.3955.672340YesYes
RNF20 56254 28-4.5646.17418--
HSF1 3297 46-4.1795.027209-Yes
SRC 6714 28-2.8066.174419Yes-
COPB2 9276 48-13.1689.06341YesYes
CKAP5 9793 46-7.2145.672130YesYes
RPS16 6217 38-5.4444.880205--
EIF2S2 8894 31-4.3205.672103Yes-
CDC42 998 44-6.9604.707276YesYes
MAEA 10296 13-2.7936.41343--
RPS11 6205 44-6.5887.555175Yes-
ARL1 400 18-4.1428.046110-Yes
NME2 4831 24-3.0344.32553--
RPS6 6194 44-5.6038.046217Yes-
MRPS12 6183 35-5.4215.516341Yes-
RAN 5901 38-3.8094.325258YesYes
UBB 7314 30-4.2896.428147--
COPB1 1315 39-6.2219.063118YesYes
SERBP1 26135 35-4.6125.516106-Yes
RPS23 6228 21-4.4856.375118Yes-
RPS13 6207 43-6.5897.555174Yes-
CDC5L 988 34-3.4195.672155--
WDR18 57418 62.3224.752213--
RPS24 6229 46-7.0348.389217Yes-
HDAC8 55869 61.2284.75216--
VIM 7431 18-3.7606.428246--
TCERG1 10915 28-3.8086.17458Yes-
RPS9 6203 45-7.1277.555140Yes-
RPS3A 6189 19-4.6477.189166Yes-
RPS4X 6191 44-6.7477.555263Yes-
COPZ1 22818 48-8.3019.06313YesYes
ATP6V1D 51382 30-4.1317.286149--
RPS15A 6210 36-5.4137.555177Yes-
WDR46 9277 31-4.2904.226101YesYes
WWOX 51741 28-2.4486.17438--
RPS27A 6233 45-5.6318.389344Yes-
RPS14 6208 23-4.8037.011204Yes-
RPS19 6223 21-4.7014.752102Yes-
SKP1 6500 26-3.7506.413203--
NFKBIB 4793 28-3.9786.17478--
SPHK2 56848 17-3.0106.37537--
RPS26 6231 43-7.4788.04660Yes-
ARCN1 372 48-8.2329.063118YesYes

Interactions (148)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CDC42 998 RPS27A 6233 pp -- int.I2D: SOURAV_MAPK_HIGH
RPS20 6224 RPS26 6231 pp -- int.I2D: YeastLow
RPS4X 6191 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS27A 6233 SKP1 6500 pp -- int.I2D: BioGrid_Yeast, YeastLow
CDC5L 988 HDAC8 55869 pd > reg.ITFP.txt: no annot
NME2 4831 RPS19 6223 pp -- int.Proteinpedia: Mass spectrometry
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
VIM 7431 SERBP1 26135 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, HPRD, BioGrid, MINT, StelzlHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
RPS11 6205 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
RPS11 6205 RPS19 6223 pp -- int.I2D: IntAct_Yeast
RPS11 6205 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
TCERG1 10915 WWOX 51741 pp -- int.I2D: BioGrid, MINT, Pawson1;
int.Mint: MI:0915(physical association)
RPS3A 6189 RPS14 6208 pp -- int.I2D: BioGrid_Yeast
EIF2S2 8894 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS13 6207 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS14 6208 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
SRC 6714 CKAP5 9793 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
RAN 5901 WDR18 57418 pd < reg.ITFP.txt: no annot
ARCN1 372 RAN 5901 pp -- int.I2D: YeastLow
RPS15 6209 RPS23 6228 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS14 6208 RPS20 6224 pp -- int.I2D: INTEROLOG, YeastMedium, BioGrid_Yeast
CDC42 998 UBB 7314 pp -- int.I2D: SOURAV_MAPK_HIGH
HDAC8 55869 WDR18 57418 pd < reg.ITFP.txt: no annot
NFKBIB 4793 UBB 7314 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS15 6209 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS14 6208 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
RPS8 6202 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS9 6203 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS20 6224 RPS23 6228 pp -- int.I2D: YeastMedium, INTEROLOG
NME2 4831 RPS16 6217 pp -- int.Proteinpedia: Mass spectrometry
RPS8 6202 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS16 6217 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
MRPS12 6183 RPS20 6224 pp -- int.I2D: YeastMedium
SKP1 6500 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPS13 6207 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS15 6209 RPS20 6224 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS11 6205 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS23 6228 pp -- int.I2D: YeastLow, BioGrid_Yeast
RAN 5901 RPS11 6205 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
CKAP5 9793 HDAC8 55869 pd > reg.ITFP.txt: no annot
RPS13 6207 WDR46 9277 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
RPS14 6208 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS23 6228 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS9 6203 pp -- int.I2D: IntAct
RPS9 6203 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS14 6208 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
MRPS12 6183 WDR18 57418 pd <> reg.ITFP.txt: no annot
RPS4X 6191 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS14 6208 pp -- int.I2D: BioGrid_Yeast
UBB 7314 WWOX 51741 pp -- int.I2D: BCI, HPRD;
int.HPRD: in vivo
UBB 7314 RNF20 56254 pp -- int.Intact: MI:0220(ubiquitination reaction);
int.I2D: IntAct
MRPS12 6183 RPS15 6209 pp -- int.I2D: YeastMedium
RPS8 6202 SKP1 6500 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
SRC 6714 WWOX 51741 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
RPS16 6217 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS20 6224 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastHigh, YeastMedium
MAEA 10296 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
ARL1 400 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS19 6223 pp -- int.I2D: IntAct_Yeast
RPS20 6224 RPS27A 6233 pp -- int.I2D: YeastLow
RPS4X 6191 RPS14 6208 pp -- int.I2D: BioGrid_Yeast
RPS27A 6233 UBB 7314 pp -- int.I2D: BIND
RPS4X 6191 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
ARL1 400 COPA 1314 pp -- int.I2D: BioGrid_Yeast
NME2 4831 VIM 7431 pp -- int.HPRD: in vivo
RAN 5901 RPS15 6209 pp -- int.I2D: YeastLow
RPS4X 6191 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast, YeastMedium, INTEROLOG
RPS8 6202 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS13 6207 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS8 6202 RPS19 6223 pp -- int.I2D: MINT
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
RPS8 6202 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS4X 6191 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
COPA 1314 COPB1 1315 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
RPS8 6202 CHMP2A 27243 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 CKAP5 9793 pd <> reg.ITFP.txt: no annot
RAN 5901 WDR46 9277 pp -- int.I2D: YeastLow
RPS3A 6189 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS23 6228 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
HSF1 3297 MAPK8 5599 pp -- int.I2D: HPRD, INNATEDB;
int.HPRD: in vitro, in vivo
RPS3A 6189 RPS8 6202 pp -- int.I2D: BioGrid_Yeast, YeastLow
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
NFKBIB 4793 SKP1 6500 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vitro
RPS6 6194 RPS14 6208 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
COPB1 1315 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium;
int.DIP: MI:0915(physical association)
COPA 1314 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS15 6209 RPS16 6217 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS3A 6189 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS8 6202 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 ARL1 400 pp -- int.I2D: BioGrid_Yeast
ARL1 400 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS14 6208 pp -- int.I2D: BioGrid_Yeast
HSF1 3297 MRPS12 6183 pd <> reg.ITFP.txt: no annot
RPS19 6223 WDR18 57418 pd < reg.ITFP.txt: no annot
RAN 5901 SPHK2 56848 pp -- int.I2D: IntAct_Yeast, BIND_Yeast, MINT_Yeast, MIPS, YeastLow
MRPS12 6183 HDAC8 55869 pd > reg.ITFP.txt: no annot
RPS4X 6191 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
RPS11 6205 RPS14 6208 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 COPA 1314 pd <> reg.ITFP.txt: no annot
CDC5L 988 EIF2S2 8894 pd > reg.ITFP.txt: no annot
COPB1 1315 COPB2 9276 pp -- int.I2D: BioGrid
ARCN1 372 COPB1 1315 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS;
int.HPRD: in vivo
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS15 6209 RPS15A 6210 pp -- int.I2D: YeastMedium, INTEROLOG
RPS6 6194 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 RPS3A 6189 pp -- int.I2D: IntAct_Yeast
RPS16 6217 RPS23 6228 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS20 6224 pp -- int.I2D: YeastLow
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
RPS6 6194 RPS8 6202 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPS4X 6191 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 RPS16 6217 pp -- int.I2D: BioGrid
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
MAPK8 5599 WWOX 51741 pp -- int.I2D: MINT, HPRD;
int.Mint: MI:0915(physical association);
int.HPRD: in vivo, yeast 2-hybrid
RPS8 6202 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS16 6217 RPS26 6231 pp -- int.I2D: BioGrid_Yeast
RAN 5901 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS15A 6210 RPS27A 6233 pp -- int.I2D: YeastLow
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
RAN 5901 SKP1 6500 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS20 6224 pp -- int.I2D: YeastMedium, INTEROLOG
RPS13 6207 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium
RPS8 6202 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS6 6194 pp -- int.I2D: BioGrid_Yeast, YeastLow

Related GO terms (581)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0022627cytosolic small ribosomal subunit1.80e-342.95e-307.212172139
GO:0019058viral life cycle2.28e-313.72e-275.8862025115
GO:0019083viral transcription4.21e-286.87e-246.157172281
GO:0006415translational termination1.60e-272.62e-236.054172287
GO:0006414translational elongation5.54e-279.03e-235.958172293
GO:0006413translational initiation3.40e-265.56e-225.5461827131
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.32e-267.05e-225.7971722104
GO:0003735structural constituent of ribosome1.38e-252.25e-215.4401824141
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay2.30e-253.75e-215.6641722114
GO:0016032viral process2.76e-234.50e-193.9182437540
GO:0006412translation3.90e-236.36e-194.7811929235
GO:0005829cytosol2.79e-224.55e-182.33438742562
GO:0016071mRNA metabolic process7.01e-221.14e-174.7791829223
GO:0016070RNA metabolic process4.54e-217.41e-174.6311829247
GO:0044822poly(A) RNA binding1.71e-172.79e-132.97925421078
GO:0010467gene expression7.72e-161.26e-113.3462036669
GO:0016020membrane1.07e-151.74e-112.44728481746
GO:0044267cellular protein metabolic process1.10e-151.79e-113.6281829495
GO:0015935small ribosomal subunit2.29e-143.74e-107.1297917
GO:0005925focal adhesion3.19e-115.21e-073.5791323370
GO:0042274ribosomal small subunit biogenesis1.38e-102.26e-067.1465612
GO:0048205COPI coating of Golgi vesicle2.25e-103.66e-067.0315613
GO:0030126COPI vesicle coat2.25e-103.66e-067.0315613
GO:0061024membrane organization3.57e-105.82e-064.390911146
GO:0070062extracellular vesicular exosome3.65e-095.95e-051.75625512516
GO:0006890retrograde vesicle-mediated transport, Golgi to ER9.03e-091.47e-046.0885625
GO:0005840ribosome1.88e-083.06e-045.11261059
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.38e-073.88e-037.673335
GO:0000028ribosomal small subunit assembly8.29e-071.35e-027.187337
GO:0005515protein binding2.86e-064.66e-020.91634876127
GO:0006364rRNA processing8.89e-061.45e-014.1465896
GO:0075733intracellular transport of virus1.58e-052.57e-015.9073317
GO:0006891intra-Golgi vesicle-mediated transport1.58e-052.57e-015.9073317
GO:0030529ribonucleoprotein complex2.05e-053.35e-013.89958114
GO:0000056ribosomal small subunit export from nucleus2.54e-054.14e-017.825223
GO:0005737cytoplasm3.15e-055.13e-011.09625653976
GO:0043066negative regulation of apoptotic process3.42e-055.58e-012.651814433
GO:0036464cytoplasmic ribonucleoprotein granule3.53e-055.77e-015.5353522
GO:0034146toll-like receptor 5 signaling pathway3.91e-056.38e-014.3874565
GO:0034166toll-like receptor 10 signaling pathway3.91e-056.38e-014.3874565
GO:0030490maturation of SSU-rRNA5.06e-058.26e-017.409224
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway5.54e-059.04e-014.2604571
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway5.54e-059.04e-014.2604571
GO:0034162toll-like receptor 9 signaling pathway5.85e-059.55e-014.2404572
GO:0034134toll-like receptor 2 signaling pathway6.18e-051.00e+004.2204573
GO:0019843rRNA binding6.65e-051.00e+005.2403427
GO:0035666TRIF-dependent toll-like receptor signaling pathway7.23e-051.00e+004.1624576
GO:0002756MyD88-independent toll-like receptor signaling pathway8.01e-051.00e+004.1244578
GO:0033119negative regulation of RNA splicing8.42e-051.00e+007.088225
GO:0002755MyD88-dependent toll-like receptor signaling pathway8.84e-051.00e+004.0884580
GO:0034138toll-like receptor 3 signaling pathway8.84e-051.00e+004.0884580
GO:0045182translation regulator activity1.26e-041.00e+006.825226
GO:0006886intracellular protein transport1.50e-041.00e+003.29756173
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway1.59e-041.00e+004.8253336
GO:0034142toll-like receptor 4 signaling pathway1.79e-041.00e+003.8254596
GO:0002224toll-like receptor signaling pathway2.92e-041.00e+003.64145109
GO:0007254JNK cascade4.50e-041.00e+004.3223351
GO:0051403stress-activated MAPK cascade5.33e-041.00e+004.2403454
GO:0019082viral protein processing5.49e-041.00e+005.8252212
GO:0032479regulation of type I interferon production6.47e-041.00e+005.7092213
GO:0071398cellular response to fatty acid6.47e-041.00e+005.7092213
GO:0016197endosomal transport6.58e-041.00e+004.1363358
GO:0000086G2/M transition of mitotic cell cycle6.94e-041.00e+003.31146137
GO:0032481positive regulation of type I interferon production7.62e-041.00e+004.0643361
GO:0000082G1/S transition of mitotic cell cycle9.74e-041.00e+003.181411150
GO:0019068virion assembly1.12e-031.00e+005.3222217
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.14e-031.00e+003.8653870
GO:0043065positive regulation of apoptotic process1.22e-031.00e+002.63356274
GO:0043005neuron projection1.27e-031.00e+003.07946161
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.34e-031.00e+003.7853874
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.61e-031.00e+003.6913879
GO:0007220Notch receptor processing1.88e-031.00e+004.9502222
GO:0007173epidermal growth factor receptor signaling pathway2.37e-031.00e+002.83245191
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway2.43e-031.00e+004.7662225
GO:0005844polysome2.43e-031.00e+004.7662225
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.63e-031.00e+004.7092226
GO:0005978glycogen biosynthetic process2.63e-031.00e+004.7092226
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity2.63e-031.00e+004.7092226
GO:0001649osteoblast differentiation2.73e-031.00e+003.4253395
GO:0005730nucleolus2.86e-031.00e+001.27712361684
GO:2001286regulation of caveolin-mediated endocytosis2.94e-031.00e+008.409111
GO:0071393cellular response to progesterone stimulus2.94e-031.00e+008.409111
GO:0033176proton-transporting V-type ATPase complex2.94e-031.00e+008.409111
GO:0004673protein histidine kinase activity2.94e-031.00e+008.409111
GO:0006669sphinganine-1-phosphate biosynthetic process2.94e-031.00e+008.409111
GO:0022605oogenesis stage2.94e-031.00e+008.409111
GO:0018106peptidyl-histidine phosphorylation2.94e-031.00e+008.409111
GO:0021691cerebellar Purkinje cell layer maturation2.94e-031.00e+008.409111
GO:0071456cellular response to hypoxia2.99e-031.00e+003.3803398
GO:0003723RNA binding3.76e-031.00e+002.260510355
GO:0032480negative regulation of type I interferon production3.97e-031.00e+004.4092232
GO:0097190apoptotic signaling pathway4.79e-031.00e+003.13633116
GO:0000209protein polyubiquitination4.79e-031.00e+003.13637116
GO:0034332adherens junction organization5.01e-031.00e+004.2402436
GO:0003713transcription coactivator activity5.27e-031.00e+002.50946239
GO:0030218erythrocyte differentiation5.57e-031.00e+004.1622238
GO:0008481sphinganine kinase activity5.87e-031.00e+007.409112
GO:0071987WD40-repeat domain binding5.87e-031.00e+007.409112
GO:0060661submandibular salivary gland formation5.87e-031.00e+007.409112
GO:1902255positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator5.87e-031.00e+007.409112
GO:0002762negative regulation of myeloid leukocyte differentiation5.87e-031.00e+007.409112
GO:0017050D-erythro-sphingosine kinase activity5.87e-031.00e+007.409112
GO:0071338positive regulation of hair follicle cell proliferation5.87e-031.00e+007.409112
GO:0002176male germ cell proliferation5.87e-031.00e+007.409112
GO:0048822enucleate erythrocyte development5.87e-031.00e+007.409112
GO:0072422signal transduction involved in DNA damage checkpoint5.87e-031.00e+007.409112
GO:0010632regulation of epithelial cell migration5.87e-031.00e+007.409112
GO:0090135actin filament branching5.87e-031.00e+007.409112
GO:0060265positive regulation of respiratory burst involved in inflammatory response5.87e-031.00e+007.409112
GO:0051092positive regulation of NF-kappaB transcription factor activity5.90e-031.00e+003.02933125
GO:0007219Notch signaling pathway5.90e-031.00e+003.02934125
GO:0000278mitotic cell cycle6.09e-031.00e+002.095516398
GO:0007249I-kappaB kinase/NF-kappaB signaling6.46e-031.00e+004.0522441
GO:0007179transforming growth factor beta receptor signaling pathway6.58e-031.00e+002.97234130
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway7.08e-031.00e+003.9832243
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.29e-031.00e+001.79269589
GO:0048011neurotrophin TRK receptor signaling pathway8.37e-031.00e+002.31745273
GO:0010641positive regulation of platelet-derived growth factor receptor signaling pathway8.80e-031.00e+006.825113
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding8.80e-031.00e+006.825113
GO:0003161cardiac conduction system development8.80e-031.00e+006.825113
GO:0090045positive regulation of deacetylase activity8.80e-031.00e+006.825113
GO:0035033histone deacetylase regulator activity8.80e-031.00e+006.825113
GO:2000017positive regulation of determination of dorsal identity8.80e-031.00e+006.825113
GO:0051683establishment of Golgi localization8.80e-031.00e+006.825123
GO:0006670sphingosine metabolic process8.80e-031.00e+006.825113
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity8.80e-031.00e+006.825113
GO:0033146regulation of intracellular estrogen receptor signaling pathway8.80e-031.00e+006.825113
GO:0005850eukaryotic translation initiation factor 2 complex8.80e-031.00e+006.825113
GO:0004705JUN kinase activity8.80e-031.00e+006.825113
GO:0060266negative regulation of respiratory burst involved in inflammatory response8.80e-031.00e+006.825113
GO:0045087innate immune response9.00e-031.00e+001.728611616
GO:0007030Golgi organization9.48e-031.00e+003.7662350
GO:0010628positive regulation of gene expression9.55e-031.00e+002.77534149
GO:0042981regulation of apoptotic process9.91e-031.00e+002.75637151
GO:0030666endocytic vesicle membrane1.10e-021.00e+003.6552254
GO:0005198structural molecule activity1.14e-021.00e+002.68235159
GO:0008543fibroblast growth factor receptor signaling pathway1.14e-021.00e+002.68233159
GO:0071922regulation of cohesin localization to chromatin1.17e-021.00e+006.409124
GO:0034191apolipoprotein A-I receptor binding1.17e-021.00e+006.409114
GO:0007000nucleolus organization1.17e-021.00e+006.409124
GO:0032463negative regulation of protein homooligomerization1.17e-021.00e+006.409114
GO:0051902negative regulation of mitochondrial depolarization1.17e-021.00e+006.409114
GO:0060020Bergmann glial cell differentiation1.17e-021.00e+006.409114
GO:0031062positive regulation of histone methylation1.17e-021.00e+006.409114
GO:0060684epithelial-mesenchymal cell signaling1.17e-021.00e+006.409114
GO:0070851growth factor receptor binding1.17e-021.00e+006.409114
GO:0051835positive regulation of synapse structural plasticity1.17e-021.00e+006.409114
GO:0090231regulation of spindle checkpoint1.17e-021.00e+006.409114
GO:0072384organelle transport along microtubule1.17e-021.00e+006.409124
GO:0007258JUN phosphorylation1.17e-021.00e+006.409114
GO:0048664neuron fate determination1.17e-021.00e+006.409114
GO:0033503HULC complex1.17e-021.00e+006.409114
GO:0045682regulation of epidermis development1.17e-021.00e+006.409114
GO:0031063regulation of histone deacetylation1.17e-021.00e+006.409114
GO:0031467Cul7-RING ubiquitin ligase complex1.17e-021.00e+006.409114
GO:0000055ribosomal large subunit export from nucleus1.17e-021.00e+006.409114
GO:0033625positive regulation of integrin activation1.17e-021.00e+006.409114
GO:0009991response to extracellular stimulus1.17e-021.00e+006.409114
GO:0038095Fc-epsilon receptor signaling pathway1.38e-021.00e+002.57733171
GO:0019901protein kinase binding1.43e-021.00e+002.08849320
GO:2000641regulation of early endosome to late endosome transport1.46e-021.00e+006.088115
GO:0036336dendritic cell migration1.46e-021.00e+006.088115
GO:0033033negative regulation of myeloid cell apoptotic process1.46e-021.00e+006.088115
GO:0035088establishment or maintenance of apical/basal cell polarity1.46e-021.00e+006.088115
GO:0051385response to mineralocorticoid1.46e-021.00e+006.088115
GO:0005826actomyosin contractile ring1.46e-021.00e+006.088115
GO:1902188positive regulation of viral release from host cell1.46e-021.00e+006.088115
GO:0097300programmed necrotic cell death1.46e-021.00e+006.088115
GO:0031256leading edge membrane1.46e-021.00e+006.088115
GO:0031584activation of phospholipase D activity1.46e-021.00e+006.088115
GO:0009404toxin metabolic process1.46e-021.00e+006.088115
GO:0071803positive regulation of podosome assembly1.46e-021.00e+006.088115
GO:0046834lipid phosphorylation1.46e-021.00e+006.088115
GO:0006417regulation of translation1.48e-021.00e+003.4322463
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway1.52e-021.00e+003.4092264
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.57e-021.00e+003.3872665
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.57e-021.00e+003.3872665
GO:0005882intermediate filament1.61e-021.00e+003.3652366
GO:0019904protein domain specific binding1.61e-021.00e+002.49533181
GO:0003682chromatin binding1.65e-021.00e+002.02644334
GO:0031295T cell costimulation1.66e-021.00e+003.3432367
GO:0050847progesterone receptor signaling pathway1.75e-021.00e+005.825116
GO:0007143female meiotic division1.75e-021.00e+005.825116
GO:0002309T cell proliferation involved in immune response1.75e-021.00e+005.825116
GO:0045056transcytosis1.75e-021.00e+005.825116
GO:0060789hair follicle placode formation1.75e-021.00e+005.825116
GO:0018105peptidyl-serine phosphorylation1.75e-021.00e+003.3012569
GO:0006333chromatin assembly or disassembly1.75e-021.00e+005.825116
GO:0048554positive regulation of metalloenzyme activity1.75e-021.00e+005.825116
GO:0050792regulation of viral process1.75e-021.00e+005.825116
GO:0002181cytoplasmic translation1.75e-021.00e+005.825126
GO:0019215intermediate filament binding1.75e-021.00e+005.825116
GO:0000974Prp19 complex1.75e-021.00e+005.825116
GO:0006924activation-induced cell death of T cells1.75e-021.00e+005.825126
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.95e-021.00e+003.2202673
GO:0003729mRNA binding1.95e-021.00e+003.2202373
GO:0010447response to acidic pH2.04e-021.00e+005.602117
GO:0009142nucleoside triphosphate biosynthetic process2.04e-021.00e+005.602117
GO:0060136embryonic process involved in female pregnancy2.04e-021.00e+005.602117
GO:0043497regulation of protein heterodimerization activity2.04e-021.00e+005.602117
GO:0050658RNA transport2.04e-021.00e+005.602117
GO:0048027mRNA 5'-UTR binding2.04e-021.00e+005.602117
GO:0007097nuclear migration2.04e-021.00e+005.602127
GO:0061512protein localization to cilium2.04e-021.00e+005.602117
GO:0003334keratinocyte development2.04e-021.00e+005.602117
GO:0051988regulation of attachment of spindle microtubules to kinetochore2.04e-021.00e+005.602117
GO:0034101erythrocyte homeostasis2.04e-021.00e+005.602117
GO:0010907positive regulation of glucose metabolic process2.04e-021.00e+005.602117
GO:0048193Golgi vesicle transport2.04e-021.00e+005.602117
GO:0030157pancreatic juice secretion2.04e-021.00e+005.602117
GO:0000930gamma-tubulin complex2.04e-021.00e+005.602117
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2.15e-021.00e+003.1432677
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis2.15e-021.00e+003.1432477
GO:0003924GTPase activity2.18e-021.00e+002.32936203
GO:0007229integrin-mediated signaling pathway2.21e-021.00e+003.1242278
GO:0010629negative regulation of gene expression2.31e-021.00e+003.0882280
GO:0039702viral budding via host ESCRT complex2.33e-021.00e+005.409118
GO:0006183GTP biosynthetic process2.33e-021.00e+005.409118
GO:0043114regulation of vascular permeability2.33e-021.00e+005.409118
GO:0045124regulation of bone resorption2.33e-021.00e+005.409118
GO:0051489regulation of filopodium assembly2.33e-021.00e+005.409118
GO:0033523histone H2B ubiquitination2.33e-021.00e+005.409118
GO:0007172signal complex assembly2.33e-021.00e+005.409118
GO:0071222cellular response to lipopolysaccharide2.37e-021.00e+003.0702481
GO:0071732cellular response to nitric oxide2.62e-021.00e+005.240119
GO:0006241CTP biosynthetic process2.62e-021.00e+005.240119
GO:0014075response to amine2.62e-021.00e+005.240119
GO:0034067protein localization to Golgi apparatus2.62e-021.00e+005.240119
GO:0006228UTP biosynthetic process2.62e-021.00e+005.240119
GO:0090136epithelial cell-cell adhesion2.62e-021.00e+005.240129
GO:0047497mitochondrion transport along microtubule2.62e-021.00e+005.240119
GO:0046628positive regulation of insulin receptor signaling pathway2.62e-021.00e+005.240119
GO:0006184GTP catabolic process2.68e-021.00e+002.21336220
GO:0050852T cell receptor signaling pathway2.76e-021.00e+002.9502288
GO:0008284positive regulation of cell proliferation2.78e-021.00e+001.79547392
GO:0000187activation of MAPK activity2.88e-021.00e+002.9182390
GO:0045618positive regulation of keratinocyte differentiation2.90e-021.00e+005.0881110
GO:0070307lens fiber cell development2.90e-021.00e+005.0881110
GO:0005798Golgi-associated vesicle2.90e-021.00e+005.0881110
GO:0031274positive regulation of pseudopodium assembly2.90e-021.00e+005.0881210
GO:0022407regulation of cell-cell adhesion2.90e-021.00e+005.0881110
GO:0060047heart contraction2.90e-021.00e+005.0881110
GO:0007067mitotic nuclear division3.04e-021.00e+002.14337231
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.12e-021.00e+002.8552794
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity3.19e-021.00e+004.9501111
GO:0051895negative regulation of focal adhesion assembly3.19e-021.00e+004.9501111
GO:0045120pronucleus3.19e-021.00e+004.9501111
GO:2000573positive regulation of DNA biosynthetic process3.19e-021.00e+004.9501211
GO:0051272positive regulation of cellular component movement3.19e-021.00e+004.9501111
GO:0045109intermediate filament organization3.19e-021.00e+004.9501111
GO:0060065uterus development3.19e-021.00e+004.9501111
GO:0010390histone monoubiquitination3.19e-021.00e+004.9501111
GO:0035518histone H2A monoubiquitination3.19e-021.00e+004.9501211
GO:0014002astrocyte development3.19e-021.00e+004.9501111
GO:0061136regulation of proteasomal protein catabolic process3.47e-021.00e+004.8251112
GO:0007051spindle organization3.47e-021.00e+004.8251112
GO:0043149stress fiber assembly3.47e-021.00e+004.8251212
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)3.47e-021.00e+004.8251112
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)3.47e-021.00e+004.8251112
GO:0043249erythrocyte maturation3.47e-021.00e+004.8251112
GO:1903543positive regulation of exosomal secretion3.47e-021.00e+004.8251112
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)3.47e-021.00e+004.8251112
GO:1901214regulation of neuron death3.47e-021.00e+004.8251112
GO:0043488regulation of mRNA stability3.76e-021.00e+004.7091113
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)3.76e-021.00e+004.7091113
GO:0031929TOR signaling3.76e-021.00e+004.7091113
GO:0061647histone H3-K9 modification3.76e-021.00e+004.7091113
GO:0005662DNA replication factor A complex3.76e-021.00e+004.7091113
GO:0007062sister chromatid cohesion3.76e-021.00e+004.7091113
GO:0060444branching involved in mammary gland duct morphogenesis3.76e-021.00e+004.7091113
GO:0004143diacylglycerol kinase activity3.76e-021.00e+004.7091113
GO:0005654nucleoplasm3.97e-021.00e+001.1207261095
GO:0035371microtubule plus-end4.04e-021.00e+004.6021114
GO:0031333negative regulation of protein complex assembly4.04e-021.00e+004.6021114
GO:0050662coenzyme binding4.04e-021.00e+004.6021114
GO:0017016Ras GTPase binding4.04e-021.00e+004.6021114
GO:0031996thioesterase binding4.04e-021.00e+004.6021114
GO:0006165nucleoside diphosphate phosphorylation4.04e-021.00e+004.6021114
GO:0048477oogenesis4.32e-021.00e+004.5031115
GO:0030131clathrin adaptor complex4.32e-021.00e+004.5031115
GO:0030225macrophage differentiation4.32e-021.00e+004.5031115
GO:0003951NAD+ kinase activity4.32e-021.00e+004.5031115
GO:0004550nucleoside diphosphate kinase activity4.32e-021.00e+004.5031115
GO:0048821erythrocyte development4.32e-021.00e+004.5031215
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand4.32e-021.00e+004.5031115
GO:0031369translation initiation factor binding4.32e-021.00e+004.5031215
GO:0051233spindle midzone4.32e-021.00e+004.5031215
GO:0014911positive regulation of smooth muscle cell migration4.61e-021.00e+004.4091116
GO:0048037cofactor binding4.61e-021.00e+004.4091116
GO:0004407histone deacetylase activity4.61e-021.00e+004.4091116
GO:0042176regulation of protein catabolic process4.61e-021.00e+004.4091416
GO:2000811negative regulation of anoikis4.61e-021.00e+004.4091116
GO:0005212structural constituent of eye lens4.61e-021.00e+004.4091116
GO:0006006glucose metabolic process4.78e-021.00e+002.51524119
GO:0002548monocyte chemotaxis4.89e-021.00e+004.3221117
GO:0070933histone H4 deacetylation4.89e-021.00e+004.3221117
GO:0030742GTP-dependent protein binding4.89e-021.00e+004.3221117
GO:0005634nucleus4.96e-021.00e+000.49420664828
GO:0070064proline-rich region binding5.17e-021.00e+004.2401118
GO:0031954positive regulation of protein autophosphorylation5.17e-021.00e+004.2401118
GO:0015949nucleobase-containing small molecule interconversion5.17e-021.00e+004.2401118
GO:0043015gamma-tubulin binding5.17e-021.00e+004.2401218
GO:0090316positive regulation of intracellular protein transport5.17e-021.00e+004.2401118
GO:0007264small GTPase mediated signal transduction5.35e-021.00e+001.81537290
GO:0006259DNA metabolic process5.45e-021.00e+004.1621119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process5.45e-021.00e+004.1621119
GO:0007088regulation of mitosis5.45e-021.00e+004.1621119
GO:0017134fibroblast growth factor binding5.45e-021.00e+004.1621219
GO:0045453bone resorption5.45e-021.00e+004.1621119
GO:0031667response to nutrient levels5.45e-021.00e+004.1621119
GO:0032148activation of protein kinase B activity5.72e-021.00e+004.0881120
GO:0051090regulation of sequence-specific DNA binding transcription factor activity5.72e-021.00e+004.0881220
GO:0043473pigmentation5.72e-021.00e+004.0881220
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator5.72e-021.00e+004.0881120
GO:0043393regulation of protein binding5.72e-021.00e+004.0881220
GO:0009615response to virus5.75e-021.00e+002.36524132
GO:0007369gastrulation6.00e-021.00e+004.0171121
GO:0070932histone H3 deacetylation6.00e-021.00e+004.0171121
GO:0046847filopodium assembly6.00e-021.00e+004.0171121
GO:0051881regulation of mitochondrial membrane potential6.00e-021.00e+004.0171121
GO:2001243negative regulation of intrinsic apoptotic signaling pathway6.28e-021.00e+003.9501122
GO:0046686response to cadmium ion6.28e-021.00e+003.9501122
GO:0033574response to testosterone6.28e-021.00e+003.9501122
GO:0001106RNA polymerase II transcription corepressor activity6.28e-021.00e+003.9501122
GO:0031435mitogen-activated protein kinase kinase kinase binding6.28e-021.00e+003.9501122
GO:0007052mitotic spindle organization6.28e-021.00e+003.9501122
GO:1900026positive regulation of substrate adhesion-dependent cell spreading6.55e-021.00e+003.8861123
GO:0071944cell periphery6.55e-021.00e+003.8861123
GO:0045787positive regulation of cell cycle6.55e-021.00e+003.8861223
GO:0002040sprouting angiogenesis6.55e-021.00e+003.8861123
GO:0051017actin filament bundle assembly6.55e-021.00e+003.8861123
GO:0001892embryonic placenta development6.55e-021.00e+003.8861123
GO:0051297centrosome organization6.55e-021.00e+003.8861223
GO:0008286insulin receptor signaling pathway6.70e-021.00e+002.24024144
GO:0008135translation factor activity, nucleic acid binding6.83e-021.00e+003.8251424
GO:0005761mitochondrial ribosome6.83e-021.00e+003.8251124
GO:0007163establishment or maintenance of cell polarity6.83e-021.00e+003.8251224
GO:0051602response to electrical stimulus6.83e-021.00e+003.8251124
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling7.03e-021.00e+002.20023148
GO:0006611protein export from nucleus7.10e-021.00e+003.7661125
GO:0031519PcG protein complex7.10e-021.00e+003.7661125
GO:0050715positive regulation of cytokine secretion7.10e-021.00e+003.7661125
GO:0048705skeletal system morphogenesis7.10e-021.00e+003.7661125
GO:0005525GTP binding7.18e-021.00e+001.63736328
GO:0045859regulation of protein kinase activity7.38e-021.00e+003.7091126
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway7.38e-021.00e+003.7091126
GO:0030148sphingolipid biosynthetic process7.38e-021.00e+003.7091126
GO:0051149positive regulation of muscle cell differentiation7.65e-021.00e+003.6551227
GO:0032720negative regulation of tumor necrosis factor production7.65e-021.00e+003.6551127
GO:2001238positive regulation of extrinsic apoptotic signaling pathway7.65e-021.00e+003.6551127
GO:0031424keratinization7.65e-021.00e+003.6551127
GO:0001103RNA polymerase II repressing transcription factor binding7.65e-021.00e+003.6551127
GO:0030331estrogen receptor binding7.65e-021.00e+003.6551127
GO:0045184establishment of protein localization7.65e-021.00e+003.6551227
GO:0031069hair follicle morphogenesis7.65e-021.00e+003.6551127
GO:0005813centrosome7.75e-021.00e+001.58939339
GO:0010008endosome membrane7.78e-021.00e+002.11522157
GO:0032467positive regulation of cytokinesis7.92e-021.00e+003.6021128
GO:0000118histone deacetylase complex7.92e-021.00e+003.6021128
GO:0042626ATPase activity, coupled to transmembrane movement of substances7.92e-021.00e+003.6021128
GO:0008022protein C-terminus binding8.13e-021.00e+002.07924161
GO:0031252cell leading edge8.19e-021.00e+003.5511329
GO:0019005SCF ubiquitin ligase complex8.19e-021.00e+003.5511129
GO:0003730mRNA 3'-UTR binding8.19e-021.00e+003.5511129
GO:0034605cellular response to heat8.19e-021.00e+003.5511129
GO:0072686mitotic spindle8.19e-021.00e+003.5511129
GO:0010977negative regulation of neuron projection development8.46e-021.00e+003.5031230
GO:0051262protein tetramerization8.46e-021.00e+003.5031130
GO:0007346regulation of mitotic cell cycle8.46e-021.00e+003.5031330
GO:0046875ephrin receptor binding8.46e-021.00e+003.5031230
GO:0042169SH2 domain binding8.46e-021.00e+003.5031130
GO:0031647regulation of protein stability8.46e-021.00e+003.5031130
GO:0040018positive regulation of multicellular organism growth8.46e-021.00e+003.5031130
GO:0006915apoptotic process8.63e-021.00e+001.25249571
GO:0034220ion transmembrane transport8.65e-021.00e+002.02622167
GO:0070555response to interleukin-18.73e-021.00e+003.4551131
GO:0007093mitotic cell cycle checkpoint8.73e-021.00e+003.4551231
GO:0045944positive regulation of transcription from RNA polymerase II promoter8.86e-021.00e+001.068511811
GO:0033572transferrin transport9.00e-021.00e+003.4091132
GO:0015992proton transport9.00e-021.00e+003.4091132
GO:0051219phosphoprotein binding9.00e-021.00e+003.4091432
GO:0032091negative regulation of protein binding9.27e-021.00e+003.3651133
GO:0005158insulin receptor binding9.27e-021.00e+003.3651233
GO:0033077T cell differentiation in thymus9.27e-021.00e+003.3651133
GO:0048812neuron projection morphogenesis9.27e-021.00e+003.3651133
GO:0001890placenta development9.54e-021.00e+003.3221134
GO:0097110scaffold protein binding9.54e-021.00e+003.3221134
GO:0042692muscle cell differentiation9.54e-021.00e+003.3221234
GO:0051701interaction with host9.54e-021.00e+003.3221134
GO:0007049cell cycle9.55e-021.00e+001.94224177
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway9.80e-021.00e+003.2801135
GO:0071333cellular response to glucose stimulus9.80e-021.00e+003.2801235
GO:2001237negative regulation of extrinsic apoptotic signaling pathway9.80e-021.00e+003.2801135
GO:0000228nuclear chromosome1.01e-011.00e+003.2401236
GO:0030178negative regulation of Wnt signaling pathway1.01e-011.00e+003.2401136
GO:0071560cellular response to transforming growth factor beta stimulus1.01e-011.00e+003.2401136
GO:0006367transcription initiation from RNA polymerase II promoter1.02e-011.00e+001.88625184
GO:0016301kinase activity1.03e-011.00e+003.2001237
GO:0018107peptidyl-threonine phosphorylation1.03e-011.00e+003.2001137
GO:0032880regulation of protein localization1.03e-011.00e+003.2001137
GO:0001568blood vessel development1.06e-011.00e+003.1621238
GO:0050681androgen receptor binding1.06e-011.00e+003.1621238
GO:0030049muscle filament sliding1.06e-011.00e+003.1621238
GO:0097191extrinsic apoptotic signaling pathway1.06e-011.00e+003.1621338
GO:0045740positive regulation of DNA replication1.06e-011.00e+003.1621138
GO:0090382phagosome maturation1.06e-011.00e+003.1621138
GO:0008047enzyme activator activity1.09e-011.00e+003.1241139
GO:0032092positive regulation of protein binding1.09e-011.00e+003.1241139
GO:0021766hippocampus development1.09e-011.00e+003.1241339
GO:0042542response to hydrogen peroxide1.11e-011.00e+003.0881140
GO:0070301cellular response to hydrogen peroxide1.14e-011.00e+003.0521141
GO:0030521androgen receptor signaling pathway1.14e-011.00e+003.0521341
GO:0045785positive regulation of cell adhesion1.14e-011.00e+003.0521141
GO:0042147retrograde transport, endosome to Golgi1.16e-011.00e+003.0171142
GO:0005902microvillus1.16e-011.00e+003.0171142
GO:0004715non-membrane spanning protein tyrosine kinase activity1.16e-011.00e+003.0171142
GO:0000139Golgi membrane1.18e-011.00e+001.32237408
GO:0007286spermatid development1.22e-011.00e+002.9501144
GO:0005080protein kinase C binding1.22e-011.00e+002.9501144
GO:0034613cellular protein localization1.22e-011.00e+002.9501244
GO:0005794Golgi apparatus1.23e-011.00e+001.06548650
GO:0009411response to UV1.24e-011.00e+002.9181245
GO:0051591response to cAMP1.24e-011.00e+002.9181145
GO:0044297cell body1.27e-011.00e+002.8861146
GO:0043525positive regulation of neuron apoptotic process1.27e-011.00e+002.8861246
GO:0045727positive regulation of translation1.27e-011.00e+002.8861146
GO:0021762substantia nigra development1.27e-011.00e+002.8861246
GO:0043406positive regulation of MAP kinase activity1.29e-011.00e+002.8551147
GO:0006921cellular component disassembly involved in execution phase of apoptosis1.29e-011.00e+002.8551147
GO:0008344adult locomotory behavior1.29e-011.00e+002.8551247
GO:0006950response to stress1.32e-011.00e+002.8251148
GO:0019003GDP binding1.32e-011.00e+002.8251148
GO:0005070SH3/SH2 adaptor activity1.35e-011.00e+002.7951149
GO:0045111intermediate filament cytoskeleton1.35e-011.00e+002.7951149
GO:0005765lysosomal membrane1.35e-011.00e+001.64122218
GO:0003743translation initiation factor activity1.35e-011.00e+002.7951549
GO:0001948glycoprotein binding1.37e-011.00e+002.7661250
GO:0035690cellular response to drug1.37e-011.00e+002.7661350
GO:0090263positive regulation of canonical Wnt signaling pathway1.40e-011.00e+002.7371151
GO:0030900forebrain development1.40e-011.00e+002.7371151
GO:0008202steroid metabolic process1.42e-011.00e+002.7091152
GO:0006952defense response1.45e-011.00e+002.6821153
GO:0030175filopodium1.45e-011.00e+002.6821253
GO:0003725double-stranded RNA binding1.47e-011.00e+002.6551254
GO:0009612response to mechanical stimulus1.47e-011.00e+002.6551154
GO:0019221cytokine-mediated signaling pathway1.47e-011.00e+001.56425230
GO:0050679positive regulation of epithelial cell proliferation1.47e-011.00e+002.6551254
GO:0097193intrinsic apoptotic signaling pathway1.50e-011.00e+002.6281255
GO:0002039p53 binding1.50e-011.00e+002.6281155
GO:0046330positive regulation of JNK cascade1.50e-011.00e+002.6281155
GO:0005793endoplasmic reticulum-Golgi intermediate compartment1.55e-011.00e+002.5771157
GO:0006879cellular iron ion homeostasis1.55e-011.00e+002.5771257
GO:0005643nuclear pore1.60e-011.00e+002.5271159
GO:0010976positive regulation of neuron projection development1.62e-011.00e+002.5031260
GO:0033138positive regulation of peptidyl-serine phosphorylation1.65e-011.00e+002.4791161
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription1.67e-011.00e+002.4551162
GO:0000151ubiquitin ligase complex1.70e-011.00e+002.4321163
GO:0005901caveola1.70e-011.00e+002.4321163
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process1.70e-011.00e+002.4321263
GO:0043025neuronal cell body1.71e-011.00e+001.42125254
GO:0045893positive regulation of transcription, DNA-templated1.72e-011.00e+001.06738487
GO:0032869cellular response to insulin stimulus1.72e-011.00e+002.4091264
GO:0004842ubiquitin-protein transferase activity1.74e-011.00e+001.40923256
GO:0016491oxidoreductase activity1.75e-011.00e+002.3871165
GO:0071260cellular response to mechanical stimulus1.77e-011.00e+002.3651366
GO:0030141secretory granule1.79e-011.00e+002.3431267
GO:0006351transcription, DNA-templated1.80e-011.00e+000.5877171585
GO:0006665sphingolipid metabolic process1.82e-011.00e+002.3221168
GO:0006281DNA repair1.82e-011.00e+001.36525264
GO:0003697single-stranded DNA binding1.84e-011.00e+002.3011469
GO:0035264multicellular organism growth1.87e-011.00e+002.2801170
GO:0042393histone binding1.89e-011.00e+002.2601171
GO:0001503ossification1.89e-011.00e+002.2601271
GO:0005739mitochondrion1.92e-011.00e+000.7015101046
GO:0055085transmembrane transport1.92e-011.00e+000.98933514
GO:0005975carbohydrate metabolic process1.93e-011.00e+001.31123274
GO:0000785chromatin1.94e-011.00e+002.2201273
GO:0055086nucleobase-containing small molecule metabolic process1.94e-011.00e+002.2201273
GO:0042826histone deacetylase binding1.96e-011.00e+002.2001174
GO:0048471perinuclear region of cytoplasm1.99e-011.00e+000.96439523
GO:0007265Ras protein signal transduction1.99e-011.00e+002.1811375
GO:0051897positive regulation of protein kinase B signaling1.99e-011.00e+002.1811175
GO:0060070canonical Wnt signaling pathway1.99e-011.00e+002.1811275
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1.99e-011.00e+002.1811175
GO:0044325ion channel binding2.03e-011.00e+002.1431377
GO:0008584male gonad development2.03e-011.00e+002.1431177
GO:0019899enzyme binding2.08e-011.00e+001.24025288
GO:0071013catalytic step 2 spliceosome2.08e-011.00e+002.1061179
GO:0031902late endosome membrane2.10e-011.00e+002.0881180
GO:0051301cell division2.13e-011.00e+002.0701281
GO:0045177apical part of cell2.15e-011.00e+002.0521182
GO:0001726ruffle2.15e-011.00e+002.0521182
GO:0004713protein tyrosine kinase activity2.15e-011.00e+002.0521182
GO:0030336negative regulation of cell migration2.17e-011.00e+002.0341283
GO:0005929cilium2.20e-011.00e+002.0171284
GO:0005179hormone activity2.20e-011.00e+002.0171184
GO:0043234protein complex2.21e-011.00e+001.18129300
GO:0042593glucose homeostasis2.31e-011.00e+001.9341189
GO:0042384cilium assembly2.33e-011.00e+001.9181290
GO:0005856cytoskeleton2.33e-011.00e+001.12926311
GO:0005777peroxisome2.33e-011.00e+001.9181190
GO:0000922spindle pole2.36e-011.00e+001.9021591
GO:0016337single organismal cell-cell adhesion2.38e-011.00e+001.8861292
GO:0006928cellular component movement2.38e-011.00e+001.8861492
GO:0016363nuclear matrix2.38e-011.00e+001.8861492
GO:0042470melanosome2.38e-011.00e+001.8861292
GO:0005200structural constituent of cytoskeleton2.40e-011.00e+001.8701693
GO:0005770late endosome2.42e-011.00e+001.8551194
GO:0007010cytoskeleton organization2.47e-011.00e+001.8251196
GO:0005178integrin binding2.49e-011.00e+001.8101197
GO:0007411axon guidance2.50e-011.00e+001.05623327
GO:0016568chromatin modification2.54e-011.00e+001.7801299
GO:0008283cell proliferation2.54e-011.00e+001.03924331
GO:0043231intracellular membrane-bounded organelle2.55e-011.00e+001.03423332
GO:0007275multicellular organismal development2.69e-011.00e+000.98322344
GO:0014069postsynaptic density2.69e-011.00e+001.68213106
GO:0030496midbody2.75e-011.00e+001.64114109
GO:0070374positive regulation of ERK1 and ERK2 cascade2.78e-011.00e+001.62811110
GO:0005815microtubule organizing center2.78e-011.00e+001.62814110
GO:0050900leukocyte migration2.80e-011.00e+001.61511111
GO:0020037heme binding2.80e-011.00e+001.61511111
GO:0015630microtubule cytoskeleton2.82e-011.00e+001.60214112
GO:0005819spindle2.86e-011.00e+001.57714114
GO:0005802trans-Golgi network2.90e-011.00e+001.55112116
GO:0032496response to lipopolysaccharide3.03e-011.00e+001.47911122
GO:0051056regulation of small GTPase mediated signal transduction3.05e-011.00e+001.46713123
GO:0007155cell adhesion3.12e-011.00e+000.82523384
GO:0006511ubiquitin-dependent protein catabolic process3.13e-011.00e+001.42113127
GO:0030036actin cytoskeleton organization3.17e-011.00e+001.39813129
GO:0030027lamellipodium3.19e-011.00e+001.38713130
GO:0046983protein dimerization activity3.21e-011.00e+001.37613131
GO:0018108peptidyl-tyrosine phosphorylation3.25e-011.00e+001.35411133
GO:0044281small molecule metabolic process3.32e-011.00e+000.3935161295
GO:0016055Wnt signaling pathway3.41e-011.00e+001.27013141
GO:0005911cell-cell junction3.43e-011.00e+001.26012142
GO:0046777protein autophosphorylation3.74e-011.00e+001.10611158
GO:0000398mRNA splicing, via spliceosome3.86e-011.00e+001.04312165
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3.92e-011.00e+001.01714168
GO:0007596blood coagulation3.98e-011.00e+000.55125464
GO:0007420brain development3.99e-011.00e+000.98313172
GO:0016607nuclear speck4.04e-011.00e+000.95812175
GO:0004672protein kinase activity4.10e-011.00e+000.93414178
GO:0031625ubiquitin protein ligase binding4.13e-011.00e+000.91814180
GO:0005764lysosome4.17e-011.00e+000.90212182
GO:0042802identical protein binding4.26e-011.00e+000.47024491
GO:0046872metal ion binding4.34e-011.00e+000.2155141465
GO:0030168platelet activation4.55e-011.00e+000.73014205
GO:0001701in utero embryonic development4.63e-011.00e+000.69512210
GO:0004871signal transducer activity4.73e-011.00e+000.65511216
GO:0016874ligase activity4.85e-011.00e+000.60212224
GO:0030425dendrite5.09e-011.00e+000.50313240
GO:0008134transcription factor binding5.18e-011.00e+000.46715246
GO:0007165signal transduction5.35e-011.00e+000.10337950
GO:0005102receptor binding5.49e-011.00e+000.34312268
GO:0000166nucleotide binding5.54e-011.00e+000.32212272
GO:0003779actin binding5.58e-011.00e+000.30613275
GO:0007283spermatogenesis5.60e-011.00e+000.30112276
GO:0005524ATP binding5.72e-011.00e+000.0064191354
GO:0042493response to drug5.75e-011.00e+000.24012288
GO:0016567protein ubiquitination5.89e-011.00e+000.18513299
GO:0005743mitochondrial inner membrane5.90e-011.00e+000.18111300
GO:0004674protein serine/threonine kinase activity6.05e-011.00e+000.12416312
GO:0035556intracellular signal transduction6.10e-011.00e+000.10115317
GO:0005886plasma membrane6.10e-011.00e+00-0.0598242834
GO:0005575cellular_component6.16e-011.00e+000.07912322
GO:0030154cell differentiation6.20e-011.00e+000.06513325
GO:0006355regulation of transcription, DNA-templated6.39e-011.00e+00-0.1143101104
GO:0003700sequence-specific DNA binding transcription factor activity6.53e-011.00e+00-0.13729748
GO:0015031protein transport6.55e-011.00e+00-0.07014357
GO:0008285negative regulation of cell proliferation6.65e-011.00e+00-0.11013367
GO:0045892negative regulation of transcription, DNA-templated7.18e-011.00e+00-0.31812424
GO:0006366transcription from RNA polymerase II promoter7.19e-011.00e+00-0.32213425
GO:0008150biological_process7.46e-011.00e+00-0.43313459
GO:0006468protein phosphorylation7.52e-011.00e+00-0.45816467
GO:0055114oxidation-reduction process7.63e-011.00e+00-0.50012481
GO:0005783endoplasmic reticulum8.40e-011.00e+00-0.84316610
GO:0042803protein homodimerization activity8.43e-011.00e+00-0.86014617
GO:0003677DNA binding9.16e-011.00e+00-0.9902141351
GO:0005887integral component of plasma membrane9.46e-011.00e+00-1.49912961
GO:0005615extracellular space9.54e-011.00e+00-1.571131010
GO:0008270zinc ion binding9.61e-011.00e+00-1.650171067