int-snw-10296

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	6.413	3.70e-138	2.79e-07	2.32e-03

tai-screen-luciferase-int-snw-10296 subnetwork

Genes (18)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
COPA	1314	32	-9.395	9.063	170	Yes	Yes
RPS24	6229	21	-7.034	8.389	217	Yes	-
RPS9	6203	18	-7.127	7.555	140	Yes	-
COPB2	9276	32	-13.168	9.063	41	Yes	Yes
RPS4X	6191	18	-6.747	7.555	263	Yes	-
COPZ1	22818	32	-8.301	9.063	13	Yes	Yes
EIF2S2	8894	2	-4.320	7.286	81	Yes	-
ATP6V1D	51382	8	-4.131	7.286	149	-	-
[ MAEA ]	10296	1	-2.793	6.413	43	-	-
RPS11	6205	17	-6.588	7.555	175	Yes	-
ARL1	400	4	-4.142	8.046	110	-	Yes
RPS6	6194	17	-5.603	8.046	208	Yes	-
SKP1	6500	4	-3.750	6.413	203	-	-
RAN	5901	4	-3.809	6.905	175	Yes	Yes
ARCN1	372	32	-8.232	9.063	118	Yes	Yes
RPS26	6231	17	-7.478	8.046	60	Yes	-
COPB1	1315	22	-6.221	9.063	118	Yes	Yes
RPS13	6207	17	-6.589	7.555	174	Yes	-

Interactions (39)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RPS9	6203	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS9	6203	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RAN	5901	RPS11	6205	pp	--	int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
RPS4X	6191	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
EIF2S2	8894	ATP6V1D	51382	pp	--	int.I2D: YeastLow
ARL1	400	COPA	1314	pp	--	int.I2D: BioGrid_Yeast
COPA	1314	COPB1	1315	pp	--	int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
RPS9	6203	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	RAN	5901	pp	--	int.I2D: YeastLow
RAN	5901	SKP1	6500	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
RPS4X	6191	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
RPS11	6205	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
COPA	1314	ATP6V1D	51382	pp	--	int.I2D: YeastLow
RPS4X	6191	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
SKP1	6500	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
ARCN1	372	ARL1	400	pp	--	int.I2D: BioGrid_Yeast
RPS4X	6191	RPS9	6203	pp	--	int.I2D: BioGrid_Yeast
MAEA	10296	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
RAN	5901	ATP6V1D	51382	pp	--	int.I2D: YeastLow
ARL1	400	RPS6	6194	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPB1	1315	pp	--	int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo
RPS6	6194	RPS26	6231	pp	--	int.I2D: YeastLow
RPS6	6194	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS4X	6191	RPS6	6194	pp	--	int.I2D: BioGrid_Yeast
RPS24	6229	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
RPS13	6207	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
ARL1	400	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
COPB1	1315	COPB2	9276	pp	--	int.I2D: BioGrid
COPB1	1315	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association)

Related GO terms (166)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0022627	cytosolic small ribosomal subunit	1.86e-14	2.69e-10	7.168	7	20	39
GO:0019058	viral life cycle	5.23e-13	7.54e-09	5.801	8	23	115
GO:0030126	COPI vesicle coat	1.30e-12	1.87e-08	8.383	5	7	12
GO:0006413	translational initiation	1.51e-12	2.18e-08	5.613	8	21	131
GO:0048205	COPI coating of Golgi vesicle	2.11e-12	3.04e-08	8.268	5	8	13
GO:0019083	viral transcription	4.09e-12	5.90e-08	6.114	7	20	81
GO:0006415	translational termination	6.85e-12	9.88e-08	6.011	7	20	87
GO:0006414	translational elongation	1.11e-11	1.60e-07	5.914	7	20	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	2.46e-11	3.55e-07	5.753	7	20	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4.74e-11	6.83e-07	5.621	7	20	114
GO:0005829	cytosol	6.68e-11	9.64e-07	2.361	16	61	2496
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	8.63e-11	1.24e-06	7.324	5	8	25
GO:0006412	translation	1.41e-10	2.04e-06	4.801	8	23	230
GO:0016032	viral process	1.49e-10	2.15e-06	3.907	10	33	534
GO:0003735	structural constituent of ribosome	1.74e-10	2.52e-06	5.355	7	22	137
GO:0015935	small ribosomal subunit	4.00e-09	5.77e-05	7.559	4	9	17
GO:0016071	mRNA metabolic process	5.29e-09	7.64e-05	4.653	7	25	223
GO:0016070	RNA metabolic process	1.08e-08	1.55e-04	4.505	7	25	247
GO:0010467	gene expression	3.14e-08	4.54e-04	3.430	9	29	669
GO:0044267	cellular protein metabolic process	4.20e-08	6.06e-04	3.757	8	23	474
GO:0016020	membrane	5.72e-08	8.25e-04	2.516	12	41	1681
GO:0044822	poly(A) RNA binding	1.08e-07	1.56e-03	2.924	10	32	1056
GO:0005840	ribosome	6.91e-07	9.96e-03	5.788	4	8	58
GO:0061024	membrane organization	7.39e-07	1.07e-02	4.788	5	12	145
GO:0006891	intra-Golgi vesicle-mediated transport	1.10e-06	1.58e-02	7.144	3	4	17
GO:0006886	intracellular protein transport	1.67e-06	2.41e-02	4.550	5	7	171
GO:0019843	rRNA binding	4.69e-06	6.76e-02	6.476	3	4	27
GO:0033119	negative regulation of RNA splicing	1.47e-05	2.12e-01	8.324	2	2	5
GO:0042274	ribosomal small subunit biogenesis	9.64e-05	1.00e+00	7.061	2	6	12
GO:0070062	extracellular vesicular exosome	1.91e-04	1.00e+00	1.739	10	40	2400
GO:0036464	cytoplasmic ribonucleoprotein granule	3.35e-04	1.00e+00	6.187	2	3	22
GO:0030529	ribonucleoprotein complex	3.42e-04	1.00e+00	4.424	3	7	112
GO:0005844	polysome	3.66e-04	1.00e+00	6.123	2	2	23
GO:0005198	structural molecule activity	8.02e-04	1.00e+00	4.002	3	6	150
GO:0005925	focal adhesion	9.41e-04	1.00e+00	3.130	4	19	366
GO:0033176	proton-transporting V-type ATPase complex	1.25e-03	1.00e+00	9.646	1	1	1
GO:0021691	cerebellar Purkinje cell layer maturation	1.25e-03	1.00e+00	9.646	1	1	1
GO:0022605	oogenesis stage	1.25e-03	1.00e+00	9.646	1	1	1
GO:0002176	male germ cell proliferation	2.49e-03	1.00e+00	8.646	1	1	2
GO:0048822	enucleate erythrocyte development	2.49e-03	1.00e+00	8.646	1	1	2
GO:0003729	mRNA binding	3.57e-03	1.00e+00	4.476	2	2	72
GO:0005850	eukaryotic translation initiation factor 2 complex	3.74e-03	1.00e+00	8.061	1	1	3
GO:0000056	ribosomal small subunit export from nucleus	3.74e-03	1.00e+00	8.061	1	2	3
GO:0009404	toxin metabolic process	3.74e-03	1.00e+00	8.061	1	1	3
GO:0031467	Cul7-RING ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	1	4
GO:0000055	ribosomal large subunit export from nucleus	4.98e-03	1.00e+00	7.646	1	1	4
GO:0006364	rRNA processing	6.01e-03	1.00e+00	4.092	2	7	94
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	6.23e-03	1.00e+00	7.324	1	3	5
GO:0031584	activation of phospholipase D activity	6.23e-03	1.00e+00	7.324	1	1	5
GO:0005826	actomyosin contractile ring	6.23e-03	1.00e+00	7.324	1	1	5
GO:0033033	negative regulation of myeloid cell apoptotic process	6.23e-03	1.00e+00	7.324	1	1	5
GO:0061512	protein localization to cilium	7.47e-03	1.00e+00	7.061	1	1	6
GO:0002309	T cell proliferation involved in immune response	7.47e-03	1.00e+00	7.061	1	1	6
GO:0045182	translation regulator activity	7.47e-03	1.00e+00	7.061	1	2	6
GO:0006924	activation-induced cell death of T cells	7.47e-03	1.00e+00	7.061	1	1	6
GO:0030157	pancreatic juice secretion	8.71e-03	1.00e+00	6.839	1	1	7
GO:0000028	ribosomal small subunit assembly	8.71e-03	1.00e+00	6.839	1	3	7
GO:0034101	erythrocyte homeostasis	8.71e-03	1.00e+00	6.839	1	1	7
GO:0048193	Golgi vesicle transport	8.71e-03	1.00e+00	6.839	1	1	7
GO:0034067	protein localization to Golgi apparatus	8.71e-03	1.00e+00	6.839	1	1	7
GO:0005798	Golgi-associated vesicle	1.24e-02	1.00e+00	6.324	1	1	10
GO:0008286	insulin receptor signaling pathway	1.33e-02	1.00e+00	3.496	2	3	142
GO:0043249	erythrocyte maturation	1.36e-02	1.00e+00	6.187	1	1	11
GO:0035518	histone H2A monoubiquitination	1.36e-02	1.00e+00	6.187	1	1	11
GO:0000082	G1/S transition of mitotic cell cycle	1.46e-02	1.00e+00	3.427	2	9	149
GO:0031929	TOR signaling	1.61e-02	1.00e+00	5.946	1	1	13
GO:0030131	clathrin adaptor complex	1.73e-02	1.00e+00	5.839	1	2	14
GO:0031369	translation initiation factor binding	1.86e-02	1.00e+00	5.739	1	1	15
GO:0048821	erythrocyte development	1.86e-02	1.00e+00	5.739	1	1	15
GO:0019904	protein domain specific binding	2.06e-02	1.00e+00	3.162	2	3	179
GO:0075733	intracellular transport of virus	2.10e-02	1.00e+00	5.559	1	3	17
GO:0006259	DNA metabolic process	2.35e-02	1.00e+00	5.398	1	1	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	2.35e-02	1.00e+00	5.398	1	1	19
GO:0007369	gastrulation	2.35e-02	1.00e+00	5.398	1	1	19
GO:0003924	GTPase activity	2.46e-02	1.00e+00	3.024	2	7	197
GO:0043473	pigmentation	2.47e-02	1.00e+00	5.324	1	1	20
GO:0005737	cytoplasm	2.55e-02	1.00e+00	0.937	9	43	3767
GO:0007052	mitotic spindle organization	2.71e-02	1.00e+00	5.187	1	1	22
GO:0006184	GTP catabolic process	2.87e-02	1.00e+00	2.905	2	7	214
GO:0008135	translation factor activity, nucleic acid binding	2.95e-02	1.00e+00	5.061	1	1	24
GO:0006611	protein export from nucleus	3.08e-02	1.00e+00	5.002	1	1	25
GO:0031519	PcG protein complex	3.08e-02	1.00e+00	5.002	1	1	25
GO:0007067	mitotic nuclear division	3.20e-02	1.00e+00	2.820	2	5	227
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	3.20e-02	1.00e+00	4.946	1	1	26
GO:0007346	regulation of mitotic cell cycle	3.56e-02	1.00e+00	4.788	1	2	29
GO:0019005	SCF ubiquitin ligase complex	3.56e-02	1.00e+00	4.788	1	1	29
GO:0015992	proton transport	3.56e-02	1.00e+00	4.788	1	1	29
GO:0033572	transferrin transport	3.68e-02	1.00e+00	4.739	1	1	30
GO:0001890	placenta development	3.80e-02	1.00e+00	4.692	1	1	31
GO:0007093	mitotic cell cycle checkpoint	3.80e-02	1.00e+00	4.692	1	1	31
GO:0005794	Golgi apparatus	3.83e-02	1.00e+00	1.978	3	9	610
GO:0051701	interaction with host	3.92e-02	1.00e+00	4.646	1	1	32
GO:0033077	T cell differentiation in thymus	4.04e-02	1.00e+00	4.602	1	1	33
GO:0090382	phagosome maturation	4.40e-02	1.00e+00	4.476	1	1	36
GO:0005730	nucleolus	4.58e-02	1.00e+00	1.288	5	24	1641
GO:0032092	positive regulation of protein binding	4.64e-02	1.00e+00	4.398	1	1	38
GO:0050681	androgen receptor binding	4.64e-02	1.00e+00	4.398	1	1	38
GO:0007264	small GTPase mediated signal transduction	4.65e-02	1.00e+00	2.522	2	7	279
GO:0008047	enzyme activator activity	4.76e-02	1.00e+00	4.361	1	1	39
GO:0007286	spermatid development	5.00e-02	1.00e+00	4.289	1	1	41
GO:0042147	retrograde transport, endosome to Golgi	5.00e-02	1.00e+00	4.289	1	1	41
GO:0030521	androgen receptor signaling pathway	5.00e-02	1.00e+00	4.289	1	1	41
GO:0045727	positive regulation of translation	5.35e-02	1.00e+00	4.187	1	1	44
GO:0008344	adult locomotory behavior	5.35e-02	1.00e+00	4.187	1	1	44
GO:0044297	cell body	5.59e-02	1.00e+00	4.123	1	1	46
GO:0005525	GTP binding	5.62e-02	1.00e+00	2.370	2	7	310
GO:0019003	GDP binding	5.71e-02	1.00e+00	4.092	1	2	47
GO:0043231	intracellular membrane-bounded organelle	5.88e-02	1.00e+00	2.333	2	5	318
GO:0007030	Golgi organization	5.95e-02	1.00e+00	4.031	1	2	49
GO:0003743	translation initiation factor activity	5.95e-02	1.00e+00	4.031	1	1	49
GO:0006879	cellular iron ion homeostasis	6.18e-02	1.00e+00	3.974	1	1	51
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	6.77e-02	1.00e+00	3.839	1	1	56
GO:0005643	nuclear pore	6.88e-02	1.00e+00	3.813	1	1	57
GO:0000139	Golgi membrane	7.34e-02	1.00e+00	2.150	2	6	361
GO:0006417	regulation of translation	7.47e-02	1.00e+00	3.692	1	2	62
GO:0008284	positive regulation of cell proliferation	8.10e-02	1.00e+00	2.069	2	7	382
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.39e-02	1.00e+00	3.517	1	8	70
GO:0000785	chromatin	8.73e-02	1.00e+00	3.456	1	1	73
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.85e-02	1.00e+00	3.437	1	8	74
GO:0008584	male gonad development	8.96e-02	1.00e+00	3.417	1	1	75
GO:0005929	cilium	9.19e-02	1.00e+00	3.379	1	1	77
GO:0005179	hormone activity	9.42e-02	1.00e+00	3.342	1	1	79
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	9.42e-02	1.00e+00	3.342	1	8	79
GO:0051301	cell division	9.65e-02	1.00e+00	3.306	1	2	81
GO:0042384	cilium assembly	1.02e-01	1.00e+00	3.220	1	1	86
GO:0042593	glucose homeostasis	1.03e-01	1.00e+00	3.203	1	1	87
GO:0007010	cytoskeleton organization	1.08e-01	1.00e+00	3.138	1	1	91
GO:0042470	melanosome	1.08e-01	1.00e+00	3.138	1	2	91
GO:0016363	nuclear matrix	1.08e-01	1.00e+00	3.138	1	2	91
GO:0001649	osteoblast differentiation	1.09e-01	1.00e+00	3.123	1	3	92
GO:0005802	trans-Golgi network	1.29e-01	1.00e+00	2.865	1	3	110
GO:0005819	spindle	1.31e-01	1.00e+00	2.839	1	2	112
GO:0007219	Notch signaling pathway	1.40e-01	1.00e+00	2.739	1	3	120
GO:0000086	G2/M transition of mitotic cell cycle	1.57e-01	1.00e+00	2.559	1	5	136
GO:0005515	protein binding	1.71e-01	1.00e+00	0.412	10	62	6024
GO:0007049	cell cycle	1.96e-01	1.00e+00	2.203	1	2	174
GO:0001701	in utero embryonic development	2.23e-01	1.00e+00	1.995	1	2	201
GO:0005765	lysosomal membrane	2.25e-01	1.00e+00	1.981	1	2	203
GO:0030425	dendrite	2.51e-01	1.00e+00	1.801	1	2	230
GO:0003713	transcription coactivator activity	2.58e-01	1.00e+00	1.757	1	4	237
GO:0004842	ubiquitin-protein transferase activity	2.75e-01	1.00e+00	1.652	1	2	255
GO:0000166	nucleotide binding	2.78e-01	1.00e+00	1.629	1	2	259
GO:0003779	actin binding	2.85e-01	1.00e+00	1.591	1	3	266
GO:0043065	positive regulation of apoptotic process	2.87e-01	1.00e+00	1.580	1	6	268
GO:0005856	cytoskeleton	3.07e-01	1.00e+00	1.461	1	4	291
GO:0016567	protein ubiquitination	3.11e-01	1.00e+00	1.442	1	3	295
GO:0007275	multicellular organismal development	3.29e-01	1.00e+00	1.342	1	1	316
GO:0019901	protein kinase binding	3.30e-01	1.00e+00	1.338	1	6	317
GO:0003682	chromatin binding	3.38e-01	1.00e+00	1.293	1	3	327
GO:0005813	centrosome	3.38e-01	1.00e+00	1.297	1	5	326
GO:0003723	RNA binding	3.51e-01	1.00e+00	1.228	1	8	342
GO:0007155	cell adhesion	3.73e-01	1.00e+00	1.119	1	3	369
GO:0000278	mitotic cell cycle	3.90e-01	1.00e+00	1.035	1	11	391
GO:0005654	nucleoplasm	3.96e-01	1.00e+00	0.567	2	15	1082
GO:0043066	negative regulation of apoptotic process	4.16e-01	1.00e+00	0.918	1	13	424
GO:0055085	transmembrane transport	4.24e-01	1.00e+00	0.881	1	3	435
GO:0045893	positive regulation of transcription, DNA-templated	4.55e-01	1.00e+00	0.745	1	5	478
GO:0048471	perinuclear region of cytoplasm	4.72e-01	1.00e+00	0.675	1	7	502
GO:0046872	metal ion binding	4.95e-01	1.00e+00	0.294	2	10	1307
GO:0005783	endoplasmic reticulum	5.07e-01	1.00e+00	0.527	1	3	556
GO:0005634	nucleus	5.26e-01	1.00e+00	0.077	6	43	4559
GO:0005887	integral component of plasma membrane	6.82e-01	1.00e+00	-0.148	1	2	888
GO:0007165	signal transduction	6.90e-01	1.00e+00	-0.179	1	3	907
GO:0005615	extracellular space	7.10e-01	1.00e+00	-0.256	1	2	957
GO:0044281	small molecule metabolic process	7.94e-01	1.00e+00	-0.596	1	15	1211
GO:0005886	plasma membrane	9.71e-01	1.00e+00	-1.688	1	20	2582

Tai-Luciferase

int-snw-10296

Statistics

Genes (18)

Interactions (39)

Related GO terms (166)