int-snw-51741

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
tai-screen-luciferase 6.174 2.67e-126 1.32e-06 4.54e-03
tai-screen-luciferase-int-snw-51741 subnetwork

Genes (24)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree List-Gonzales GI Tai-Hits
MAPK8 5599 2-4.4036.468153--
COPA 1314 32-9.3959.063170YesYes
RNF20 56254 1-4.5646.17418--
HSF1 3297 1-4.1796.17471-Yes
RPS24 6229 21-7.0348.389217Yes-
TCERG1 10915 1-3.8086.17458Yes-
RPS9 6203 18-7.1277.555140Yes-
SRC 6714 1-2.8066.174419Yes-
COPB2 9276 32-13.1689.06341YesYes
CKAP5 9793 1-7.2146.17441YesYes
RPS4X 6191 18-6.7477.555263Yes-
COPZ1 22818 32-8.3019.06313YesYes
RPS15A 6210 8-5.4137.555177Yes-
CDC42 998 11-6.9608.389265YesYes
RPS27A 6233 15-5.6318.389342Yes-
[ WWOX ] 51741 1-2.4486.17438--
RPS11 6205 17-6.5887.555175Yes-
RPS6 6194 17-5.6038.046208Yes-
UBB 7314 3-4.2896.428147--
NFKBIB 4793 1-3.9786.17478--
RPS26 6231 17-7.4788.04660Yes-
ARCN1 372 32-8.2329.063118YesYes
COPB1 1315 22-6.2219.063118YesYes
RPS13 6207 17-6.5897.555174Yes-

Interactions (44)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
CDC42 998 RPS27A 6233 pp -- int.I2D: SOURAV_MAPK_HIGH
RPS4X 6191 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
SRC 6714 WWOX 51741 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
RPS27A 6233 UBB 7314 pp -- int.I2D: BIND
COPA 1314 COPB1 1315 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
RPS4X 6191 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
NFKBIB 4793 UBB 7314 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
RPS9 6203 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
HSF1 3297 MAPK8 5599 pp -- int.I2D: HPRD, INNATEDB;
int.HPRD: in vitro, in vivo
TCERG1 10915 WWOX 51741 pp -- int.I2D: BioGrid, MINT, Pawson1;
int.Mint: MI:0915(physical association)
UBB 7314 RNF20 56254 pp -- int.Intact: MI:0220(ubiquitination reaction);
int.I2D: IntAct
RPS13 6207 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
CDC42 998 UBB 7314 pp -- int.I2D: SOURAV_MAPK_HIGH
RPS4X 6191 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS27A 6233 pp -- int.I2D: YeastLow
UBB 7314 WWOX 51741 pp -- int.I2D: BCI, HPRD;
int.HPRD: in vivo
RPS11 6205 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPB1 1315 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS;
int.HPRD: in vivo
RPS15A 6210 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
RPS6 6194 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
MAPK8 5599 WWOX 51741 pp -- int.I2D: MINT, HPRD;
int.Mint: MI:0915(physical association);
int.HPRD: in vivo, yeast 2-hybrid
SRC 6714 CKAP5 9793 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
COPB1 1315 COPB2 9276 pp -- int.I2D: BioGrid
RPS4X 6191 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast, YeastMedium, INTEROLOG
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium
COPB1 1315 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium;
int.DIP: MI:0915(physical association)

Related GO terms (417)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0022627cytosolic small ribosomal subunit3.63e-185.23e-147.11692039
GO:0019058viral life cycle1.24e-151.80e-115.7081023115
GO:0019083viral transcription4.29e-156.19e-116.06192081
GO:0006415translational termination8.40e-151.21e-105.95892087
GO:0006414translational elongation1.57e-142.26e-105.86292093
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.43e-146.38e-105.701920104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.03e-131.49e-095.568920114
GO:0005829cytosol1.11e-131.60e-092.33821612496
GO:0006413translational initiation3.71e-135.35e-095.368921131
GO:0003735structural constituent of ribosome5.59e-138.07e-095.303922137
GO:0016071mRNA metabolic process1.04e-121.49e-084.7521025223
GO:0016070RNA metabolic process2.87e-124.15e-084.6051025247
GO:0030126COPI vesicle coat6.43e-129.27e-087.9685712
GO:0048205COPI coating of Golgi vesicle1.04e-111.50e-077.8535813
GO:0016032viral process1.06e-111.53e-073.7551233534
GO:0015935small ribosomal subunit4.99e-117.20e-077.4665917
GO:0061024membrane organization5.52e-117.96e-075.051812145
GO:0006412translation6.06e-118.74e-074.556923230
GO:0006890retrograde vesicle-mediated transport, Golgi to ER4.25e-106.13e-066.9095825
GO:0044267cellular protein metabolic process3.49e-085.04e-043.512923474
GO:0010467gene expression4.68e-086.76e-043.1671029669
GO:0016020membrane5.10e-087.36e-042.32314411681
GO:0044822poly(A) RNA binding3.16e-074.56e-032.64611321056
GO:0005840ribosome2.36e-063.40e-025.3734858
GO:0006891intra-Golgi vesicle-mediated transport2.71e-063.91e-026.7293417
GO:0034166toll-like receptor 10 signaling pathway3.73e-065.38e-025.2094465
GO:0034146toll-like receptor 5 signaling pathway3.73e-065.38e-025.2094465
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway5.32e-067.67e-025.0814471
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway5.32e-067.67e-025.0814471
GO:0034162toll-like receptor 9 signaling pathway5.62e-068.11e-025.0614472
GO:0034134toll-like receptor 2 signaling pathway5.94e-068.57e-025.0414473
GO:0036464cytoplasmic ribonucleoprotein granule6.11e-068.81e-026.3573322
GO:0035666TRIF-dependent toll-like receptor signaling pathway6.98e-061.01e-014.9834476
GO:0002756MyD88-independent toll-like receptor signaling pathway7.75e-061.12e-014.9464478
GO:0006886intracellular protein transport7.82e-061.13e-014.13557171
GO:0034138toll-like receptor 3 signaling pathway8.15e-061.18e-014.9274479
GO:0002755MyD88-dependent toll-like receptor signaling pathway8.57e-061.24e-014.9094480
GO:0019843rRNA binding1.15e-051.66e-016.0613427
GO:0034142toll-like receptor 4 signaling pathway1.77e-052.55e-014.6464496
GO:0033119negative regulation of RNA splicing2.65e-053.82e-017.909225
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway2.79e-054.02e-015.6463336
GO:0002224toll-like receptor signaling pathway2.92e-054.21e-014.46344109
GO:0043065positive regulation of apoptotic process6.79e-059.79e-013.48756268
GO:0007254JNK cascade7.09e-051.00e+005.2013349
GO:0051403stress-activated MAPK cascade9.50e-051.00e+005.0613354
GO:0032481positive regulation of type I interferon production1.37e-041.00e+004.8853361
GO:0042274ribosomal small subunit biogenesis1.73e-041.00e+006.6462612
GO:0019082viral protein processing1.73e-041.00e+006.6462212
GO:0032479regulation of type I interferon production2.05e-041.00e+006.5312213
GO:0007173epidermal growth factor receptor signaling pathway2.47e-041.00e+003.66944189
GO:0005925focal adhesion2.92e-041.00e+003.037519366
GO:0045087innate immune response3.45e-041.00e+002.59768596
GO:0075733intracellular transport of virus3.55e-041.00e+006.1442317
GO:0019068virion assembly3.55e-041.00e+006.1442217
GO:0071456cellular response to hypoxia4.61e-041.00e+004.2933392
GO:0043066negative regulation of apoptotic process5.74e-041.00e+002.825513424
GO:0007220Notch receptor processing6.01e-041.00e+005.7722222
GO:0005844polysome6.57e-041.00e+005.7082223
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway7.78e-041.00e+005.5872225
GO:0070062extracellular vesicular exosome7.93e-041.00e+001.46211402400
GO:0030529ribonucleoprotein complex8.19e-041.00e+004.00937112
GO:0097190apoptotic signaling pathway8.41e-041.00e+003.99633113
GO:0005978glycogen biosynthetic process8.42e-041.00e+005.5312226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia8.42e-041.00e+005.5312226
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity8.42e-041.00e+005.5312226
GO:0000209protein polyubiquitination9.07e-041.00e+003.95837116
GO:0048011neurotrophin TRK receptor signaling pathway9.37e-041.00e+003.16044269
GO:0051092positive regulation of NF-kappaB transcription factor activity1.10e-031.00e+003.86233124
GO:0007179transforming growth factor beta receptor signaling pathway1.21e-031.00e+003.81633128
GO:0032480negative regulation of type I interferon production1.28e-031.00e+005.2312232
GO:0000086G2/M transition of mitotic cell cycle1.44e-031.00e+003.72935136
GO:0034332adherens junction organization1.62e-031.00e+005.0612236
GO:2001286regulation of caveolin-mediated endocytosis1.66e-031.00e+009.231111
GO:0022605oogenesis stage1.66e-031.00e+009.231111
GO:0071393cellular response to progesterone stimulus1.66e-031.00e+009.231111
GO:0021691cerebellar Purkinje cell layer maturation1.66e-031.00e+009.231111
GO:0000082G1/S transition of mitotic cell cycle1.87e-031.00e+003.59739149
GO:0005198structural molecule activity1.90e-031.00e+003.58736150
GO:0007249I-kappaB kinase/NF-kappaB signaling2.09e-031.00e+004.8742341
GO:0008543fibroblast growth factor receptor signaling pathway2.13e-031.00e+003.53133156
GO:0043005neuron projection2.17e-031.00e+003.52136157
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway2.30e-031.00e+004.8052243
GO:0038095Fc-epsilon receptor signaling pathway2.62e-031.00e+003.42433168
GO:0071338positive regulation of hair follicle cell proliferation3.33e-031.00e+008.231112
GO:0060661submandibular salivary gland formation3.33e-031.00e+008.231112
GO:1902255positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator3.33e-031.00e+008.231112
GO:0010632regulation of epithelial cell migration3.33e-031.00e+008.231112
GO:0090135actin filament branching3.33e-031.00e+008.231112
GO:0030666endocytic vesicle membrane3.47e-031.00e+004.5032253
GO:0016197endosomal transport4.01e-031.00e+004.3982357
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway4.57e-031.00e+004.3002261
GO:0051683establishment of Golgi localization4.98e-031.00e+007.646123
GO:0034191apolipoprotein A-I receptor binding4.98e-031.00e+007.646113
GO:0010641positive regulation of platelet-derived growth factor receptor signaling pathway4.98e-031.00e+007.646113
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding4.98e-031.00e+007.646113
GO:0003161cardiac conduction system development4.98e-031.00e+007.646113
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity4.98e-031.00e+007.646113
GO:0033146regulation of intracellular estrogen receptor signaling pathway4.98e-031.00e+007.646113
GO:0090045positive regulation of deacetylase activity4.98e-031.00e+007.646113
GO:0035033histone deacetylase regulator activity4.98e-031.00e+007.646113
GO:2000017positive regulation of determination of dorsal identity4.98e-031.00e+007.646113
GO:0004705JUN kinase activity4.98e-031.00e+007.646113
GO:0033625positive regulation of integrin activation4.98e-031.00e+007.646113
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.02e-031.00e+004.2312664
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.18e-031.00e+004.2092665
GO:0031295T cell costimulation5.18e-031.00e+004.2092365
GO:0018105peptidyl-serine phosphorylation5.82e-031.00e+004.1232469
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.98e-031.00e+004.1022870
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.32e-031.00e+004.0612672
GO:0003729mRNA binding6.32e-031.00e+004.0612272
GO:0007258JUN phosphorylation6.64e-031.00e+007.231114
GO:0048664neuron fate determination6.64e-031.00e+007.231114
GO:0033503HULC complex6.64e-031.00e+007.231114
GO:0032463negative regulation of protein homooligomerization6.64e-031.00e+007.231114
GO:0051902negative regulation of mitochondrial depolarization6.64e-031.00e+007.231114
GO:0045056transcytosis6.64e-031.00e+007.231114
GO:0031062positive regulation of histone methylation6.64e-031.00e+007.231114
GO:0031063regulation of histone deacetylation6.64e-031.00e+007.231114
GO:0060684epithelial-mesenchymal cell signaling6.64e-031.00e+007.231114
GO:0070851growth factor receptor binding6.64e-031.00e+007.231114
GO:0051835positive regulation of synapse structural plasticity6.64e-031.00e+007.231114
GO:0090231regulation of spindle checkpoint6.64e-031.00e+007.231114
GO:0072384organelle transport along microtubule6.64e-031.00e+007.231124
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.66e-031.00e+004.0222274
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.66e-031.00e+004.0222874
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.84e-031.00e+004.0022675
GO:0003713transcription coactivator activity6.87e-031.00e+002.92734237
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process7.56e-031.00e+003.9272879
GO:0071222cellular response to lipopolysaccharide7.94e-031.00e+003.8912381
GO:2000641regulation of early endosome to late endosome transport8.29e-031.00e+006.909115
GO:0036336dendritic cell migration8.29e-031.00e+006.909115
GO:0035088establishment or maintenance of apical/basal cell polarity8.29e-031.00e+006.909115
GO:0051385response to mineralocorticoid8.29e-031.00e+006.909115
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)8.29e-031.00e+006.909135
GO:0097300programmed necrotic cell death8.29e-031.00e+006.909115
GO:0031256leading edge membrane8.29e-031.00e+006.909115
GO:0071803positive regulation of podosome assembly8.29e-031.00e+006.909115
GO:0050852T cell receptor signaling pathway8.71e-031.00e+003.8222285
GO:0000187activation of MAPK activity9.72e-031.00e+003.7392290
GO:0007097nuclear migration9.94e-031.00e+006.646116
GO:0050847progesterone receptor signaling pathway9.94e-031.00e+006.646116
GO:0007143female meiotic division9.94e-031.00e+006.646116
GO:0003334keratinocyte development9.94e-031.00e+006.646116
GO:0010447response to acidic pH9.94e-031.00e+006.646116
GO:0002309T cell proliferation involved in immune response9.94e-031.00e+006.646116
GO:0045182translation regulator activity9.94e-031.00e+006.646126
GO:0060789hair follicle placode formation9.94e-031.00e+006.646116
GO:0048554positive regulation of metalloenzyme activity9.94e-031.00e+006.646116
GO:0006924activation-induced cell death of T cells9.94e-031.00e+006.646116
GO:0043497regulation of protein heterodimerization activity9.94e-031.00e+006.646116
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.01e-021.00e+003.7082692
GO:0001649osteoblast differentiation1.01e-021.00e+003.7082392
GO:0005737cytoplasm1.03e-021.00e+000.93712433767
GO:0006364rRNA processing1.06e-021.00e+003.6772794
GO:0050658RNA transport1.16e-021.00e+006.424117
GO:0043114regulation of vascular permeability1.16e-021.00e+006.424117
GO:0051988regulation of attachment of spindle microtubules to kinetochore1.16e-021.00e+006.424117
GO:0000028ribosomal small subunit assembly1.16e-021.00e+006.424137
GO:0034101erythrocyte homeostasis1.16e-021.00e+006.424117
GO:0010907positive regulation of glucose metabolic process1.16e-021.00e+006.424117
GO:0051489regulation of filopodium assembly1.16e-021.00e+006.424117
GO:0030157pancreatic juice secretion1.16e-021.00e+006.424117
GO:0060136embryonic process involved in female pregnancy1.16e-021.00e+006.424117
GO:0000930gamma-tubulin complex1.16e-021.00e+006.424117
GO:0005515protein binding1.21e-021.00e+000.67516626024
GO:0045124regulation of bone resorption1.32e-021.00e+006.231118
GO:0033523histone H2B ubiquitination1.32e-021.00e+006.231118
GO:0007172signal complex assembly1.32e-021.00e+006.231118
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.37e-021.00e+002.07647570
GO:0005730nucleolus1.47e-021.00e+001.3587241641
GO:0022407regulation of cell-cell adhesion1.49e-021.00e+006.061119
GO:0090136epithelial cell-cell adhesion1.49e-021.00e+006.061119
GO:0047497mitochondrion transport along microtubule1.49e-021.00e+006.061119
GO:0071732cellular response to nitric oxide1.49e-021.00e+006.061119
GO:0046628positive regulation of insulin receptor signaling pathway1.49e-021.00e+006.061119
GO:0006006glucose metabolic process1.63e-021.00e+003.34823118
GO:0031274positive regulation of pseudopodium assembly1.65e-021.00e+005.9091210
GO:0051895negative regulation of focal adhesion assembly1.65e-021.00e+005.9091110
GO:0005798Golgi-associated vesicle1.65e-021.00e+005.9091110
GO:0060047heart contraction1.65e-021.00e+005.9091110
GO:0007219Notch signaling pathway1.68e-021.00e+003.32423120
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity1.82e-021.00e+005.7721111
GO:0007051spindle organization1.82e-021.00e+005.7721111
GO:0060065uterus development1.82e-021.00e+005.7721111
GO:0045120pronucleus1.82e-021.00e+005.7721111
GO:0010390histone monoubiquitination1.82e-021.00e+005.7721111
GO:2000573positive regulation of DNA biosynthetic process1.82e-021.00e+005.7721111
GO:0009615response to virus1.84e-021.00e+003.25422126
GO:0061136regulation of proteasomal protein catabolic process1.98e-021.00e+005.6461112
GO:0071398cellular response to fatty acid1.98e-021.00e+005.6461212
GO:0043149stress fiber assembly1.98e-021.00e+005.6461112
GO:1901214regulation of neuron death1.98e-021.00e+005.6461112
GO:0031929TOR signaling2.14e-021.00e+005.5311113
GO:0048477oogenesis2.14e-021.00e+005.5311113
GO:0050662coenzyme binding2.14e-021.00e+005.5311113
GO:0060444branching involved in mammary gland duct morphogenesis2.14e-021.00e+005.5311113
GO:0035371microtubule plus-end2.31e-021.00e+005.4241114
GO:0031333negative regulation of protein complex assembly2.31e-021.00e+005.4241114
GO:0031996thioesterase binding2.31e-021.00e+005.4241114
GO:0030131clathrin adaptor complex2.31e-021.00e+005.4241214
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2.40e-021.00e+003.05123145
GO:0010628positive regulation of gene expression2.43e-021.00e+003.04124146
GO:0048821erythrocyte development2.47e-021.00e+005.3241115
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand2.47e-021.00e+005.3241115
GO:0008284positive regulation of cell proliferation2.47e-021.00e+002.23937382
GO:0030225macrophage differentiation2.47e-021.00e+005.3241115
GO:0031369translation initiation factor binding2.47e-021.00e+005.3241115
GO:0051233spindle midzone2.47e-021.00e+005.3241215
GO:0034220ion transmembrane transport2.52e-021.00e+003.01222149
GO:0042981regulation of apoptotic process2.55e-021.00e+003.00227150
GO:0010008endosome membrane2.58e-021.00e+002.99325151
GO:0000278mitotic cell cycle2.62e-021.00e+002.205311391
GO:0042176regulation of protein catabolic process2.63e-021.00e+005.2311316
GO:0014911positive regulation of smooth muscle cell migration2.63e-021.00e+005.2311116
GO:2000811negative regulation of anoikis2.63e-021.00e+005.2311116
GO:0048037cofactor binding2.63e-021.00e+005.2311116
GO:0030742GTP-dependent protein binding2.79e-021.00e+005.1441117
GO:0090316positive regulation of intracellular protein transport2.79e-021.00e+005.1441117
GO:0070064proline-rich region binding2.95e-021.00e+005.0611118
GO:0007088regulation of mitosis2.95e-021.00e+005.0611118
GO:0031954positive regulation of protein autophosphorylation2.95e-021.00e+005.0611118
GO:0046847filopodium assembly3.12e-021.00e+004.9831119
GO:0007369gastrulation3.12e-021.00e+004.9831119
GO:0045453bone resorption3.12e-021.00e+004.9831119
GO:0031667response to nutrient levels3.12e-021.00e+004.9831119
GO:0032148activation of protein kinase B activity3.28e-021.00e+004.9091120
GO:0051881regulation of mitochondrial membrane potential3.28e-021.00e+004.9091120
GO:0051090regulation of sequence-specific DNA binding transcription factor activity3.28e-021.00e+004.9091120
GO:0043473pigmentation3.28e-021.00e+004.9091120
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator3.28e-021.00e+004.9091120
GO:0043393regulation of protein binding3.28e-021.00e+004.9091220
GO:0001106RNA polymerase II transcription corepressor activity3.44e-021.00e+004.8391121
GO:0031435mitogen-activated protein kinase kinase kinase binding3.44e-021.00e+004.8391121
GO:2001243negative regulation of intrinsic apoptotic signaling pathway3.44e-021.00e+004.8391121
GO:0031424keratinization3.60e-021.00e+004.7721122
GO:0051297centrosome organization3.60e-021.00e+004.7721222
GO:0050715positive regulation of cytokine secretion3.60e-021.00e+004.7721122
GO:0045787positive regulation of cell cycle3.60e-021.00e+004.7721222
GO:0046686response to cadmium ion3.60e-021.00e+004.7721122
GO:0006367transcription initiation from RNA polymerase II promoter3.72e-021.00e+002.70823184
GO:0001892embryonic placenta development3.76e-021.00e+004.7081123
GO:1900026positive regulation of substrate adhesion-dependent cell spreading3.76e-021.00e+004.7081123
GO:0002040sprouting angiogenesis3.76e-021.00e+004.7081123
GO:0051017actin filament bundle assembly3.76e-021.00e+004.7081123
GO:0007163establishment or maintenance of cell polarity3.92e-021.00e+004.6461124
GO:0051602response to electrical stimulus3.92e-021.00e+004.6461124
GO:0048705skeletal system morphogenesis3.92e-021.00e+004.6461124
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.94e-021.00e+001.60746789
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway4.24e-021.00e+004.5311126
GO:0045859regulation of protein kinase activity4.24e-021.00e+004.5311126
GO:0051149positive regulation of muscle cell differentiation4.40e-021.00e+004.4761127
GO:0032467positive regulation of cytokinesis4.40e-021.00e+004.4761127
GO:0032720negative regulation of tumor necrosis factor production4.40e-021.00e+004.4761127
GO:0001103RNA polymerase II repressing transcription factor binding4.40e-021.00e+004.4761127
GO:0030331estrogen receptor binding4.40e-021.00e+004.4761127
GO:2001238positive regulation of extrinsic apoptotic signaling pathway4.40e-021.00e+004.4761127
GO:0031069hair follicle morphogenesis4.40e-021.00e+004.4761127
GO:0034605cellular response to heat4.56e-021.00e+004.4241128
GO:0072686mitotic spindle4.72e-021.00e+004.3731129
GO:0070555response to interleukin-14.88e-021.00e+004.3241130
GO:0042169SH2 domain binding4.88e-021.00e+004.3241130
GO:0031647regulation of protein stability4.88e-021.00e+004.3241130
GO:0040018positive regulation of multicellular organism growth4.88e-021.00e+004.3241130
GO:0046875ephrin receptor binding4.88e-021.00e+004.3241130
GO:0048812neuron projection morphogenesis5.04e-021.00e+004.2771231
GO:0001890placenta development5.04e-021.00e+004.2771131
GO:0007093mitotic cell cycle checkpoint5.04e-021.00e+004.2771131
GO:0019221cytokine-mediated signaling pathway5.17e-021.00e+002.44322221
GO:0032091negative regulation of protein binding5.20e-021.00e+004.2311132
GO:0005158insulin receptor binding5.20e-021.00e+004.2311132
GO:0051219phosphoprotein binding5.20e-021.00e+004.2311132
GO:0016301kinase activity5.35e-021.00e+004.1871233
GO:0033077T cell differentiation in thymus5.35e-021.00e+004.1871133
GO:0007067mitotic nuclear division5.43e-021.00e+002.40525227
GO:0042692muscle cell differentiation5.51e-021.00e+004.1441134
GO:2001237negative regulation of extrinsic apoptotic signaling pathway5.67e-021.00e+004.1021135
GO:0030178negative regulation of Wnt signaling pathway5.67e-021.00e+004.1021135
GO:0045740positive regulation of DNA replication5.83e-021.00e+004.0611136
GO:0071560cellular response to transforming growth factor beta stimulus5.83e-021.00e+004.0611136
GO:0008202steroid metabolic process5.98e-021.00e+004.0221137
GO:0018107peptidyl-threonine phosphorylation5.98e-021.00e+004.0221137
GO:0032880regulation of protein localization5.98e-021.00e+004.0221137
GO:0005902microvillus6.14e-021.00e+003.9831138
GO:0097191extrinsic apoptotic signaling pathway6.14e-021.00e+003.9831238
GO:0043025neuronal cell body6.21e-021.00e+002.29424245
GO:0042542response to hydrogen peroxide6.30e-021.00e+003.9461139
GO:0006915apoptotic process6.30e-021.00e+001.70039555
GO:0045785positive regulation of cell adhesion6.45e-021.00e+003.9091140
GO:0005975carbohydrate metabolic process6.57e-021.00e+002.24823253
GO:0070301cellular response to hydrogen peroxide6.61e-021.00e+003.8741241
GO:0004715non-membrane spanning protein tyrosine kinase activity6.76e-021.00e+003.8391142
GO:0005080protein kinase C binding6.92e-021.00e+003.8051143
GO:0006281DNA repair6.94e-021.00e+002.20324261
GO:0021762substantia nigra development7.08e-021.00e+003.7721144
GO:0034613cellular protein localization7.08e-021.00e+003.7721244
GO:0045727positive regulation of translation7.08e-021.00e+003.7721144
GO:0008344adult locomotory behavior7.08e-021.00e+003.7721144
GO:0009411response to UV7.08e-021.00e+003.7721144
GO:0006950response to stress7.39e-021.00e+003.7081146
GO:0044297cell body7.39e-021.00e+003.7081146
GO:0043525positive regulation of neuron apoptotic process7.39e-021.00e+003.7081246
GO:0043406positive regulation of MAP kinase activity7.39e-021.00e+003.7081246
GO:0006952defense response7.54e-021.00e+003.6771147
GO:0090263positive regulation of canonical Wnt signaling pathway7.69e-021.00e+003.6461248
GO:0005070SH3/SH2 adaptor activity7.69e-021.00e+003.6461148
GO:0019899enzyme binding7.69e-021.00e+002.11722277
GO:0007030Golgi organization7.85e-021.00e+003.6161249
GO:0030900forebrain development7.85e-021.00e+003.6161149
GO:0005794Golgi apparatus7.89e-021.00e+001.56339610
GO:0009612response to mechanical stimulus8.00e-021.00e+003.5871150
GO:0030175filopodium8.00e-021.00e+003.5871250
GO:0005739mitochondrion8.01e-021.00e+001.26848998
GO:0043234protein complex8.57e-021.00e+002.02726295
GO:0097193intrinsic apoptotic signaling pathway8.77e-021.00e+003.4501155
GO:0002039p53 binding8.77e-021.00e+003.4501155
GO:0046330positive regulation of JNK cascade8.77e-021.00e+003.4501155
GO:0016491oxidoreductase activity8.77e-021.00e+003.4501155
GO:0005793endoplasmic reticulum-Golgi intermediate compartment8.92e-021.00e+003.4241156
GO:0033138positive regulation of peptidyl-serine phosphorylation9.38e-021.00e+003.3481159
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription9.38e-021.00e+003.3481159
GO:0019901protein kinase binding9.69e-021.00e+001.92326317
GO:0043231intracellular membrane-bounded organelle9.74e-021.00e+001.91825318
GO:0007411axon guidance9.79e-021.00e+001.91423319
GO:0005901caveola9.83e-021.00e+003.2771162
GO:0030141secretory granule9.83e-021.00e+003.2771162
GO:0006417regulation of translation9.83e-021.00e+003.2771262
GO:0000151ubiquitin ligase complex9.98e-021.00e+003.2541163
GO:0032869cellular response to insulin stimulus9.98e-021.00e+003.2541263
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process9.98e-021.00e+003.2541263
GO:0001503ossification1.01e-011.00e+003.2311164
GO:0003682chromatin binding1.02e-011.00e+001.87823327
GO:0005634nucleus1.02e-011.00e+000.53611434559
GO:0071260cellular response to mechanical stimulus1.03e-011.00e+003.2091265
GO:0035264multicellular organism growth1.06e-011.00e+003.1651167
GO:0042393histone binding1.09e-011.00e+003.1231169
GO:0051897positive regulation of protein kinase B signaling1.10e-011.00e+003.1021270
GO:0042826histone deacetylase binding1.13e-011.00e+003.0611172
GO:0044325ion channel binding1.18e-011.00e+003.0021375
GO:0060070canonical Wnt signaling pathway1.18e-011.00e+003.0021175
GO:0007265Ras protein signal transduction1.18e-011.00e+003.0021175
GO:0000139Golgi membrane1.20e-011.00e+001.73526361
GO:0010629negative regulation of gene expression1.21e-011.00e+002.9641277
GO:0030336negative regulation of cell migration1.22e-011.00e+002.9461178
GO:0007229integrin-mediated signaling pathway1.22e-011.00e+002.9461378
GO:0005179hormone activity1.24e-011.00e+002.9271179
GO:0045177apical part of cell1.27e-011.00e+002.8911181
GO:0004713protein tyrosine kinase activity1.28e-011.00e+002.8741182
GO:0016337single organismal cell-cell adhesion1.31e-011.00e+002.8391184
GO:0042593glucose homeostasis1.35e-011.00e+002.7881187
GO:0000922spindle pole1.35e-011.00e+002.7881387
GO:0020037heme binding1.44e-011.00e+002.6921193
GO:0005770late endosome1.44e-011.00e+002.6921193
GO:0005178integrin binding1.48e-011.00e+002.6461296
GO:0014069postsynaptic density1.61e-011.00e+002.51713105
GO:0070374positive regulation of ERK1 and ERK2 cascade1.62e-011.00e+002.50311106
GO:0055085transmembrane transport1.63e-011.00e+001.46623435
GO:0030496midbody1.65e-011.00e+002.47612108
GO:0005815microtubule organizing center1.67e-011.00e+002.46313109
GO:0050900leukocyte migration1.68e-011.00e+002.45011110
GO:0015630microtubule cytoskeleton1.68e-011.00e+002.45013110
GO:0007596blood coagulation1.74e-011.00e+001.40123455
GO:0051056regulation of small GTPase mediated signal transduction1.75e-011.00e+002.38614115
GO:0046983protein dimerization activity1.79e-011.00e+002.34811118
GO:0032496response to lipopolysaccharide1.83e-011.00e+002.31211121
GO:0030036actin cytoskeleton organization1.86e-011.00e+002.28912123
GO:0045893positive regulation of transcription, DNA-templated1.88e-011.00e+001.33025478
GO:0006511ubiquitin-dependent protein catabolic process1.90e-011.00e+002.25412126
GO:0018108peptidyl-tyrosine phosphorylation1.98e-011.00e+002.18711132
GO:0005911cell-cell junction2.04e-011.00e+002.14412136
GO:0016055Wnt signaling pathway2.06e-011.00e+002.12311138
GO:0008286insulin receptor signaling pathway2.12e-011.00e+002.08113142
GO:0006351transcription, DNA-templated2.15e-011.00e+000.733461446
GO:0046777protein autophosphorylation2.32e-011.00e+001.92711158
GO:0008022protein C-terminus binding2.36e-011.00e+001.90013161
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.41e-011.00e+001.86511165
GO:0005886plasma membrane2.50e-011.00e+000.4826202582
GO:0005764lysosome2.50e-011.00e+001.80511172
GO:0007049cell cycle2.53e-011.00e+001.78812174
GO:0004672protein kinase activity2.57e-011.00e+001.76414177
GO:0031625ubiquitin protein ligase binding2.58e-011.00e+001.75512178
GO:0005654nucleoplasm2.67e-011.00e+000.7373151082
GO:0003924GTPase activity2.81e-011.00e+001.60917197
GO:0030168platelet activation2.91e-011.00e+001.55212205
GO:0004871signal transducer activity2.95e-011.00e+001.53112208
GO:0006184GTP catabolic process3.02e-011.00e+001.49017214
GO:0016874ligase activity3.02e-011.00e+001.49011214
GO:0030425dendrite3.20e-011.00e+001.38612230
GO:0004842ubiquitin-protein transferase activity3.48e-011.00e+001.23712255
GO:0000166nucleotide binding3.53e-011.00e+001.21412259
GO:0005102receptor binding3.54e-011.00e+001.20911260
GO:0007283spermatogenesis3.56e-011.00e+001.19811262
GO:0005743mitochondrial inner membrane3.72e-011.00e+001.11712277
GO:0007264small GTPase mediated signal transduction3.74e-011.00e+001.10717279
GO:0042493response to drug3.80e-011.00e+001.08112284
GO:0035556intracellular signal transduction3.99e-011.00e+000.98814303
GO:0004674protein serine/threonine kinase activity4.05e-011.00e+000.96415308
GO:0005525GTP binding4.07e-011.00e+000.95517310
GO:0007275multicellular organismal development4.13e-011.00e+000.92711316
GO:0005813centrosome4.23e-011.00e+000.88215326
GO:0008283cell proliferation4.25e-011.00e+000.87414328
GO:0003723RNA binding4.38e-011.00e+000.81318342
GO:0008285negative regulation of cell proliferation4.49e-011.00e+000.76811353
GO:0007165signal transduction4.51e-011.00e+000.40623907
GO:0045892negative regulation of transcription, DNA-templated5.02e-011.00e+000.54111413
GO:0006366transcription from RNA polymerase II promoter5.07e-011.00e+000.52012419
GO:0055114oxidation-reduction process5.08e-011.00e+000.51712420
GO:0006468protein phosphorylation5.41e-011.00e+000.38616460
GO:0042802identical protein binding5.60e-011.00e+000.31213484
GO:0048471perinuclear region of cytoplasm5.73e-011.00e+000.26017502
GO:0044281small molecule metabolic process6.10e-011.00e+00-0.0112151211
GO:0005783endoplasmic reticulum6.11e-011.00e+000.11213556
GO:0005524ATP binding6.49e-011.00e+00-0.1112151298
GO:0003700sequence-specific DNA binding transcription factor activity6.97e-011.00e+00-0.21813699
GO:0005615extracellular space8.08e-011.00e+00-0.67112957
GO:0006355regulation of transcription, DNA-templated8.21e-011.00e+00-0.73013997
GO:0008270zinc ion binding8.21e-011.00e+00-0.73013997
GO:0046872metal ion binding8.98e-011.00e+00-1.1211101307