meta-reg-snw-10198

Interacting subnets

Subnetwork	Dataset	Score	p-value 1	p-value 2	p-value 3	Size	Highlighted genes
int-snw-56848	tai-screen-luciferase	6.375	2.94e-136	3.59e-07	2.58e-03	24	19
reg-snw-10198	tai-screen-luciferase	4.688	3.15e-24	5.65e-04	9.12e-04	9	5
int-snw-10296	tai-screen-luciferase	6.413	3.70e-138	2.79e-07	2.32e-03	18	15
int-snw-51382	tai-screen-luciferase	7.286	3.65e-186	4.21e-10	1.27e-04	13	12
int-snw-51741	tai-screen-luciferase	6.174	2.67e-126	1.32e-06	4.54e-03	24	19

tai-screen-luciferase-meta-reg-snw-10198 subnetwork

Genes (41)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	List-Gonzales GI	Tai-Hits
RPS8	6202	33	-5.545	7.555	234	-	-
MAPK8	5599	28	-4.403	6.468	153	-	-
CHMP2A	27243	33	-9.037	7.555	41	Yes	Yes
RPS15	6209	30	-5.040	7.011	116	Yes	-
COPA	1314	48	-9.395	5.672	340	Yes	Yes
RNF20	56254	28	-4.564	6.174	18	-	-
HSF1	3297	46	-4.179	5.027	209	-	Yes
SRC	6714	28	-2.806	6.174	419	Yes	-
COPB2	9276	48	-13.168	9.063	41	Yes	Yes
CKAP5	9793	46	-7.214	5.672	130	Yes	Yes
RPS16	6217	38	-5.444	4.880	205	-	-
EIF2S2	8894	31	-4.320	5.672	103	Yes	-
CDC42	998	44	-6.960	4.707	276	Yes	Yes
MAEA	10296	13	-2.793	6.413	43	-	-
ARL1	400	18	-4.142	8.046	110	-	Yes
RPS11	6205	44	-6.588	7.555	175	Yes	-
RPS6	6194	44	-5.603	8.046	217	Yes	-
MRPS12	6183	35	-5.421	5.516	341	Yes	-
TLK2	11011	21	-4.011	5.672	14	-	-
RAN	5901	38	-3.809	4.325	258	Yes	Yes
UBB	7314	30	-4.289	6.428	147	-	-
MPHOSPH9	10198	5	2.055	4.688	41	-	-
COPB1	1315	39	-6.221	9.063	118	Yes	Yes
RPS13	6207	43	-6.589	7.555	174	Yes	-
CDC5L	988	34	-3.419	5.672	155	-	-
RPS24	6229	46	-7.034	8.389	217	Yes	-
TCERG1	10915	28	-3.808	6.174	58	Yes	-
RPS9	6203	45	-7.127	7.555	140	Yes	-
RPS4X	6191	44	-6.747	7.555	263	Yes	-
COPZ1	22818	48	-8.301	9.063	13	Yes	Yes
ATP6V1D	51382	30	-4.131	7.286	149	-	-
RPS15A	6210	36	-5.413	7.555	177	Yes	-
WDR46	9277	31	-4.290	4.226	101	Yes	Yes
WWOX	51741	28	-2.448	6.174	38	-	-
RPS27A	6233	45	-5.631	8.389	344	Yes	-
UACA	55075	5	-2.177	4.688	76	-	-
SKP1	6500	26	-3.750	6.413	203	-	-
NFKBIB	4793	28	-3.978	6.174	78	-	-
SPHK2	56848	17	-3.010	6.375	37	-	-
RPS26	6231	43	-7.478	8.046	60	Yes	-
ARCN1	372	48	-8.232	9.063	118	Yes	Yes

Interactions (101)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CDC42	998	RPS27A	6233	pp	--	int.I2D: SOURAV_MAPK_HIGH
RPS4X	6191	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
RPS27A	6233	SKP1	6500	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ARCN1	372	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
RPS11	6205	RPS15	6209	pp	--	int.I2D: INTEROLOG, YeastMedium
RPS11	6205	RPS15A	6210	pp	--	int.I2D: BioGrid_Yeast
TCERG1	10915	WWOX	51741	pp	--	int.I2D: BioGrid, MINT, Pawson1; int.Mint: MI:0915(physical association)
EIF2S2	8894	ATP6V1D	51382	pp	--	int.I2D: YeastLow
RPS6	6194	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
SRC	6714	CKAP5	9793	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
RPS6	6194	RPS26	6231	pp	--	int.I2D: YeastLow
ARCN1	372	RAN	5901	pp	--	int.I2D: YeastLow
CDC42	998	UBB	7314	pp	--	int.I2D: SOURAV_MAPK_HIGH
NFKBIB	4793	UBB	7314	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
RPS15	6209	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS9	6203	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RPS8	6202	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RPS4X	6191	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS9	6203	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
RPS8	6202	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS9	6203	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
SKP1	6500	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
RPS13	6207	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
RAN	5901	RPS11	6205	pp	--	int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
RPS13	6207	WDR46	9277	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	RPS15	6209	pp	--	int.I2D: BioGrid_Yeast
HSF1	3297	UACA	55075	pd	<>	reg.ITFP.txt: no annot
RPS9	6203	RPS15A	6210	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
MPHOSPH9	10198	UACA	55075	pd	<	reg.ITFP.txt: no annot
RPS4X	6191	RPS9	6203	pp	--	int.I2D: BioGrid_Yeast
UBB	7314	WWOX	51741	pp	--	int.I2D: BCI, HPRD; int.HPRD: in vivo
UBB	7314	RNF20	56254	pp	--	int.Intact: MI:0220(ubiquitination reaction); int.I2D: IntAct
MRPS12	6183	RPS15	6209	pp	--	int.I2D: YeastMedium
RPS8	6202	SKP1	6500	pp	--	int.I2D: BioGrid_Yeast
RPS15A	6210	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS11	6205	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
RPS8	6202	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
SRC	6714	WWOX	51741	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
RPS16	6217	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
MAEA	10296	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
ARL1	400	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
RPS27A	6233	UBB	7314	pp	--	int.I2D: BIND
RPS4X	6191	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
ARL1	400	COPA	1314	pp	--	int.I2D: BioGrid_Yeast
RAN	5901	RPS15	6209	pp	--	int.I2D: YeastLow
RPS4X	6191	RPS15A	6210	pp	--	int.I2D: BioGrid_Yeast, YeastMedium, INTEROLOG
RPS8	6202	RPS9	6203	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
RPS13	6207	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
RPS6	6194	RPS27A	6233	pp	--	int.I2D: YeastLow
RPS6	6194	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
COPA	1314	COPB1	1315	pp	--	int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
RPS8	6202	CHMP2A	27243	pp	--	int.I2D: BioGrid_Yeast
CDC5L	988	MPHOSPH9	10198	pd	>	reg.ITFP.txt: no annot
RPS24	6229	ATP6V1D	51382	pp	--	int.I2D: BioGrid_Yeast
CDC5L	988	CKAP5	9793	pd	<>	reg.ITFP.txt: no annot
RAN	5901	WDR46	9277	pp	--	int.I2D: YeastLow
HSF1	3297	MAPK8	5599	pp	--	int.I2D: HPRD, INNATEDB; int.HPRD: in vitro, in vivo
COPA	1314	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
NFKBIB	4793	SKP1	6500	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vitro
COPA	1314	COPB2	9276	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vivo
COPB1	1315	COPZ1	22818	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium; int.DIP: MI:0915(physical association)
COPA	1314	ATP6V1D	51382	pp	--	int.I2D: YeastLow
RPS15	6209	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS4X	6191	RPS8	6202	pp	--	int.I2D: BioGrid_Yeast
RPS4X	6191	RPS13	6207	pp	--	int.I2D: BioGrid_Yeast
RPS15A	6210	RPS24	6229	pp	--	int.I2D: BioGrid_Yeast
CDC5L	988	TLK2	11011	pd	>	reg.ITFP.txt: no annot
RPS13	6207	RPS15A	6210	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	ARL1	400	pp	--	int.I2D: BioGrid_Yeast
ARL1	400	RPS6	6194	pp	--	int.I2D: BioGrid_Yeast
HSF1	3297	MRPS12	6183	pd	<>	reg.ITFP.txt: no annot
RAN	5901	SPHK2	56848	pp	--	int.I2D: IntAct_Yeast, BIND_Yeast, MINT_Yeast, MIPS, YeastLow
RPS4X	6191	RPS15	6209	pp	--	int.I2D: INTEROLOG, YeastMedium
CDC5L	988	COPA	1314	pd	<>	reg.ITFP.txt: no annot
CDC5L	988	EIF2S2	8894	pd	>	reg.ITFP.txt: no annot
COPB1	1315	COPB2	9276	pp	--	int.I2D: BioGrid
CKAP5	9793	MPHOSPH9	10198	pd	>	reg.ITFP.txt: no annot
ARCN1	372	COPB1	1315	pp	--	int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS; int.HPRD: in vivo
RPS9	6203	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
RPS15	6209	RPS15A	6210	pp	--	int.I2D: YeastMedium, INTEROLOG
RPS6	6194	RPS16	6217	pp	--	int.I2D: BioGrid_Yeast
ARCN1	372	COPA	1314	pp	--	int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core; int.HPRD: in vivo
RPS6	6194	RPS8	6202	pp	--	int.I2D: BioGrid_Yeast, YeastLow
RPS4X	6191	RPS6	6194	pp	--	int.I2D: BioGrid_Yeast
CDC5L	988	RPS16	6217	pp	--	int.I2D: BioGrid
COPA	1314	RPS27A	6233	pp	--	int.I2D: YeastLow
MAPK8	5599	WWOX	51741	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0915(physical association); int.HPRD: in vivo, yeast 2-hybrid
RPS8	6202	RPS15A	6210	pp	--	int.I2D: BioGrid_Yeast
RPS16	6217	RPS26	6231	pp	--	int.I2D: BioGrid_Yeast
RAN	5901	ATP6V1D	51382	pp	--	int.I2D: YeastLow
RPS15A	6210	RPS27A	6233	pp	--	int.I2D: YeastLow
ARCN1	372	COPB2	9276	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
RAN	5901	SKP1	6500	pp	--	int.I2D: BioGrid_Yeast
RPS13	6207	RPS15	6209	pp	--	int.I2D: BioGrid_Yeast
RPS24	6229	RPS27A	6233	pp	--	int.I2D: YeastMedium
RPS8	6202	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (524)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0022627	cytosolic small ribosomal subunit	3.98e-23	6.49e-19	6.936	12	21	39
GO:0019058	viral life cycle	1.11e-22	1.81e-18	5.698	15	25	115
GO:0019083	viral transcription	6.71e-19	1.10e-14	5.882	12	22	81
GO:0006415	translational termination	1.67e-18	2.72e-14	5.779	12	22	87
GO:0006414	translational elongation	3.88e-18	6.33e-14	5.683	12	22	93
GO:0006413	translational initiation	4.55e-18	7.42e-14	5.304	13	27	131
GO:0003735	structural constituent of ribosome	1.22e-17	1.99e-13	5.198	13	24	141
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	1.58e-17	2.58e-13	5.521	12	22	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4.97e-17	8.10e-13	5.389	12	22	114
GO:0016032	viral process	1.70e-16	2.78e-12	3.730	18	37	540
GO:0006412	translation	2.79e-16	4.55e-12	4.568	14	29	235
GO:0005829	cytosol	3.42e-16	5.58e-12	2.221	30	74	2562
GO:0016071	mRNA metabolic process	5.12e-15	8.36e-11	4.536	13	29	223
GO:0015935	small ribosomal subunit	7.02e-15	1.15e-10	7.357	7	9	17
GO:0016070	RNA metabolic process	1.93e-14	3.14e-10	4.389	13	29	247
GO:0016020	membrane	1.08e-13	1.76e-09	2.452	24	48	1746
GO:0044822	poly(A) RNA binding	1.97e-12	3.21e-08	2.811	19	42	1078
GO:0010467	gene expression	3.12e-11	5.10e-07	3.158	15	36	669
GO:0061024	membrane organization	7.86e-11	1.28e-06	4.617	9	11	146
GO:0048205	COPI coating of Golgi vesicle	9.85e-11	1.61e-06	7.258	5	6	13
GO:0030126	COPI vesicle coat	9.85e-11	1.61e-06	7.258	5	6	13
GO:0044267	cellular protein metabolic process	1.27e-10	2.08e-06	3.386	13	29	495
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	3.98e-09	6.49e-05	6.315	5	6	25
GO:0042274	ribosomal small subunit biogenesis	1.67e-08	2.73e-04	7.052	4	6	12
GO:0070062	extracellular vesicular exosome	2.75e-06	4.49e-02	1.588	19	51	2516
GO:0005925	focal adhesion	3.21e-06	5.24e-02	3.106	8	23	370
GO:0075733	intracellular transport of virus	9.76e-06	1.59e-01	6.134	3	3	17
GO:0006891	intra-Golgi vesicle-mediated transport	9.76e-06	1.59e-01	6.134	3	3	17
GO:0005840	ribosome	1.41e-05	2.30e-01	4.754	4	10	59
GO:0000056	ribosomal small subunit export from nucleus	1.84e-05	3.01e-01	8.052	2	2	3
GO:0034146	toll-like receptor 5 signaling pathway	2.08e-05	3.39e-01	4.615	4	5	65
GO:0034166	toll-like receptor 10 signaling pathway	2.08e-05	3.39e-01	4.615	4	5	65
GO:0036464	cytoplasmic ribonucleoprotein granule	2.19e-05	3.58e-01	5.762	3	5	22
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	2.95e-05	4.81e-01	4.487	4	5	71
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	2.95e-05	4.81e-01	4.487	4	5	71
GO:0034162	toll-like receptor 9 signaling pathway	3.12e-05	5.09e-01	4.467	4	5	72
GO:0034134	toll-like receptor 2 signaling pathway	3.29e-05	5.37e-01	4.447	4	5	73
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	3.86e-05	6.30e-01	4.389	4	5	76
GO:0019843	rRNA binding	4.13e-05	6.74e-01	5.467	3	4	27
GO:0002756	MyD88-independent toll-like receptor signaling pathway	4.27e-05	6.98e-01	4.351	4	5	78
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	4.72e-05	7.71e-01	4.315	4	5	80
GO:0034138	toll-like receptor 3 signaling pathway	4.72e-05	7.71e-01	4.315	4	5	80
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	6.13e-05	1.00e+00	7.315	2	3	5
GO:0033119	negative regulation of RNA splicing	6.13e-05	1.00e+00	7.315	2	2	5
GO:0005515	protein binding	6.26e-05	1.00e+00	0.863	28	87	6127
GO:0006886	intracellular protein transport	6.95e-05	1.00e+00	3.524	5	6	173
GO:0034142	toll-like receptor 4 signaling pathway	9.63e-05	1.00e+00	4.052	4	5	96
GO:0006364	rRNA processing	9.63e-05	1.00e+00	4.052	4	8	96
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	9.92e-05	1.00e+00	5.052	3	3	36
GO:0002224	toll-like receptor signaling pathway	1.58e-04	1.00e+00	3.869	4	5	109
GO:0030529	ribonucleoprotein complex	1.87e-04	1.00e+00	3.804	4	8	114
GO:0007254	JNK cascade	2.82e-04	1.00e+00	4.549	3	3	51
GO:0051403	stress-activated MAPK cascade	3.34e-04	1.00e+00	4.467	3	4	54
GO:0000086	G2/M transition of mitotic cell cycle	3.78e-04	1.00e+00	3.539	4	6	137
GO:0019082	viral protein processing	4.00e-04	1.00e+00	6.052	2	2	12
GO:0016197	endosomal transport	4.12e-04	1.00e+00	4.364	3	3	58
GO:0032479	regulation of type I interferon production	4.72e-04	1.00e+00	5.936	2	2	13
GO:0032481	positive regulation of type I interferon production	4.79e-04	1.00e+00	4.291	3	3	61
GO:0000082	G1/S transition of mitotic cell cycle	5.33e-04	1.00e+00	3.408	4	11	150
GO:0043065	positive regulation of apoptotic process	5.88e-04	1.00e+00	2.861	5	6	274
GO:0018105	peptidyl-serine phosphorylation	6.87e-04	1.00e+00	4.113	3	5	69
GO:0043066	negative regulation of apoptotic process	6.89e-04	1.00e+00	2.464	6	14	433
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.17e-04	1.00e+00	4.093	3	8	70
GO:0019068	virion assembly	8.18e-04	1.00e+00	5.549	2	2	17
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.43e-04	1.00e+00	4.012	3	8	74
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.02e-03	1.00e+00	3.918	3	8	79
GO:0007173	epidermal growth factor receptor signaling pathway	1.31e-03	1.00e+00	3.059	4	5	191
GO:0007220	Notch receptor processing	1.38e-03	1.00e+00	5.177	2	2	22
GO:0001649	osteoblast differentiation	1.74e-03	1.00e+00	3.652	3	3	95
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	1.78e-03	1.00e+00	4.993	2	2	25
GO:0005844	polysome	1.78e-03	1.00e+00	4.993	2	2	25
GO:0071456	cellular response to hypoxia	1.90e-03	1.00e+00	3.607	3	3	98
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.93e-03	1.00e+00	4.936	2	2	26
GO:0005978	glycogen biosynthetic process	1.93e-03	1.00e+00	4.936	2	2	26
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	1.93e-03	1.00e+00	4.936	2	2	26
GO:2001286	regulation of caveolin-mediated endocytosis	2.51e-03	1.00e+00	8.637	1	1	1
GO:0071393	cellular response to progesterone stimulus	2.51e-03	1.00e+00	8.637	1	1	1
GO:0033176	proton-transporting V-type ATPase complex	2.51e-03	1.00e+00	8.637	1	1	1
GO:0006669	sphinganine-1-phosphate biosynthetic process	2.51e-03	1.00e+00	8.637	1	1	1
GO:0022605	oogenesis stage	2.51e-03	1.00e+00	8.637	1	1	1
GO:0021691	cerebellar Purkinje cell layer maturation	2.51e-03	1.00e+00	8.637	1	1	1
GO:0032480	negative regulation of type I interferon production	2.91e-03	1.00e+00	4.637	2	2	32
GO:0003713	transcription coactivator activity	2.97e-03	1.00e+00	2.736	4	6	239
GO:0097190	apoptotic signaling pathway	3.06e-03	1.00e+00	3.364	3	3	116
GO:0000209	protein polyubiquitination	3.06e-03	1.00e+00	3.364	3	7	116
GO:0034332	adherens junction organization	3.67e-03	1.00e+00	4.467	2	4	36
GO:0051092	positive regulation of NF-kappaB transcription factor activity	3.78e-03	1.00e+00	3.256	3	3	125
GO:0007219	Notch signaling pathway	3.78e-03	1.00e+00	3.256	3	4	125
GO:0045087	innate immune response	4.12e-03	1.00e+00	1.955	6	11	616
GO:0007179	transforming growth factor beta receptor signaling pathway	4.22e-03	1.00e+00	3.199	3	4	130
GO:0005737	cytoplasm	4.72e-03	1.00e+00	0.850	18	65	3976
GO:0007249	I-kappaB kinase/NF-kappaB signaling	4.75e-03	1.00e+00	4.279	2	4	41
GO:0048011	neurotrophin TRK receptor signaling pathway	4.77e-03	1.00e+00	2.544	4	5	273
GO:0008481	sphinganine kinase activity	5.02e-03	1.00e+00	7.637	1	1	2
GO:0071987	WD40-repeat domain binding	5.02e-03	1.00e+00	7.637	1	1	2
GO:0060661	submandibular salivary gland formation	5.02e-03	1.00e+00	7.637	1	1	2
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	5.02e-03	1.00e+00	7.637	1	1	2
GO:0017050	D-erythro-sphingosine kinase activity	5.02e-03	1.00e+00	7.637	1	1	2
GO:0071338	positive regulation of hair follicle cell proliferation	5.02e-03	1.00e+00	7.637	1	1	2
GO:0002176	male germ cell proliferation	5.02e-03	1.00e+00	7.637	1	1	2
GO:0048822	enucleate erythrocyte development	5.02e-03	1.00e+00	7.637	1	1	2
GO:0072422	signal transduction involved in DNA damage checkpoint	5.02e-03	1.00e+00	7.637	1	1	2
GO:0010632	regulation of epithelial cell migration	5.02e-03	1.00e+00	7.637	1	1	2
GO:0001672	regulation of chromatin assembly or disassembly	5.02e-03	1.00e+00	7.637	1	1	2
GO:0090135	actin filament branching	5.02e-03	1.00e+00	7.637	1	1	2
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	5.21e-03	1.00e+00	4.211	2	2	43
GO:0009411	response to UV	5.69e-03	1.00e+00	4.145	2	2	45
GO:0007030	Golgi organization	6.99e-03	1.00e+00	3.993	2	3	50
GO:0005198	structural molecule activity	7.38e-03	1.00e+00	2.909	3	5	159
GO:0008543	fibroblast growth factor receptor signaling pathway	7.38e-03	1.00e+00	2.909	3	3	159
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	7.52e-03	1.00e+00	7.052	1	1	3
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	7.52e-03	1.00e+00	7.052	1	1	3
GO:0043293	apoptosome	7.52e-03	1.00e+00	7.052	1	1	3
GO:0003161	cardiac conduction system development	7.52e-03	1.00e+00	7.052	1	1	3
GO:0090045	positive regulation of deacetylase activity	7.52e-03	1.00e+00	7.052	1	1	3
GO:0035033	histone deacetylase regulator activity	7.52e-03	1.00e+00	7.052	1	1	3
GO:2000017	positive regulation of determination of dorsal identity	7.52e-03	1.00e+00	7.052	1	1	3
GO:0051683	establishment of Golgi localization	7.52e-03	1.00e+00	7.052	1	2	3
GO:0006670	sphingosine metabolic process	7.52e-03	1.00e+00	7.052	1	1	3
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	7.52e-03	1.00e+00	7.052	1	1	3
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	7.52e-03	1.00e+00	7.052	1	1	3
GO:0005850	eukaryotic translation initiation factor 2 complex	7.52e-03	1.00e+00	7.052	1	1	3
GO:0004705	JUN kinase activity	7.52e-03	1.00e+00	7.052	1	1	3
GO:0043005	neuron projection	7.63e-03	1.00e+00	2.891	3	6	161
GO:0030666	endocytic vesicle membrane	8.11e-03	1.00e+00	3.882	2	2	54
GO:0038095	Fc-epsilon receptor signaling pathway	9.00e-03	1.00e+00	2.804	3	3	171
GO:0003682	chromatin binding	9.61e-03	1.00e+00	2.253	4	4	334
GO:0007049	cell cycle	9.88e-03	1.00e+00	2.754	3	4	177
GO:0034191	apolipoprotein A-I receptor binding	1.00e-02	1.00e+00	6.637	1	1	4
GO:0032463	negative regulation of protein homooligomerization	1.00e-02	1.00e+00	6.637	1	1	4
GO:0051902	negative regulation of mitochondrial depolarization	1.00e-02	1.00e+00	6.637	1	1	4
GO:0031062	positive regulation of histone methylation	1.00e-02	1.00e+00	6.637	1	1	4
GO:0060684	epithelial-mesenchymal cell signaling	1.00e-02	1.00e+00	6.637	1	1	4
GO:0070851	growth factor receptor binding	1.00e-02	1.00e+00	6.637	1	1	4
GO:0051835	positive regulation of synapse structural plasticity	1.00e-02	1.00e+00	6.637	1	1	4
GO:0090231	regulation of spindle checkpoint	1.00e-02	1.00e+00	6.637	1	1	4
GO:0072384	organelle transport along microtubule	1.00e-02	1.00e+00	6.637	1	2	4
GO:0007258	JUN phosphorylation	1.00e-02	1.00e+00	6.637	1	1	4
GO:0048664	neuron fate determination	1.00e-02	1.00e+00	6.637	1	1	4
GO:0033503	HULC complex	1.00e-02	1.00e+00	6.637	1	1	4
GO:0031063	regulation of histone deacetylation	1.00e-02	1.00e+00	6.637	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	1.00e-02	1.00e+00	6.637	1	1	4
GO:0000055	ribosomal large subunit export from nucleus	1.00e-02	1.00e+00	6.637	1	1	4
GO:0033625	positive regulation of integrin activation	1.00e-02	1.00e+00	6.637	1	1	4
GO:0019904	protein domain specific binding	1.05e-02	1.00e+00	2.722	3	3	181
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	1.12e-02	1.00e+00	3.637	2	2	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.16e-02	1.00e+00	3.615	2	6	65
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.16e-02	1.00e+00	3.615	2	6	65
GO:0031295	T cell costimulation	1.23e-02	1.00e+00	3.571	2	3	67
GO:2000641	regulation of early endosome to late endosome transport	1.25e-02	1.00e+00	6.315	1	1	5
GO:0036336	dendritic cell migration	1.25e-02	1.00e+00	6.315	1	1	5
GO:0033033	negative regulation of myeloid cell apoptotic process	1.25e-02	1.00e+00	6.315	1	1	5
GO:0035088	establishment or maintenance of apical/basal cell polarity	1.25e-02	1.00e+00	6.315	1	1	5
GO:0051385	response to mineralocorticoid	1.25e-02	1.00e+00	6.315	1	1	5
GO:0005826	actomyosin contractile ring	1.25e-02	1.00e+00	6.315	1	1	5
GO:1902188	positive regulation of viral release from host cell	1.25e-02	1.00e+00	6.315	1	1	5
GO:0097300	programmed necrotic cell death	1.25e-02	1.00e+00	6.315	1	1	5
GO:0031256	leading edge membrane	1.25e-02	1.00e+00	6.315	1	1	5
GO:0031584	activation of phospholipase D activity	1.25e-02	1.00e+00	6.315	1	1	5
GO:0009404	toxin metabolic process	1.25e-02	1.00e+00	6.315	1	1	5
GO:0071803	positive regulation of podosome assembly	1.25e-02	1.00e+00	6.315	1	1	5
GO:0046834	lipid phosphorylation	1.25e-02	1.00e+00	6.315	1	1	5
GO:0003924	GTPase activity	1.43e-02	1.00e+00	2.557	3	6	203
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.45e-02	1.00e+00	3.447	2	6	73
GO:0003729	mRNA binding	1.45e-02	1.00e+00	3.447	2	3	73
GO:0050847	progesterone receptor signaling pathway	1.50e-02	1.00e+00	6.052	1	1	6
GO:0007143	female meiotic division	1.50e-02	1.00e+00	6.052	1	1	6
GO:0002309	T cell proliferation involved in immune response	1.50e-02	1.00e+00	6.052	1	1	6
GO:0045182	translation regulator activity	1.50e-02	1.00e+00	6.052	1	2	6
GO:0045056	transcytosis	1.50e-02	1.00e+00	6.052	1	1	6
GO:0060789	hair follicle placode formation	1.50e-02	1.00e+00	6.052	1	1	6
GO:0048554	positive regulation of metalloenzyme activity	1.50e-02	1.00e+00	6.052	1	1	6
GO:0050792	regulation of viral process	1.50e-02	1.00e+00	6.052	1	1	6
GO:0000974	Prp19 complex	1.50e-02	1.00e+00	6.052	1	1	6
GO:0006924	activation-induced cell death of T cells	1.50e-02	1.00e+00	6.052	1	2	6
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.60e-02	1.00e+00	3.370	2	6	77
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	1.60e-02	1.00e+00	3.370	2	4	77
GO:0008284	positive regulation of cell proliferation	1.65e-02	1.00e+00	2.022	4	7	392
GO:0000278	mitotic cell cycle	1.73e-02	1.00e+00	2.000	4	16	398
GO:0010447	response to acidic pH	1.75e-02	1.00e+00	5.830	1	1	7
GO:0060136	embryonic process involved in female pregnancy	1.75e-02	1.00e+00	5.830	1	1	7
GO:0043497	regulation of protein heterodimerization activity	1.75e-02	1.00e+00	5.830	1	1	7
GO:0050658	RNA transport	1.75e-02	1.00e+00	5.830	1	1	7
GO:0007097	nuclear migration	1.75e-02	1.00e+00	5.830	1	2	7
GO:0061512	protein localization to cilium	1.75e-02	1.00e+00	5.830	1	1	7
GO:0003334	keratinocyte development	1.75e-02	1.00e+00	5.830	1	1	7
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	1.75e-02	1.00e+00	5.830	1	1	7
GO:0000028	ribosomal small subunit assembly	1.75e-02	1.00e+00	5.830	1	3	7
GO:0034101	erythrocyte homeostasis	1.75e-02	1.00e+00	5.830	1	1	7
GO:0010907	positive regulation of glucose metabolic process	1.75e-02	1.00e+00	5.830	1	1	7
GO:0048193	Golgi vesicle transport	1.75e-02	1.00e+00	5.830	1	1	7
GO:0030157	pancreatic juice secretion	1.75e-02	1.00e+00	5.830	1	1	7
GO:0000930	gamma-tubulin complex	1.75e-02	1.00e+00	5.830	1	1	7
GO:0071222	cellular response to lipopolysaccharide	1.76e-02	1.00e+00	3.297	2	4	81
GO:0006184	GTP catabolic process	1.77e-02	1.00e+00	2.440	3	6	220
GO:0000139	Golgi membrane	1.88e-02	1.00e+00	1.964	4	7	408
GO:0039702	viral budding via host ESCRT complex	1.99e-02	1.00e+00	5.637	1	1	8
GO:0043114	regulation of vascular permeability	1.99e-02	1.00e+00	5.637	1	1	8
GO:0045124	regulation of bone resorption	1.99e-02	1.00e+00	5.637	1	1	8
GO:0051489	regulation of filopodium assembly	1.99e-02	1.00e+00	5.637	1	1	8
GO:0033523	histone H2B ubiquitination	1.99e-02	1.00e+00	5.637	1	1	8
GO:0007172	signal complex assembly	1.99e-02	1.00e+00	5.637	1	1	8
GO:0007067	mitotic nuclear division	2.01e-02	1.00e+00	2.370	3	7	231
GO:0050852	T cell receptor signaling pathway	2.06e-02	1.00e+00	3.177	2	2	88
GO:0000187	activation of MAPK activity	2.15e-02	1.00e+00	3.145	2	3	90
GO:0005730	nucleolus	2.17e-02	1.00e+00	1.089	9	36	1684
GO:0071732	cellular response to nitric oxide	2.24e-02	1.00e+00	5.467	1	1	9
GO:0034067	protein localization to Golgi apparatus	2.24e-02	1.00e+00	5.467	1	1	9
GO:0090136	epithelial cell-cell adhesion	2.24e-02	1.00e+00	5.467	1	2	9
GO:0047497	mitochondrion transport along microtubule	2.24e-02	1.00e+00	5.467	1	1	9
GO:0042347	negative regulation of NF-kappaB import into nucleus	2.24e-02	1.00e+00	5.467	1	1	9
GO:0046628	positive regulation of insulin receptor signaling pathway	2.24e-02	1.00e+00	5.467	1	1	9
GO:0005794	Golgi apparatus	2.26e-02	1.00e+00	1.615	5	8	650
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	2.33e-02	1.00e+00	3.082	2	7	94
GO:0005798	Golgi-associated vesicle	2.48e-02	1.00e+00	5.315	1	1	10
GO:0031274	positive regulation of pseudopodium assembly	2.48e-02	1.00e+00	5.315	1	2	10
GO:0022407	regulation of cell-cell adhesion	2.48e-02	1.00e+00	5.315	1	1	10
GO:0060047	heart contraction	2.48e-02	1.00e+00	5.315	1	1	10
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	2.73e-02	1.00e+00	5.177	1	1	11
GO:0051895	negative regulation of focal adhesion assembly	2.73e-02	1.00e+00	5.177	1	1	11
GO:0045120	pronucleus	2.73e-02	1.00e+00	5.177	1	1	11
GO:2000573	positive regulation of DNA biosynthetic process	2.73e-02	1.00e+00	5.177	1	2	11
GO:0060065	uterus development	2.73e-02	1.00e+00	5.177	1	1	11
GO:0010390	histone monoubiquitination	2.73e-02	1.00e+00	5.177	1	1	11
GO:0035518	histone H2A monoubiquitination	2.73e-02	1.00e+00	5.177	1	2	11
GO:0061136	regulation of proteasomal protein catabolic process	2.97e-02	1.00e+00	5.052	1	1	12
GO:0007051	spindle organization	2.97e-02	1.00e+00	5.052	1	1	12
GO:0043149	stress fiber assembly	2.97e-02	1.00e+00	5.052	1	2	12
GO:0043249	erythrocyte maturation	2.97e-02	1.00e+00	5.052	1	1	12
GO:1903543	positive regulation of exosomal secretion	2.97e-02	1.00e+00	5.052	1	1	12
GO:1901214	regulation of neuron death	2.97e-02	1.00e+00	5.052	1	1	12
GO:0031929	TOR signaling	3.22e-02	1.00e+00	4.936	1	1	13
GO:0005662	DNA replication factor A complex	3.22e-02	1.00e+00	4.936	1	1	13
GO:0071398	cellular response to fatty acid	3.22e-02	1.00e+00	4.936	1	2	13
GO:0060444	branching involved in mammary gland duct morphogenesis	3.22e-02	1.00e+00	4.936	1	1	13
GO:0004143	diacylglycerol kinase activity	3.22e-02	1.00e+00	4.936	1	1	13
GO:0035371	microtubule plus-end	3.46e-02	1.00e+00	4.830	1	1	14
GO:0031333	negative regulation of protein complex assembly	3.46e-02	1.00e+00	4.830	1	1	14
GO:0050662	coenzyme binding	3.46e-02	1.00e+00	4.830	1	1	14
GO:0017016	Ras GTPase binding	3.46e-02	1.00e+00	4.830	1	1	14
GO:0071480	cellular response to gamma radiation	3.46e-02	1.00e+00	4.830	1	1	14
GO:0031996	thioesterase binding	3.46e-02	1.00e+00	4.830	1	1	14
GO:0006006	glucose metabolic process	3.59e-02	1.00e+00	2.742	2	4	119
GO:0007264	small GTPase mediated signal transduction	3.60e-02	1.00e+00	2.042	3	7	290
GO:0005634	nucleus	3.61e-02	1.00e+00	0.570	18	66	4828
GO:0048477	oogenesis	3.70e-02	1.00e+00	4.730	1	1	15
GO:0030131	clathrin adaptor complex	3.70e-02	1.00e+00	4.730	1	1	15
GO:0030225	macrophage differentiation	3.70e-02	1.00e+00	4.730	1	1	15
GO:0003951	NAD+ kinase activity	3.70e-02	1.00e+00	4.730	1	1	15
GO:0048821	erythrocyte development	3.70e-02	1.00e+00	4.730	1	2	15
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	3.70e-02	1.00e+00	4.730	1	1	15
GO:0042307	positive regulation of protein import into nucleus	3.70e-02	1.00e+00	4.730	1	2	15
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	3.70e-02	1.00e+00	4.730	1	1	15
GO:0031369	translation initiation factor binding	3.70e-02	1.00e+00	4.730	1	2	15
GO:0051233	spindle midzone	3.70e-02	1.00e+00	4.730	1	2	15
GO:0014911	positive regulation of smooth muscle cell migration	3.95e-02	1.00e+00	4.637	1	1	16
GO:0048037	cofactor binding	3.95e-02	1.00e+00	4.637	1	1	16
GO:0042176	regulation of protein catabolic process	3.95e-02	1.00e+00	4.637	1	4	16
GO:2000811	negative regulation of anoikis	3.95e-02	1.00e+00	4.637	1	1	16
GO:0030742	GTP-dependent protein binding	4.19e-02	1.00e+00	4.549	1	1	17
GO:0009615	response to virus	4.34e-02	1.00e+00	2.592	2	4	132
GO:0070064	proline-rich region binding	4.43e-02	1.00e+00	4.467	1	1	18
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	4.43e-02	1.00e+00	4.467	1	1	18
GO:0031954	positive regulation of protein autophosphorylation	4.43e-02	1.00e+00	4.467	1	1	18
GO:0010507	negative regulation of autophagy	4.43e-02	1.00e+00	4.467	1	1	18
GO:0090316	positive regulation of intracellular protein transport	4.43e-02	1.00e+00	4.467	1	1	18
GO:0006259	DNA metabolic process	4.67e-02	1.00e+00	4.389	1	1	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	4.67e-02	1.00e+00	4.389	1	1	19
GO:0007088	regulation of mitosis	4.67e-02	1.00e+00	4.389	1	1	19
GO:0045453	bone resorption	4.67e-02	1.00e+00	4.389	1	1	19
GO:0031667	response to nutrient levels	4.67e-02	1.00e+00	4.389	1	1	19
GO:0005525	GTP binding	4.89e-02	1.00e+00	1.864	3	6	328
GO:0032148	activation of protein kinase B activity	4.91e-02	1.00e+00	4.315	1	1	20
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	4.91e-02	1.00e+00	4.315	1	2	20
GO:0043473	pigmentation	4.91e-02	1.00e+00	4.315	1	2	20
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	4.91e-02	1.00e+00	4.315	1	1	20
GO:0043393	regulation of protein binding	4.91e-02	1.00e+00	4.315	1	2	20
GO:0008286	insulin receptor signaling pathway	5.07e-02	1.00e+00	2.467	2	4	144
GO:0007369	gastrulation	5.15e-02	1.00e+00	4.245	1	1	21
GO:0046847	filopodium assembly	5.15e-02	1.00e+00	4.245	1	1	21
GO:0051881	regulation of mitochondrial membrane potential	5.15e-02	1.00e+00	4.245	1	1	21
GO:0005813	centrosome	5.30e-02	1.00e+00	1.817	3	9	339
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	5.32e-02	1.00e+00	2.427	2	3	148
GO:0010628	positive regulation of gene expression	5.38e-02	1.00e+00	2.418	2	4	149
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	5.39e-02	1.00e+00	4.177	1	1	22
GO:0046686	response to cadmium ion	5.39e-02	1.00e+00	4.177	1	1	22
GO:0001106	RNA polymerase II transcription corepressor activity	5.39e-02	1.00e+00	4.177	1	1	22
GO:0031435	mitogen-activated protein kinase kinase kinase binding	5.39e-02	1.00e+00	4.177	1	1	22
GO:0007052	mitotic spindle organization	5.39e-02	1.00e+00	4.177	1	1	22
GO:0005654	nucleoplasm	5.41e-02	1.00e+00	1.125	6	26	1095
GO:0042981	regulation of apoptotic process	5.51e-02	1.00e+00	2.398	2	7	151
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	5.62e-02	1.00e+00	4.113	1	1	23
GO:0045787	positive regulation of cell cycle	5.62e-02	1.00e+00	4.113	1	2	23
GO:0002040	sprouting angiogenesis	5.62e-02	1.00e+00	4.113	1	1	23
GO:0051017	actin filament bundle assembly	5.62e-02	1.00e+00	4.113	1	1	23
GO:0001892	embryonic placenta development	5.62e-02	1.00e+00	4.113	1	1	23
GO:0051297	centrosome organization	5.62e-02	1.00e+00	4.113	1	2	23
GO:0008135	translation factor activity, nucleic acid binding	5.86e-02	1.00e+00	4.052	1	4	24
GO:0005761	mitochondrial ribosome	5.86e-02	1.00e+00	4.052	1	1	24
GO:0007163	establishment or maintenance of cell polarity	5.86e-02	1.00e+00	4.052	1	2	24
GO:0051602	response to electrical stimulus	5.86e-02	1.00e+00	4.052	1	1	24
GO:0010008	endosome membrane	5.91e-02	1.00e+00	2.342	2	2	157
GO:0003723	RNA binding	5.93e-02	1.00e+00	1.750	3	10	355
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	5.94e-02	1.00e+00	1.435	4	9	589
GO:0006611	protein export from nucleus	6.10e-02	1.00e+00	3.993	1	1	25
GO:0031519	PcG protein complex	6.10e-02	1.00e+00	3.993	1	1	25
GO:0050715	positive regulation of cytokine secretion	6.10e-02	1.00e+00	3.993	1	1	25
GO:0048705	skeletal system morphogenesis	6.10e-02	1.00e+00	3.993	1	1	25
GO:0045859	regulation of protein kinase activity	6.34e-02	1.00e+00	3.936	1	1	26
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	6.34e-02	1.00e+00	3.936	1	1	26
GO:0030148	sphingolipid biosynthetic process	6.34e-02	1.00e+00	3.936	1	1	26
GO:0051149	positive regulation of muscle cell differentiation	6.57e-02	1.00e+00	3.882	1	2	27
GO:0032720	negative regulation of tumor necrosis factor production	6.57e-02	1.00e+00	3.882	1	1	27
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	6.57e-02	1.00e+00	3.882	1	1	27
GO:0031424	keratinization	6.57e-02	1.00e+00	3.882	1	1	27
GO:0001103	RNA polymerase II repressing transcription factor binding	6.57e-02	1.00e+00	3.882	1	1	27
GO:0030331	estrogen receptor binding	6.57e-02	1.00e+00	3.882	1	1	27
GO:0045184	establishment of protein localization	6.57e-02	1.00e+00	3.882	1	2	27
GO:0031069	hair follicle morphogenesis	6.57e-02	1.00e+00	3.882	1	1	27
GO:0034220	ion transmembrane transport	6.58e-02	1.00e+00	2.253	2	2	167
GO:0032467	positive regulation of cytokinesis	6.81e-02	1.00e+00	3.830	1	1	28
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	6.81e-02	1.00e+00	3.830	1	1	28
GO:0019005	SCF ubiquitin ligase complex	7.04e-02	1.00e+00	3.779	1	1	29
GO:0034605	cellular response to heat	7.04e-02	1.00e+00	3.779	1	1	29
GO:0072686	mitotic spindle	7.04e-02	1.00e+00	3.779	1	1	29
GO:0007346	regulation of mitotic cell cycle	7.27e-02	1.00e+00	3.730	1	3	30
GO:0046875	ephrin receptor binding	7.27e-02	1.00e+00	3.730	1	2	30
GO:0042169	SH2 domain binding	7.27e-02	1.00e+00	3.730	1	1	30
GO:0031647	regulation of protein stability	7.27e-02	1.00e+00	3.730	1	1	30
GO:0040018	positive regulation of multicellular organism growth	7.27e-02	1.00e+00	3.730	1	1	30
GO:0070555	response to interleukin-1	7.51e-02	1.00e+00	3.683	1	1	31
GO:0007093	mitotic cell cycle checkpoint	7.51e-02	1.00e+00	3.683	1	2	31
GO:0033572	transferrin transport	7.74e-02	1.00e+00	3.637	1	1	32
GO:0015992	proton transport	7.74e-02	1.00e+00	3.637	1	1	32
GO:0051219	phosphoprotein binding	7.74e-02	1.00e+00	3.637	1	4	32
GO:0006367	transcription initiation from RNA polymerase II promoter	7.79e-02	1.00e+00	2.113	2	5	184
GO:0032091	negative regulation of protein binding	7.97e-02	1.00e+00	3.592	1	1	33
GO:0005158	insulin receptor binding	7.97e-02	1.00e+00	3.592	1	2	33
GO:0033077	T cell differentiation in thymus	7.97e-02	1.00e+00	3.592	1	1	33
GO:0048812	neuron projection morphogenesis	7.97e-02	1.00e+00	3.592	1	1	33
GO:0001890	placenta development	8.20e-02	1.00e+00	3.549	1	1	34
GO:0042692	muscle cell differentiation	8.20e-02	1.00e+00	3.549	1	2	34
GO:0051701	interaction with host	8.20e-02	1.00e+00	3.549	1	1	34
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	8.44e-02	1.00e+00	3.508	1	1	35
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	8.44e-02	1.00e+00	3.508	1	1	35
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	8.67e-02	1.00e+00	3.467	1	2	36
GO:0030178	negative regulation of Wnt signaling pathway	8.67e-02	1.00e+00	3.467	1	1	36
GO:0071560	cellular response to transforming growth factor beta stimulus	8.67e-02	1.00e+00	3.467	1	1	36
GO:0016301	kinase activity	8.90e-02	1.00e+00	3.427	1	2	37
GO:0018107	peptidyl-threonine phosphorylation	8.90e-02	1.00e+00	3.427	1	1	37
GO:0032880	regulation of protein localization	8.90e-02	1.00e+00	3.427	1	1	37
GO:0001568	blood vessel development	9.13e-02	1.00e+00	3.389	1	2	38
GO:0050681	androgen receptor binding	9.13e-02	1.00e+00	3.389	1	2	38
GO:0097191	extrinsic apoptotic signaling pathway	9.13e-02	1.00e+00	3.389	1	3	38
GO:0045740	positive regulation of DNA replication	9.13e-02	1.00e+00	3.389	1	1	38
GO:0090382	phagosome maturation	9.13e-02	1.00e+00	3.389	1	1	38
GO:0008047	enzyme activator activity	9.35e-02	1.00e+00	3.351	1	1	39
GO:0032092	positive regulation of protein binding	9.35e-02	1.00e+00	3.351	1	1	39
GO:0042542	response to hydrogen peroxide	9.58e-02	1.00e+00	3.315	1	1	40
GO:0070301	cellular response to hydrogen peroxide	9.81e-02	1.00e+00	3.279	1	1	41
GO:0030521	androgen receptor signaling pathway	9.81e-02	1.00e+00	3.279	1	3	41
GO:0045785	positive regulation of cell adhesion	9.81e-02	1.00e+00	3.279	1	1	41
GO:0042147	retrograde transport, endosome to Golgi	1.00e-01	1.00e+00	3.245	1	1	42
GO:0005902	microvillus	1.00e-01	1.00e+00	3.245	1	1	42
GO:0004715	non-membrane spanning protein tyrosine kinase activity	1.00e-01	1.00e+00	3.245	1	1	42
GO:0005765	lysosomal membrane	1.04e-01	1.00e+00	1.869	2	2	218
GO:0007286	spermatid development	1.05e-01	1.00e+00	3.177	1	1	44
GO:0005080	protein kinase C binding	1.05e-01	1.00e+00	3.177	1	1	44
GO:0034613	cellular protein localization	1.05e-01	1.00e+00	3.177	1	2	44
GO:0044297	cell body	1.09e-01	1.00e+00	3.113	1	1	46
GO:0043525	positive regulation of neuron apoptotic process	1.09e-01	1.00e+00	3.113	1	2	46
GO:0045727	positive regulation of translation	1.09e-01	1.00e+00	3.113	1	1	46
GO:0021762	substantia nigra development	1.09e-01	1.00e+00	3.113	1	2	46
GO:0043406	positive regulation of MAP kinase activity	1.12e-01	1.00e+00	3.082	1	1	47
GO:0008344	adult locomotory behavior	1.12e-01	1.00e+00	3.082	1	2	47
GO:0019221	cytokine-mediated signaling pathway	1.13e-01	1.00e+00	1.791	2	5	230
GO:0006950	response to stress	1.14e-01	1.00e+00	3.052	1	1	48
GO:0019003	GDP binding	1.14e-01	1.00e+00	3.052	1	1	48
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	1.16e-01	1.00e+00	3.022	1	2	49
GO:0005070	SH3/SH2 adaptor activity	1.16e-01	1.00e+00	3.022	1	1	49
GO:0003743	translation initiation factor activity	1.16e-01	1.00e+00	3.022	1	5	49
GO:0005739	mitochondrion	1.20e-01	1.00e+00	0.928	5	10	1046
GO:0090263	positive regulation of canonical Wnt signaling pathway	1.21e-01	1.00e+00	2.964	1	1	51
GO:0030900	forebrain development	1.21e-01	1.00e+00	2.964	1	1	51
GO:0045893	positive regulation of transcription, DNA-templated	1.23e-01	1.00e+00	1.294	3	8	487
GO:0008202	steroid metabolic process	1.23e-01	1.00e+00	2.936	1	1	52
GO:0006952	defense response	1.25e-01	1.00e+00	2.909	1	1	53
GO:0030175	filopodium	1.25e-01	1.00e+00	2.909	1	2	53
GO:0009612	response to mechanical stimulus	1.27e-01	1.00e+00	2.882	1	1	54
GO:0097193	intrinsic apoptotic signaling pathway	1.29e-01	1.00e+00	2.856	1	2	55
GO:0002039	p53 binding	1.29e-01	1.00e+00	2.856	1	1	55
GO:0046330	positive regulation of JNK cascade	1.29e-01	1.00e+00	2.856	1	1	55
GO:0043025	neuronal cell body	1.33e-01	1.00e+00	1.648	2	5	254
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	1.34e-01	1.00e+00	2.804	1	1	57
GO:0006879	cellular iron ion homeostasis	1.34e-01	1.00e+00	2.804	1	2	57
GO:0004842	ubiquitin-protein transferase activity	1.35e-01	1.00e+00	1.637	2	3	256
GO:0005643	nuclear pore	1.38e-01	1.00e+00	2.754	1	1	59
GO:0055085	transmembrane transport	1.38e-01	1.00e+00	1.216	3	3	514
GO:0050728	negative regulation of inflammatory response	1.40e-01	1.00e+00	2.730	1	2	60
GO:0033138	positive regulation of peptidyl-serine phosphorylation	1.42e-01	1.00e+00	2.706	1	1	61
GO:0006281	DNA repair	1.42e-01	1.00e+00	1.592	2	5	264
GO:0048471	perinuclear region of cytoplasm	1.43e-01	1.00e+00	1.191	3	9	523
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.45e-01	1.00e+00	0.973	4	11	811
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	1.45e-01	1.00e+00	2.683	1	1	62
GO:0000151	ubiquitin ligase complex	1.47e-01	1.00e+00	2.660	1	1	63
GO:0005901	caveola	1.47e-01	1.00e+00	2.660	1	1	63
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	1.47e-01	1.00e+00	2.660	1	2	63
GO:0006417	regulation of translation	1.47e-01	1.00e+00	2.660	1	4	63
GO:0007059	chromosome segregation	1.49e-01	1.00e+00	2.637	1	3	64
GO:0032869	cellular response to insulin stimulus	1.49e-01	1.00e+00	2.637	1	2	64
GO:0005975	carbohydrate metabolic process	1.51e-01	1.00e+00	1.539	2	3	274
GO:0016491	oxidoreductase activity	1.51e-01	1.00e+00	2.615	1	1	65
GO:0005882	intermediate filament	1.53e-01	1.00e+00	2.592	1	3	66
GO:0071260	cellular response to mechanical stimulus	1.53e-01	1.00e+00	2.592	1	3	66
GO:0030141	secretory granule	1.55e-01	1.00e+00	2.571	1	2	67
GO:0006665	sphingolipid metabolic process	1.58e-01	1.00e+00	2.549	1	1	68
GO:0035264	multicellular organism growth	1.62e-01	1.00e+00	2.508	1	1	70
GO:0019899	enzyme binding	1.63e-01	1.00e+00	1.467	2	5	288
GO:0042393	histone binding	1.64e-01	1.00e+00	2.487	1	1	71
GO:0001503	ossification	1.64e-01	1.00e+00	2.487	1	2	71
GO:0000785	chromatin	1.68e-01	1.00e+00	2.447	1	2	73
GO:0042826	histone deacetylase binding	1.70e-01	1.00e+00	2.427	1	1	74
GO:0007265	Ras protein signal transduction	1.72e-01	1.00e+00	2.408	1	3	75
GO:0051897	positive regulation of protein kinase B signaling	1.72e-01	1.00e+00	2.408	1	1	75
GO:0006915	apoptotic process	1.72e-01	1.00e+00	1.065	3	9	571
GO:0060070	canonical Wnt signaling pathway	1.72e-01	1.00e+00	2.408	1	2	75
GO:0043234	protein complex	1.74e-01	1.00e+00	1.408	2	9	300
GO:0044325	ion channel binding	1.76e-01	1.00e+00	2.370	1	3	77
GO:0008584	male gonad development	1.76e-01	1.00e+00	2.370	1	1	77
GO:0007229	integrin-mediated signaling pathway	1.79e-01	1.00e+00	2.351	1	2	78
GO:0071013	catalytic step 2 spliceosome	1.81e-01	1.00e+00	2.333	1	1	79
GO:0010629	negative regulation of gene expression	1.83e-01	1.00e+00	2.315	1	2	80
GO:0031902	late endosome membrane	1.83e-01	1.00e+00	2.315	1	1	80
GO:0005814	centriole	1.83e-01	1.00e+00	2.315	1	1	80
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	1.356	2	6	311
GO:0004674	protein serine/threonine kinase activity	1.85e-01	1.00e+00	1.351	2	6	312
GO:0051301	cell division	1.85e-01	1.00e+00	2.297	1	2	81
GO:0045177	apical part of cell	1.87e-01	1.00e+00	2.279	1	1	82
GO:0004713	protein tyrosine kinase activity	1.87e-01	1.00e+00	2.279	1	1	82
GO:0030336	negative regulation of cell migration	1.89e-01	1.00e+00	2.262	1	2	83
GO:0035556	intracellular signal transduction	1.89e-01	1.00e+00	1.329	2	5	317
GO:0005929	cilium	1.91e-01	1.00e+00	2.245	1	2	84
GO:0005179	hormone activity	1.91e-01	1.00e+00	2.245	1	1	84
GO:0019901	protein kinase binding	1.92e-01	1.00e+00	1.315	2	9	320
GO:0007411	axon guidance	1.98e-01	1.00e+00	1.284	2	3	327
GO:0042593	glucose homeostasis	2.01e-01	1.00e+00	2.161	1	1	89
GO:0008283	cell proliferation	2.02e-01	1.00e+00	1.266	2	4	331
GO:0042384	cilium assembly	2.03e-01	1.00e+00	2.145	1	2	90
GO:0043231	intracellular membrane-bounded organelle	2.03e-01	1.00e+00	1.262	2	3	332
GO:0000922	spindle pole	2.05e-01	1.00e+00	2.129	1	5	91
GO:0016337	single organismal cell-cell adhesion	2.07e-01	1.00e+00	2.113	1	2	92
GO:0016363	nuclear matrix	2.07e-01	1.00e+00	2.113	1	4	92
GO:0042470	melanosome	2.07e-01	1.00e+00	2.113	1	2	92
GO:0005770	late endosome	2.11e-01	1.00e+00	2.082	1	1	94
GO:0007010	cytoskeleton organization	2.15e-01	1.00e+00	2.052	1	1	96
GO:0005178	integrin binding	2.17e-01	1.00e+00	2.037	1	1	97
GO:0016568	chromatin modification	2.21e-01	1.00e+00	2.008	1	2	99
GO:0014069	postsynaptic density	2.35e-01	1.00e+00	1.909	1	3	106
GO:0030496	midbody	2.40e-01	1.00e+00	1.869	1	4	109
GO:0070374	positive regulation of ERK1 and ERK2 cascade	2.42e-01	1.00e+00	1.856	1	1	110
GO:0005815	microtubule organizing center	2.42e-01	1.00e+00	1.856	1	4	110
GO:0050900	leukocyte migration	2.44e-01	1.00e+00	1.842	1	1	111
GO:0020037	heme binding	2.44e-01	1.00e+00	1.842	1	1	111
GO:0015630	microtubule cytoskeleton	2.46e-01	1.00e+00	1.830	1	4	112
GO:0005819	spindle	2.50e-01	1.00e+00	1.804	1	4	114
GO:0005802	trans-Golgi network	2.54e-01	1.00e+00	1.779	1	2	116
GO:0005635	nuclear envelope	2.54e-01	1.00e+00	1.779	1	2	116
GO:0032496	response to lipopolysaccharide	2.65e-01	1.00e+00	1.706	1	1	122
GO:0051056	regulation of small GTPase mediated signal transduction	2.67e-01	1.00e+00	1.694	1	3	123
GO:0006511	ubiquitin-dependent protein catabolic process	2.74e-01	1.00e+00	1.648	1	3	127
GO:0030036	actin cytoskeleton organization	2.78e-01	1.00e+00	1.626	1	3	129
GO:0046983	protein dimerization activity	2.82e-01	1.00e+00	1.603	1	3	131
GO:0018108	peptidyl-tyrosine phosphorylation	2.85e-01	1.00e+00	1.582	1	1	133
GO:0016055	Wnt signaling pathway	3.00e-01	1.00e+00	1.497	1	3	141
GO:0005911	cell-cell junction	3.01e-01	1.00e+00	1.487	1	2	142
GO:0008150	biological_process	3.21e-01	1.00e+00	0.795	2	3	459
GO:0007596	blood coagulation	3.26e-01	1.00e+00	0.779	2	5	464
GO:0006974	cellular response to DNA damage stimulus	3.29e-01	1.00e+00	1.333	1	3	158
GO:0046777	protein autophosphorylation	3.29e-01	1.00e+00	1.333	1	1	158
GO:0006468	protein phosphorylation	3.29e-01	1.00e+00	0.770	2	6	467
GO:0008022	protein C-terminus binding	3.34e-01	1.00e+00	1.306	1	4	161
GO:0000398	mRNA splicing, via spliceosome	3.41e-01	1.00e+00	1.271	1	2	165
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	3.46e-01	1.00e+00	1.245	1	4	168
GO:0007420	brain development	3.53e-01	1.00e+00	1.211	1	3	172
GO:0016607	nuclear speck	3.58e-01	1.00e+00	1.186	1	2	175
GO:0004672	protein kinase activity	3.62e-01	1.00e+00	1.161	1	4	178
GO:0031625	ubiquitin protein ligase binding	3.66e-01	1.00e+00	1.145	1	4	180
GO:0006351	transcription, DNA-templated	3.67e-01	1.00e+00	0.329	5	17	1585
GO:0005764	lysosome	3.69e-01	1.00e+00	1.129	1	2	182
GO:0030168	platelet activation	4.05e-01	1.00e+00	0.957	1	4	205
GO:0001701	in utero embryonic development	4.12e-01	1.00e+00	0.923	1	2	210
GO:0044281	small molecule metabolic process	4.12e-01	1.00e+00	0.298	4	16	1295
GO:0004871	signal transducer activity	4.21e-01	1.00e+00	0.882	1	1	216
GO:0007165	signal transduction	4.30e-01	1.00e+00	0.330	3	7	950
GO:0016874	ligase activity	4.33e-01	1.00e+00	0.830	1	2	224
GO:0005524	ATP binding	4.46e-01	1.00e+00	0.234	4	19	1354
GO:0030425	dendrite	4.56e-01	1.00e+00	0.730	1	3	240
GO:0005102	receptor binding	4.93e-01	1.00e+00	0.571	1	2	268
GO:0000166	nucleotide binding	4.98e-01	1.00e+00	0.549	1	2	272
GO:0003779	actin binding	5.02e-01	1.00e+00	0.534	1	3	275
GO:0007283	spermatogenesis	5.03e-01	1.00e+00	0.528	1	2	276
GO:0042493	response to drug	5.18e-01	1.00e+00	0.467	1	2	288
GO:0016567	protein ubiquitination	5.32e-01	1.00e+00	0.413	1	3	299
GO:0005743	mitochondrial inner membrane	5.33e-01	1.00e+00	0.408	1	1	300
GO:0005575	cellular_component	5.59e-01	1.00e+00	0.306	1	2	322
GO:0007275	multicellular organismal development	5.83e-01	1.00e+00	0.211	1	2	344
GO:0005886	plasma membrane	5.84e-01	1.00e+00	-0.024	7	24	2834
GO:0015031	protein transport	5.97e-01	1.00e+00	0.157	1	4	357
GO:0008285	negative regulation of cell proliferation	6.07e-01	1.00e+00	0.117	1	3	367
GO:0007155	cell adhesion	6.24e-01	1.00e+00	0.052	1	3	384
GO:0045892	negative regulation of transcription, DNA-templated	6.61e-01	1.00e+00	-0.091	1	2	424
GO:0006366	transcription from RNA polymerase II promoter	6.61e-01	1.00e+00	-0.094	1	3	425
GO:0055114	oxidation-reduction process	7.07e-01	1.00e+00	-0.273	1	2	481
GO:0042802	identical protein binding	7.15e-01	1.00e+00	-0.303	1	4	491
GO:0046872	metal ion binding	7.25e-01	1.00e+00	-0.295	3	14	1465
GO:0003674	molecular_function	7.38e-01	1.00e+00	-0.397	1	1	524
GO:0006355	regulation of transcription, DNA-templated	7.75e-01	1.00e+00	-0.472	2	10	1104
GO:0005783	endoplasmic reticulum	7.91e-01	1.00e+00	-0.616	1	6	610
GO:0003700	sequence-specific DNA binding transcription factor activity	8.54e-01	1.00e+00	-0.910	1	9	748
GO:0003677	DNA binding	8.64e-01	1.00e+00	-0.763	2	14	1351
GO:0005887	integral component of plasma membrane	9.17e-01	1.00e+00	-1.272	1	2	961
GO:0005615	extracellular space	9.27e-01	1.00e+00	-1.343	1	3	1010
GO:0005576	extracellular region	9.35e-01	1.00e+00	-1.398	1	4	1049
GO:0008270	zinc ion binding	9.38e-01	1.00e+00	-1.422	1	7	1067

Tai-Luciferase

meta-reg-snw-10198

Interacting subnets

Genes (41)

Interactions (101)

Related GO terms (524)