int-snw-9086

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.957	7.60e-17	1.04e-04	1.14e-03

chia-screen-data-Fav-int-snw-9086 subnetwork

Genes (14)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
LARS	51520	14	-2.574	3.157	105	Yes	Yes
EIF2S2	8894	9	-2.999	2.968	81	Yes	Yes
[ EIF1AY ]	9086	1	-1.266	2.957	14	-	-
EIF2B1	1967	1	-2.059	2.957	117	Yes	Yes
TADA2B	93624	11	-3.061	3.082	19	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
EIF2B2	8892	8	-2.462	2.968	95	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
EIF2B3	8891	1	-2.546	2.957	9	Yes	Yes
TPM1	7168	2	-2.686	2.957	44	Yes	Yes
EIF2B4	8890	2	-2.471	2.957	47	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (19)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EIF2B1	1967	EIF1AY	9086	pp	--	int.I2D: IntAct_Worm, MINT_Worm
TPM1	7168	LARS	51520	pp	--	int.I2D: IntAct_Worm
EIF2B1	1967	EIF2S2	8894	pp	--	int.I2D: BioGrid_Yeast, HPRD, IntAct_Yeast, MINT_Yeast, YeastHigh; int.HPRD: in vitro
EIF2B4	8890	EIF2B2	8892	pp	--	int.I2D: BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, Krogan_Core, MINT_Fly, MINT_Yeast, MIPS, YeastHigh, BioGrid_Fly, FlyHigh, HPRD, IntAct_Fly, Tarassov_PCA; int.HPRD: in vitro, in vivo
TPM1	7168	EIF1AY	9086	pp	--	int.I2D: IntAct_Worm
PSMD2	5708	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
EIF2B1	1967	EIF2B3	8891	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid, IntAct
EIF2B2	8892	EIF2S2	8894	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
EIF2B4	8890	EIF2S2	8894	pp	--	int.I2D: BioGrid_Yeast, HPRD, YeastHigh; int.HPRD: in vitro
EIF2B2	8892	TADA2B	93624	pp	--	int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
EIF2B1	1967	EIF2B4	8890	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh
PSMD2	5708	EIF2B2	8892	pp	--	int.I2D: IntAct_Yeast
EIF2B1	1967	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
DDIT3	1649	EIF1AY	9086	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
EIF2B1	1967	EIF2B2	8892	pp	--	int.I2D: BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, MIPS, YeastHigh, HPRD, Tarassov_PCA; int.HPRD: in vitro
EIF2B3	8891	EIF2S2	8894	pp	--	int.I2D: HPRD; int.HPRD: in vitro
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (180)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0051716	cellular response to stimulus	5.55e-13	8.01e-09	10.009	4	4	4
GO:0003743	translation initiation factor activity	3.29e-12	4.75e-08	6.979	6	7	49
GO:0005851	eukaryotic translation initiation factor 2B complex	8.32e-12	1.20e-07	9.424	4	4	6
GO:0006413	translational initiation	1.42e-09	2.04e-05	5.560	6	7	131
GO:0010467	gene expression	1.53e-09	2.21e-05	3.793	9	45	669
GO:0014003	oligodendrocyte development	2.67e-09	3.85e-05	7.687	4	5	20
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	2.91e-09	4.20e-05	9.594	3	3	4
GO:0032057	negative regulation of translational initiation in response to stress	7.27e-09	1.05e-04	9.272	3	3	5
GO:0009408	response to heat	4.98e-08	7.18e-04	6.687	4	6	40
GO:0019509	L-methionine biosynthetic process from methylthioadenosine	6.09e-08	8.79e-04	8.424	3	3	9
GO:0043434	response to peptide hormone	8.09e-08	1.17e-03	6.517	4	5	45
GO:0009749	response to glucose	3.41e-07	4.92e-03	6.009	4	7	64
GO:0005085	guanyl-nucleotide exchange factor activity	5.20e-07	7.50e-03	5.859	4	5	71
GO:0005829	cytosol	8.90e-07	1.28e-02	2.183	11	86	2496
GO:0006412	translation	1.76e-06	2.54e-02	4.485	5	8	230
GO:0044267	cellular protein metabolic process	2.93e-06	4.22e-02	3.705	6	20	474
GO:0006446	regulation of translational initiation	5.10e-06	7.36e-02	6.424	3	4	36
GO:0043547	positive regulation of GTPase activity	2.13e-05	3.07e-01	4.517	4	9	180
GO:0042789	mRNA transcription from RNA polymerase II promoter	6.78e-05	9.78e-01	7.308	2	2	13
GO:0030234	enzyme regulator activity	6.78e-05	9.78e-01	7.308	2	2	13
GO:0008135	translation factor activity, nucleic acid binding	2.39e-04	1.00e+00	6.424	2	3	24
GO:0042552	myelination	5.11e-04	1.00e+00	5.879	2	4	35
GO:0044212	transcription regulatory region DNA binding	5.14e-04	1.00e+00	4.201	3	17	168
GO:0001541	ovarian follicle development	5.72e-04	1.00e+00	5.799	2	2	37
GO:0005515	protein binding	9.66e-04	1.00e+00	1.037	12	198	6024
GO:0003065	positive regulation of heart rate by epinephrine	9.71e-04	1.00e+00	10.009	1	1	1
GO:0060795	cell fate commitment involved in formation of primary germ layer	9.71e-04	1.00e+00	10.009	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	9.71e-04	1.00e+00	10.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	9.71e-04	1.00e+00	10.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	9.71e-04	1.00e+00	10.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	9.71e-04	1.00e+00	10.009	1	1	1
GO:0006429	leucyl-tRNA aminoacylation	1.94e-03	1.00e+00	9.009	1	1	2
GO:0060242	contact inhibition	1.94e-03	1.00e+00	9.009	1	1	2
GO:0002176	male germ cell proliferation	1.94e-03	1.00e+00	9.009	1	1	2
GO:0009786	regulation of asymmetric cell division	1.94e-03	1.00e+00	9.009	1	1	2
GO:0004823	leucine-tRNA ligase activity	1.94e-03	1.00e+00	9.009	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.94e-03	1.00e+00	9.009	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.94e-03	1.00e+00	9.009	1	1	2
GO:0005654	nucleoplasm	2.66e-03	1.00e+00	2.251	5	64	1082
GO:0005850	eukaryotic translation initiation factor 2 complex	2.91e-03	1.00e+00	8.424	1	1	3
GO:0060913	cardiac cell fate determination	2.91e-03	1.00e+00	8.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.91e-03	1.00e+00	8.424	1	1	3
GO:0005862	muscle thin filament tropomyosin	3.88e-03	1.00e+00	8.009	1	1	4
GO:0070461	SAGA-type complex	4.84e-03	1.00e+00	7.687	1	2	5
GO:0001714	endodermal cell fate specification	4.84e-03	1.00e+00	7.687	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	4.84e-03	1.00e+00	7.687	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	4.84e-03	1.00e+00	7.687	1	2	5
GO:0070937	CRD-mediated mRNA stability complex	5.81e-03	1.00e+00	7.424	1	3	6
GO:0032059	bleb	6.78e-03	1.00e+00	7.201	1	1	7
GO:0002161	aminoacyl-tRNA editing activity	6.78e-03	1.00e+00	7.201	1	2	7
GO:0016779	nucleotidyltransferase activity	6.78e-03	1.00e+00	7.201	1	1	7
GO:0001955	blood vessel maturation	7.74e-03	1.00e+00	7.009	1	1	8
GO:0006983	ER overload response	8.70e-03	1.00e+00	6.839	1	1	9
GO:0006450	regulation of translational fidelity	8.70e-03	1.00e+00	6.839	1	2	9
GO:0006974	cellular response to DNA damage stimulus	9.12e-03	1.00e+00	3.770	2	7	151
GO:0035413	positive regulation of catenin import into nucleus	9.67e-03	1.00e+00	6.687	1	2	10
GO:0045662	negative regulation of myoblast differentiation	1.06e-02	1.00e+00	6.549	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	1.06e-02	1.00e+00	6.549	1	4	11
GO:0045947	negative regulation of translational initiation	1.16e-02	1.00e+00	6.424	1	2	12
GO:0005838	proteasome regulatory particle	1.16e-02	1.00e+00	6.424	1	1	12
GO:0035198	miRNA binding	1.16e-02	1.00e+00	6.424	1	1	12
GO:0003714	transcription corepressor activity	1.25e-02	1.00e+00	3.533	2	11	178
GO:0071480	cellular response to gamma radiation	1.26e-02	1.00e+00	6.308	1	1	13
GO:0030914	STAGA complex	1.26e-02	1.00e+00	6.308	1	3	13
GO:0006937	regulation of muscle contraction	1.26e-02	1.00e+00	6.308	1	1	13
GO:0006355	regulation of transcription, DNA-templated	1.30e-02	1.00e+00	2.047	4	43	997
GO:0034614	cellular response to reactive oxygen species	1.35e-02	1.00e+00	6.201	1	2	14
GO:0031369	translation initiation factor binding	1.45e-02	1.00e+00	6.102	1	2	15
GO:0031529	ruffle organization	1.45e-02	1.00e+00	6.102	1	1	15
GO:0001824	blastocyst development	1.45e-02	1.00e+00	6.102	1	2	15
GO:0042176	regulation of protein catabolic process	1.54e-02	1.00e+00	6.009	1	2	16
GO:0001701	in utero embryonic development	1.58e-02	1.00e+00	3.358	2	8	201
GO:0022624	proteasome accessory complex	1.64e-02	1.00e+00	5.921	1	1	17
GO:0032757	positive regulation of interleukin-8 production	1.92e-02	1.00e+00	5.687	1	1	20
GO:0031941	filamentous actin	2.12e-02	1.00e+00	5.549	1	2	22
GO:0036464	cytoplasmic ribonucleoprotein granule	2.12e-02	1.00e+00	5.549	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	2.21e-02	1.00e+00	5.485	1	1	23
GO:0008134	transcription factor binding	2.23e-02	1.00e+00	3.090	2	18	242
GO:0032781	positive regulation of ATPase activity	2.31e-02	1.00e+00	5.424	1	1	24
GO:0055010	ventricular cardiac muscle tissue morphogenesis	2.31e-02	1.00e+00	5.424	1	1	24
GO:0035329	hippo signaling	2.50e-02	1.00e+00	5.308	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	2.50e-02	1.00e+00	5.308	1	1	26
GO:0045214	sarcomere organization	2.50e-02	1.00e+00	5.308	1	2	26
GO:0003677	DNA binding	2.55e-02	1.00e+00	1.758	4	49	1218
GO:0008016	regulation of heart contraction	2.87e-02	1.00e+00	5.102	1	1	30
GO:0042594	response to starvation	2.97e-02	1.00e+00	5.055	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	3.06e-02	1.00e+00	5.009	1	2	32
GO:0030017	sarcomere	3.25e-02	1.00e+00	4.921	1	2	34
GO:0005525	GTP binding	3.53e-02	1.00e+00	2.733	2	12	310
GO:0030049	muscle filament sliding	3.63e-02	1.00e+00	4.761	1	3	38
GO:0051496	positive regulation of stress fiber assembly	3.63e-02	1.00e+00	4.761	1	4	38
GO:0060048	cardiac muscle contraction	3.72e-02	1.00e+00	4.723	1	1	39
GO:0035019	somatic stem cell maintenance	3.82e-02	1.00e+00	4.687	1	6	40
GO:0045785	positive regulation of cell adhesion	3.82e-02	1.00e+00	4.687	1	2	40
GO:0008307	structural constituent of muscle	3.91e-02	1.00e+00	4.651	1	2	41
GO:0006418	tRNA aminoacylation for protein translation	4.00e-02	1.00e+00	4.616	1	3	42
GO:0003723	RNA binding	4.23e-02	1.00e+00	2.591	2	18	342
GO:0043565	sequence-specific DNA binding	4.32e-02	1.00e+00	2.574	2	11	346
GO:0043525	positive regulation of neuron apoptotic process	4.38e-02	1.00e+00	4.485	1	4	46
GO:0019003	GDP binding	4.47e-02	1.00e+00	4.454	1	1	47
GO:0008092	cytoskeletal protein binding	4.47e-02	1.00e+00	4.454	1	1	47
GO:0006521	regulation of cellular amino acid metabolic process	4.75e-02	1.00e+00	4.365	1	1	50
GO:0006986	response to unfolded protein	4.75e-02	1.00e+00	4.365	1	4	50
GO:0005737	cytoplasm	4.77e-02	1.00e+00	0.937	7	124	3767
GO:0034976	response to endoplasmic reticulum stress	4.84e-02	1.00e+00	4.336	1	2	51
GO:0045454	cell redox homeostasis	4.84e-02	1.00e+00	4.336	1	1	51
GO:0009611	response to wounding	4.93e-02	1.00e+00	4.308	1	5	52
GO:0001725	stress fiber	5.21e-02	1.00e+00	4.227	1	4	55
GO:0000502	proteasome complex	5.49e-02	1.00e+00	4.151	1	3	58
GO:0006396	RNA processing	5.58e-02	1.00e+00	4.126	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	5.58e-02	1.00e+00	4.126	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	5.76e-02	1.00e+00	4.078	1	2	61
GO:0006417	regulation of translation	5.86e-02	1.00e+00	4.055	1	2	62
GO:0042060	wound healing	6.04e-02	1.00e+00	4.009	1	2	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.04e-02	1.00e+00	4.009	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.13e-02	1.00e+00	3.986	1	2	65
GO:0010468	regulation of gene expression	6.40e-02	1.00e+00	3.921	1	2	68
GO:0032587	ruffle membrane	6.59e-02	1.00e+00	3.879	1	3	70
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.59e-02	1.00e+00	3.879	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	6.77e-02	1.00e+00	3.839	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	6.95e-02	1.00e+00	3.799	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.95e-02	1.00e+00	3.799	1	2	74
GO:0008584	male gonad development	7.04e-02	1.00e+00	3.780	1	3	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	7.04e-02	1.00e+00	3.780	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.04e-02	1.00e+00	3.780	1	1	75
GO:0071013	catalytic step 2 spliceosome	7.31e-02	1.00e+00	3.723	1	7	78
GO:0030336	negative regulation of cell migration	7.31e-02	1.00e+00	3.723	1	1	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	7.40e-02	1.00e+00	3.705	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	7.40e-02	1.00e+00	3.705	1	2	79
GO:0009653	anatomical structure morphogenesis	7.77e-02	1.00e+00	3.634	1	2	83
GO:0044822	poly(A) RNA binding	7.77e-02	1.00e+00	1.549	3	50	1056
GO:0090090	negative regulation of canonical Wnt signaling pathway	8.04e-02	1.00e+00	3.582	1	8	86
GO:0006936	muscle contraction	8.13e-02	1.00e+00	3.566	1	3	87
GO:0007010	cytoskeleton organization	8.48e-02	1.00e+00	3.501	1	4	91
GO:0006928	cellular component movement	8.48e-02	1.00e+00	3.501	1	3	91
GO:0005200	structural constituent of cytoskeleton	8.48e-02	1.00e+00	3.501	1	6	91
GO:0001649	osteoblast differentiation	8.57e-02	1.00e+00	3.485	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	8.57e-02	1.00e+00	3.485	1	1	92
GO:0005770	late endosome	8.66e-02	1.00e+00	3.470	1	2	93
GO:0007417	central nervous system development	8.93e-02	1.00e+00	3.424	1	5	96
GO:0030529	ribonucleoprotein complex	1.03e-01	1.00e+00	3.201	1	5	112
GO:0000209	protein polyubiquitination	1.07e-01	1.00e+00	3.151	1	3	116
GO:0006325	chromatin organization	1.09e-01	1.00e+00	3.126	1	12	118
GO:0007050	cell cycle arrest	1.14e-01	1.00e+00	3.055	1	5	124
GO:0005524	ATP binding	1.25e-01	1.00e+00	1.252	3	31	1298
GO:0016055	Wnt signaling pathway	1.26e-01	1.00e+00	2.900	1	4	138
GO:0000082	G1/S transition of mitotic cell cycle	1.35e-01	1.00e+00	2.790	1	3	149
GO:0042981	regulation of apoptotic process	1.36e-01	1.00e+00	2.780	1	4	150
GO:0003700	sequence-specific DNA binding transcription factor activity	1.45e-01	1.00e+00	1.560	2	39	699
GO:0000398	mRNA splicing, via spliceosome	1.48e-01	1.00e+00	2.651	1	15	164
GO:0034641	cellular nitrogen compound metabolic process	1.54e-01	1.00e+00	2.591	1	2	171
GO:0005667	transcription factor complex	1.57e-01	1.00e+00	2.558	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.60e-01	1.00e+00	2.533	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.65e-01	1.00e+00	2.485	1	22	184
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.76e-01	1.00e+00	1.385	2	41	789
GO:0016071	mRNA metabolic process	1.96e-01	1.00e+00	2.208	1	8	223
GO:0008380	RNA splicing	2.00e-01	1.00e+00	2.176	1	22	228
GO:0003713	transcription coactivator activity	2.07e-01	1.00e+00	2.120	1	24	237
GO:0016070	RNA metabolic process	2.15e-01	1.00e+00	2.060	1	8	247
GO:0016020	membrane	2.18e-01	1.00e+00	0.879	3	46	1681
GO:0003779	actin binding	2.30e-01	1.00e+00	1.953	1	10	266
GO:0005856	cytoskeleton	2.48e-01	1.00e+00	1.824	1	9	291
GO:0003682	chromatin binding	2.75e-01	1.00e+00	1.656	1	19	327
GO:0008283	cell proliferation	2.75e-01	1.00e+00	1.651	1	14	328
GO:0046982	protein heterodimerization activity	3.12e-01	1.00e+00	1.439	1	8	380
GO:0000278	mitotic cell cycle	3.20e-01	1.00e+00	1.398	1	15	391
GO:0009986	cell surface	3.27e-01	1.00e+00	1.358	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	3.34e-01	1.00e+00	1.319	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	3.38e-01	1.00e+00	1.298	1	30	419
GO:0043066	negative regulation of apoptotic process	3.42e-01	1.00e+00	1.281	1	16	424
GO:0045893	positive regulation of transcription, DNA-templated	3.76e-01	1.00e+00	1.108	1	24	478
GO:0016032	viral process	4.10e-01	1.00e+00	0.948	1	26	534
GO:0006915	apoptotic process	4.23e-01	1.00e+00	0.892	1	12	555
GO:0005634	nucleus	4.69e-01	1.00e+00	0.176	5	159	4559
GO:0008270	zinc ion binding	6.33e-01	1.00e+00	0.047	1	27	997
GO:0044281	small molecule metabolic process	7.07e-01	1.00e+00	-0.233	1	20	1211
GO:0046872	metal ion binding	7.36e-01	1.00e+00	-0.343	1	29	1307
GO:0006351	transcription, DNA-templated	7.72e-01	1.00e+00	-0.489	1	57	1446
GO:0070062	extracellular vesicular exosome	9.22e-01	1.00e+00	-1.220	1	57	2400
GO:0005886	plasma membrane	9.37e-01	1.00e+00	-1.326	1	49	2582

chia-Fav

int-snw-9086

Statistics

Genes (14)

Interactions (19)

Related GO terms (180)