int-snw-79661

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.817	2.60e-15	6.01e-04	3.95e-03

chia-screen-data-Fav-int-snw-79661 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
[ NEIL1 ]	79661	1	-1.226	2.817	3	-	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
APLF	200558	2	-2.206	2.866	10	Yes	-
XRCC1	7515	3	-2.092	3.043	34	Yes	Yes

Interactions (6)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
POU5F1	5460	XRCC1	7515	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
XRCC1	7515	NEIL1	79661	pp	--	int.I2D: BioGrid, BIND, HPRD; int.HPRD: in vitro
XRCC1	7515	APLF	200558	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid

Related GO terms (104)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000012	single strand break repair	4.24e-06	6.11e-02	9.201	2	3	7
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	9.07e-06	1.31e-01	8.687	2	2	10
GO:0006366	transcription from RNA polymerase II promoter	2.29e-05	3.31e-01	4.298	4	30	419
GO:0000737	DNA catabolic process, endonucleolytic	1.19e-04	1.00e+00	6.879	2	2	35
GO:0006284	base-excision repair	1.33e-04	1.00e+00	6.799	2	3	37
GO:0003684	damaged DNA binding	2.35e-04	1.00e+00	6.394	2	2	49
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0032074	negative regulation of nuclease activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0005654	nucleoplasm	9.17e-04	1.00e+00	2.929	4	64	1082
GO:0019046	release from viral latency	9.70e-04	1.00e+00	10.009	1	2	2
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0051106	positive regulation of DNA ligation	1.46e-03	1.00e+00	9.424	1	1	3
GO:0045191	regulation of isotype switching	1.94e-03	1.00e+00	9.009	1	1	4
GO:0019104	DNA N-glycosylase activity	1.94e-03	1.00e+00	9.009	1	1	4
GO:0070461	SAGA-type complex	2.42e-03	1.00e+00	8.687	1	2	5
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0004520	endodeoxyribonuclease activity	2.91e-03	1.00e+00	8.424	1	1	6
GO:0016798	hydrolase activity, acting on glycosyl bonds	3.39e-03	1.00e+00	8.201	1	1	7
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0043254	regulation of protein complex assembly	3.88e-03	1.00e+00	8.009	1	1	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	4.36e-03	1.00e+00	7.839	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	4.36e-03	1.00e+00	7.839	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	4.36e-03	1.00e+00	7.839	1	5	9
GO:0048188	Set1C/COMPASS complex	4.36e-03	1.00e+00	7.839	1	4	9
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0005634	nucleus	5.08e-03	1.00e+00	1.439	6	159	4559
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	6.29e-03	1.00e+00	7.308	1	2	13
GO:0000166	nucleotide binding	6.36e-03	1.00e+00	3.992	2	13	259
GO:0006281	DNA repair	6.45e-03	1.00e+00	3.981	2	14	261
GO:0031011	Ino80 complex	6.78e-03	1.00e+00	7.201	1	6	14
GO:0043981	histone H4-K5 acetylation	7.26e-03	1.00e+00	7.102	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	7.26e-03	1.00e+00	7.102	1	3	15
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0043982	histone H4-K8 acetylation	7.26e-03	1.00e+00	7.102	1	5	15
GO:0008408	3'-5' exonuclease activity	7.74e-03	1.00e+00	7.009	1	1	16
GO:0043274	phospholipase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0035861	site of double-strand break	8.71e-03	1.00e+00	6.839	1	1	18
GO:0043984	histone H4-K16 acetylation	9.19e-03	1.00e+00	6.761	1	5	19
GO:0006355	regulation of transcription, DNA-templated	9.33e-03	1.00e+00	2.632	3	43	997
GO:0000123	histone acetyltransferase complex	1.01e-02	1.00e+00	6.616	1	6	21
GO:0045787	positive regulation of cell cycle	1.06e-02	1.00e+00	6.549	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.06e-02	1.00e+00	6.549	1	4	22
GO:0071339	MLL1 complex	1.30e-02	1.00e+00	6.254	1	6	27
GO:0010033	response to organic substance	1.30e-02	1.00e+00	6.254	1	1	27
GO:0021766	hippocampus development	1.83e-02	1.00e+00	5.761	1	1	38
GO:0035019	somatic stem cell maintenance	1.93e-02	1.00e+00	5.687	1	6	40
GO:0031124	mRNA 3'-end processing	2.02e-02	1.00e+00	5.616	1	2	42
GO:0006369	termination of RNA polymerase II transcription	2.16e-02	1.00e+00	5.517	1	2	45
GO:0005515	protein binding	2.38e-02	1.00e+00	1.037	6	198	6024
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0090305	nucleic acid phosphodiester bond hydrolysis	2.54e-02	1.00e+00	5.281	1	3	53
GO:0006406	mRNA export from nucleus	2.92e-02	1.00e+00	5.078	1	4	61
GO:0006302	double-strand break repair	2.97e-02	1.00e+00	5.055	1	3	62
GO:0006310	DNA recombination	3.11e-02	1.00e+00	4.986	1	7	65
GO:0006289	nucleotide-excision repair	3.25e-02	1.00e+00	4.921	1	5	68
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0005694	chromosome	3.35e-02	1.00e+00	4.879	1	2	70
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0002020	protease binding	3.54e-02	1.00e+00	4.799	1	6	74
GO:0005730	nucleolus	3.62e-02	1.00e+00	1.913	3	66	1641
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0006979	response to oxidative stress	4.15e-02	1.00e+00	4.566	1	6	87
GO:0003700	sequence-specific DNA binding transcription factor activity	4.19e-02	1.00e+00	2.560	2	39	699
GO:0050821	protein stabilization	4.19e-02	1.00e+00	4.549	1	3	88
GO:0005815	microtubule organizing center	5.17e-02	1.00e+00	4.241	1	3	109
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	5.22e-02	1.00e+00	2.385	2	41	789
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	12	118
GO:0010628	positive regulation of gene expression	6.88e-02	1.00e+00	3.819	1	7	146
GO:0001666	response to hypoxia	7.01e-02	1.00e+00	3.790	1	7	149
GO:0006974	cellular response to DNA damage stimulus	7.10e-02	1.00e+00	3.770	1	7	151
GO:0008022	protein C-terminus binding	7.56e-02	1.00e+00	3.678	1	8	161
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	15	164
GO:0044212	transcription regulatory region DNA binding	7.88e-02	1.00e+00	3.616	1	17	168
GO:0016607	nuclear speck	8.06e-02	1.00e+00	3.582	1	12	172
GO:0005737	cytoplasm	8.13e-02	1.00e+00	1.130	4	124	3767
GO:0007049	cell cycle	8.15e-02	1.00e+00	3.566	1	6	174
GO:0005667	transcription factor complex	8.19e-02	1.00e+00	3.558	1	17	175
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0044822	poly(A) RNA binding	8.79e-02	1.00e+00	1.964	2	50	1056
GO:0008380	RNA splicing	1.06e-01	1.00e+00	3.176	1	22	228
GO:0003713	transcription coactivator activity	1.10e-01	1.00e+00	3.120	1	24	237
GO:0008134	transcription factor binding	1.12e-01	1.00e+00	3.090	1	18	242
GO:0043025	neuronal cell body	1.13e-01	1.00e+00	3.072	1	9	245
GO:0003677	DNA binding	1.13e-01	1.00e+00	1.758	2	49	1218
GO:0006954	inflammatory response	1.27e-01	1.00e+00	2.895	1	6	277
GO:0042493	response to drug	1.30e-01	1.00e+00	2.859	1	6	284
GO:0003682	chromatin binding	1.48e-01	1.00e+00	2.656	1	19	327
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	18	342
GO:0043565	sequence-specific DNA binding	1.56e-01	1.00e+00	2.574	1	11	346
GO:0042802	identical protein binding	2.13e-01	1.00e+00	2.090	1	19	484
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	37	570
GO:0010467	gene expression	2.83e-01	1.00e+00	1.623	1	45	669
GO:0005829	cytosol	3.48e-01	1.00e+00	0.723	2	86	2496
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	27	997
GO:0005739	mitochondrion	3.95e-01	1.00e+00	1.046	1	23	998
GO:0046872	metal ion binding	4.86e-01	1.00e+00	0.657	1	29	1307
GO:0016020	membrane	5.80e-01	1.00e+00	0.294	1	46	1681

chia-Fav

int-snw-79661

Statistics

Genes (7)

Interactions (6)

Related GO terms (104)