int-snw-6850

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.067	4.07e-18	2.24e-05	3.84e-04

chia-screen-data-Fav-int-snw-6850 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PXN	5829	19	-2.554	3.193	206	Yes	Yes
MS4A2	2206	2	-2.182	3.067	9	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
MVP	9961	16	-2.846	3.193	20	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
[ SYK ]	6850	2	-1.934	3.067	115	-	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
PXN	5829	SYK	6850	pp	--	int.I2D: BioGrid, BCI, HPRD; int.HPRD: in vitro, in vivo
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	SYK	6850	pp	--	int.I2D: BCI, HPRD; int.HPRD: in vitro
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
MS4A2	2206	SYK	6850	pp	--	int.I2D: BioGrid, HPRD; int.HPRD: in vitro, in vivo
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (205)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0043306	positive regulation of mast cell degranulation	1.24e-05	1.79e-01	8.476	2	2	9
GO:0019901	protein kinase binding	2.64e-05	3.81e-01	4.338	4	18	317
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.69e-05	3.88e-01	7.946	2	2	13
GO:0044212	transcription regulatory region DNA binding	1.24e-04	1.00e+00	4.839	3	17	168
GO:0005654	nucleoplasm	2.30e-04	1.00e+00	2.889	5	64	1082
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0032928	regulation of superoxide anion generation	6.24e-04	1.00e+00	10.646	1	1	1
GO:0042991	transcription factor import into nucleus	6.24e-04	1.00e+00	10.646	1	1	1
GO:0023057	negative regulation of signaling	6.24e-04	1.00e+00	10.646	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0072376	protein activation cascade	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090237	regulation of arachidonic acid secretion	6.24e-04	1.00e+00	10.646	1	1	1
GO:0051435	BH4 domain binding	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0071226	cellular response to molecule of fungal origin	6.24e-04	1.00e+00	10.646	1	1	1
GO:0008283	cell proliferation	8.84e-04	1.00e+00	3.874	3	14	328
GO:0007229	integrin-mediated signaling pathway	1.01e-03	1.00e+00	5.361	2	3	78
GO:0060242	contact inhibition	1.25e-03	1.00e+00	9.646	1	1	2
GO:0032998	Fc-epsilon receptor I complex	1.25e-03	1.00e+00	9.646	1	1	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0045401	positive regulation of interleukin-3 biosynthetic process	1.25e-03	1.00e+00	9.646	1	1	2
GO:0043366	beta selection	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002366	leukocyte activation involved in immune response	1.25e-03	1.00e+00	9.646	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.25e-03	1.00e+00	9.646	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.25e-03	1.00e+00	9.646	1	1	2
GO:0043313	regulation of neutrophil degranulation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005178	integrin binding	1.53e-03	1.00e+00	5.061	2	4	96
GO:0002554	serotonin secretion by platelet	1.87e-03	1.00e+00	9.061	1	1	3
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	1.87e-03	1.00e+00	9.061	1	1	3
GO:0002283	neutrophil activation involved in immune response	1.87e-03	1.00e+00	9.061	1	1	3
GO:0019815	B cell receptor complex	1.87e-03	1.00e+00	9.061	1	1	3
GO:0019767	IgE receptor activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0030529	ribonucleoprotein complex	2.08e-03	1.00e+00	4.839	2	5	112
GO:0038127	ERBB signaling pathway	2.49e-03	1.00e+00	8.646	1	1	4
GO:0010543	regulation of platelet activation	2.49e-03	1.00e+00	8.646	1	1	4
GO:0090330	regulation of platelet aggregation	2.49e-03	1.00e+00	8.646	1	1	4
GO:0032009	early phagosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0018108	peptidyl-tyrosine phosphorylation	2.87e-03	1.00e+00	4.602	2	4	132
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0019863	IgE binding	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.12e-03	1.00e+00	8.324	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.12e-03	1.00e+00	8.324	1	2	5
GO:0045588	positive regulation of gamma-delta T cell differentiation	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006974	cellular response to DNA damage stimulus	3.74e-03	1.00e+00	4.408	2	7	151
GO:0001945	lymph vessel development	3.74e-03	1.00e+00	8.061	1	1	6
GO:0050764	regulation of phagocytosis	3.74e-03	1.00e+00	8.061	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	3.74e-03	1.00e+00	8.061	1	3	6
GO:0002281	macrophage activation involved in immune response	3.74e-03	1.00e+00	8.061	1	1	6
GO:0050663	cytokine secretion	4.36e-03	1.00e+00	7.839	1	1	7
GO:0061099	negative regulation of protein tyrosine kinase activity	4.36e-03	1.00e+00	7.839	1	1	7
GO:0000398	mRNA splicing, via spliceosome	4.39e-03	1.00e+00	4.289	2	15	164
GO:0038095	Fc-epsilon receptor signaling pathway	4.60e-03	1.00e+00	4.254	2	5	168
GO:0001955	blood vessel maturation	4.98e-03	1.00e+00	7.646	1	1	8
GO:0051279	regulation of release of sequestered calcium ion into cytosol	4.98e-03	1.00e+00	7.646	1	1	8
GO:0007172	signal complex assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0060396	growth hormone receptor signaling pathway	4.98e-03	1.00e+00	7.646	1	1	8
GO:0003714	transcription corepressor activity	5.15e-03	1.00e+00	4.170	2	11	178
GO:0005515	protein binding	5.23e-03	1.00e+00	1.090	8	198	6024
GO:0006983	ER overload response	5.60e-03	1.00e+00	7.476	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	5.60e-03	1.00e+00	7.476	1	1	9
GO:0007167	enzyme linked receptor protein signaling pathway	5.60e-03	1.00e+00	7.476	1	1	9
GO:0004716	receptor signaling protein tyrosine kinase activity	5.60e-03	1.00e+00	7.476	1	1	9
GO:0046638	positive regulation of alpha-beta T cell differentiation	5.60e-03	1.00e+00	7.476	1	1	9
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	159	4559
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0046641	positive regulation of alpha-beta T cell proliferation	6.22e-03	1.00e+00	7.324	1	1	10
GO:0045579	positive regulation of B cell differentiation	6.22e-03	1.00e+00	7.324	1	1	10
GO:0010467	gene expression	6.76e-03	1.00e+00	2.845	3	45	669
GO:0045780	positive regulation of bone resorption	6.85e-03	1.00e+00	7.187	1	1	11
GO:0045662	negative regulation of myoblast differentiation	6.85e-03	1.00e+00	7.187	1	3	11
GO:0017166	vinculin binding	6.85e-03	1.00e+00	7.187	1	1	11
GO:0033630	positive regulation of cell adhesion mediated by integrin	6.85e-03	1.00e+00	7.187	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0071480	cellular response to gamma radiation	8.09e-03	1.00e+00	6.946	1	1	13
GO:0042101	T cell receptor complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0019370	leukotriene biosynthetic process	8.09e-03	1.00e+00	6.946	1	1	13
GO:0008380	RNA splicing	8.32e-03	1.00e+00	3.813	2	22	228
GO:0034614	cellular response to reactive oxygen species	8.70e-03	1.00e+00	6.839	1	2	14
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0008134	transcription factor binding	9.34e-03	1.00e+00	3.727	2	18	242
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0070372	regulation of ERK1 and ERK2 cascade	1.06e-02	1.00e+00	6.559	1	2	17
GO:0048514	blood vessel morphogenesis	1.06e-02	1.00e+00	6.559	1	1	17
GO:0050850	positive regulation of calcium-mediated signaling	1.18e-02	1.00e+00	6.398	1	1	19
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	1.24e-02	1.00e+00	6.324	1	3	20
GO:0032757	positive regulation of interleukin-8 production	1.24e-02	1.00e+00	6.324	1	1	20
GO:0005737	cytoplasm	1.25e-02	1.00e+00	1.352	6	124	3767
GO:0048041	focal adhesion assembly	1.30e-02	1.00e+00	6.254	1	1	21
GO:0050715	positive regulation of cytokine secretion	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.43e-02	1.00e+00	6.123	1	1	23
GO:0035329	hippo signaling	1.61e-02	1.00e+00	5.946	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.61e-02	1.00e+00	5.946	1	1	26
GO:0048754	branching morphogenesis of an epithelial tube	1.67e-02	1.00e+00	5.891	1	1	27
GO:0007159	leukocyte cell-cell adhesion	1.67e-02	1.00e+00	5.891	1	1	27
GO:0002250	adaptive immune response	1.73e-02	1.00e+00	5.839	1	1	28
GO:0005875	microtubule associated complex	1.73e-02	1.00e+00	5.839	1	1	28
GO:0030032	lamellipodium assembly	1.80e-02	1.00e+00	5.788	1	1	29
GO:0050853	B cell receptor signaling pathway	1.80e-02	1.00e+00	5.788	1	2	29
GO:0003723	RNA binding	1.81e-02	1.00e+00	3.228	2	18	342
GO:0043565	sequence-specific DNA binding	1.85e-02	1.00e+00	3.212	2	11	346
GO:0042169	SH2 domain binding	1.86e-02	1.00e+00	5.739	1	2	30
GO:0042594	response to starvation	1.92e-02	1.00e+00	5.692	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.98e-02	1.00e+00	5.646	1	2	32
GO:0051219	phosphoprotein binding	1.98e-02	1.00e+00	5.646	1	1	32
GO:0006355	regulation of transcription, DNA-templated	2.02e-02	1.00e+00	2.270	3	43	997
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	2.16e-02	1.00e+00	5.517	1	2	35
GO:0034446	substrate adhesion-dependent cell spreading	2.22e-02	1.00e+00	5.476	1	2	36
GO:0007257	activation of JUN kinase activity	2.22e-02	1.00e+00	5.476	1	5	36
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	50	1056
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0030593	neutrophil chemotaxis	2.53e-02	1.00e+00	5.289	1	2	41
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2.59e-02	1.00e+00	5.254	1	3	42
GO:0031124	mRNA 3'-end processing	2.59e-02	1.00e+00	5.254	1	2	42
GO:0006366	transcription from RNA polymerase II promoter	2.65e-02	1.00e+00	2.935	2	30	419
GO:0006369	termination of RNA polymerase II transcription	2.77e-02	1.00e+00	5.154	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	2.83e-02	1.00e+00	5.123	1	4	46
GO:0006986	response to unfolded protein	3.08e-02	1.00e+00	5.002	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.14e-02	1.00e+00	4.974	1	2	51
GO:0045454	cell redox homeostasis	3.14e-02	1.00e+00	4.974	1	1	51
GO:0051028	mRNA transport	3.20e-02	1.00e+00	4.946	1	4	52
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0001725	stress fiber	3.38e-02	1.00e+00	4.865	1	4	55
GO:0007202	activation of phospholipase C activity	3.38e-02	1.00e+00	4.865	1	1	55
GO:0003677	DNA binding	3.43e-02	1.00e+00	1.981	3	49	1218
GO:0005643	nuclear pore	3.50e-02	1.00e+00	4.813	1	11	57
GO:0006396	RNA processing	3.62e-02	1.00e+00	4.764	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.62e-02	1.00e+00	4.764	1	6	59
GO:0008013	beta-catenin binding	3.68e-02	1.00e+00	4.739	1	9	60
GO:0042742	defense response to bacterium	3.68e-02	1.00e+00	4.739	1	5	60
GO:0006406	mRNA export from nucleus	3.74e-02	1.00e+00	4.715	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.74e-02	1.00e+00	4.715	1	2	61
GO:0019903	protein phosphatase binding	3.80e-02	1.00e+00	4.692	1	2	62
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	3	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	2	74
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	4.59e-02	1.00e+00	4.417	1	2	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	1	75
GO:0071013	catalytic step 2 spliceosome	4.76e-02	1.00e+00	4.361	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.82e-02	1.00e+00	4.342	1	2	79
GO:0004713	protein tyrosine kinase activity	5.00e-02	1.00e+00	4.289	1	3	82
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0045087	innate immune response	5.06e-02	1.00e+00	2.427	2	15	596
GO:0009887	organ morphogenesis	5.24e-02	1.00e+00	4.220	1	5	86
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.24e-02	1.00e+00	4.220	1	8	86
GO:0006936	muscle contraction	5.30e-02	1.00e+00	4.203	1	3	87
GO:0005829	cytosol	5.42e-02	1.00e+00	1.361	4	86	2496
GO:0000187	activation of MAPK activity	5.48e-02	1.00e+00	4.154	1	3	90
GO:0007010	cytoskeleton organization	5.54e-02	1.00e+00	4.138	1	4	91
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	3	91
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	5	92
GO:0005770	late endosome	5.66e-02	1.00e+00	4.107	1	2	93
GO:0008360	regulation of cell shape	6.25e-02	1.00e+00	3.960	1	4	103
GO:0005938	cell cortex	6.31e-02	1.00e+00	3.946	1	5	104
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0007050	cell cycle arrest	7.48e-02	1.00e+00	3.692	1	5	124
GO:0030027	lamellipodium	7.54e-02	1.00e+00	3.680	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	7.71e-02	1.00e+00	3.646	1	11	128
GO:0016055	Wnt signaling pathway	8.29e-02	1.00e+00	3.538	1	4	138
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.33e-02	1.00e+00	2.022	2	41	789
GO:0045121	membrane raft	9.33e-02	1.00e+00	3.361	1	3	156
GO:0046777	protein autophosphorylation	9.44e-02	1.00e+00	3.342	1	4	158
GO:0005768	endosome	1.01e-01	1.00e+00	3.245	1	3	169
GO:0016607	nuclear speck	1.02e-01	1.00e+00	3.220	1	12	172
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0009897	external side of plasma membrane	1.05e-01	1.00e+00	3.179	1	3	177
GO:0004672	protein kinase activity	1.05e-01	1.00e+00	3.179	1	3	177
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.09e-01	1.00e+00	3.123	1	22	184
GO:0007173	epidermal growth factor receptor signaling pathway	1.12e-01	1.00e+00	3.084	1	5	189
GO:0001525	angiogenesis	1.13e-01	1.00e+00	3.069	1	7	191
GO:0030168	platelet activation	1.21e-01	1.00e+00	2.967	1	6	205
GO:0003713	transcription coactivator activity	1.39e-01	1.00e+00	2.757	1	24	237
GO:0000166	nucleotide binding	1.51e-01	1.00e+00	2.629	1	13	259
GO:0006954	inflammatory response	1.60e-01	1.00e+00	2.532	1	6	277
GO:0006955	immune response	1.66e-01	1.00e+00	2.476	1	1	288
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	9	291
GO:0043234	protein complex	1.70e-01	1.00e+00	2.442	1	11	295
GO:0004674	protein serine/threonine kinase activity	1.77e-01	1.00e+00	2.379	1	6	308
GO:0005524	ATP binding	1.91e-01	1.00e+00	1.304	2	31	1298
GO:0015031	protein transport	1.94e-01	1.00e+00	2.233	1	11	341
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	5	369
GO:0005886	plasma membrane	2.08e-01	1.00e+00	0.897	3	49	2582
GO:0046982	protein heterodimerization activity	2.14e-01	1.00e+00	2.076	1	8	380
GO:0009986	cell surface	2.25e-01	1.00e+00	1.995	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.30e-01	1.00e+00	1.956	1	24	413
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	11	455
GO:0006468	protein phosphorylation	2.53e-01	1.00e+00	1.801	1	10	460
GO:0044267	cellular protein metabolic process	2.60e-01	1.00e+00	1.757	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.62e-01	1.00e+00	1.745	1	24	478
GO:0048471	perinuclear region of cytoplasm	2.73e-01	1.00e+00	1.675	1	8	502
GO:0016020	membrane	2.83e-01	1.00e+00	0.931	2	46	1681
GO:0016032	viral process	2.88e-01	1.00e+00	1.585	1	26	534
GO:0005887	integral component of plasma membrane	4.36e-01	1.00e+00	0.852	1	10	888
GO:0007165	signal transduction	4.43e-01	1.00e+00	0.821	1	13	907
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	27	997
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	66	1641
GO:0070062	extracellular vesicular exosome	8.06e-01	1.00e+00	-0.583	1	57	2400

chia-Fav

int-snw-6850

Statistics

Genes (9)

Interactions (9)

Related GO terms (205)