int-snw-663

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.989	3.32e-17	6.78e-05	8.42e-04

chia-screen-data-Fav-int-snw-663 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
NCBP1	4686	6	-2.510	3.149	40	Yes	Yes
CDC42	998	9	-2.199	3.119	265	Yes	Yes
TBC1D10A	83874	8	-2.544	2.989	26	Yes	-
NXF1	10482	10	-2.426	3.538	65	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ BNIP2 ]	663	1	-1.953	2.989	10	-	-

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	NXF1	10482	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association)
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
BNIP2	663	CDC42	998	pp	--	int.I2D: BioGrid, BCI, HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
NCBP1	4686	NXF1	10482	pp	--	int.Mint: MI:0914(association)
HNRNPU	3192	NXF1	10482	pp	--	int.Intact: MI:0914(association)
CDC42	998	TBC1D10A	83874	pp	--	int.I2D: BioGrid_Yeast
BNIP2	663	NCBP1	4686	pp	--	int.I2D: BioGrid

Related GO terms (191)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006406	mRNA export from nucleus	5.94e-06	8.56e-02	6.300	3	4	61
GO:0005654	nucleoplasm	1.21e-05	1.75e-01	3.152	6	64	1082
GO:0010467	gene expression	2.28e-05	3.29e-01	3.582	5	45	669
GO:0036464	cytoplasmic ribonucleoprotein granule	7.94e-05	1.00e+00	7.187	2	2	22
GO:0000398	mRNA splicing, via spliceosome	1.15e-04	1.00e+00	4.874	3	15	164
GO:0051149	positive regulation of muscle cell differentiation	1.21e-04	1.00e+00	6.891	2	4	27
GO:0042692	muscle cell differentiation	1.92e-04	1.00e+00	6.559	2	4	34
GO:0044822	poly(A) RNA binding	2.05e-04	1.00e+00	2.924	5	50	1056
GO:0031124	mRNA 3'-end processing	2.94e-04	1.00e+00	6.254	2	2	42
GO:0008380	RNA splicing	3.05e-04	1.00e+00	4.398	3	22	228
GO:0006369	termination of RNA polymerase II transcription	3.38e-04	1.00e+00	6.154	2	2	45
GO:0005515	protein binding	3.85e-04	1.00e+00	1.260	9	198	6024
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0003723	RNA binding	9.98e-04	1.00e+00	3.813	3	18	342
GO:0071338	positive regulation of hair follicle cell proliferation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060242	contact inhibition	1.25e-03	1.00e+00	9.646	1	1	2
GO:0090135	actin filament branching	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005846	nuclear cap binding complex	1.25e-03	1.00e+00	9.646	1	1	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060661	submandibular salivary gland formation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005829	cytosol	1.39e-03	1.00e+00	1.946	6	86	2496
GO:0006366	transcription from RNA polymerase II promoter	1.79e-03	1.00e+00	3.520	3	30	419
GO:0051683	establishment of Golgi localization	1.87e-03	1.00e+00	9.061	1	1	3
GO:0034191	apolipoprotein A-I receptor binding	1.87e-03	1.00e+00	9.061	1	1	3
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003161	cardiac conduction system development	1.87e-03	1.00e+00	9.061	1	1	3
GO:0030529	ribonucleoprotein complex	2.08e-03	1.00e+00	4.839	2	5	112
GO:0060684	epithelial-mesenchymal cell signaling	2.49e-03	1.00e+00	8.646	1	1	4
GO:0051835	positive regulation of synapse structural plasticity	2.49e-03	1.00e+00	8.646	1	1	4
GO:0048664	neuron fate determination	2.49e-03	1.00e+00	8.646	1	1	4
GO:0072384	organelle transport along microtubule	2.49e-03	1.00e+00	8.646	1	1	4
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0035088	establishment or maintenance of apical/basal cell polarity	3.12e-03	1.00e+00	8.324	1	1	5
GO:0045292	mRNA cis splicing, via spliceosome	3.12e-03	1.00e+00	8.324	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.12e-03	1.00e+00	8.324	1	2	5
GO:0036336	dendritic cell migration	3.12e-03	1.00e+00	8.324	1	1	5
GO:0031442	positive regulation of mRNA 3'-end processing	3.12e-03	1.00e+00	8.324	1	1	5
GO:0031256	leading edge membrane	3.12e-03	1.00e+00	8.324	1	1	5
GO:0060789	hair follicle placode formation	3.74e-03	1.00e+00	8.061	1	2	6
GO:0007097	nuclear migration	3.74e-03	1.00e+00	8.061	1	1	6
GO:0003334	keratinocyte development	3.74e-03	1.00e+00	8.061	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	3.74e-03	1.00e+00	8.061	1	3	6
GO:0048554	positive regulation of metalloenzyme activity	3.74e-03	1.00e+00	8.061	1	1	6
GO:0043497	regulation of protein heterodimerization activity	3.74e-03	1.00e+00	8.061	1	1	6
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	4.36e-03	1.00e+00	7.839	1	2	7
GO:0051489	regulation of filopodium assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0044212	transcription regulatory region DNA binding	4.60e-03	1.00e+00	4.254	2	17	168
GO:0016607	nuclear speck	4.82e-03	1.00e+00	4.220	2	12	172
GO:0097202	activation of cysteine-type endopeptidase activity	4.98e-03	1.00e+00	7.646	1	1	8
GO:0016973	poly(A)+ mRNA export from nucleus	4.98e-03	1.00e+00	7.646	1	1	8
GO:0000339	RNA cap binding	4.98e-03	1.00e+00	7.646	1	1	8
GO:0042405	nuclear inclusion body	5.60e-03	1.00e+00	7.476	1	2	9
GO:0006379	mRNA cleavage	5.60e-03	1.00e+00	7.476	1	1	9
GO:0090136	epithelial cell-cell adhesion	5.60e-03	1.00e+00	7.476	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0031274	positive regulation of pseudopodium assembly	6.22e-03	1.00e+00	7.324	1	2	10
GO:0060047	heart contraction	6.22e-03	1.00e+00	7.324	1	1	10
GO:0005845	mRNA cap binding complex	6.85e-03	1.00e+00	7.187	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0008334	histone mRNA metabolic process	7.47e-03	1.00e+00	7.061	1	1	12
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0071480	cellular response to gamma radiation	8.09e-03	1.00e+00	6.946	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.09e-03	1.00e+00	6.946	1	2	13
GO:0000346	transcription export complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0031333	negative regulation of protein complex assembly	8.70e-03	1.00e+00	6.839	1	1	14
GO:0031996	thioesterase binding	8.70e-03	1.00e+00	6.839	1	1	14
GO:0005487	nucleocytoplasmic transporter activity	8.70e-03	1.00e+00	6.839	1	3	14
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0051233	spindle midzone	9.32e-03	1.00e+00	6.739	1	2	15
GO:0030225	macrophage differentiation	9.32e-03	1.00e+00	6.739	1	2	15
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0042176	regulation of protein catabolic process	9.94e-03	1.00e+00	6.646	1	2	16
GO:0030742	GTP-dependent protein binding	1.06e-02	1.00e+00	6.559	1	1	17
GO:0000166	nucleotide binding	1.06e-02	1.00e+00	3.629	2	13	259
GO:0090316	positive regulation of intracellular protein transport	1.06e-02	1.00e+00	6.559	1	2	17
GO:0007088	regulation of mitosis	1.12e-02	1.00e+00	6.476	1	1	18
GO:0046847	filopodium assembly	1.18e-02	1.00e+00	6.398	1	1	19
GO:0005737	cytoplasm	1.25e-02	1.00e+00	1.352	6	124	3767
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1.30e-02	1.00e+00	6.254	1	1	21
GO:0045862	positive regulation of proteolysis	1.30e-02	1.00e+00	6.254	1	2	21
GO:0031424	keratinization	1.36e-02	1.00e+00	6.187	1	1	22
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1.43e-02	1.00e+00	6.123	1	3	23
GO:0002040	sprouting angiogenesis	1.43e-02	1.00e+00	6.123	1	2	23
GO:0051017	actin filament bundle assembly	1.43e-02	1.00e+00	6.123	1	1	23
GO:0034660	ncRNA metabolic process	1.43e-02	1.00e+00	6.123	1	1	23
GO:0007163	establishment or maintenance of cell polarity	1.49e-02	1.00e+00	6.061	1	2	24
GO:1902017	regulation of cilium assembly	1.49e-02	1.00e+00	6.061	1	2	24
GO:0031047	gene silencing by RNA	1.55e-02	1.00e+00	6.002	1	2	25
GO:0035329	hippo signaling	1.61e-02	1.00e+00	5.946	1	5	26
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	1.61e-02	1.00e+00	5.946	1	3	26
GO:0045859	regulation of protein kinase activity	1.61e-02	1.00e+00	5.946	1	1	26
GO:0032467	positive regulation of cytokinesis	1.67e-02	1.00e+00	5.891	1	2	27
GO:0000387	spliceosomal snRNP assembly	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031069	hair follicle morphogenesis	1.67e-02	1.00e+00	5.891	1	1	27
GO:0072686	mitotic spindle	1.80e-02	1.00e+00	5.788	1	3	29
GO:0006370	7-methylguanosine mRNA capping	1.86e-02	1.00e+00	5.739	1	5	30
GO:0031647	regulation of protein stability	1.86e-02	1.00e+00	5.739	1	4	30
GO:1903507	negative regulation of nucleic acid-templated transcription	1.98e-02	1.00e+00	5.646	1	2	32
GO:0005097	Rab GTPase activator activity	2.10e-02	1.00e+00	5.559	1	1	34
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	2	36
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	2.22e-02	1.00e+00	5.476	1	2	36
GO:0045740	positive regulation of DNA replication	2.22e-02	1.00e+00	5.476	1	1	36
GO:0006446	regulation of translational initiation	2.22e-02	1.00e+00	5.476	1	4	36
GO:0005902	microvillus	2.35e-02	1.00e+00	5.398	1	3	38
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0042147	retrograde transport, endosome to Golgi	2.53e-02	1.00e+00	5.289	1	1	41
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	4	44
GO:0050434	positive regulation of viral transcription	2.71e-02	1.00e+00	5.187	1	5	44
GO:0034613	cellular protein localization	2.71e-02	1.00e+00	5.187	1	2	44
GO:0043525	positive regulation of neuron apoptotic process	2.83e-02	1.00e+00	5.123	1	4	46
GO:0007030	Golgi organization	3.02e-02	1.00e+00	5.031	1	3	49
GO:0030175	filopodium	3.08e-02	1.00e+00	5.002	1	1	50
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0032851	positive regulation of Rab GTPase activity	3.26e-02	1.00e+00	4.918	1	2	53
GO:0046330	positive regulation of JNK cascade	3.38e-02	1.00e+00	4.865	1	2	55
GO:0042802	identical protein binding	3.46e-02	1.00e+00	2.727	2	19	484
GO:0005643	nuclear pore	3.50e-02	1.00e+00	4.813	1	11	57
GO:0033138	positive regulation of peptidyl-serine phosphorylation	3.62e-02	1.00e+00	4.764	1	2	59
GO:0006396	RNA processing	3.62e-02	1.00e+00	4.764	1	5	59
GO:0030141	secretory granule	3.80e-02	1.00e+00	4.692	1	4	62
GO:0031295	T cell costimulation	3.98e-02	1.00e+00	4.624	1	1	65
GO:0006368	transcription elongation from RNA polymerase II promoter	4.11e-02	1.00e+00	4.580	1	6	67
GO:0035264	multicellular organism growth	4.11e-02	1.00e+00	4.580	1	2	67
GO:0016032	viral process	4.14e-02	1.00e+00	2.585	2	26	534
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0005085	guanyl-nucleotide exchange factor activity	4.35e-02	1.00e+00	4.496	1	5	71
GO:0003729	mRNA binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	2	74
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0060070	canonical Wnt signaling pathway	4.59e-02	1.00e+00	4.417	1	4	75
GO:0010629	negative regulation of gene expression	4.70e-02	1.00e+00	4.379	1	4	77
GO:0071013	catalytic step 2 spliceosome	4.76e-02	1.00e+00	4.361	1	7	78
GO:0045177	apical part of cell	4.94e-02	1.00e+00	4.306	1	3	81
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	5	92
GO:0030165	PDZ domain binding	5.72e-02	1.00e+00	4.092	1	1	94
GO:0005096	GTPase activator activity	6.19e-02	1.00e+00	3.974	1	2	102
GO:0030496	midbody	6.54e-02	1.00e+00	3.891	1	2	108
GO:0005815	microtubule organizing center	6.60e-02	1.00e+00	3.878	1	3	109
GO:0005635	nuclear envelope	6.84e-02	1.00e+00	3.826	1	5	113
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	4	114
GO:0051056	regulation of small GTPase mediated signal transduction	6.95e-02	1.00e+00	3.801	1	3	115
GO:0030036	actin cytoskeleton organization	7.42e-02	1.00e+00	3.704	1	3	123
GO:0005911	cell-cell junction	8.18e-02	1.00e+00	3.559	1	2	136
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	7	146
GO:0006974	cellular response to DNA damage stimulus	9.04e-02	1.00e+00	3.408	1	7	151
GO:0043005	neuron projection	9.38e-02	1.00e+00	3.352	1	3	157
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0003714	transcription corepressor activity	1.06e-01	1.00e+00	3.170	1	11	178
GO:0043547	positive regulation of GTPase activity	1.07e-01	1.00e+00	3.154	1	9	180
GO:0006367	transcription initiation from RNA polymerase II promoter	1.09e-01	1.00e+00	3.123	1	22	184
GO:0007173	epidermal growth factor receptor signaling pathway	1.12e-01	1.00e+00	3.084	1	5	189
GO:0003924	GTPase activity	1.16e-01	1.00e+00	3.024	1	7	197
GO:0006355	regulation of transcription, DNA-templated	1.24e-01	1.00e+00	1.685	2	43	997
GO:0006184	GTP catabolic process	1.26e-01	1.00e+00	2.905	1	7	214
GO:0016071	mRNA metabolic process	1.31e-01	1.00e+00	2.845	1	8	223
GO:0003713	transcription coactivator activity	1.39e-01	1.00e+00	2.757	1	24	237
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	18	242
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0016070	RNA metabolic process	1.44e-01	1.00e+00	2.698	1	8	247
GO:0007264	small GTPase mediated signal transduction	1.61e-01	1.00e+00	2.522	1	3	279
GO:0003677	DNA binding	1.73e-01	1.00e+00	1.396	2	49	1218
GO:0005525	GTP binding	1.78e-01	1.00e+00	2.370	1	12	310
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	18	317
GO:0043231	intracellular membrane-bounded organelle	1.82e-01	1.00e+00	2.333	1	6	318
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	5	319
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0043565	sequence-specific DNA binding	1.96e-01	1.00e+00	2.212	1	11	346
GO:0000139	Golgi membrane	2.04e-01	1.00e+00	2.150	1	7	361
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0005886	plasma membrane	2.08e-01	1.00e+00	0.897	3	49	2582
GO:0009986	cell surface	2.25e-01	1.00e+00	1.995	1	9	402
GO:0043066	negative regulation of apoptotic process	2.36e-01	1.00e+00	1.918	1	16	424
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	11	455
GO:0048471	perinuclear region of cytoplasm	2.73e-01	1.00e+00	1.675	1	8	502
GO:0016020	membrane	2.83e-01	1.00e+00	0.931	2	46	1681
GO:0005509	calcium ion binding	2.87e-01	1.00e+00	1.594	1	11	531
GO:0006915	apoptotic process	2.98e-01	1.00e+00	1.530	1	12	555
GO:0005634	nucleus	3.08e-01	1.00e+00	0.492	4	159	4559
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	15	596
GO:0003700	sequence-specific DNA binding transcription factor activity	3.61e-01	1.00e+00	1.197	1	39	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.97e-01	1.00e+00	1.022	1	41	789
GO:0070062	extracellular vesicular exosome	4.56e-01	1.00e+00	0.417	2	57	2400
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	23	998
GO:0005524	ATP binding	5.72e-01	1.00e+00	0.304	1	31	1298
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	66	1641

chia-Fav

int-snw-663

Statistics

Genes (9)

Interactions (9)

Related GO terms (191)