int-snw-54458

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.901	3.17e-16	2.14e-04	1.90e-03

chia-screen-data-Fav-int-snw-54458 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
GPAA1	8733	1	-1.762	2.901	19	-	-
[ PRR13 ]	54458	1	-1.227	2.901	8	-	-
GPI	2821	1	-1.904	2.901	57	-	-
NAP1L4	4676	4	-1.947	3.119	187	-	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
GPAA1	8733	PRR13	54458	pp	--	int.Intact: MI:0915(physical association); int.I2D: MINT, StelzlLow, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
GPI	2821	NAP1L4	4676	pp	--	int.I2D: IntAct_Yeast
DDIT3	1649	NAP1L4	4676	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
GPI	2821	GPAA1	8733	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
GPI	2821	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
DDIT3	1649	GPI	2821	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (145)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.69e-05	3.88e-01	7.946	2	2	13
GO:0044212	transcription regulatory region DNA binding	1.24e-04	1.00e+00	4.839	3	17	168
GO:0005654	nucleoplasm	2.30e-04	1.00e+00	2.889	5	64	1082
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0004347	glucose-6-phosphate isomerase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0016866	intramolecular transferase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0019242	methylglyoxal biosynthetic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060242	contact inhibition	1.25e-03	1.00e+00	9.646	1	1	2
GO:0046185	aldehyde catabolic process	1.25e-03	1.00e+00	9.646	1	1	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.25e-03	1.00e+00	9.646	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006355	regulation of transcription, DNA-templated	2.16e-03	1.00e+00	2.685	4	43	997
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.12e-03	1.00e+00	8.324	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.12e-03	1.00e+00	8.324	1	2	5
GO:0003923	GPI-anchor transamidase activity	3.12e-03	1.00e+00	8.324	1	1	5
GO:0042765	GPI-anchor transamidase complex	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006974	cellular response to DNA damage stimulus	3.74e-03	1.00e+00	4.408	2	7	151
GO:0070937	CRD-mediated mRNA stability complex	3.74e-03	1.00e+00	8.061	1	3	6
GO:0048029	monosaccharide binding	3.74e-03	1.00e+00	8.061	1	1	6
GO:0051156	glucose 6-phosphate metabolic process	4.36e-03	1.00e+00	7.839	1	1	7
GO:0016255	attachment of GPI anchor to protein	4.36e-03	1.00e+00	7.839	1	1	7
GO:0034235	GPI anchor binding	4.36e-03	1.00e+00	7.839	1	1	7
GO:0006621	protein retention in ER lumen	4.98e-03	1.00e+00	7.646	1	1	8
GO:0001955	blood vessel maturation	4.98e-03	1.00e+00	7.646	1	1	8
GO:0003714	transcription corepressor activity	5.15e-03	1.00e+00	4.170	2	11	178
GO:0006983	ER overload response	5.60e-03	1.00e+00	7.476	1	1	9
GO:0007599	hemostasis	5.60e-03	1.00e+00	7.476	1	2	9
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	159	4559
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0010467	gene expression	6.76e-03	1.00e+00	2.845	3	45	669
GO:0045662	negative regulation of myoblast differentiation	6.85e-03	1.00e+00	7.187	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0005838	proteasome regulatory particle	7.47e-03	1.00e+00	7.061	1	1	12
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0071480	cellular response to gamma radiation	8.09e-03	1.00e+00	6.946	1	1	13
GO:0030234	enzyme regulator activity	8.09e-03	1.00e+00	6.946	1	2	13
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0008134	transcription factor binding	9.34e-03	1.00e+00	3.727	2	18	242
GO:0042176	regulation of protein catabolic process	9.94e-03	1.00e+00	6.646	1	2	16
GO:0005829	cytosol	1.05e-02	1.00e+00	1.683	5	86	2496
GO:0022624	proteasome accessory complex	1.06e-02	1.00e+00	6.559	1	1	17
GO:0032757	positive regulation of interleukin-8 production	1.24e-02	1.00e+00	6.324	1	1	20
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	2	22
GO:0016020	membrane	1.43e-02	1.00e+00	1.931	4	46	1681
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.43e-02	1.00e+00	6.123	1	1	23
GO:0035329	hippo signaling	1.61e-02	1.00e+00	5.946	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.61e-02	1.00e+00	5.946	1	1	26
GO:0006501	C-terminal protein lipidation	1.61e-02	1.00e+00	5.946	1	1	26
GO:0015631	tubulin binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:0043565	sequence-specific DNA binding	1.85e-02	1.00e+00	3.212	2	11	346
GO:0042594	response to starvation	1.92e-02	1.00e+00	5.692	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.98e-02	1.00e+00	5.646	1	2	32
GO:0007611	learning or memory	2.10e-02	1.00e+00	5.559	1	1	34
GO:0006096	glycolytic process	2.35e-02	1.00e+00	5.398	1	3	38
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	50	1056
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0006094	gluconeogenesis	2.65e-02	1.00e+00	5.220	1	1	43
GO:0043525	positive regulation of neuron apoptotic process	2.83e-02	1.00e+00	5.123	1	4	46
GO:0006959	humoral immune response	2.90e-02	1.00e+00	5.092	1	3	47
GO:0006521	regulation of cellular amino acid metabolic process	3.08e-02	1.00e+00	5.002	1	1	50
GO:0006986	response to unfolded protein	3.08e-02	1.00e+00	5.002	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.14e-02	1.00e+00	4.974	1	2	51
GO:0045454	cell redox homeostasis	3.14e-02	1.00e+00	4.974	1	1	51
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0005515	protein binding	3.23e-02	1.00e+00	0.897	7	198	6024
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	20	474
GO:0003677	DNA binding	3.43e-02	1.00e+00	1.981	3	49	1218
GO:0000502	proteasome complex	3.56e-02	1.00e+00	4.788	1	3	58
GO:0006396	RNA processing	3.62e-02	1.00e+00	4.764	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.62e-02	1.00e+00	4.764	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.74e-02	1.00e+00	4.715	1	2	61
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	3.86e-02	1.00e+00	4.669	1	4	63
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.92e-02	1.00e+00	4.646	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.98e-02	1.00e+00	4.624	1	2	65
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.29e-02	1.00e+00	4.517	1	2	70
GO:0006334	nucleosome assembly	4.41e-02	1.00e+00	4.476	1	3	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.41e-02	1.00e+00	4.476	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.53e-02	1.00e+00	4.437	1	2	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.59e-02	1.00e+00	4.417	1	1	75
GO:0071013	catalytic step 2 spliceosome	4.76e-02	1.00e+00	4.361	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.82e-02	1.00e+00	4.342	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	4.82e-02	1.00e+00	4.342	1	2	79
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.24e-02	1.00e+00	4.220	1	8	86
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.60e-02	1.00e+00	4.123	1	1	92
GO:0005770	late endosome	5.66e-02	1.00e+00	4.107	1	2	93
GO:0051082	unfolded protein binding	5.66e-02	1.00e+00	4.107	1	7	93
GO:0006461	protein complex assembly	6.72e-02	1.00e+00	3.852	1	4	111
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	5	112
GO:0000209	protein polyubiquitination	7.01e-02	1.00e+00	3.788	1	3	116
GO:0043524	negative regulation of neuron apoptotic process	7.07e-02	1.00e+00	3.776	1	5	117
GO:0006006	glucose metabolic process	7.13e-02	1.00e+00	3.764	1	5	118
GO:0007050	cell cycle arrest	7.48e-02	1.00e+00	3.692	1	5	124
GO:0016055	Wnt signaling pathway	8.29e-02	1.00e+00	3.538	1	4	138
GO:0005125	cytokine activity	8.29e-02	1.00e+00	3.538	1	2	138
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.33e-02	1.00e+00	2.022	2	41	789
GO:0008083	growth factor activity	8.46e-02	1.00e+00	3.507	1	3	141
GO:0000082	G1/S transition of mitotic cell cycle	8.92e-02	1.00e+00	3.427	1	3	149
GO:0042981	regulation of apoptotic process	8.98e-02	1.00e+00	3.417	1	4	150
GO:0043005	neuron projection	9.38e-02	1.00e+00	3.352	1	3	157
GO:0043687	post-translational protein modification	9.67e-02	1.00e+00	3.306	1	5	162
GO:0000398	mRNA splicing, via spliceosome	9.78e-02	1.00e+00	3.289	1	15	164
GO:0034641	cellular nitrogen compound metabolic process	1.02e-01	1.00e+00	3.228	1	2	171
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.09e-01	1.00e+00	3.123	1	22	184
GO:0001525	angiogenesis	1.13e-01	1.00e+00	3.069	1	7	191
GO:0016071	mRNA metabolic process	1.31e-01	1.00e+00	2.845	1	8	223
GO:0008380	RNA splicing	1.34e-01	1.00e+00	2.813	1	22	228
GO:0003713	transcription coactivator activity	1.39e-01	1.00e+00	2.757	1	24	237
GO:0016070	RNA metabolic process	1.44e-01	1.00e+00	2.698	1	8	247
GO:0005975	carbohydrate metabolic process	1.47e-01	1.00e+00	2.663	1	8	253
GO:0044281	small molecule metabolic process	1.71e-01	1.00e+00	1.404	2	20	1211
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	124	3767
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	18	342
GO:0046982	protein heterodimerization activity	2.14e-01	1.00e+00	2.076	1	8	380
GO:0000278	mitotic cell cycle	2.19e-01	1.00e+00	2.035	1	15	391
GO:0009986	cell surface	2.25e-01	1.00e+00	1.995	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.30e-01	1.00e+00	1.956	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	2.33e-01	1.00e+00	1.935	1	30	419
GO:0043066	negative regulation of apoptotic process	2.36e-01	1.00e+00	1.918	1	16	424
GO:0045893	positive regulation of transcription, DNA-templated	2.62e-01	1.00e+00	1.745	1	24	478
GO:0016032	viral process	2.88e-01	1.00e+00	1.585	1	26	534
GO:0006915	apoptotic process	2.98e-01	1.00e+00	1.530	1	12	555
GO:0005789	endoplasmic reticulum membrane	3.04e-01	1.00e+00	1.491	1	9	570
GO:0070062	extracellular vesicular exosome	4.56e-01	1.00e+00	0.417	2	57	2400
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	20	957
GO:0005524	ATP binding	5.72e-01	1.00e+00	0.304	1	31	1298
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	57	1446
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	66	1641
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	49	2582

chia-Fav

int-snw-54458

Statistics

Genes (9)

Interactions (9)

Related GO terms (145)