int-snw-5073

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.938	1.24e-16	1.33e-04	1.36e-03

chia-screen-data-Fav-int-snw-5073 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
RNF40	9810	2	-2.082	2.938	25	Yes	-
NCBP1	4686	6	-2.510	3.149	40	Yes	Yes
NXF1	10482	10	-2.426	3.538	65	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ PARN ]	5073	1	-1.333	2.938	10	-	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	NXF1	10482	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association)
NCBP1	4686	RNF40	9810	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid, HPRD, VidalHuman_core; int.HPRD: yeast 2-hybrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
NCBP1	4686	NXF1	10482	pp	--	int.Mint: MI:0914(association)
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	NXF1	10482	pp	--	int.Intact: MI:0914(association)
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
NCBP1	4686	PARN	5073	pp	--	int.I2D: MINT; int.Mint: MI:0407(direct interaction)

Related GO terms (140)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	4.13e-07	5.96e-03	3.374	7	64	1082
GO:0010467	gene expression	7.26e-07	1.05e-02	3.845	6	45	669
GO:0006406	mRNA export from nucleus	5.94e-06	8.56e-02	6.300	3	4	61
GO:0044822	poly(A) RNA binding	1.05e-05	1.52e-01	3.187	6	50	1056
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.69e-05	3.88e-01	7.946	2	2	13
GO:0000398	mRNA splicing, via spliceosome	1.15e-04	1.00e+00	4.874	3	15	164
GO:0044212	transcription regulatory region DNA binding	1.24e-04	1.00e+00	4.839	3	17	168
GO:0031124	mRNA 3'-end processing	2.94e-04	1.00e+00	6.254	2	2	42
GO:0008380	RNA splicing	3.05e-04	1.00e+00	4.398	3	22	228
GO:0006369	termination of RNA polymerase II transcription	3.38e-04	1.00e+00	6.154	2	2	45
GO:0005515	protein binding	3.85e-04	1.00e+00	1.260	9	198	6024
GO:0000166	nucleotide binding	4.44e-04	1.00e+00	4.214	3	13	259
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0009451	RNA modification	6.24e-04	1.00e+00	10.646	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0003723	RNA binding	9.98e-04	1.00e+00	3.813	3	18	342
GO:0060242	contact inhibition	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005846	nuclear cap binding complex	1.25e-03	1.00e+00	9.646	1	1	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.25e-03	1.00e+00	9.646	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005829	cytosol	1.39e-03	1.00e+00	1.946	6	86	2496
GO:0006366	transcription from RNA polymerase II promoter	1.79e-03	1.00e+00	3.520	3	30	419
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0030529	ribonucleoprotein complex	2.08e-03	1.00e+00	4.839	2	5	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	2.15e-03	1.00e+00	4.813	2	4	114
GO:0033503	HULC complex	2.49e-03	1.00e+00	8.646	1	1	4
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0045292	mRNA cis splicing, via spliceosome	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.12e-03	1.00e+00	8.324	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.12e-03	1.00e+00	8.324	1	2	5
GO:0031442	positive regulation of mRNA 3'-end processing	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006974	cellular response to DNA damage stimulus	3.74e-03	1.00e+00	4.408	2	7	151
GO:0070937	CRD-mediated mRNA stability complex	3.74e-03	1.00e+00	8.061	1	3	6
GO:0016607	nuclear speck	4.82e-03	1.00e+00	4.220	2	12	172
GO:0016973	poly(A)+ mRNA export from nucleus	4.98e-03	1.00e+00	7.646	1	1	8
GO:0001955	blood vessel maturation	4.98e-03	1.00e+00	7.646	1	1	8
GO:0000339	RNA cap binding	4.98e-03	1.00e+00	7.646	1	1	8
GO:0033523	histone H2B ubiquitination	4.98e-03	1.00e+00	7.646	1	1	8
GO:0031625	ubiquitin protein ligase binding	5.15e-03	1.00e+00	4.170	2	5	178
GO:0003714	transcription corepressor activity	5.15e-03	1.00e+00	4.170	2	11	178
GO:0042405	nuclear inclusion body	5.60e-03	1.00e+00	7.476	1	2	9
GO:0006379	mRNA cleavage	5.60e-03	1.00e+00	7.476	1	1	9
GO:0006983	ER overload response	5.60e-03	1.00e+00	7.476	1	1	9
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	159	4559
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0004518	nuclease activity	6.22e-03	1.00e+00	7.324	1	1	10
GO:0005845	mRNA cap binding complex	6.85e-03	1.00e+00	7.187	1	1	11
GO:0004535	poly(A)-specific ribonuclease activity	6.85e-03	1.00e+00	7.187	1	2	11
GO:0045662	negative regulation of myoblast differentiation	6.85e-03	1.00e+00	7.187	1	3	11
GO:0010390	histone monoubiquitination	6.85e-03	1.00e+00	7.187	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0008334	histone mRNA metabolic process	7.47e-03	1.00e+00	7.061	1	1	12
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0016071	mRNA metabolic process	7.98e-03	1.00e+00	3.845	2	8	223
GO:0071480	cellular response to gamma radiation	8.09e-03	1.00e+00	6.946	1	1	13
GO:0000346	transcription export complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0005487	nucleocytoplasmic transporter activity	8.70e-03	1.00e+00	6.839	1	3	14
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0008134	transcription factor binding	9.34e-03	1.00e+00	3.727	2	18	242
GO:0016070	RNA metabolic process	9.71e-03	1.00e+00	3.698	2	8	247
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0007292	female gamete generation	9.94e-03	1.00e+00	6.646	1	1	16
GO:0017075	syntaxin-1 binding	1.18e-02	1.00e+00	6.398	1	1	19
GO:0032757	positive regulation of interleukin-8 production	1.24e-02	1.00e+00	6.324	1	1	20
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.43e-02	1.00e+00	6.123	1	1	23
GO:0034660	ncRNA metabolic process	1.43e-02	1.00e+00	6.123	1	1	23
GO:0031047	gene silencing by RNA	1.55e-02	1.00e+00	6.002	1	2	25
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	1.55e-02	1.00e+00	6.002	1	3	25
GO:0035329	hippo signaling	1.61e-02	1.00e+00	5.946	1	5	26
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	1.61e-02	1.00e+00	5.946	1	2	26
GO:0051209	release of sequestered calcium ion into cytosol	1.61e-02	1.00e+00	5.946	1	1	26
GO:0003730	mRNA 3'-UTR binding	1.61e-02	1.00e+00	5.946	1	2	26
GO:0000387	spliceosomal snRNP assembly	1.67e-02	1.00e+00	5.891	1	2	27
GO:0043565	sequence-specific DNA binding	1.85e-02	1.00e+00	3.212	2	11	346
GO:0006370	7-methylguanosine mRNA capping	1.86e-02	1.00e+00	5.739	1	5	30
GO:0042594	response to starvation	1.92e-02	1.00e+00	5.692	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.98e-02	1.00e+00	5.646	1	2	32
GO:0006355	regulation of transcription, DNA-templated	2.02e-02	1.00e+00	2.270	3	43	997
GO:0006446	regulation of translational initiation	2.22e-02	1.00e+00	5.476	1	4	36
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0050434	positive regulation of viral transcription	2.71e-02	1.00e+00	5.187	1	5	44
GO:0043525	positive regulation of neuron apoptotic process	2.83e-02	1.00e+00	5.123	1	4	46
GO:0006986	response to unfolded protein	3.08e-02	1.00e+00	5.002	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.14e-02	1.00e+00	4.974	1	2	51
GO:0045454	cell redox homeostasis	3.14e-02	1.00e+00	4.974	1	1	51
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0090305	nucleic acid phosphodiester bond hydrolysis	3.26e-02	1.00e+00	4.918	1	3	53
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	3.26e-02	1.00e+00	4.918	1	4	53
GO:0003677	DNA binding	3.43e-02	1.00e+00	1.981	3	49	1218
GO:0005643	nuclear pore	3.50e-02	1.00e+00	4.813	1	11	57
GO:0006396	RNA processing	3.62e-02	1.00e+00	4.764	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.62e-02	1.00e+00	4.764	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.74e-02	1.00e+00	4.715	1	2	61
GO:0000151	ubiquitin ligase complex	3.86e-02	1.00e+00	4.669	1	1	63
GO:0006368	transcription elongation from RNA polymerase II promoter	4.11e-02	1.00e+00	4.580	1	6	67
GO:0016032	viral process	4.14e-02	1.00e+00	2.585	2	26	534
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0003729	mRNA binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	1	75
GO:0071013	catalytic step 2 spliceosome	4.76e-02	1.00e+00	4.361	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.82e-02	1.00e+00	4.342	1	2	79
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.24e-02	1.00e+00	4.220	1	8	86
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	5	92
GO:0005770	late endosome	5.66e-02	1.00e+00	4.107	1	2	93
GO:0005737	cytoplasm	5.81e-02	1.00e+00	1.089	5	124	3767
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0007050	cell cycle arrest	7.48e-02	1.00e+00	3.692	1	5	124
GO:0006511	ubiquitin-dependent protein catabolic process	7.60e-02	1.00e+00	3.669	1	5	126
GO:0016055	Wnt signaling pathway	8.29e-02	1.00e+00	3.538	1	4	138
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	8.33e-02	1.00e+00	2.022	2	41	789
GO:0043005	neuron projection	9.38e-02	1.00e+00	3.352	1	3	157
GO:0005667	transcription factor complex	1.04e-01	1.00e+00	3.195	1	17	175
GO:0032403	protein complex binding	1.09e-01	1.00e+00	3.130	1	6	183
GO:0006367	transcription initiation from RNA polymerase II promoter	1.09e-01	1.00e+00	3.123	1	22	184
GO:0016874	ligase activity	1.26e-01	1.00e+00	2.905	1	4	214
GO:0003713	transcription coactivator activity	1.39e-01	1.00e+00	2.757	1	24	237
GO:0004842	ubiquitin-protein transferase activity	1.48e-01	1.00e+00	2.652	1	5	255
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	18	317
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0046982	protein heterodimerization activity	2.14e-01	1.00e+00	2.076	1	8	380
GO:0009986	cell surface	2.25e-01	1.00e+00	1.995	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.30e-01	1.00e+00	1.956	1	24	413
GO:0044267	cellular protein metabolic process	2.60e-01	1.00e+00	1.757	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.62e-01	1.00e+00	1.745	1	24	478
GO:0005730	nucleolus	2.73e-01	1.00e+00	0.966	2	66	1641
GO:0016020	membrane	2.83e-01	1.00e+00	0.931	2	46	1681
GO:0042803	protein homodimerization activity	3.16e-01	1.00e+00	1.429	1	19	595
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	27	997
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	23	998
GO:0005524	ATP binding	5.72e-01	1.00e+00	0.304	1	31	1298
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	29	1307
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	49	2582

chia-Fav

int-snw-5073

Statistics

Genes (9)

Interactions (9)

Related GO terms (140)