int-snw-4653

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.922	1.88e-16	1.65e-04	1.58e-03

chia-screen-data-Fav-int-snw-4653 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
FTL	2512	2	-2.396	2.922	25	Yes	Yes
PXN	5829	19	-2.554	3.193	206	Yes	Yes
PKLR	5313	1	-2.026	2.922	46	Yes	-
[ MYOC ]	4653	1	-1.812	2.922	38	-	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
MVP	9961	16	-2.846	3.193	20	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
FUBP1	8880	3	-2.414	2.955	23	Yes	Yes

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
MYOC	4653	FUBP1	8880	pp	--	int.I2D: HPRD; int.HPRD: yeast 2-hybrid
MYOC	4653	PKLR	5313	pp	--	int.I2D: HPRD; int.HPRD: yeast 2-hybrid
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
FTL	2512	MYOC	4653	pp	--	int.I2D: HPRD; int.HPRD: yeast 2-hybrid
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
PKLR	5313	PXN	5829	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3	1649	PKLR	5313	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (204)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	4.11e-05	5.92e-01	7.656	2	2	13
GO:0044212	transcription regulatory region DNA binding	2.39e-04	1.00e+00	4.549	3	17	168
GO:0005654	nucleoplasm	7.42e-04	1.00e+00	2.599	5	64	1082
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:0023057	negative regulation of signaling	7.63e-04	1.00e+00	10.357	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	7.63e-04	1.00e+00	10.357	1	1	1
GO:0072376	protein activation cascade	7.63e-04	1.00e+00	10.357	1	1	1
GO:0014734	skeletal muscle hypertrophy	7.63e-04	1.00e+00	10.357	1	1	1
GO:0051435	BH4 domain binding	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0038133	ERBB2-ERBB3 signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0005515	protein binding	1.10e-03	1.00e+00	1.122	10	198	6024
GO:0004743	pyruvate kinase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0008043	intracellular ferritin complex	1.52e-03	1.00e+00	9.357	1	1	2
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.52e-03	1.00e+00	9.357	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.52e-03	1.00e+00	9.357	1	1	2
GO:0001649	osteoblast differentiation	2.13e-03	1.00e+00	4.833	2	5	92
GO:0032027	myosin light chain binding	2.29e-03	1.00e+00	8.772	1	1	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0038127	ERBB signaling pathway	3.05e-03	1.00e+00	8.357	1	1	4
GO:0042866	pyruvate biosynthetic process	3.05e-03	1.00e+00	8.357	1	1	4
GO:0051707	response to other organism	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030529	ribonucleoprotein complex	3.14e-03	1.00e+00	4.549	2	5	112
GO:0006366	transcription from RNA polymerase II promoter	3.38e-03	1.00e+00	3.231	3	30	419
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade	3.81e-03	1.00e+00	8.035	1	1	5
GO:0051901	positive regulation of mitochondrial depolarization	4.57e-03	1.00e+00	7.772	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0030955	potassium ion binding	5.33e-03	1.00e+00	7.549	1	1	7
GO:0061099	negative regulation of protein tyrosine kinase activity	5.33e-03	1.00e+00	7.549	1	1	7
GO:0045162	clustering of voltage-gated sodium channels	5.33e-03	1.00e+00	7.549	1	1	7
GO:0006974	cellular response to DNA damage stimulus	5.63e-03	1.00e+00	4.118	2	7	151
GO:0031325	positive regulation of cellular metabolic process	6.09e-03	1.00e+00	7.357	1	1	8
GO:0001955	blood vessel maturation	6.09e-03	1.00e+00	7.357	1	1	8
GO:0007172	signal complex assembly	6.09e-03	1.00e+00	7.357	1	1	8
GO:0060396	growth hormone receptor signaling pathway	6.09e-03	1.00e+00	7.357	1	1	8
GO:0044822	poly(A) RNA binding	6.21e-03	1.00e+00	2.312	4	50	1056
GO:0000398	mRNA splicing, via spliceosome	6.61e-03	1.00e+00	3.999	2	15	164
GO:0008199	ferric iron binding	6.85e-03	1.00e+00	7.187	1	1	9
GO:0006983	ER overload response	6.85e-03	1.00e+00	7.187	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	6.85e-03	1.00e+00	7.187	1	1	9
GO:0006826	iron ion transport	6.85e-03	1.00e+00	7.187	1	1	9
GO:0051497	negative regulation of stress fiber assembly	6.85e-03	1.00e+00	7.187	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0010226	response to lithium ion	7.60e-03	1.00e+00	7.035	1	2	10
GO:0003714	transcription corepressor activity	7.74e-03	1.00e+00	3.881	2	11	178
GO:0035024	negative regulation of Rho protein signal transduction	8.36e-03	1.00e+00	6.897	1	1	11
GO:0045662	negative regulation of myoblast differentiation	8.36e-03	1.00e+00	6.897	1	3	11
GO:0017166	vinculin binding	8.36e-03	1.00e+00	6.897	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0001953	negative regulation of cell-matrix adhesion	9.12e-03	1.00e+00	6.772	1	2	12
GO:0022011	myelination in peripheral nervous system	9.12e-03	1.00e+00	6.772	1	1	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0034614	cellular response to reactive oxygen species	1.06e-02	1.00e+00	6.549	1	2	14
GO:0043408	regulation of MAPK cascade	1.06e-02	1.00e+00	6.549	1	1	14
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0033268	node of Ranvier	1.21e-02	1.00e+00	6.357	1	2	16
GO:0043274	phospholipase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0033198	response to ATP	1.21e-02	1.00e+00	6.357	1	1	16
GO:0010467	gene expression	1.24e-02	1.00e+00	2.556	3	45	669
GO:0008380	RNA splicing	1.25e-02	1.00e+00	3.524	2	22	228
GO:0051894	positive regulation of focal adhesion assembly	1.36e-02	1.00e+00	6.187	1	1	18
GO:0006754	ATP biosynthetic process	1.36e-02	1.00e+00	6.187	1	2	18
GO:0008134	transcription factor binding	1.40e-02	1.00e+00	3.438	2	18	242
GO:0003700	sequence-specific DNA binding transcription factor activity	1.40e-02	1.00e+00	2.492	3	39	699
GO:0032757	positive regulation of interleukin-8 production	1.52e-02	1.00e+00	6.035	1	1	20
GO:0048041	focal adhesion assembly	1.59e-02	1.00e+00	5.964	1	1	21
GO:0055072	iron ion homeostasis	1.59e-02	1.00e+00	5.964	1	2	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.67e-02	1.00e+00	5.897	1	4	22
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1.74e-02	1.00e+00	5.833	1	3	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.74e-02	1.00e+00	5.833	1	1	23
GO:0001968	fibronectin binding	1.89e-02	1.00e+00	5.713	1	1	25
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.93e-02	1.00e+00	2.318	3	41	789
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.97e-02	1.00e+00	5.656	1	1	26
GO:0048754	branching morphogenesis of an epithelial tube	2.04e-02	1.00e+00	5.602	1	1	27
GO:0005875	microtubule associated complex	2.12e-02	1.00e+00	5.549	1	1	28
GO:0030032	lamellipodium assembly	2.19e-02	1.00e+00	5.499	1	1	29
GO:0019901	protein kinase binding	2.32e-02	1.00e+00	3.048	2	18	317
GO:0005109	frizzled binding	2.34e-02	1.00e+00	5.402	1	1	31
GO:0042594	response to starvation	2.34e-02	1.00e+00	5.402	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0008283	cell proliferation	2.48e-02	1.00e+00	2.999	2	14	328
GO:0060348	bone development	2.49e-02	1.00e+00	5.312	1	2	33
GO:0030971	receptor tyrosine kinase binding	2.49e-02	1.00e+00	5.312	1	2	33
GO:0031018	endocrine pancreas development	2.64e-02	1.00e+00	5.227	1	2	35
GO:0005791	rough endoplasmic reticulum	2.64e-02	1.00e+00	5.227	1	1	35
GO:0003723	RNA binding	2.68e-02	1.00e+00	2.939	2	18	342
GO:0034446	substrate adhesion-dependent cell spreading	2.71e-02	1.00e+00	5.187	1	2	36
GO:0043565	sequence-specific DNA binding	2.74e-02	1.00e+00	2.922	2	11	346
GO:0005829	cytosol	2.85e-02	1.00e+00	1.393	5	86	2496
GO:0006096	glycolytic process	2.86e-02	1.00e+00	5.109	1	3	38
GO:0051496	positive regulation of stress fiber assembly	2.86e-02	1.00e+00	5.109	1	4	38
GO:0005634	nucleus	2.89e-02	1.00e+00	1.010	7	159	4559
GO:0009408	response to heat	3.01e-02	1.00e+00	5.035	1	6	40
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0031124	mRNA 3'-end processing	3.16e-02	1.00e+00	4.964	1	2	42
GO:0006892	post-Golgi vesicle-mediated transport	3.23e-02	1.00e+00	4.930	1	2	43
GO:0051591	response to cAMP	3.38e-02	1.00e+00	4.865	1	4	45
GO:0006369	termination of RNA polymerase II transcription	3.38e-02	1.00e+00	4.865	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	3.45e-02	1.00e+00	4.833	1	4	46
GO:0006355	regulation of transcription, DNA-templated	3.57e-02	1.00e+00	1.980	3	43	997
GO:0006986	response to unfolded protein	3.75e-02	1.00e+00	4.713	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.82e-02	1.00e+00	4.684	1	2	51
GO:0045454	cell redox homeostasis	3.82e-02	1.00e+00	4.684	1	1	51
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	3.82e-02	1.00e+00	4.684	1	2	51
GO:0006879	cellular iron ion homeostasis	3.82e-02	1.00e+00	4.684	1	3	51
GO:0051028	mRNA transport	3.90e-02	1.00e+00	4.656	1	4	52
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0001725	stress fiber	4.12e-02	1.00e+00	4.575	1	4	55
GO:0005758	mitochondrial intermembrane space	4.19e-02	1.00e+00	4.549	1	1	56
GO:0005643	nuclear pore	4.26e-02	1.00e+00	4.524	1	11	57
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.41e-02	1.00e+00	4.474	1	6	59
GO:0008013	beta-catenin binding	4.48e-02	1.00e+00	4.450	1	9	60
GO:0006406	mRNA export from nucleus	4.56e-02	1.00e+00	4.426	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.56e-02	1.00e+00	4.426	1	2	61
GO:0019903	protein phosphatase binding	4.63e-02	1.00e+00	4.402	1	2	62
GO:0032869	cellular response to insulin stimulus	4.70e-02	1.00e+00	4.379	1	1	63
GO:0009749	response to glucose	4.78e-02	1.00e+00	4.357	1	7	64
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	3	68
GO:0003697	single-stranded DNA binding	5.07e-02	1.00e+00	4.269	1	5	68
GO:0051897	positive regulation of protein kinase B signaling	5.21e-02	1.00e+00	4.227	1	2	70
GO:0007584	response to nutrient	5.29e-02	1.00e+00	4.207	1	3	71
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	1	75
GO:0031175	neuron projection development	5.58e-02	1.00e+00	4.128	1	1	75
GO:0005929	cilium	5.72e-02	1.00e+00	4.090	1	2	77
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0007229	integrin-mediated signaling pathway	5.79e-02	1.00e+00	4.071	1	3	78
GO:0030968	endoplasmic reticulum unfolded protein response	5.86e-02	1.00e+00	4.053	1	2	79
GO:0003677	DNA binding	5.93e-02	1.00e+00	1.691	3	49	1218
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	6.37e-02	1.00e+00	3.930	1	8	86
GO:0006936	muscle contraction	6.44e-02	1.00e+00	3.914	1	3	87
GO:0016310	phosphorylation	6.66e-02	1.00e+00	3.865	1	2	90
GO:0000187	activation of MAPK activity	6.66e-02	1.00e+00	3.865	1	3	90
GO:0007010	cytoskeleton organization	6.73e-02	1.00e+00	3.849	1	4	91
GO:0006928	cellular component movement	6.73e-02	1.00e+00	3.849	1	3	91
GO:0005770	late endosome	6.87e-02	1.00e+00	3.817	1	2	93
GO:0006112	energy reserve metabolic process	7.01e-02	1.00e+00	3.787	1	2	95
GO:0005178	integrin binding	7.09e-02	1.00e+00	3.772	1	4	96
GO:0008360	regulation of cell shape	7.58e-02	1.00e+00	3.670	1	4	103
GO:0031410	cytoplasmic vesicle	7.58e-02	1.00e+00	3.670	1	4	103
GO:0005938	cell cortex	7.65e-02	1.00e+00	3.656	1	5	104
GO:0005506	iron ion binding	7.73e-02	1.00e+00	3.642	1	3	105
GO:0016023	cytoplasmic membrane-bounded vesicle	7.73e-02	1.00e+00	3.642	1	8	105
GO:0005741	mitochondrial outer membrane	7.73e-02	1.00e+00	3.642	1	1	105
GO:0006006	glucose metabolic process	8.64e-02	1.00e+00	3.474	1	5	118
GO:0007050	cell cycle arrest	9.06e-02	1.00e+00	3.402	1	5	124
GO:0030027	lamellipodium	9.13e-02	1.00e+00	3.391	1	7	125
GO:0030335	positive regulation of cell migration	9.27e-02	1.00e+00	3.368	1	5	127
GO:0007179	transforming growth factor beta receptor signaling pathway	9.34e-02	1.00e+00	3.357	1	11	128
GO:0070062	extracellular vesicular exosome	9.50e-02	1.00e+00	1.128	4	57	2400
GO:0018108	peptidyl-tyrosine phosphorylation	9.62e-02	1.00e+00	3.312	1	4	132
GO:0016055	Wnt signaling pathway	1.00e-01	1.00e+00	3.248	1	4	138
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	4	145
GO:0010628	positive regulation of gene expression	1.06e-01	1.00e+00	3.167	1	7	146
GO:0001666	response to hypoxia	1.08e-01	1.00e+00	3.137	1	7	149
GO:0031012	extracellular matrix	1.11e-01	1.00e+00	3.090	1	6	154
GO:0005578	proteinaceous extracellular matrix	1.16e-01	1.00e+00	3.035	1	4	160
GO:0000287	magnesium ion binding	1.18e-01	1.00e+00	2.999	1	4	164
GO:0016607	nuclear speck	1.24e-01	1.00e+00	2.930	1	12	172
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	5	178
GO:0016020	membrane	1.28e-01	1.00e+00	1.227	3	46	1681
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0005737	cytoplasm	1.33e-01	1.00e+00	0.799	5	124	3767
GO:0007173	epidermal growth factor receptor signaling pathway	1.35e-01	1.00e+00	2.794	1	5	189
GO:0003713	transcription coactivator activity	1.67e-01	1.00e+00	2.468	1	24	237
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	8	253
GO:0000166	nucleotide binding	1.81e-01	1.00e+00	2.340	1	13	259
GO:0005743	mitochondrial inner membrane	1.92e-01	1.00e+00	2.243	1	6	277
GO:0005856	cytoskeleton	2.01e-01	1.00e+00	2.172	1	9	291
GO:0015031	protein transport	2.31e-01	1.00e+00	1.943	1	11	341
GO:0005925	focal adhesion	2.46e-01	1.00e+00	1.841	1	9	366
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	5	369
GO:0046982	protein heterodimerization activity	2.55e-01	1.00e+00	1.787	1	8	380
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	31	1298
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.74e-01	1.00e+00	1.667	1	24	413
GO:0055085	transmembrane transport	2.86e-01	1.00e+00	1.592	1	8	435
GO:0044267	cellular protein metabolic process	3.08e-01	1.00e+00	1.468	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	3.10e-01	1.00e+00	1.456	1	24	478
GO:0042802	identical protein binding	3.13e-01	1.00e+00	1.438	1	19	484
GO:0048471	perinuclear region of cytoplasm	3.23e-01	1.00e+00	1.385	1	8	502
GO:0005783	endoplasmic reticulum	3.51e-01	1.00e+00	1.238	1	13	556
GO:0005730	nucleolus	3.61e-01	1.00e+00	0.676	2	66	1641
GO:0005794	Golgi apparatus	3.78e-01	1.00e+00	1.104	1	9	610
GO:0007165	signal transduction	5.11e-01	1.00e+00	0.532	1	13	907
GO:0005615	extracellular space	5.30e-01	1.00e+00	0.454	1	20	957
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	27	997
GO:0044281	small molecule metabolic process	6.19e-01	1.00e+00	0.115	1	20	1211
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	49	2582

chia-Fav

int-snw-4653

Statistics

Genes (11)

Interactions (11)

Related GO terms (204)