int-snw-4216

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.976 4.62e-17 8.04e-05 9.51e-04
chia-screen-data-Fav-int-snw-4216 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
[ MAP3K4 ] 4216 2-1.9402.976101--
TPR 7175 18-2.6383.07228YesYes
PRDX6 9588 2-2.3642.97665Yes-
CDC42 998 9-2.1993.119265YesYes
TBC1D10A 83874 8-2.5442.98926Yes-
YAP1 10413 94-4.2563.53853Yes-
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
DDIT3 1649 60-2.8253.504343YesYes

Interactions (8)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
MAP3K4 4216 TPR 7175 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, IntAct, SOURAV_MAPK_HIGH
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
CDC42 998 MAP3K4 4216 pp -- int.I2D: BCI, BioGrid, HPRD, INNATEDB_Mouse;
int.HPRD: in vitro
CDC42 998 TBC1D10A 83874 pp -- int.I2D: BioGrid_Yeast
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
MAP3K4 4216 PRDX6 9588 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
DDIT3 1649 PRDX6 9588 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (256)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0042789mRNA transcription from RNA polymerase II promoter2.69e-053.88e-017.9462213
GO:0090316positive regulation of intracellular protein transport4.68e-056.76e-017.5592217
GO:0036464cytoplasmic ribonucleoprotein granule7.94e-051.00e+007.1872222
GO:0044212transcription regulatory region DNA binding1.24e-041.00e+004.839317168
GO:0072686mitotic spindle1.39e-041.00e+006.7882329
GO:0031647regulation of protein stability1.49e-041.00e+006.7392430
GO:0005654nucleoplasm2.30e-041.00e+002.8895641082
GO:0043525positive regulation of neuron apoptotic process3.53e-041.00e+006.1232446
GO:0005515protein binding3.85e-041.00e+001.26091986024
GO:1901673regulation of spindle assembly involved in mitosis6.24e-041.00e+0010.646111
GO:0043578nuclear matrix organization6.24e-041.00e+0010.646111
GO:2000016negative regulation of determination of dorsal identity6.24e-041.00e+0010.646111
GO:0010965regulation of mitotic sister chromatid separation6.24e-041.00e+0010.646111
GO:0006404RNA import into nucleus6.24e-041.00e+0010.646111
GO:0090308regulation of methylation-dependent chromatin silencing6.24e-041.00e+0010.646111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway6.24e-041.00e+0010.646111
GO:0060965negative regulation of gene silencing by miRNA6.24e-041.00e+0010.646111
GO:0060795cell fate commitment involved in formation of primary germ layer6.24e-041.00e+0010.646111
GO:0031453positive regulation of heterochromatin assembly6.24e-041.00e+0010.646111
GO:0010468regulation of gene expression7.72e-041.00e+005.5592268
GO:0019100male germ-line sex determination1.25e-031.00e+009.646112
GO:0071338positive regulation of hair follicle cell proliferation1.25e-031.00e+009.646112
GO:0060242contact inhibition1.25e-031.00e+009.646112
GO:0031990mRNA export from nucleus in response to heat stress1.25e-031.00e+009.646122
GO:0009786regulation of asymmetric cell division1.25e-031.00e+009.646112
GO:0070840dynein complex binding1.25e-031.00e+009.646112
GO:0060661submandibular salivary gland formation1.25e-031.00e+009.646112
GO:0046832negative regulation of RNA export from nucleus1.25e-031.00e+009.646112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.25e-031.00e+009.646112
GO:0000189MAPK import into nucleus1.25e-031.00e+009.646112
GO:0090135actin filament branching1.25e-031.00e+009.646112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.25e-031.00e+009.646112
GO:0051683establishment of Golgi localization1.87e-031.00e+009.061113
GO:0034191apolipoprotein A-I receptor binding1.87e-031.00e+009.061113
GO:0051920peroxiredoxin activity1.87e-031.00e+009.061113
GO:0042306regulation of protein import into nucleus1.87e-031.00e+009.061123
GO:0060913cardiac cell fate determination1.87e-031.00e+009.061113
GO:0003161cardiac conduction system development1.87e-031.00e+009.061113
GO:0006405RNA export from nucleus1.87e-031.00e+009.061123
GO:0003130BMP signaling pathway involved in heart induction1.87e-031.00e+009.061113
GO:0048664neuron fate determination2.49e-031.00e+008.646114
GO:0060718chorionic trophoblast cell differentiation2.49e-031.00e+008.646114
GO:0060684epithelial-mesenchymal cell signaling2.49e-031.00e+008.646114
GO:0051835positive regulation of synapse structural plasticity2.49e-031.00e+008.646114
GO:0006999nuclear pore organization2.49e-031.00e+008.646114
GO:0072384organelle transport along microtubule2.49e-031.00e+008.646114
GO:0044615nuclear pore nuclear basket2.49e-031.00e+008.646114
GO:0001714endodermal cell fate specification3.12e-031.00e+008.324115
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint3.12e-031.00e+008.324115
GO:0043620regulation of DNA-templated transcription in response to stress3.12e-031.00e+008.324115
GO:0070934CRD-mediated mRNA stabilization3.12e-031.00e+008.324125
GO:0036336dendritic cell migration3.12e-031.00e+008.324115
GO:0035088establishment or maintenance of apical/basal cell polarity3.12e-031.00e+008.324115
GO:0031256leading edge membrane3.12e-031.00e+008.324115
GO:0010793regulation of mRNA export from nucleus3.12e-031.00e+008.324115
GO:0070849response to epidermal growth factor3.12e-031.00e+008.324115
GO:0007097nuclear migration3.74e-031.00e+008.061116
GO:0003334keratinocyte development3.74e-031.00e+008.061116
GO:0006974cellular response to DNA damage stimulus3.74e-031.00e+004.40827151
GO:0070937CRD-mediated mRNA stability complex3.74e-031.00e+008.061136
GO:0060789hair follicle placode formation3.74e-031.00e+008.061126
GO:0048554positive regulation of metalloenzyme activity3.74e-031.00e+008.061116
GO:0043497regulation of protein heterodimerization activity3.74e-031.00e+008.061116
GO:0046825regulation of protein export from nucleus4.36e-031.00e+007.839127
GO:0051988regulation of attachment of spindle microtubules to kinetochore4.36e-031.00e+007.839127
GO:0051489regulation of filopodium assembly4.36e-031.00e+007.839117
GO:0097202activation of cysteine-type endopeptidase activity4.98e-031.00e+007.646118
GO:0051292nuclear pore complex assembly4.98e-031.00e+007.646148
GO:0001955blood vessel maturation4.98e-031.00e+007.646118
GO:0035457cellular response to interferon-alpha4.98e-031.00e+007.646118
GO:1900745positive regulation of p38MAPK cascade4.98e-031.00e+007.646118
GO:0003714transcription corepressor activity5.15e-031.00e+004.170211178
GO:0042405nuclear inclusion body5.60e-031.00e+007.476129
GO:0010225response to UV-C5.60e-031.00e+007.476129
GO:0090136epithelial cell-cell adhesion5.60e-031.00e+007.476119
GO:0006983ER overload response5.60e-031.00e+007.476119
GO:0043495protein anchor5.60e-031.00e+007.476119
GO:0031274positive regulation of pseudopodium assembly6.22e-031.00e+007.3241210
GO:0035413positive regulation of catenin import into nucleus6.22e-031.00e+007.3241210
GO:0060047heart contraction6.22e-031.00e+007.3241110
GO:0009395phospholipid catabolic process6.85e-031.00e+007.1871111
GO:0045662negative regulation of myoblast differentiation6.85e-031.00e+007.1871311
GO:0004623phospholipase A2 activity6.85e-031.00e+007.1871111
GO:0060391positive regulation of SMAD protein import into nucleus6.85e-031.00e+007.1871411
GO:0045947negative regulation of translational initiation7.47e-031.00e+007.0611212
GO:0034399nuclear periphery7.47e-031.00e+007.0611512
GO:0035198miRNA binding7.47e-031.00e+007.0611112
GO:0071480cellular response to gamma radiation8.09e-031.00e+006.9461113
GO:0051019mitogen-activated protein kinase binding8.09e-031.00e+006.9461213
GO:0004602glutathione peroxidase activity8.09e-031.00e+006.9461113
GO:0005868cytoplasmic dynein complex8.09e-031.00e+006.9461113
GO:0046827positive regulation of protein export from nucleus8.09e-031.00e+006.9461113
GO:0031333negative regulation of protein complex assembly8.70e-031.00e+006.8391114
GO:0016209antioxidant activity8.70e-031.00e+006.8391214
GO:0031996thioesterase binding8.70e-031.00e+006.8391114
GO:0005487nucleocytoplasmic transporter activity8.70e-031.00e+006.8391314
GO:0042307positive regulation of protein import into nucleus9.32e-031.00e+006.7391415
GO:0030225macrophage differentiation9.32e-031.00e+006.7391215
GO:0001824blastocyst development9.32e-031.00e+006.7391215
GO:0051233spindle midzone9.32e-031.00e+006.7391215
GO:0008134transcription factor binding9.34e-031.00e+003.727218242
GO:0042176regulation of protein catabolic process9.94e-031.00e+006.6461216
GO:0005829cytosol1.05e-021.00e+001.6835862496
GO:0030742GTP-dependent protein binding1.06e-021.00e+006.5591117
GO:0042744hydrogen peroxide catabolic process1.12e-021.00e+006.4761118
GO:0007088regulation of mitosis1.12e-021.00e+006.4761118
GO:0004709MAP kinase kinase kinase activity1.12e-021.00e+006.4761218
GO:0046847filopodium assembly1.18e-021.00e+006.3981119
GO:0032757positive regulation of interleukin-8 production1.24e-021.00e+006.3241120
GO:0005737cytoplasm1.25e-021.00e+001.35261243767
GO:0031435mitogen-activated protein kinase kinase kinase binding1.30e-021.00e+006.2541121
GO:0045862positive regulation of proteolysis1.30e-021.00e+006.2541221
GO:0031424keratinization1.36e-021.00e+006.1871122
GO:1900026positive regulation of substrate adhesion-dependent cell spreading1.43e-021.00e+006.1231323
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.43e-021.00e+006.1231123
GO:0002040sprouting angiogenesis1.43e-021.00e+006.1231223
GO:0051017actin filament bundle assembly1.43e-021.00e+006.1231123
GO:0007163establishment or maintenance of cell polarity1.49e-021.00e+006.0611224
GO:1902017regulation of cilium assembly1.49e-021.00e+006.0611224
GO:0006611protein export from nucleus1.55e-021.00e+006.0021325
GO:0035329hippo signaling1.61e-021.00e+005.9461526
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity1.61e-021.00e+005.9461326
GO:0051209release of sequestered calcium ion into cytosol1.61e-021.00e+005.9461126
GO:0045859regulation of protein kinase activity1.61e-021.00e+005.9461126
GO:0015631tubulin binding1.67e-021.00e+005.8911227
GO:0051149positive regulation of muscle cell differentiation1.67e-021.00e+005.8911427
GO:0032467positive regulation of cytokinesis1.67e-021.00e+005.8911227
GO:0031069hair follicle morphogenesis1.67e-021.00e+005.8911127
GO:0043507positive regulation of JUN kinase activity1.73e-021.00e+005.8391128
GO:0034605cellular response to heat1.73e-021.00e+005.8391128
GO:0043565sequence-specific DNA binding1.85e-021.00e+003.212211346
GO:0006606protein import into nucleus1.86e-021.00e+005.7391230
GO:0010827regulation of glucose transport1.86e-021.00e+005.7391430
GO:0042594response to starvation1.92e-021.00e+005.6921431
GO:0001890placenta development1.92e-021.00e+005.6921331
GO:0007094mitotic spindle assembly checkpoint1.92e-021.00e+005.6921331
GO:1903507negative regulation of nucleic acid-templated transcription1.98e-021.00e+005.6461232
GO:0006355regulation of transcription, DNA-templated2.02e-021.00e+002.270343997
GO:0031072heat shock protein binding2.04e-021.00e+005.6021233
GO:0005097Rab GTPase activator activity2.10e-021.00e+005.5591134
GO:0042692muscle cell differentiation2.10e-021.00e+005.5591434
GO:0034332adherens junction organization2.22e-021.00e+005.4761236
GO:0007077mitotic nuclear envelope disassembly2.22e-021.00e+005.4761436
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway2.22e-021.00e+005.4761236
GO:0045740positive regulation of DNA replication2.22e-021.00e+005.4761136
GO:0005902microvillus2.35e-021.00e+005.3981338
GO:0044822poly(A) RNA binding2.35e-021.00e+002.1873501056
GO:0008645hexose transport2.41e-021.00e+005.3611439
GO:0035019somatic stem cell maintenance2.47e-021.00e+005.3241640
GO:0042147retrograde transport, endosome to Golgi2.53e-021.00e+005.2891141
GO:0019898extrinsic component of membrane2.59e-021.00e+005.2541242
GO:0021762substantia nigra development2.71e-021.00e+005.1871444
GO:0034613cellular protein localization2.71e-021.00e+005.1871244
GO:0007030Golgi organization3.02e-021.00e+005.0311349
GO:0006986response to unfolded protein3.08e-021.00e+005.0021450
GO:0030175filopodium3.08e-021.00e+005.0021150
GO:0034976response to endoplasmic reticulum stress3.14e-021.00e+004.9741251
GO:0045454cell redox homeostasis3.14e-021.00e+004.9741151
GO:0009611response to wounding3.20e-021.00e+004.9461552
GO:0032851positive regulation of Rab GTPase activity3.26e-021.00e+004.9181253
GO:0000186activation of MAPKK activity3.32e-021.00e+004.8911254
GO:0015758glucose transport3.38e-021.00e+004.8651455
GO:0046330positive regulation of JNK cascade3.38e-021.00e+004.8651255
GO:0003677DNA binding3.43e-021.00e+001.9813491218
GO:0005643nuclear pore3.50e-021.00e+004.81311157
GO:0033138positive regulation of peptidyl-serine phosphorylation3.62e-021.00e+004.7641259
GO:0006396RNA processing3.62e-021.00e+004.7641559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity3.62e-021.00e+004.7641659
GO:0006987activation of signaling protein activity involved in unfolded protein response3.74e-021.00e+004.7151261
GO:0030141secretory granule3.80e-021.00e+004.6921462
GO:0000776kinetochore3.86e-021.00e+004.6691563
GO:0031295T cell costimulation3.98e-021.00e+004.6241165
GO:0035264multicellular organism growth4.11e-021.00e+004.5801267
GO:0005085guanyl-nucleotide exchange factor activity4.35e-021.00e+004.4961571
GO:0000165MAPK cascade4.41e-021.00e+004.4761272
GO:0003729mRNA binding4.41e-021.00e+004.4761472
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity4.53e-021.00e+004.4371474
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171175
GO:0060070canonical Wnt signaling pathway4.59e-021.00e+004.4171475
GO:0010629negative regulation of gene expression4.70e-021.00e+004.3791477
GO:0071013catalytic step 2 spliceosome4.76e-021.00e+004.3611778
GO:0030968endoplasmic reticulum unfolded protein response4.82e-021.00e+004.3421279
GO:0045177apical part of cell4.94e-021.00e+004.3061381
GO:0009653anatomical structure morphogenesis5.06e-021.00e+004.2711283
GO:0090090negative regulation of canonical Wnt signaling pathway5.24e-021.00e+004.2201886
GO:0006979response to oxidative stress5.30e-021.00e+004.2031687
GO:0001649osteoblast differentiation5.60e-021.00e+004.1231592
GO:0005770late endosome5.66e-021.00e+004.1071293
GO:0030165PDZ domain binding5.72e-021.00e+004.0921194
GO:0010467gene expression6.23e-021.00e+002.260245669
GO:0016023cytoplasmic membrane-bounded vesicle6.37e-021.00e+003.93218105
GO:0030496midbody6.54e-021.00e+003.89112108
GO:0005815microtubule organizing center6.60e-021.00e+003.87813109
GO:0003700sequence-specific DNA binding transcription factor activity6.73e-021.00e+002.197239699
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83915112
GO:0005635nuclear envelope6.84e-021.00e+003.82615113
GO:0051056regulation of small GTPase mediated signal transduction6.95e-021.00e+003.80113115
GO:0030036actin cytoskeleton organization7.42e-021.00e+003.70413123
GO:0007050cell cycle arrest7.48e-021.00e+003.69215124
GO:0016020membrane7.75e-021.00e+001.5163461681
GO:0005215transporter activity7.83e-021.00e+003.62413130
GO:0005911cell-cell junction8.18e-021.00e+003.55912136
GO:0016055Wnt signaling pathway8.29e-021.00e+003.53814138
GO:0045944positive regulation of transcription from RNA polymerase II promoter8.33e-021.00e+002.022241789
GO:0010628positive regulation of gene expression8.75e-021.00e+003.45617146
GO:0043005neuron projection9.38e-021.00e+003.35213157
GO:0000398mRNA splicing, via spliceosome9.78e-021.00e+003.289115164
GO:0031965nuclear membrane1.00e-011.00e+003.254110168
GO:0005764lysosome1.02e-011.00e+003.22012172
GO:0005667transcription factor complex1.04e-011.00e+003.195117175
GO:0031625ubiquitin protein ligase binding1.06e-011.00e+003.17015178
GO:0006367transcription initiation from RNA polymerase II promoter1.09e-011.00e+003.123122184
GO:0007173epidermal growth factor receptor signaling pathway1.12e-011.00e+003.08415189
GO:0003924GTPase activity1.16e-011.00e+003.02417197
GO:0005634nucleus1.20e-011.00e+000.81451594559
GO:0006184GTP catabolic process1.26e-011.00e+002.90517214
GO:0019221cytokine-mediated signaling pathway1.30e-011.00e+002.85818221
GO:0007067mitotic nuclear division1.33e-011.00e+002.82016227
GO:0008380RNA splicing1.34e-011.00e+002.813122228
GO:0003713transcription coactivator activity1.39e-011.00e+002.757124237
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0005975carbohydrate metabolic process1.47e-011.00e+002.66318253
GO:0007264small GTPase mediated signal transduction1.61e-011.00e+002.52213279
GO:0035556intracellular signal transduction1.74e-011.00e+002.40319303
GO:0070062extracellular vesicular exosome1.78e-011.00e+001.0023572400
GO:0005525GTP binding1.78e-011.00e+002.370112310
GO:0019901protein kinase binding1.81e-011.00e+002.338118317
GO:0007411axon guidance1.82e-011.00e+002.32915319
GO:0008283cell proliferation1.87e-011.00e+002.289114328
GO:0003682chromatin binding1.87e-011.00e+002.293119327
GO:0005524ATP binding1.91e-011.00e+001.3042311298
GO:0003723RNA binding1.94e-011.00e+002.228118342
GO:0000139Golgi membrane2.04e-011.00e+002.15017361
GO:0005925focal adhesion2.07e-011.00e+002.13019366
GO:0046982protein heterodimerization activity2.14e-011.00e+002.07618380
GO:0000278mitotic cell cycle2.19e-011.00e+002.035115391
GO:0009986cell surface2.25e-011.00e+001.99519402
GO:0045892negative regulation of transcription, DNA-templated2.30e-011.00e+001.956124413
GO:0006366transcription from RNA polymerase II promoter2.33e-011.00e+001.935130419
GO:0055114oxidation-reduction process2.34e-011.00e+001.932110420
GO:0055085transmembrane transport2.41e-011.00e+001.88118435
GO:0007596blood coagulation2.51e-011.00e+001.816111455
GO:0006468protein phosphorylation2.53e-011.00e+001.801110460
GO:0044267cellular protein metabolic process2.60e-011.00e+001.757120474
GO:0045893positive regulation of transcription, DNA-templated2.62e-011.00e+001.745124478
GO:0042802identical protein binding2.65e-011.00e+001.727119484
GO:0048471perinuclear region of cytoplasm2.73e-011.00e+001.67518502
GO:0016032viral process2.88e-011.00e+001.585126534
GO:0000122negative regulation of transcription from RNA polymerase II promoter3.04e-011.00e+001.491137570
GO:0042803protein homodimerization activity3.16e-011.00e+001.429119595
GO:0045087innate immune response3.16e-011.00e+001.427115596
GO:0005615extracellular space4.61e-011.00e+000.744120957
GO:0005886plasma membrane4.98e-011.00e+000.3122492582
GO:0044281small molecule metabolic process5.46e-011.00e+000.4041201211
GO:0046872metal ion binding5.75e-011.00e+000.2941291307