int-snw-4076

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.014	1.69e-17	4.76e-05	6.56e-04

chia-screen-data-Fav-int-snw-4076 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PXN	5829	19	-2.554	3.193	206	Yes	Yes
[ CAPRIN1 ]	4076	1	-1.934	3.014	27	-	-
NXF1	10482	10	-2.426	3.538	65	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
MVP	9961	16	-2.846	3.193	20	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
ULK2	9706	9	-2.292	3.197	312	Yes	Yes

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	NXF1	10482	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association)
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
HNRNPU	3192	NXF1	10482	pp	--	int.Intact: MI:0914(association)
SRSF3	6428	ULK2	9706	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
CAPRIN1	4076	ULK2	9706	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
CAPRIN1	4076	NXF1	10482	pp	--	int.Intact: MI:0914(association)
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
HNRNPU	3192	ULK2	9706	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
CAPRIN1	4076	PXN	5829	pp	--	int.I2D: BIND
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3	1649	CAPRIN1	4076	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (156)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	2.84e-05	4.09e-01	3.000	6	64	1082
GO:0042789	mRNA transcription from RNA polymerase II promoter	3.36e-05	4.85e-01	7.794	2	2	13
GO:0044212	transcription regulatory region DNA binding	1.75e-04	1.00e+00	4.687	3	17	168
GO:0042594	response to starvation	1.99e-04	1.00e+00	6.540	2	4	31
GO:0044822	poly(A) RNA binding	3.85e-04	1.00e+00	2.772	5	50	1056
GO:0005643	nuclear pore	6.77e-04	1.00e+00	5.661	2	11	57
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:0023057	negative regulation of signaling	6.93e-04	1.00e+00	10.494	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0072376	protein activation cascade	6.93e-04	1.00e+00	10.494	1	1	1
GO:0051435	BH4 domain binding	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0010467	gene expression	7.70e-04	1.00e+00	3.108	4	45	669
GO:0006406	mRNA export from nucleus	7.75e-04	1.00e+00	5.563	2	4	61
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.39e-03	1.00e+00	9.494	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.39e-03	1.00e+00	9.494	1	1	2
GO:0003723	RNA binding	1.40e-03	1.00e+00	3.661	3	18	342
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	198	6024
GO:0030529	ribonucleoprotein complex	2.58e-03	1.00e+00	4.687	2	5	112
GO:0038127	ERBB signaling pathway	2.77e-03	1.00e+00	8.494	1	1	4
GO:0034273	ATG1/UKL1 signaling complex	2.77e-03	1.00e+00	8.494	1	1	4
GO:0005829	cytosol	2.97e-03	1.00e+00	1.794	6	86	2496
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.46e-03	1.00e+00	8.172	1	2	5
GO:0048671	negative regulation of collateral sprouting	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	4.15e-03	1.00e+00	7.909	1	3	6
GO:0006974	cellular response to DNA damage stimulus	4.64e-03	1.00e+00	4.256	2	7	151
GO:0061099	negative regulation of protein tyrosine kinase activity	4.84e-03	1.00e+00	7.687	1	1	7
GO:0000398	mRNA splicing, via spliceosome	5.45e-03	1.00e+00	4.137	2	15	164
GO:0016973	poly(A)+ mRNA export from nucleus	5.53e-03	1.00e+00	7.494	1	1	8
GO:0001955	blood vessel maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0007172	signal complex assembly	5.53e-03	1.00e+00	7.494	1	1	8
GO:0060396	growth hormone receptor signaling pathway	5.53e-03	1.00e+00	7.494	1	1	8
GO:0061003	positive regulation of dendritic spine morphogenesis	5.53e-03	1.00e+00	7.494	1	1	8
GO:0016607	nuclear speck	5.97e-03	1.00e+00	4.068	2	12	172
GO:0042405	nuclear inclusion body	6.22e-03	1.00e+00	7.324	1	2	9
GO:0006983	ER overload response	6.22e-03	1.00e+00	7.324	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	6.22e-03	1.00e+00	7.324	1	1	9
GO:0003714	transcription corepressor activity	6.39e-03	1.00e+00	4.018	2	11	178
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0045662	negative regulation of myoblast differentiation	7.60e-03	1.00e+00	7.035	1	3	11
GO:0017166	vinculin binding	7.60e-03	1.00e+00	7.035	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0034045	pre-autophagosomal structure membrane	8.29e-03	1.00e+00	6.909	1	2	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0000346	transcription export complex	8.98e-03	1.00e+00	6.794	1	1	13
GO:0034614	cellular response to reactive oxygen species	9.67e-03	1.00e+00	6.687	1	2	14
GO:0005487	nucleocytoplasmic transporter activity	9.67e-03	1.00e+00	6.687	1	3	14
GO:0008380	RNA splicing	1.03e-02	1.00e+00	3.661	2	22	228
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0050775	positive regulation of dendrite morphogenesis	1.04e-02	1.00e+00	6.587	1	1	15
GO:0043274	phospholipase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0008134	transcription factor binding	1.15e-02	1.00e+00	3.575	2	18	242
GO:0000166	nucleotide binding	1.31e-02	1.00e+00	3.477	2	13	259
GO:0032757	positive regulation of interleukin-8 production	1.38e-02	1.00e+00	6.172	1	1	20
GO:0048041	focal adhesion assembly	1.45e-02	1.00e+00	6.102	1	1	21
GO:0048675	axon extension	1.45e-02	1.00e+00	6.102	1	2	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	2	22
GO:0010506	regulation of autophagy	1.58e-02	1.00e+00	5.971	1	2	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.58e-02	1.00e+00	5.971	1	1	23
GO:0035329	hippo signaling	1.79e-02	1.00e+00	5.794	1	5	26
GO:0000045	autophagic vacuole assembly	1.79e-02	1.00e+00	5.794	1	2	26
GO:0051209	release of sequestered calcium ion into cytosol	1.79e-02	1.00e+00	5.794	1	1	26
GO:0048754	branching morphogenesis of an epithelial tube	1.86e-02	1.00e+00	5.739	1	1	27
GO:0019901	protein kinase binding	1.93e-02	1.00e+00	3.186	2	18	317
GO:0005875	microtubule associated complex	1.93e-02	1.00e+00	5.687	1	1	28
GO:0030032	lamellipodium assembly	1.99e-02	1.00e+00	5.636	1	1	29
GO:0008283	cell proliferation	2.06e-02	1.00e+00	3.137	2	14	328
GO:0010494	cytoplasmic stress granule	2.06e-02	1.00e+00	5.587	1	2	30
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0005737	cytoplasm	2.44e-02	1.00e+00	1.200	6	124	3767
GO:0034446	substrate adhesion-dependent cell spreading	2.47e-02	1.00e+00	5.324	1	2	36
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0017148	negative regulation of translation	2.74e-02	1.00e+00	5.172	1	2	40
GO:0006355	regulation of transcription, DNA-templated	2.74e-02	1.00e+00	2.118	3	43	997
GO:0031124	mRNA 3'-end processing	2.88e-02	1.00e+00	5.102	1	2	42
GO:0006369	termination of RNA polymerase II transcription	3.08e-02	1.00e+00	5.002	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	4	46
GO:0006366	transcription from RNA polymerase II promoter	3.25e-02	1.00e+00	2.783	2	30	419
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.48e-02	1.00e+00	4.822	1	2	51
GO:0045454	cell redox homeostasis	3.48e-02	1.00e+00	4.822	1	1	51
GO:0051028	mRNA transport	3.55e-02	1.00e+00	4.794	1	4	52
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0000932	cytoplasmic mRNA processing body	3.68e-02	1.00e+00	4.739	1	4	54
GO:0001725	stress fiber	3.75e-02	1.00e+00	4.713	1	4	55
GO:0006396	RNA processing	4.02e-02	1.00e+00	4.612	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.02e-02	1.00e+00	4.612	1	6	59
GO:0008013	beta-catenin binding	4.08e-02	1.00e+00	4.587	1	9	60
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.15e-02	1.00e+00	4.563	1	2	61
GO:0019903	protein phosphatase binding	4.22e-02	1.00e+00	4.540	1	2	62
GO:0003677	DNA binding	4.60e-02	1.00e+00	1.829	3	49	1218
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0034329	cell junction assembly	4.62e-02	1.00e+00	4.407	1	3	68
GO:0003729	mRNA binding	4.88e-02	1.00e+00	4.324	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0007229	integrin-mediated signaling pathway	5.28e-02	1.00e+00	4.209	1	3	78
GO:0030968	endoplasmic reticulum unfolded protein response	5.35e-02	1.00e+00	4.190	1	2	79
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.81e-02	1.00e+00	4.068	1	8	86
GO:0006936	muscle contraction	5.87e-02	1.00e+00	4.051	1	3	87
GO:0005634	nucleus	6.02e-02	1.00e+00	0.925	6	159	4559
GO:0000187	activation of MAPK activity	6.07e-02	1.00e+00	4.002	1	3	90
GO:0007010	cytoskeleton organization	6.14e-02	1.00e+00	3.986	1	4	91
GO:0006928	cellular component movement	6.14e-02	1.00e+00	3.986	1	3	91
GO:0001649	osteoblast differentiation	6.20e-02	1.00e+00	3.971	1	5	92
GO:0005770	late endosome	6.27e-02	1.00e+00	3.955	1	2	93
GO:0005178	integrin binding	6.46e-02	1.00e+00	3.909	1	4	96
GO:0030659	cytoplasmic vesicle membrane	6.79e-02	1.00e+00	3.836	1	2	101
GO:0008360	regulation of cell shape	6.92e-02	1.00e+00	3.808	1	4	103
GO:0005938	cell cortex	6.98e-02	1.00e+00	3.794	1	5	104
GO:0003700	sequence-specific DNA binding transcription factor activity	8.15e-02	1.00e+00	2.045	2	39	699
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0030027	lamellipodium	8.34e-02	1.00e+00	3.528	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	8.53e-02	1.00e+00	3.494	1	11	128
GO:0018108	peptidyl-tyrosine phosphorylation	8.79e-02	1.00e+00	3.450	1	4	132
GO:0016055	Wnt signaling pathway	9.17e-02	1.00e+00	3.386	1	4	138
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.00e-01	1.00e+00	1.870	2	41	789
GO:0016020	membrane	1.01e-01	1.00e+00	1.364	3	46	1681
GO:0046777	protein autophosphorylation	1.04e-01	1.00e+00	3.190	1	4	158
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.21e-01	1.00e+00	2.971	1	22	184
GO:0007173	epidermal growth factor receptor signaling pathway	1.24e-01	1.00e+00	2.932	1	5	189
GO:0007165	signal transduction	1.27e-01	1.00e+00	1.669	2	13	907
GO:0030425	dendrite	1.49e-01	1.00e+00	2.649	1	6	230
GO:0003713	transcription coactivator activity	1.53e-01	1.00e+00	2.605	1	24	237
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	9	291
GO:0004674	protein serine/threonine kinase activity	1.94e-01	1.00e+00	2.227	1	6	308
GO:0015031	protein transport	2.13e-01	1.00e+00	2.081	1	11	341
GO:0005524	ATP binding	2.25e-01	1.00e+00	1.152	2	31	1298
GO:0005925	focal adhesion	2.27e-01	1.00e+00	1.978	1	9	366
GO:0007155	cell adhesion	2.28e-01	1.00e+00	1.967	1	5	369
GO:0046982	protein heterodimerization activity	2.34e-01	1.00e+00	1.924	1	8	380
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.52e-01	1.00e+00	1.804	1	24	413
GO:0044267	cellular protein metabolic process	2.84e-01	1.00e+00	1.605	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.86e-01	1.00e+00	1.593	1	24	478
GO:0048471	perinuclear region of cytoplasm	2.98e-01	1.00e+00	1.523	1	8	502
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0005887	integral component of plasma membrane	4.70e-01	1.00e+00	0.700	1	10	888
GO:0008270	zinc ion binding	5.12e-01	1.00e+00	0.533	1	27	997
GO:0005730	nucleolus	7.01e-01	1.00e+00	-0.186	1	66	1641
GO:0070062	extracellular vesicular exosome	8.38e-01	1.00e+00	-0.735	1	57	2400
GO:0005886	plasma membrane	8.61e-01	1.00e+00	-0.840	1	49	2582

chia-Fav

int-snw-4076

Statistics

Genes (10)

Interactions (14)

Related GO terms (156)