int-snw-3184

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.117	1.05e-18	1.07e-05	2.28e-04

chia-screen-data-Fav-int-snw-3184 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
SYNCRIP	10492	9	-2.401	3.197	103	Yes	Yes
[ HNRNPD ]	3184	5	-2.153	3.117	123	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
ULK2	9706	9	-2.292	3.197	312	Yes	Yes

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
DDIT3	1649	HNRNPD	3184	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
HNRNPD	3184	ULK2	9706	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPD	3184	HNRNPU	3192	pp	--	int.Mint: MI:0915(physical association)
HNRNPU	3192	SYNCRIP	10492	pp	--	int.Mint: MI:0915(physical association)
SRSF3	6428	ULK2	9706	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPD	3184	SYNCRIP	10492	pp	--	int.I2D: HPRD, BCI; int.HPRD: in vivo
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	ULK2	9706	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
ULK2	9706	SYNCRIP	10492	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (118)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	9.82e-08	1.42e-03	3.544	7	64	1082
GO:0000398	mRNA splicing, via spliceosome	1.09e-06	1.57e-02	5.459	4	15	164
GO:0070934	CRD-mediated mRNA stabilization	2.69e-06	3.88e-02	9.494	2	2	5
GO:0006396	RNA processing	3.59e-06	5.18e-02	6.518	3	5	59
GO:0070937	CRD-mediated mRNA stability complex	4.03e-06	5.82e-02	9.231	2	3	6
GO:0008380	RNA splicing	4.05e-06	5.84e-02	4.983	4	22	228
GO:0003723	RNA binding	2.02e-05	2.91e-01	4.398	4	18	342
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0030529	ribonucleoprotein complex	2.48e-05	3.58e-01	5.594	3	5	112
GO:0044212	transcription regulatory region DNA binding	8.33e-05	1.00e+00	5.009	3	17	168
GO:0044822	poly(A) RNA binding	9.68e-05	1.00e+00	3.094	5	50	1056
GO:0042594	response to starvation	1.24e-04	1.00e+00	6.862	2	4	31
GO:0010467	gene expression	2.77e-04	1.00e+00	3.430	4	45	669
GO:0000166	nucleotide binding	3.00e-04	1.00e+00	4.384	3	13	259
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0071013	catalytic step 2 spliceosome	7.92e-04	1.00e+00	5.531	2	7	78
GO:0005515	protein binding	9.24e-04	1.00e+00	1.260	8	198	6024
GO:0001649	osteoblast differentiation	1.10e-03	1.00e+00	5.293	2	5	92
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0060242	contact inhibition	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006355	regulation of transcription, DNA-templated	1.27e-03	1.00e+00	2.855	4	43	997
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0097167	circadian regulation of translation	2.22e-03	1.00e+00	8.816	1	1	4
GO:0097452	GAIT complex	2.22e-03	1.00e+00	8.816	1	1	4
GO:0034273	ATG1/UKL1 signaling complex	2.22e-03	1.00e+00	8.816	1	1	4
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0048671	negative regulation of collateral sprouting	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006974	cellular response to DNA damage stimulus	2.93e-03	1.00e+00	4.578	2	7	151
GO:0071204	histone pre-mRNA 3'end processing complex	3.32e-03	1.00e+00	8.231	1	1	6
GO:0003714	transcription corepressor activity	4.04e-03	1.00e+00	4.340	2	11	178
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0005829	cytosol	5.45e-03	1.00e+00	1.853	5	86	2496
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0042162	telomeric DNA binding	6.09e-03	1.00e+00	7.357	1	1	11
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0034045	pre-autophagosomal structure membrane	6.64e-03	1.00e+00	7.231	1	2	12
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0008143	poly(A) binding	6.64e-03	1.00e+00	7.231	1	2	12
GO:0071480	cellular response to gamma radiation	7.19e-03	1.00e+00	7.116	1	1	13
GO:0043488	regulation of mRNA stability	7.19e-03	1.00e+00	7.116	1	1	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0006401	RNA catabolic process	7.74e-03	1.00e+00	7.009	1	1	14
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0043274	phospholipase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0048675	axon extension	1.16e-02	1.00e+00	6.424	1	2	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	2	22
GO:0071346	cellular response to interferon-gamma	1.27e-02	1.00e+00	6.293	1	1	23
GO:0010506	regulation of autophagy	1.27e-02	1.00e+00	6.293	1	2	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:0035329	hippo signaling	1.43e-02	1.00e+00	6.116	1	5	26
GO:0000045	autophagic vacuole assembly	1.43e-02	1.00e+00	6.116	1	2	26
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0005634	nucleus	1.49e-02	1.00e+00	1.247	6	159	4559
GO:1903507	negative regulation of nucleic acid-templated transcription	1.76e-02	1.00e+00	5.816	1	2	32
GO:0042752	regulation of circadian rhythm	2.03e-02	1.00e+00	5.607	1	3	37
GO:0006366	transcription from RNA polymerase II promoter	2.10e-02	1.00e+00	3.105	2	30	419
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0017148	negative regulation of translation	2.20e-02	1.00e+00	5.494	1	2	40
GO:0031124	mRNA 3'-end processing	2.31e-02	1.00e+00	5.424	1	2	42
GO:0045727	positive regulation of translation	2.42e-02	1.00e+00	5.357	1	2	44
GO:0003677	DNA binding	2.44e-02	1.00e+00	2.151	3	49	1218
GO:0006369	termination of RNA polymerase II transcription	2.47e-02	1.00e+00	5.324	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0045893	positive regulation of transcription, DNA-templated	2.69e-02	1.00e+00	2.915	2	24	478
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0006406	mRNA export from nucleus	3.33e-02	1.00e+00	4.885	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0030659	cytoplasmic vesicle membrane	5.47e-02	1.00e+00	4.158	1	2	101
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.72e-02	1.00e+00	2.192	2	41	789
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0046777	protein autophosphorylation	8.44e-02	1.00e+00	3.512	1	4	158
GO:0016607	nuclear speck	9.15e-02	1.00e+00	3.390	1	12	172
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	9.76e-02	1.00e+00	3.293	1	22	184
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	8	223
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	24	237
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	8	247
GO:0005524	ATP binding	1.58e-01	1.00e+00	1.474	2	31	1298
GO:0004674	protein serine/threonine kinase activity	1.59e-01	1.00e+00	2.549	1	6	308
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	20	474
GO:0016020	membrane	2.37e-01	1.00e+00	1.101	2	46	1681
GO:0016032	viral process	2.61e-01	1.00e+00	1.755	1	26	534
GO:0005783	endoplasmic reticulum	2.70e-01	1.00e+00	1.697	1	13	556
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	124	3767
GO:0007165	signal transduction	4.05e-01	1.00e+00	0.991	1	13	907
GO:0006351	transcription, DNA-templated	5.71e-01	1.00e+00	0.318	1	57	1446
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	66	1641
GO:0070062	extracellular vesicular exosome	7.67e-01	1.00e+00	-0.413	1	57	2400

chia-Fav

int-snw-3184

Statistics

Genes (8)

Interactions (12)

Related GO terms (118)